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morphology AND histology AND vessels

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https://www.readbyqxmd.com/read/27864704/a-clinicopathologic-study-of-extraventricular-neurocytoma
#1
Li Xu, Zhaolian Ouyang, Junmei Wang, Zhaoxia Liu, Jingyi Fang, Jiang Du, Yanjiao He, Guilin Li
In 2007, extraventricular neurocytoma was classified as a separate entity among glioneuronal tumors. However, extraventricular neurocytoma is not fully understood and may be misdiagnosed. Here, we describe the clinical and pathological features, prognoses, and treatments of 13 extraventricular neurocytoma cases, and compare their immunophenotypes with those of oligodendroglioma, diffuse astrocytoma, and ependymoma. Six typical and 7 atypical cases comprised the 13 extraventricular neurocytoma cases. Histological features included oligodendroglioma-like perinuclear halo, neuropil-like matrix, ganglion or ganglioid cells, perivascular pseudorosettes, vessel hyalinization, calcifications, and myxoid degeneration...
November 18, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27836896/reduced-nitric-oxide-bioavailability-mediates-cerebroarterial-dysfunction-independent-of-cerebral-amyloid-angiopathy-in-a-mouse-model-of-alzheimer-s-disease
#2
Mario Merlini, Yi Shi, Stephan Keller, Gianluigi Savarese, Alexander Akhmedov, Rebecca Derungs, Remo Daniel Spescha, Luka Kulic, Roger Nitsch, Thomas Lüscher, Giovanni Camici
In Alzheimer's disease (AD), cerebral arteries, in contrast to cerebral microvessels, show both cerebral amyloid angiopathy- (CAA) dependent and -independent vessel wall pathology. However, it remains unclear whether CAA-independent vessel wall pathology affects arterial function thereby chronically reducing cerebral perfusion, and if so which mechanisms mediate this effect. To this end, we assessed the ex vivo vascular function of the basilar artery and a similar-sized peripheral artery (femoral artery) in the Swedish-Arctic (SweArc) transgenic AD mouse model at different disease stages...
November 11, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27819873/hydrophilic-polymer-associated-ischemic-enterocolitis
#3
Jesus A Chavez, Wei Chen, Wendy L Frankel, Christina A Arnold
Hydrophilic polymer coating of medical devices serves to lubricate the device and prevent device-related complications. The coating can be mechanically disrupted and result in downstream injury via presumed thromboembolism. This process has been reported in the brain, heart, lung, and skin, and has been replicated through animal studies and in vitro histologic processing of the polymer coating. We report the first description of hydrophilic polymer-associated ischemic enterocolitis in a series of 7 specimens (small bowel=2, colon=4, aortic thrombus=1) from 3 patients...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27814787/relation-between-renal-function-and-coronary-plaque-morphology-from-the-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-virtual-histology-intravascular-ultrasound-substudy
#4
Chee Yang Chin, Gary S Mintz, Shigeo Saito, Bernhard Witzenbichler, D Christopher Metzger, Michael J Rinaldi, Ernest L Mazzaferri, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Claire Litherland, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
We sought to examine the relation between various degrees of renal function and coronary plaque morphology by grayscale and virtual histology intravascular ultrasound (IVUS). ADAPT-DES was a prospective, multicenter registry of 8,582 consecutive patients treated using coronary drug-eluting stents with a prespecified grayscale and virtual histology-IVUS substudy. A lesion-level analysis of study participants was performed by comparing IVUS parameters of culprit and nonculprit lesions across tertiles of estimated creatinine clearance (CrCl)...
October 7, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27810998/postnatal-deletion-of-podoplanin-in-lymphatic-endothelium-results-in-blood-filling-of-the-lymphatic-system-and-impairs-dendritic-cell-migration-to-lymph-nodes
#5
Roberta Bianchi, Erica Russo, Samia B Bachmann, Steven T Proulx, Marko Sesartic, Nora Smaadahl, Steve P Watson, Christopher D Buckley, Cornelia Halin, Michael Detmar
OBJECTIVE: The lymphatic vascular system exerts major physiological functions in the transport of interstitial fluid from peripheral tissues back to the blood circulation and in the trafficking of immune cells to lymph nodes. Previous studies in global constitutive knockout mice for the lymphatic transmembrane molecule podoplanin reported perinatal lethality and a complex phenotype with lung abnormalities, cardiac defects, lymphedema, blood-filled lymphatic vessels, and lack of lymph node organization, reflecting the importance of podoplanin expression not only by the lymphatic endothelium but also by a variety of nonendothelial cell types...
