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morphology AND histology AND vessels

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https://www.readbyqxmd.com/read/28343356/development-of-a-novel-strategy-to-target-cd39-antithrombotic-activity-to-the-endothelial-platelet-microenvironment-in-kidney-ischemia-reperfusion-injury
#1
Maithili Sashindranath, Karen M Dwyer, Shala Dezfouli, Carly Selan, Sandra Crikis, Bo Lu, Yuping Yuan, Michael J Hickey, Karlheinz Peter, Simon C Robson, Peter J Cowan, Harshal H Nandurkar
Kidney ischemia-reperfusion injury (IRI) is common during transplantation. IRI is characterised by inflammation and thrombosis and associated with acute and chronic graft dysfunction. P-selectin and its ligand PSGL-1 are cell adhesion molecules that control leukocyte-endothelial and leukocyte-platelet interactions under inflammatory conditions. CD39 is the dominant vascular nucleotidase that facilitates adenosine generation via extracellular ATP/ADP-phosphohydrolysis. Adenosine signalling is protective in renal IRI, but CD39 catalytic activity is lost with exposure to oxidant stress...
March 25, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28339395/effect-of-ovariectomy-and-sideritis-euboea-extract-administration-on-large-artery-mechanics-morphology-and-structure-in-middle-aged-rats
#2
Dimitrios P Sokolis, Constantinos A Dimitriou, Pavlos Lelovas, Nikolaos G Kostomitsopoulos, Ismene A Dontas
BACKGROUND: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea". METHODS: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups...
March 20, 2017: Biorheology
https://www.readbyqxmd.com/read/28333368/morphological-specializations-of-the-yolk-sac-for-yolk-processing-in-embryonic-corn-snakes-pantherophis-guttatus-colubridae
#3
Kathryn G Powers, Daniel G Blackburn
Non-avian reptiles commonly are assumed to be like birds in their overall patterns of development. However, colubrid corn snakes (Pantherophis guttatus) have mechanisms of yolk cellularization and processing that are entirely different from the avian pattern. In birds, a vascular "yolk sac" surrounds and digests the liquid yolk. In contrast, in corn snakes, the yolk material is converted into vascularized cords of yolk-filled cells. In this study, we used stereomicroscopy, histology, and scanning electron microscopy to analyze this unusual developmental pattern in corn snakes...
March 23, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28325446/segmentation-of-elastic-fibres-in-images-of-vessel-wall-sections-stained-with-weigert-s-resorcin-fuchsin
#4
Pablo Hernández-Morera, Carlos M Travieso-González, Irene Castaño-González, Blanca Mompeó-Corredera, Francisco Ortega-Santana
BACKGROUND AND OBJECTIVE: The elastic fibres are an essential component of the extracellular matrix in blood vessel walls that allows a long-range of deformability and passive recoil without energy input. The quantitative determination of elastic fibres will provide information on the state of the vascular wall and to determine the role and behaviour of this key structural element in different physiological and pathological vascular processes. METHODS: We present a segmentation method to identify and quantify elastic fibres based on a local threshold technique and some morphological characteristics measured on the segmented objects that facilitate the discrimination between elastic fibres and other image components...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28304220/high-resolution-magnetic-resonance-imaging-of-carotid-atherosclerotic-plaques-a-correlation-study-with-histopathology
#5
Zhangyong Xia, Hua Yang, Xiaochun Yuan, Jiyue Wang, Shigang Zhang, Liyong Zhang, Yang Qu, Jun Chen, Liqun Jiao, Le-Xin Wang, Yifeng Du
BACKGROUND: This study aimed to utilize high-resolution magnetic resonance imaging (MRI) to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. PATIENTS AND METHODS: High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fibrous cap rupture...
March 17, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28301852/high-fat-diet-in-the-absence-of-obesity-does-not-aggravate-surgically-induced-lymphoedema-in-mice
#6
Epameinondas Gousopoulos, Sinem Karaman, Steven T Proulx, Kristin Leu, Dorina Buschle, Michael Detmar
BACKGROUND: Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model...
