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morphology AND histology AND vessels

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https://www.readbyqxmd.com/read/28099955/dermoscopy-of-granuloma-annulare-a-clinical-and-histological-correlation-study
#1
Enzo Errichetti, Aimilios Lallas, Zoe Apalla, Alessandro Di Stefani, Giuseppe Stinco
BACKGROUND: Dermoscopy of granuloma annulare has been investigated by several studies, but none of them took into account the variability of dermoscopic findings according to clinical characteristics and/or histological subtype. OBJECTIVE: To describe the dermoscopic features of classic granuloma annulare and seek possible dermoscopic clues related to specific clinical findings/histological subpatterns. METHODS: A representative dermoscopic image of a target lesion (the most active lesion underwent histological examination) was retrospectively assessed for the presence of specific morphological findings, correlating them with clinical variables, i...
January 19, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28094892/histological-features-of-the-vomeronasal-organ-in-the-giraffe-giraffa-camelopardalis
#2
Daisuke Kondoh, Kentaro G Nakamura, Yurie S Ono, Kazutoshi Yuhara, Gen Bando, Kenichi Watanabe, Noriyuki Horiuchi, Yoshiyasu Kobayashi, Motoki Sasaki, Nobuo Kitamura
The vomeronasal organ (VNO) that preferentially detects species-specific substances is diverse among animal species, and its morphological properties seem to reflect the ecological features of animals. This histological study of two female reticulated giraffes (Giraffa camelopardalis reticulata) found that the VNO is developed in giraffes. The lateral and medial regions of the vomeronasal lumen were covered with sensory and nonsensory epithelia, respectively. The vomeronasal glands were positive for periodic acid-Schiff and alcian blue (pH 2...
January 17, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28007877/mechanical-reperfusion-with-leucocyte-filtered-blood-does-not-prevent-injury-following-global-cerebral-ischaemia
#3
Rickard P F Lindblom, Thomas Tovedal, Bo Norlin, Lars Hillered, Svetlana N Popova, Irina Alafuzoff, Stefan Thelin
OBJECTIVES: Prolonged global cerebral ischaemia leads to irreversible injury, often with lethal outcome. Brain injuries are partly caused by the uncontrolled reperfusion that occurs once the circulation is re-established. Recent animal experiments suggest that controlled reperfusion following lengthy ischaemia might prevent severe brain injury. This study aimed at further exploring cerebral alterations and outcome following prolonged global cerebral ischaemia and mechanically manipulated reperfusion...
December 22, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27957815/evolution-of-graft-morphology-and-function-after-recellularization-of-decellularized-rat-livers
#4
Antje Butter, Khalid Aliyev, Karl-Herbert Hillebrandt, Nathanael Raschzok, Martin Kluge, Nicolai Seiffert, Peter Tang, Hendrik Napierala, Muhammad Imtiaz Ashraf, Anja Reutzel-Selke, Andreas Andreou, Johann Pratschke, Igor Maximilian Sauer, Benjamin Struecker
Decellularization of livers is a well-established procedure. Data on different reseeding techniques or the functional evolution and re-organization processes of repopulated grafts remains limited. We established a proprietary, customized bioreactor to repopulate decellularized rat livers (n = 21) with primary rat hepatocytes (150 x 10(6) cells) via the hepatic artery and to subsequently evaluate graft morphology and function during seven days of ex vivo perfusion. Grafts were analyzed at 1 h, 6 h, 12 h, 24 h, 3d, 5d and 7d after recellularization (all n = 3) by immuno-histologic evaluation, hepatocyte-related enzyme (AST, ALT, LDH) and albumin measurement in the perfusate...
December 13, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27956273/high-endothelial-venule-like-vessels-and-lymphocyte-recruitment-in-diffuse-sclerosing-variant-of-papillary-thyroid-carcinoma
#5
Shulin Low, Yasuhiro Sakai, Hitomi Hoshino, Mitsuyoshi Hirokawa, Hiroto Kawashima, Kayoko Higuchi, Yoshiaki Imamura, Motohiro Kobayashi
Diffuse sclerosing variant of papillary thyroid carcinoma (DSPTC) is a rare subtype of papillary thyroid carcinoma with a high incidence of lymph node metastasis. One of its characteristic histological features is the presence of dense lymphocyte infiltrates; however, how these lymphocytes are recruited in this pathological setting remains unclear. Here, we analysed 17 DSPTC cases immunohistologically for cell adhesion molecules expressed on endothelial cells. We found that venules morphologically similar to high endothelial venules (HEVs) in secondary lymphoid organs were induced in lymphoid aggregates in DSPTC, and such HEV-like vessels expressed 6-sulfo sialyl Lewis X (sLeX) glycans as well as intercellular adhesion molecule 1 (ICAM-1)...