November 3, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27806099/plaque-vulnerability-as-assessed-by-radiofrequency-intravascular-ultrasound-in-patients-with-valvular-calcification
#6
Nagendra Boopathy Senguttuvan, Sharath Kumar, Wang-Soo Lee, Sundeep Mishra, Jun Hwan Cho, Jee Eun Kwon, Seong Hyeop Hyeon, Yun Sang Jeong, Hoyoun Won, Seung Yong Shin, Kwang Je Lee, Tae Ho Kim, Chee Jeong Kim, Sang-Wook Kim
BACKGROUND: Cardiac valvular calcification is associated with the overall coronary plaque burden and considered an independent cardiovascular risk and prognostic factor. The purpose of this study was to evaluate the relationship between the presence of valvular calcification and plaque morphology and/or vulnerability. METHODS: Transthoracic echocardiography was used to assess valvular calcification in 280 patients with coronary artery disease who underwent radiofrequency intravascular ultrasound (Virtual Histology IVUS, VH-IVUS)...
2016: PloS One
https://www.readbyqxmd.com/read/27804942/-morphometric-and-molecular-biological-features-of-femoral-head-tissue-in-different-nosological-entities-of-coxarthrosis
#7
D A Davydov, A M Avdalyan, V V Agadzhanyan, E L Lushnikova, I M Ust'yantseva
AIM: to comparatively analyze the morphometric and molecular biological characteristics of femoral head tissue in different nosological entities of coxarthrosis. MATERIAL AND METHODS: A total of 95 samples of femoral head tissue extirpated during hip endoprosthesis in patients with coxarthrosis were investigated. Clinical findings were used to identify the following nosological entities of coxarthrosis: dysplastic, postischemic and posttraumatic. Histological, immunohistochemical and morphometric studies were used...
2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27760611/-clinicopathologic-analysis-of-anastomosing-hemangioma-of-the-kidney-and-adrenal-gland
#8
M Zhao, M Kong, J J Yu, X L He, D H Zhang, X D Teng
Objective: To investigate the clinical and histopathologic characteristics, diagnosis, differential diagnosis and prognostic features of anastomosing hemangioma. Methods: Five cases of anastomosing hemangioma of the kidney and adrenal gland were collected, the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed with review of literature. Results: Three patients were male and two were female with ages ranging from 47 to 77 years; three were located in adrenal gland and 2 originated from the kidney...
October 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27751893/optical-coherence-tomography-based-microangiography-provides-an-ability-to-longitudinally-image-arteriogenesis-in-vivo
#9
Yuandong Li, Woo June Choi, Wan Qin, Utku Baran, Lauren M Habenicht, Ruikang K Wang
BACKGROUND: Arteriogenesis describes the active growth of the pre-existing collateral arterioles, which is a crucial tissue-saving process in occlusive vascular diseases. NEW METHOD: We propose to use optical coherence tomography (OCT)-based microangiography (OMAG) to monitor arteriogenesis following artery transection in mouse ear and focal stroke in mouse brain. RESULTS: Our longitudinal mouse ear study shows that the growth phase of arteriogenesis, indicated by changes in collateral vessel diameter and velocity, occurs between 12 and 24h after vessel transection...
December 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27751875/the-valley-sign-in-small-and-diminutive-adenomas-prevalence-interobserver-agreement-and-validation-as-an-adenoma-marker
#10
Douglas K Rex, Prasanna Ponugoti, Charles Kahi
BACKGROUND: Classification schemes for differentiation of conventional colorectal adenomas from serrated lesions rely on patterns of blood vessels and pits. Morphologic features have not been validated as predictors of histology. AIM: Describe the prevalence of the "valley sign" and validate it as a marker of conventional adenomas METHODS: Three experts judged the prevalence of the valley sign in 301 consecutive small adenomas. Medical students were taught to recognize the valley and tested on their recognition of the valley sign...