March 17, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28295009/-refractory-form-of-orbital-granulomatosis-with-polyangiitis-a-clinical-and-morphological-study
#7
E A Kogan, Ya O Grusha, D S Ismailova, P I Novikov, Yu V Abramova, A D Meshkov, E F Rizopulu
Orbital granulomatosis with polyangiitis (Wegener's granulomatosis, GPA), which is characterized by granulomatous inflammation with small-vessel vasculitis, can develop in local and generalized forms of the disease. The introduction of current immunosuppressive therapy regimens has improved the prognosis of the disease; however, there are immunosuppressive treatment-refractory forms of GPA, the morphology of which has been inadequately investigated. The paper describes a clinical case of refractory GPA involving the orbit, as evidenced by histological and immunohistochemical examinations...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28295004/-serrated-adenomas-of-the-colon-clinical-morphological-and-molecular-genetic-characteristics
#8
L M Mikhaleva, R A Komleva, A E Biryukov, N K Shakhpazyan
AIM: to investigate the clinical, morphological, and molecular genetic characteristics of serrated adenomas of the colon. MATERIAL AND METHODS: The study included 82 colon adenomas from 63 patients aged 29 to 81 years, who underwent colonoscopy with biopsy or polypectomy. The mean age of men was 63.3 years; that of women was 56.8 years. Comprehensive clinical, morphological, immunohistochemical, and molecular genetic examinations were made. RESULTS: The histological examination showed that sessile serrated adenomas (SSA) of the colon were most common (46...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28282429/high-altitude-hypoxia-as-a-factor-that-promotes-tibial-growth-plate-development-in-broiler-chickens
#9
Shucheng Huang, Lihong Zhang, Mujeeb Ur Rehman, Muhammad Kashif Iqbal, Yanfang Lan, Khalid Mehmood, Hui Zhang, Gang Qiu, Fazul Nabi, Wangyuan Yao, Meng Wang, Jiakui Li
Tibial dyschondroplasia (TD) is one of the most common problems in the poultry industry and leads to lameness by affecting the proximal growth plate of the tibia. However, due to the unique environmental and geographical conditions of Tibet, no case of TD has been reported in Tibetan chickens (TBCs). The present study was designed to investigate the effect of high altitude hypoxia on blood parameters and tibial growth plate development in chickens using the complete blood count, morphology, and histological examination...
2017: PloS One
https://www.readbyqxmd.com/read/28257867/cobalamin-supplementation-during-in%C3%A2-vitro-maturation-improves-developmental-competence-of-sheep-oocytes
#10
Federica Zacchini, Paola Toschi, Grazyna Ewa Ptak
Pregnancies obtained by Assisted Reproductive Technologies are at higher risk of miscarriage than those obtained naturally. Previously, we reported impaired placental vascular development of in vitro produced (IVP) sheep embryos and defective DNA methylation in the placentae of those embryos. One reason behind these observed defects may be an impaired One Carbon Metabolism (OCM) The present study was performed to test the hypothesis that Cobalamin (Vitamin B12, an important OCM co-factor) supplementation during IVM corrects DNA methylation of IVP embryos and, consequently, ameliorates placental vasculogenesis...
April 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28252205/oxidative-damage-and-nitric-oxide-synthase-induction-by-surgical-uteroplacental-circulation-restriction-in-the-rabbit-fetal-heart
#11
Horacio Figueroa, Cristobal Alvarado, Jorge Cifuentes, Mauricio Lozano, Jocelyn Rocco, Claudia Cabezas, Sebastian Illanes, Elisenda Eixarch, Edgar Hernández-Andrade, Eduard Gratacós, Carlos E Irarrazabal
OBJECTIVE: This study investigated the role of oxidative damage and nitric oxide (NO) synthases in the fetal heart using a model of intrauterine growth restriction (IUGR) induced by uteroplacental circulation restriction (UCR). METHODS: New Zealand white rabbits kept under 12 hr light cycles, with food and water provided ad libitum, were subjected at day 25 of pregnancy to 40%-50% uteroplacental artery ligation. We analyzed the gene expression of enzymes linked to nitric oxide synthesis (iNOS, eNOS, HO-1, and ARG-2), HIF-1α and the state of oxidative stress (protein carbonyl levels) in fetal heart homogenates...