December 2016: Pathology
https://www.readbyqxmd.com/read/27919850/detection-and-differentiation-of-early-hepatocellular-carcinoma-from-cirrhosis-using-ct-perfusion-in-a-rat-liver-model
#6
Jin-Ping Li, Guang-Long Feng, Da-Qing Li, Hai-Bo Wang, De-Li Zhao, Yong Wan, Hui-Jie Jiang
BACKGROUND: Functional imaging such as CT perfusion can detect morphological and hemodynamic changes in hepatocellular carcinoma (HCC). Pre-carcinoma and early HCC nodules are difficult to differentiate by observing only their hemodynamics changes. The present study aimed to investigate hemodynamic parameters and evaluate their differential diagnostic cut-off between pre-carcinoma and early HCC nodules using CT perfusion and receiver operating characteristic (ROC) curves. METHODS: Male Wistar rats were randomly divided into control (n=20) and experimental (n=70) groups...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27864704/a-clinicopathologic-study-of-extraventricular-neurocytoma
#7
Li Xu, Zhaolian Ouyang, Junmei Wang, Zhaoxia Liu, Jingyi Fang, Jiang Du, Yanjiao He, Guilin Li
In 2007, extraventricular neurocytoma was classified as a separate entity among glioneuronal tumors. However, extraventricular neurocytoma is not fully understood and may be misdiagnosed. Here, we describe the clinical and pathological features, prognoses, and treatments of 13 extraventricular neurocytoma cases, and compare their immunophenotypes with those of oligodendroglioma, diffuse astrocytoma, and ependymoma. Six typical and 7 atypical cases comprised the 13 extraventricular neurocytoma cases. Histological features included oligodendroglioma-like perinuclear halo, neuropil-like matrix, ganglion or ganglioid cells, perivascular pseudorosettes, vessel hyalinization, calcifications, and myxoid degeneration...
November 18, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27836896/reduced-nitric-oxide-bioavailability-mediates-cerebroarterial-dysfunction-independent-of-cerebral-amyloid-angiopathy-in-a-mouse-model-of-alzheimer-s-disease
#8
Mario Merlini, Yi Shi, Stephan Keller, Gianluigi Savarese, Alexander Akhmedov, Rebecca Derungs, Remo Daniel Spescha, Luka Kulic, Roger M Nitsch, Thomas F Lüscher, Giovanni G Camici
In Alzheimer's disease (AD), cerebral arteries, in contrast to cerebral microvessels, show both cerebral amyloid angiopathy- (CAA) dependent and -independent vessel wall pathology. However, it remains unclear whether CAA-independent vessel wall pathology affects arterial function thereby chronically reducing cerebral perfusion, and if so which mechanisms mediate this effect. To this end, we assessed the ex vivo vascular function of the basilar artery and a similar-sized peripheral artery (femoral artery) in the Swedish-Arctic (SweArc) transgenic AD mouse model at different disease stages...
November 11, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27819873/hydrophilic-polymer-associated-ischemic-enterocolitis
#9
Jesus A Chavez, Wei Chen, Wendy L Frankel, Christina A Arnold
Hydrophilic polymer coating of medical devices serves to lubricate the device and prevent device-related complications. The coating can be mechanically disrupted and result in downstream injury via presumed thromboembolism. This process has been reported in the brain, heart, lung, and skin, and has been replicated through animal studies and in vitro histologic processing of the polymer coating. We report the first description of hydrophilic polymer-associated ischemic enterocolitis in a series of 7 specimens (small bowel=2, colon=4, aortic thrombus=1) from 3 patients...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27814787/relation-between-renal-function-and-coronary-plaque-morphology-from-the-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-virtual-histology-intravascular-ultrasound-substudy
#10
Chee Yang Chin, Gary S Mintz, Shigeo Saito, Bernhard Witzenbichler, D Christopher Metzger, Michael J Rinaldi, Ernest L Mazzaferri, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Claire Litherland, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
We sought to examine the relation between various degrees of renal function and coronary plaque morphology by grayscale and virtual histology intravascular ultrasound (IVUS). ADAPT-DES was a prospective, multicenter registry of 8,582 consecutive patients treated using coronary drug-eluting stents with a prespecified grayscale and virtual histology-IVUS substudy. A lesion-level analysis of study participants was performed by comparing IVUS parameters of culprit and nonculprit lesions across tertiles of estimated creatinine clearance (CrCl)...
