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https://www.readbyqxmd.com/read/29455049/poststroke-epilepsy-following-transient-unilateral-middle-cerebral-and-common-carotid-artery-occlusion-in-young-adult-and-aged-f344-rats
#1
Kevin M Kelly, Peter I Jukkola, Guo Yin, Eric R Miller, Elena A Kharlamov, Deng-Shan Shiau, Roger Strong, Jaroslaw Aronowski
The mechanisms of injured brain that establish poststroke seizures and epilepsy are not well understood, largely because animal modeling has had limited development. The main objective of this study was to determine whether an arterial occlusion model of cortical stroke in young adult and aged rats was capable of generating either focal or generalized epileptic seizures within 2 months of lesioning. Four- and 20-month-old male Fischer 344 (F344) sham-operated controls and those lesioned by transient (3 h) unilateral middle cerebral artery (MCA) and common carotid artery (CCA) occlusion (MCA/CCAo) were studied by video-EEG recordings up to 2 months post-procedure...
February 10, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29447763/scaling-of-bony-canals-for-encephalic-vessels-in-euarchontans-implications-for-the-role-of-the-vertebral-artery-and-brain-metabolism
#2
Doug M Boyer, Arianna R Harrington
Supplying the central nervous system with oxygen and glucose for metabolic activities is a critical function for all animals at physiologic, anatomical, and behavioral levels. A relatively proximate challenge to nourishing the brain is maintaining adequate blood flow. Euarchontans (primates, dermopterans and treeshrews) display a diversity of solutions to this challenge. Although the vertebral artery is a major encephalic vessel, previous research has questioned its importance for irrigating the cerebrum. This presents a puzzling scenario for certain strepsirrhine primates (non-cheirogaleid lemuriforms) that have reduced promontorial branches of the internal carotid artery and no apparent alternative encephalic vascular route except for the vertebral artery...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29441571/arterial-and-microvascular-supply-of-cerebral-hemispheres-in-the-nude-mouse-revealed-using-corrosion-casting-and-scanning-electron-microscopy
#3
Simone Sangiorgi, Alessandro De Benedictis, Marcella Reguzzoni, Andrea Trezza, Silvia Cossu, Carlo Efisio Marras, Silvio Bellocchi, Alessandro Manelli, Marina Protasoni
Morphological analyses of cerebral vascularization are not only important for the characterization of the anatomical and physiological relationships between vascular and nervous tissue, but also required to understand structural modifications that occur in many pathological conditions affecting the brain. The aim of this study was to generate a three-dimensional vascular map of the cerebral hemispheres in the nude mouse brain, a widely used animal model for studying tumour biology. We used the corrosion casting (CC) technique to isolate blood vessels from 30 nude mouse brains...
February 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29440276/accurate-depth-of-radiofrequency-induced-lesions-in-renal-sympathetic-denervation-based-on-a-fine-histological-sectioning-approach-in-a-porcine-model
#4
Atsushi Sakaoka, Hisako Terao, Shintaro Nakamura, Hitomi Hagiwara, Toshihito Furukawa, Kiyoshi Matsumura, Kenichi Sakakura
BACKGROUND: Ablation lesion depth caused by radiofrequency-based renal denervation (RDN) was limited to <4 mm in previous animal studies, suggesting that radiofrequency-RDN cannot ablate a substantial percentage of renal sympathetic nerves. We aimed to define the true lesion depth achieved with radiofrequency-RDN using a fine sectioning method and to investigate biophysical parameters that could predict lesion depth. METHODS AND RESULTS: Radiofrequency was delivered to 87 sites in 14 renal arteries from 9 farm pigs at various ablation settings: 2, 4, 6, and 9 W for 60 seconds and 6 W for 120 seconds...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29438731/neuroprotective-effect-of-the-group-iii-mglu-receptor-agonist-acpt-i-after-ischemic-stroke-in-rats-with-essential-hypertension
#5
Helena Domin, Łukasz Przykaza, Ewa Kozniewska, Paweł M Boguszewski, Maria Śmiałowska
Our previous studies have shown that ACPT-I [(1S, 3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid], a blood-brain barrier permeable agonist of group III metabotropic glutamate (mGlu) receptors, was neuroprotective against middle cerebral artery occlusion/reperfusion (MCAO/R) in normotensive rats. Preclinical studies are typically performed on healthy animals, whereas stroke patients predominately exhibit comorbidities, such as hypertension; therefore, in the present study, we investigated the effect of ACPT-I in spontaneously hypertensive rats (SHR) after MCAO/R...