October 14, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27720318/heterogeneous-histomorphology-yet-homogeneous-vascular-smooth-muscle-cell-dedifferentiation-characterize-human-aneurysm-disease
#11
Albert Busch, Elena Hartmann, Caroline Grimm, Süleyman Ergün, Ralph Kickuth, Christoph Otto, Richard Kellersmann, Udo Lorenz
OBJECTIVE: Abdominal aortic aneurysm (AAA) is a frequent, potentially life-threatening, disease that can only be treated by surgical means such as open surgery or endovascular repair. No alternative treatment is currently available, and despite expanding knowledge about the pathomechanism, clinical trials on medical aneurysm abrogation have led to inconclusive results. The heterogeneity of human AAA based on histologic examination is thereby generally neglected. In this study we aimed to further elucidate the role of these differences in aneurysm disease...
October 5, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27717363/content-based-analysis-of-ki-67-stained-meningioma-specimens-for-automatic-hot-spot-selection
#12
Zaneta Swiderska-Chadaj, Tomasz Markiewicz, Bartlomiej Grala, Malgorzata Lorent
BACKGROUND: Hot-spot based examination of immunohistochemically stained histological specimens is one of the most important procedures in pathomorphological practice. The development of image acquisition equipment and computational units allows for the automation of this process. Moreover, a lot of possible technical problems occur in everyday histological material, which increases the complexity of the problem. Thus, a full context-based analysis of histological specimens is also needed in the quantification of immunohistochemically stained specimens...
October 7, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27680942/large-scale-tissue-clearing-pact-technical-evaluation-and-new-perspectives-in-immunofluorescence-histology-and-ultrastructure
#13
Peter H Neckel, Ulrich Mattheus, Bernhard Hirt, Lothar Just, Andreas F Mack
Novel techniques, like CLARITY and PACT, render large tissue specimens transparent and thereby suitable for microscopic analysis. We used these techniques to evaluate their potential in the intestine as an exemplary organ with a complex tissue composition. Immunohistochemistry, light sheet-, and confocal scanning-microscopy enabled us to follow complex three-dimensional structures, like nerve fibers, vessels, and epithelial barriers throughout the entire organ. Moreover, in a systematic electron microscopic study, we analyzed the morphology and preservation of tissue on ultrastructural level during the clearing process...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27669342/traumatic-basal-subarachnoid-haemorrhage-or-ruptured-brain-aneurysm-in-16-year-old-boy-case-report
#14
R Skowronek, M Kobek, Z Jankowski, E Zielińska-Pająk, A Pałasz, J Pilch-Kowalczyk, R Kwarta, K Rygol, M Szczepański, C Chowaniec
Traumatic basal subarachnoid haemorrhage (TBSAH) represents only 1.8% of all subarachnoid haemorrhage cases diagnosed during autopsy. This report presents such a case from the current practice of the authors. Sixteen-year-old boy was beaten by the aggressors. Suddenly he lost his consciousness and fall after he received a single blow in the neck. He was resuscitated immediately, but died at the scene. During the external examination we did not find any significant external injuries. Autopsy revealed large contusion of right sternocleidomastoid muscle...