January 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27810998/postnatal-deletion-of-podoplanin-in-lymphatic-endothelium-results-in-blood-filling-of-the-lymphatic-system-and-impairs-dendritic-cell-migration-to-lymph-nodes
#11
Roberta Bianchi, Erica Russo, Samia B Bachmann, Steven T Proulx, Marko Sesartic, Nora Smaadahl, Steve P Watson, Christopher D Buckley, Cornelia Halin, Michael Detmar
OBJECTIVE: The lymphatic vascular system exerts major physiological functions in the transport of interstitial fluid from peripheral tissues back to the blood circulation and in the trafficking of immune cells to lymph nodes. Previous studies in global constitutive knockout mice for the lymphatic transmembrane molecule podoplanin reported perinatal lethality and a complex phenotype with lung abnormalities, cardiac defects, lymphedema, blood-filled lymphatic vessels, and lack of lymph node organization, reflecting the importance of podoplanin expression not only by the lymphatic endothelium but also by a variety of nonendothelial cell types...
January 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27806099/plaque-vulnerability-as-assessed-by-radiofrequency-intravascular-ultrasound-in-patients-with-valvular-calcification
#12
Nagendra Boopathy Senguttuvan, Sharath Kumar, Wang-Soo Lee, Sundeep Mishra, Jun Hwan Cho, Jee Eun Kwon, Seong Hyeop Hyeon, Yun Sang Jeong, Hoyoun Won, Seung Yong Shin, Kwang Je Lee, Tae Ho Kim, Chee Jeong Kim, Sang-Wook Kim
BACKGROUND: Cardiac valvular calcification is associated with the overall coronary plaque burden and considered an independent cardiovascular risk and prognostic factor. The purpose of this study was to evaluate the relationship between the presence of valvular calcification and plaque morphology and/or vulnerability. METHODS: Transthoracic echocardiography was used to assess valvular calcification in 280 patients with coronary artery disease who underwent radiofrequency intravascular ultrasound (Virtual Histology IVUS, VH-IVUS)...
2016: PloS One
https://www.readbyqxmd.com/read/27804942/-morphometric-and-molecular-biological-features-of-femoral-head-tissue-in-different-nosological-entities-of-coxarthrosis
#13
D A Davydov, A M Avdalyan, V V Agadzhanyan, E L Lushnikova, I M Ust'yantseva
AIM: to comparatively analyze the morphometric and molecular biological characteristics of femoral head tissue in different nosological entities of coxarthrosis. MATERIAL AND METHODS: A total of 95 samples of femoral head tissue extirpated during hip endoprosthesis in patients with coxarthrosis were investigated. Clinical findings were used to identify the following nosological entities of coxarthrosis: dysplastic, postischemic and posttraumatic. Histological, immunohistochemical and morphometric studies were used...
2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27760611/-clinicopathologic-analysis-of-anastomosing-hemangioma-of-the-kidney-and-adrenal-gland
#14
M Zhao, M Kong, J J Yu, X L He, D H Zhang, X D Teng
Objective: To investigate the clinical and histopathologic characteristics, diagnosis, differential diagnosis and prognostic features of anastomosing hemangioma. Methods: Five cases of anastomosing hemangioma of the kidney and adrenal gland were collected, the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed with review of literature. Results: Three patients were male and two were female with ages ranging from 47 to 77 years; three were located in adrenal gland and 2 originated from the kidney...