February 10, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29433570/role-of-atp-sensitive-potassium-channels-on-hypoxic-pulmonary-vasoconstriction-in-endotoxemia
#6
Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A Weigand, Cornelius J Busch
BACKGROUND: ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 has been reported in animal models of endotoxemia, we studied the expression and physiological effects of Kir6.1 in murine endotoxemic lungs. We hypothesized that inhibition of overexpressed Kir6...
February 13, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29428638/elevated-20-hete-in-metabolic-syndrome-regulates-arterial-stiffness-and-systolic-hypertension-via-mmp12-activation
#7
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Jenny Yang, Frank Fan Zhang, Sachindra Raj Joshi, Chastity Bradford, Katherine H Gotlinger, Rachana Maniyar, John R Falck, Spencer Proctor, Michal Laniado Schwartzman, Sachin A Gupte, Petra Rocic
Arterial stiffness plays a causal role in development of systolic hypertension. 20-hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic acid metabolite, is known to be elevated in resistance arteries in hypertensive animal models and loosely associated with obesity in humans. However, the role of 20-HETE in the regulation of large artery remodeling in metabolic syndrome has not been investigated. We hypothesized that elevated 20-HETE in metabolic syndrome increases matrix metalloproteinase 12 (MMP12) activation leading to increased degradation of elastin, increased large artery stiffness and increased systolic blood pressure...
February 8, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29427784/evaluation-of-the-treatment-with-resveratrol-loaded-nanoparticles-in-intestinal-injury-model-caused-by-ischemia-and-reperfusion
#8
Stephanie Carvalho Borges, Paulo Emílio Botura Ferreira, Luisa Mota da Silva, Maria Fernanda de Paula Werner, Juan Manuel Irache, Osvaldo Albuquerque Cavalcanti, Nilza Cristina Buttow
The gastrointestinal tract is extremely sensitive to ischemia and reperfusion (I/R). Studies have reported that resveratrol (RSV) is able to combat damage caused by intestinal I/R. Because of its effectiveness in increasing the permanence and bioavailability of resveratrol in the intestinal epithelium, we investigated whether the effect of resveratrol-loaded in poly(anhydride) nanoparticles reduce oxidative stress and promote myenteric neuroprotection in the ileum of rats subjected to I/R. Physicochemical evaluations were performed on nanoparticles...
February 7, 2018: Toxicology
https://www.readbyqxmd.com/read/29426680/effects-of-memantine-on-nitric-oxide-production-and-hydroxyl-radical-metabolism-during-cerebral-ischemia-and-reperfusion-in-mice
#9
Ai Tanaka, Yasuo Ito, Hitoshi Kawasaki, Chika Kitabayashi, Ryoji Nishioka, Masamizu Yamazato, Keisuke Ishizawa, Toshinori Nagai, Makiko Hirayama, Kazushi Takahashi, Toshimasa Yamamoto, Nobuo Araki
BACKGROUND: The purpose of this study was to investigate the effects of memantine on brain ischemia. Because we can measure nitric oxide (NO) production and hydroxyl radical metabolism continuously, we investigated the effect of memantine on NO production and hydroxyl radical metabolism in cerebral ischemia and reperfusion. METHODS: Memantine (25 µmol/kg) was administered intraperitoneally to 6 C57BL/6 mice 30 minutes before ischemia. Seven additional mice received no injection (controls)...
February 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29425776/the-effects-of-hemoglobin-glutamer-200-and-ino-on-pulmonary-vascular-tone-and-arterial-oxygenation-in-an-experimental-acute-respiratory-distress-syndrome
#10
Maria Theresa Voelker, Andreas Bergmann, Thilo Busch, Nora Jahn, Sven Laudi, Katharina Noreikat, Philipp Simon, Sven Bercker
INTRODUCTION: Hemoglobin-based oxygen carriers (HBOC) have been developed as an alternative to blood transfusions. Their nitric-oxide-scavenging properties HBOC also induce vasoconstriction. In acute lung injury, an excess of nitric oxide results in a general vasodilation, reducing oxygenation by impairing the hypoxic pulmonary vasoconstriction. Inhaled nitric oxide (iNO) is used to correct the ventilation perfusion mismatch. We hypothesized that the additional use of HBOC might increase this effect...