March 2, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28218397/segmentation-of-digitized-histological-sections-for-quantification-of-the-muscularized-vasculature-in-the-mouse-hind-limb
#12
Yiwen Xu, J Geoffrey Pickering, Zengxuan Nong, Aaron D Ward
Immunohistochemical tissue staining enhances microvasculature characteristics, including the smooth muscle in the medial layer of the vessel walls that is responsible for regulation of blood flow. The vasculature can be imaged in a comprehensive fashion using whole-slide scanning. However, since each such image potentially contains hundreds of small vessels, manual vessel delineation and quantification is not practically feasible. In this work, we present a fully automatic segmentation and vasculature quantification algorithm for whole-slide images...
February 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28203394/structural-features-of-bone-marrow
#13
REVIEW
Anatolii Romaniuk, Yuliia Lyndina, Vladyslav Sikora, Mykola Lyndin, Ludmyla Karpenko, Oksana Gladchenko, Igor Masalitin
PURPOSE: This article is devoted to the investigation of the structural features of the bone marrow of mature rats. MATERIALS AND METHODS: The investigation of the structural features of the bone marrow was performed on the femurs of the mature male rats. General structure of the organ was studied with hematoxylin-eosin and Van Gieson staining of samples. Certain features of the bone marrow structure were studied using immunohistochemical method (CD3, CD79α, S100, myeloperoxidase, and cyclin D1)...
September 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28197783/freezing-nitrogen-ethanol-composite-may-be-a-viable-approach-for-cryotherapy-of-human-giant-cell-tumor-of-bone
#14
Po-Kuei Wu, Cheng-Fong Chen, Jir-You Wang, Paul Chih-Hsueh Chen, Ming-Chau Chang, Shih-Chieh Hung, Wei-Ming Chen
BACKGROUND: Liquid nitrogen has been used as adjuvant cryotherapy for treating giant cell tumor (GCT) of bone. However, the liquid phase and ultrafreezing (-196° C) properties increase the risk of damage to the adjacent tissues and may lead to perioperative complications. A novel semisolid cryogen, freezing nitrogen ethanol composite, might mitigate these shortcomings because of less-extreme freezing. We therefore wished to evaluate freezing nitrogen ethanol composite as a coolant to determine its properties in tumor cryoablation...
February 14, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28186882/multi-modality-imaging-enables-detailed-hemodynamic-simulations-in-dissecting-aneurysms-in-mice
#15
Evan Phillips, Paolo Di Achille, Matthew Bersi, Jay Humphrey, Craig Goergen
A multi-modality imaging based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting abdominal aortic aneurysms induced in male apolipoprotein E-null mice by high-dose angiotensin II infusion...
February 6, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28178293/%C3%AE-ct-of-ex-vivo-stained-mouse-hearts-and-embryos-enables-a-precise-match-between-3d-virtual-histology-classical-histology-and-immunochemistry
#16
Christian Dullin, Roser Ufartes, Emanuel Larsson, Sabine Martin, Marcio Lazzarini, Giuliana Tromba, Jeannine Missbach-Guentner, Diana Pinkert-Leetsch, Dörthe M Katschinski, Frauke Alves
The small size of the adult and developing mouse heart poses a great challenge for imaging in preclinical research. The aim of the study was to establish a phosphotungstic acid (PTA) ex-vivo staining approach that efficiently enhances the x-ray attenuation of soft-tissue to allow high resolution 3D visualization of mouse hearts by synchrotron radiation based μCT (SRμCT) and classical μCT. We demonstrate that SRμCT of PTA stained mouse hearts ex-vivo allows imaging of the cardiac atrium, ventricles, myocardium especially its fibre structure and vessel walls in great detail and furthermore enables the depiction of growth and anatomical changes during distinct developmental stages of hearts in mouse embryos...