2016: Archiwum Medycyny Sa̧dowej i Kryminologii
https://www.readbyqxmd.com/read/27562394/nasal-polyp-an-incidental-paraganglioma
#15
Ruchi Srivastava, Neelam Wadhwa, Shikha Gupta, Urvashi Razdan
The nose is an uncommon site for head and neck paraganglioma. The diagnosis is seldom established pre-operatively; its rarity, infrequent functionality and often benign biologic outcome underlie this fact. We present one such case in a 60-year-old man who presented with right nasal obstruction and episodic epistaxis. Rhinoscopy revealed a fleshy polypoid mass arising from the anterior cartilaginous nasal septum. Imaging studies excluded extra-nasal extension. The tumor was highly vascular showing numerous variable sized, mostly thin walled branching blood vessels akin to stag-horn shape simulating a vascular neoplasm...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27529640/superb-microvascular-imaging-in-diagnosis-of-breast-lesions-a-comparative-study-with-contrast-enhanced-ultrasonographic-microvascular-imaging
#16
Xiao-Yun Xiao, Xin Chen, Xiao-Feng Guan, Huan Wu, Wei Qin, Bao-Ming Luo
OBJECTIVE: To evaluate the diagnostic performance of superb microvascular imaging (SMI) in breast lesions, comparing with contrast-enhanced ultrasonographic microvascular imaging (MVI). METHODS: From April to November 2015, 132 patients (with 132 breast lesions) were enrolled in the retrospective study. All lesions were evaluated with colour Doppler flow imaging (CDFI), colour SMI (cSMI), monochrome SMI (mSMI) and contrast-enhanced ultrasonographic MVI. Receiver-operating characteristic curve analysis was performed to compare the diagnostic performance of SMI and MVI for discrimination between benign and malignant breast lesions...
October 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27474892/multichannel-silk-protein-laminin-grafts-for-spinal-cord-injury-repair
#17
Qiang Zhang, Shuqin Yan, Renchuan You, David L Kaplan, Yu Liu, Jing Qu, Xiufang Li, Mingzhong Li, Xin Wang
The physical, chemical and bioactive cues provided by biomaterials are critical for spinal cord regeneration following injury. In this study, we investigated the bioactivity of a silk-based scaffold for nerve tissue remodeling that featured morphological guidance in the form of ridges as well as bioactive molecules. Multichannel/laminin (LN) silk scaffolds stimulated growth, development, and the extension of primary hippocampal neurons after 7 days of culture in vitro. And then, the multichannel/LN silk scaffolds were implanted into 2-mm-long hemisection defects in Sprague-Dawley rat spinal cords for 70 days to evaluate their bioactivities of spinal cord remolding...
July 30, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27446651/monitoring-the-primo-vascular-system-in-lymphatic-vessels-by-using-window-chambers
#18
Jungdae Kim, Dong-Hyun Kim, Sharon Jiyoon Jung, Hyun-Ji Gil, Seung Zhoo Yoon, Young-Il Kim, Kwang-Sup Soh
This study aims to develop a window chamber system in the skin of rats and to monitor the primo vascular system (PVS) inside the lymphatic vessels along the superficial epigastric vessels. The PVS in lymphatic vessels has been observed through many experiments under in vivo conditions, but monitoring the in vivo PVS in situ inside lymphatic vessels for a long time is difficult. To overcome the obstacles, we adapted the window chamber system for monitoring the PVS and Alcian blue (AB) staining dye solution for the contrast agent...
April 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27446279/preoperative-graft-assessment-in-aortocoronary-bypass-surgery
#19
Grigore Tinica, Cristina Luca Vartic, Veronica Mocanu, Dana Baran, Doina Butcovan
Coronary artery bypass graft (CABG) is a surgical procedure able to improve the blood supply to the myocardium. In the present study, the distal segments of grafts taken from the internal thoracic artery (ITA), radial artery (RA) and saphenous vein (SV) for use in aortocoronary bypass surgery were examined. The morphologies of the grafts were investigated in order to draw conclusions concerning their patency and viability. In addition, clinical and laboratory risk factors considered to be significant predictors of lesion severity in graft vessels used in CABGs were investigated...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27363062/effects-of-nicotine-on-rat-tongue-mucosa-histopathological-and-immunohistochemical-analyses
#20
Veysel Eratilla, Ibrahim Uysal, Engin Deveci, Rojdan Ferman Güneş, Elif Eratilla, Ismail Yildiz, Sevda Söker
OBJECTIVE: To evaluate the histopathological and immunohistochemical effects of systemically administered nicotine on rat tongue mucosa. STUDY DESIGN: Rats were assigned to one of two groups: the experimental group received nicotine systemically (nicotine sulphate 2 mg/kg subcutaneously daily for 28 days), while the rats in the control group were administered physiological saline (1.5 mL subcutaneously for 28 days). All animals were sacrificed at the end of the study, and tongue tissue samples were removed and prepared according to routine histological procedures...
February 2016: Analytical and Quantitative Cytopathology and Histopathology
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