October 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27751893/optical-coherence-tomography-based-microangiography-provides-an-ability-to-longitudinally-image-arteriogenesis-in-vivo
#15
Yuandong Li, Woo June Choi, Wan Qin, Utku Baran, Lauren M Habenicht, Ruikang K Wang
BACKGROUND: Arteriogenesis describes the active growth of the pre-existing collateral arterioles, which is a crucial tissue-saving process in occlusive vascular diseases. NEW METHOD: We propose to use optical coherence tomography (OCT)-based microangiography (OMAG) to monitor arteriogenesis following artery transection in mouse ear and focal stroke in mouse brain. RESULTS: Our longitudinal mouse ear study shows that the growth phase of arteriogenesis, indicated by changes in collateral vessel diameter and velocity, occurs between 12 and 24h after vessel transection...
December 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27751875/the-valley-sign-in-small-and-diminutive-adenomas-prevalence-interobserver-agreement-and-validation-as-an-adenoma-marker
#16
Douglas K Rex, Prasanna Ponugoti, Charles Kahi
BACKGROUND AND AIMS: Classification schemes for differentiation of conventional colorectal adenomas from serrated lesions rely on patterns of blood vessels and pits. Morphologic features have not been validated as predictors of histology. The aim of this study was to describe the prevalence of the "valley sign" and validate it as a marker of conventional adenomas. METHODS: Three experts judged the prevalence of the valley sign in 301 consecutive small adenomas. Medical students were taught to recognize the valley and were tested on their recognition of the valley sign...
October 15, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27720318/heterogeneous-histomorphology-yet-homogeneous-vascular-smooth-muscle-cell-dedifferentiation-characterize-human-aneurysm-disease
#17
Albert Busch, Elena Hartmann, Caroline Grimm, Süleyman Ergün, Ralph Kickuth, Christoph Otto, Richard Kellersmann, Udo Lorenz
OBJECTIVE: Abdominal aortic aneurysm (AAA) is a frequent, potentially life-threatening, disease that can only be treated by surgical means such as open surgery or endovascular repair. No alternative treatment is currently available, and despite expanding knowledge about the pathomechanism, clinical trials on medical aneurysm abrogation have led to inconclusive results. The heterogeneity of human AAA based on histologic examination is thereby generally neglected. In this study we aimed to further elucidate the role of these differences in aneurysm disease...
October 5, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27717363/content-based-analysis-of-ki-67-stained-meningioma-specimens-for-automatic-hot-spot-selection
#18
Zaneta Swiderska-Chadaj, Tomasz Markiewicz, Bartlomiej Grala, Malgorzata Lorent
BACKGROUND: Hot-spot based examination of immunohistochemically stained histological specimens is one of the most important procedures in pathomorphological practice. The development of image acquisition equipment and computational units allows for the automation of this process. Moreover, a lot of possible technical problems occur in everyday histological material, which increases the complexity of the problem. Thus, a full context-based analysis of histological specimens is also needed in the quantification of immunohistochemically stained specimens...
October 7, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27680942/large-scale-tissue-clearing-pact-technical-evaluation-and-new-perspectives-in-immunofluorescence-histology-and-ultrastructure
#19
Peter H Neckel, Ulrich Mattheus, Bernhard Hirt, Lothar Just, Andreas F Mack
Novel techniques, like CLARITY and PACT, render large tissue specimens transparent and thereby suitable for microscopic analysis. We used these techniques to evaluate their potential in the intestine as an exemplary organ with a complex tissue composition. Immunohistochemistry, light sheet-, and confocal scanning-microscopy enabled us to follow complex three-dimensional structures, like nerve fibers, vessels, and epithelial barriers throughout the entire organ. Moreover, in a systematic electron microscopic study, we analyzed the morphology and preservation of tissue on ultrastructural level during the clearing process...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27669342/traumatic-basal-subarachnoid-haemorrhage-or-ruptured-brain-aneurysm-in-16-year-old-boy-case-report
#20
R Skowronek, M Kobek, Z Jankowski, E Zielińska-Pająk, A Pałasz, J Pilch-Kowalczyk, R Kwarta, K Rygol, M Szczepański, C Chowaniec
Traumatic basal subarachnoid haemorrhage (TBSAH) represents only 1.8% of all subarachnoid haemorrhage cases diagnosed during autopsy. This report presents such a case from the current practice of the authors. Sixteen-year-old boy was beaten by the aggressors. Suddenly he lost his consciousness and fall after he received a single blow in the neck. He was resuscitated immediately, but died at the scene. During the external examination we did not find any significant external injuries. Autopsy revealed large contusion of right sternocleidomastoid muscle...
2016: Archiwum Medycyny Sa̧dowej i Kryminologii
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