2017: PloS One
https://www.readbyqxmd.com/read/28169309/correlative-imaging-of-the-murine-hind-limb-vasculature-and-muscle-tissue-by-microct-and-light-microscopy
#17
Laura Schaad, Ruslan Hlushchuk, Sébastien Barré, Roberto Gianni-Barrera, David Haberthür, Andrea Banfi, Valentin Djonov
A detailed vascular visualization and adequate quantification is essential for the proper assessment of novel angiomodulating strategies. Here, we introduce an ex vivo micro-computed tomography (microCT)-based imaging approach for the 3D visualization of the entire vasculature down to the capillary level and rapid estimation of the vascular volume and vessel size distribution. After perfusion with μAngiofil®, a novel polymerizing contrast agent, low- and high-resolution scans (voxel side length: 2.58-0.66 μm) of the entire vasculature were acquired...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164558/increased-number-of-mast-cells-in-atherosclerotic-lesions-correlates-with-the-presence-of-myeloid-but-not-plasmacytoid-dendritic-cells-as-well-as-pro-inflammatory-t-cells
#18
Ilonka Rohm, Sandra Sattler, Yevgeniya Atiskova, Daniel Kretzschmar, Rudin Pistulli, Marcus Franz, Christian Jung, Gita Mall, Thomas Kronert, Paul C Schulze, Atilla Yilmaz
BACKGROUND: Atherosclerosis is an inflammatory disease of the vessel wall promoted by different immune cells and inflammatory mediators. METHODS: In this study, 26 human plaques and 12 control vessels without atherosclerosis were immunohistochemically stained to analyze the emergence of mast cells dependent on plaque morphology and to correlate mast cell occurrence with the emergence of myeloid as well as plasmacytoid dendritic cells. Also, mast cell emergence was correlated with the number of pro-inflammatory T cells...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28150849/from-thrombosis-to-fibrosis-in-chronic-thromboembolic-pulmonary-hypertension
#19
Magdalena L Bochenek, Nico S Rosinus, Mareike Lankeit, Lukas Hobohm, Felix Bremmer, Eva Schütz, Frederikus A Klok, Sven Horke, Christoph B Wiedenroth, Thomas Münzel, Irene M Lang, Eckhard Mayer, Stavros Konstantinides, Katrin Schäfer
The pathomechanisms underlying the development of thrombofibrotic pulmonary artery occlusions in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) are largely unknown. The aim of this study was to allocate distinct cellular processes playing a role in thrombus resolution, such as inflammation, hypoxia, proliferation, apoptosis and angiogenesis, to different stages of thrombofibrotic remodelling. A total of 182 pulmonary endarterectomy (PEA) specimens were collected from 31 CTEPH patients. To facilitate co-localisation, Tissue MicroArrays were prepared and processed for (immuno)-histochemistry and confocal fluorescence microscopy...
February 2, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28150291/presence-of-multiple-coronary-angiographic-characteristics-for-the-diagnosis-of-acute-coronary-thrombus
#20
Alok R Amraotkar, Shahab Ghafghazi, Patrick J Trainor, Charles W Hargis, Affan B Irfan, Shesh N Rai, Aruni Bhatnagar, Andrew P DeFilippis
BACKGROUND: Coronary angiography is frequently employed to aid in the diagnosis of acute coronary thrombosis, but there is limited data to support its efficacy. The aim of the study was to evaluate sensitivity and specificity of five commonly used angiographic characteristics for diagnosis of acute coronary thrombosis: Ambrose complex lesion morphology; spherical, ovoid, or irregular filling defect; abrupt vessel cutoff; intraluminal staining; and any coronary filling defect. METHODS: Coronary angiography of 80 acute myocardial infarction or stable coronary artery disease subjects were assessed in blinded fashion, for the presence or absence of five angiographic characteristics...
2017: Cardiology Journal
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