February 6, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29424463/spin-lock-imaging-of-early-tissue-ph-changes-in-ischemic-rat-brain
#11
Zhongliang Zu, Aqeela Afzal, Hua Li, Jingping Xie, John C Gore
We have previously reported that the dispersion of spin-lattice relaxation rates in the rotating frame (R1ρ ) of tissue water protons at high field can be dominated by chemical exchange contributions. Ischemia in brain causes changes in tissue pH, which in turn may affect proton exchange rates. Amide proton transfer (APT, a form of chemical exchange saturation transfer) has been shown to be sensitive to chemical exchange rates and able to detect pH changes non-invasively following ischemic stroke. However, the specificity of APT to pH changes is decreased because of the influence of several other factors that affect magnetization transfer...
February 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29420089/characterization-of-vascular-dysregulation-in-meriones-shawi-after-high-calorie-diet-feeding
#12
Badiaa Lyoussi, Khadija Cherkaoui-Tangi, Nicole Morel, Maurice Wibo
The present study was initiated to characterize vascular dysregulations (contraction and relaxation) associated with metabolic defects in Merions shawi, a rodent from the gerbillidae family, submitted to 12 weeks high-calorie diet. This diet induces a type 2 diabetes/metabolic syndrome phenotype with hypertension. In diabetic meriones, body weight increase was associated with hyperglycemia, increased insulinemia, and insulin resistance. Compared to lean meriones, diabetic meriones showed decreased aorta contraction to noradrenaline, which was normalized after NOS inhibition...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29411543/lumped-parameter-models-of-the-pulmonary-vasculature-during-the-progression-of-pulmonary-arterial-hypertension
#13
Jesse W Gerringer, Julie C Wagner, Daniela Vélez-Rendón, Daniela Valdez-Jasso
A longitudinal study of monocrotaline-induced pulmonary arterial hypertension (PAH) was carried out in Sprague-Dawley rats to investigate the changes in impedance (comprising resistance and compliance) produced by elevated blood pressure. Using invasively measured blood flow as an input, blood pressure was predicted using 3- and 4-element Windkessel (3WK, 4WK) type lumped-parameter models. Resistance, compliance, and inductance model parameters were obtained for the five different treatment groups via least-squares errors...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29408903/vitamin-d-deficiency-causes-inward-hypertrophic-remodeling-and-alters-vascular-reactivity-of-rat-cerebral-arterioles
#14
Éva Pál, Leila Hadjadj, Zoltán Fontányi, Anna Monori-Kiss, Zsuzsanna Mezei, Norbert Lippai, Attila Magyar, Andrea Heinzlmann, Gellért Karvaly, Emil Monos, György Nádasy, Zoltán Benyó, Szabolcs Várbíró
BACKGROUND AND PURPOSE: Vitamin D deficiency (VDD) is a global health problem, which can lead to several pathophysiological consequences including cardiovascular diseases. Its impact on the cerebrovascular system is not well understood. The goal of the present work was to examine the effects of VDD on the morphological, biomechanical and functional properties of cerebral arterioles. METHODS: Four-week-old male Wistar rats (n = 11 per group) were either fed with vitamin D deficient diet or received conventional rat chow with per os vitamin D supplementation...
2018: PloS One
https://www.readbyqxmd.com/read/29408288/neuroprotective-nature-of-adipokine-resistin-in-the-early-stages-of-focal-cerebral-ischemia-in-a-stroke-mouse-model
#15
Sedigheh Behrouzifar, Abedin Vakili, Ahmad Reza Bandegi, Parviz Kokhaei
New evidence suggests that resistin may have a therapeutic potential effect in management of neurodegenerative disease; but its role in the pathophysiology of stroke-induced injuries is not understood. However, further investigations are required to elucidate the effect of resistin and explore its possible molecular mechanisms on the ischemic reperfusion injury. Transient focal cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO) in mice. Animal treated with resistin at doses of 25, 50, 100, 200, and 400 ng/mouse, on the MCAO commencement...
February 2, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29402957/selective-inhibition-of-succinate-dehydrogenase-in-reperfused-myocardium-with-intracoronary-malonate-reduces-infarct-size
#16
Laura Valls-Lacalle, Ignasi Barba, Elisabet Miró-Casas, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, David García-Dorado
Inhibition of succinate dehydrogenase (SDH) with malonate during reperfusion reduces infarct size in isolated mice hearts submitted to global ischemia. However, malonate has toxic effects that preclude its systemic administration in animals. Here we investigated the effect of intracoronary malonate on infarct size in pigs submitted to transient coronary occlusion. Under baseline conditions, 50 mmol/L of intracoronary disodium malonate, but not lower concentrations, transiently reduced systolic segment shortening in the region perfused by the left anterior descending coronary artery (LAD) in open-chest pigs...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402362/-effects-of-mild-hypothermia-on-%C3%AE-adrenergic-signaling-pathway-in-a-cardiac-arrest-swine-model
#17
Fangfang Zhu, Xianfei Ji, Xia Zhong, Haoran Hu, Lining Liang, Jibin Chen, Deya Shang
OBJECTIVE: To observe the effect of mild hypothermia on myocardial β-adrenergic receptor (β-AR) signal pathway after cardiopulmonary resuscitation (CPR) in pigs with cardiac arrest (CA) and explore the mechanism of myocardial protection. METHODS: Healthy male Landraces were collected for reproducing the CA-CPR model (after 8-minute untreated ventricular fibrillation, CPR was implemented). The animals were divided into two groups according to random number table (n = 8)...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29399092/expression-of-caspase-3-bax-and-bcl-2-in-hippocampus-of-rats-with-diabetes-and-subarachnoid-hemorrhage
#18
Xin He, Jiankui Sun, Xiaoyu Huang
The expression of caspase-3, Bax and Bcl-2 in hippocampus of rats with diabetes and subarachnoid hemorrhage (SAH) were investigated. Diabetes mellitus model was established by intraperitoneal injection of STZ. On the basis of diabetes mellitus model, SAH animal model was established by injecting fresh autologous femoral artery blood into cerebellomedullary cisten. Rats were divided into blank control group, diabetes control group and diabetes + SAH group. TUNEL method was used to detect cell apoptosis of hippocampus...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398670/the-effect-of-sedation-with-a-combination-of-butorphanol-and-midazolam-on-quantitative-contrast-enhanced-ultrasonography-of-duodenum-in-healthy-dogs
#19
Khoirun Nisa, Sue Yee Lim, Tatsuyuki Osuga, Nozomu Yokoyama, Masahiro Tamura, Noriyuki Nagata, Kazuyoshi Sasaoka, Angkhana Dermlim, Rommaneeya Leela-Arporn, Tomoya Morita, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Hiroshi Ohta, Mitsuyoshi Takiguchi
Quantitative contrast-enhanced ultrasonography (CEUS) enables non-invasive and objective evaluation of intestinal perfusion by quantifying the intensity of enhancement on the intestine after microbubble contrast administration. During CEUS scanning, sedation is sometimes necessary to maintain animal cooperation. Nevertheless, the effect of sedative administration on the canine intestinal CEUS is unknown. This study aimed to investigate the effect of sedation with a combination of butorphanol and midazolam on the duodenal CEUS-derived perfusion parameters of healthy dogs...
February 2, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29398450/changes-of-electrocardiogram-and-hemodynamics-in-response-to-dipyridamole-in%C3%A2-vivo-comparative-analyses-using-anesthetized-beagle-dogs-and-microminipigs
#20
Kentaro Ando, Akira Takahara, Yuji Nakamura, Takeshi Wada, Koki Chiba, Ai Goto, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kiyotaka Hoshiai, Yasuki Akie, Atsuhiko T Naito, Atsushi Sugiyama
Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both microminipigs and beagle dogs, and compared the results. Dipyridamole in doses of 0.056 and 0.56 mg/kg were intravenously infused over 10 min (n = 4 for each animal). Dipyridamole decreased the systolic/diastolic blood pressures and double product in dogs as well as in microminipigs; but it did not significantly alter the heart rate or the global balance between the myocardial oxygen demand and supply in either animal...
February 1, 2018: Journal of Pharmacological Sciences
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