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https://www.readbyqxmd.com/read/29028763/effects-of-hyperoxia-during-resuscitation-from-hemorrhagic-shock-in-swine-with-preexisting-coronary-artery-disease
#1
Clair Hartmann, Maurizio Loconte, Elena Antonucci, Michael Holzhauser, Tobias Hölle, David Katzsch, Tamara Merz, Oscar McCook, Ulrich Wachter, Josef A Vogt, Andrea Hoffmann, Martin Wepler, Michael Gröger, Martin Matejovic, Enrico Calzia, Michael Georgieff, Pierre Asfar, Peter Radermacher, Benedikt L Nussbaum
OBJECTIVES: Investigation of the effects of hyperoxia during resuscitation from hemorrhagic shock in swine with preexisting coronary artery disease. DESIGN: Prospective, controlled, randomized trial. SETTING: University animal research laboratory. SUBJECTS: Nineteen hypercholesterolemic pigs with preexisting coronary artery disease. INTERVENTIONS: Anesthetized, mechanically ventilated, and surgically instrumented pigs underwent 3 hours of hemorrhagic shock (removal of 30% of the calculated blood volume and subsequent titration of mean arterial blood pressure ≈40 mm Hg)...
October 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29026002/risk-of-bias-reporting-in-the-recent-animal-focal-cerebral-ischaemia-literature
#2
REVIEW
Zsanett Bahor, Jing Liao, Malcolm R Macleod, Alexandra Bannach-Brown, Sarah K McCann, Kimberley E Wever, James Thomas, Thomas Ottavi, David W Howells, Andrew Rice, Sophia Ananiadou, Emily Sena
BACKGROUND: Findings from in vivo research may be less reliable where studies do not report measures to reduce risks of bias. The experimental stroke community has been at the forefront of implementing changes to improve reporting, but it is not known whether these efforts are associated with continuous improvements. Our aims here were firstly to validate an automated tool to assess risks of bias in published works, and secondly to assess the reporting of measures taken to reduce the risk of bias within recent literature for two experimental models of stroke...
October 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29018978/identification-of-zfpm2-mutations-in-sporadic-conotruncal-heart-defect-patients
#3
Tian Pu, Yang Liu, Rang Xu, Fen Li, Sun Chen, Kun Sun
Conotruncal heart defects (CTDs) are a group of cardiac malformations that involve outflow tract anomalies and the arterial pole of the heart. Recent reports have identified mutations in a number of genes associated with CTDs in human and animal models. ZFPM2 plays a role in cardiac development by acting as a transcriptional cofactor that interacts with GATA4. Because ZFPM2 was found to be important for cardiac development in a knockout mouse model, we screened for ZFPM2 mutations in 528 CTD patients. We identified six rare and nonsynonymous ZFPM2 variants, and this was the first time that five of these variants (R698Q, R736L, E1005K, T32A, and I488V) were reported in East Asians...
October 10, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29018332/the-beneficial-effects-of-melatonin-administration-following-hypoxia-ischemia-in-preterm-fetal-sheep
#4
Tamara Yawno, Mawin Mahen, Jingang Li, Michael C Fahey, Graham Jenkin, Suzanne L Miller
Melatonin (MLT) is an endogenous hormone that controls circadian cycle. MLT has additional important properties that make it appealing as a neuroprotective agent-it is a potent anti-oxidant, with anti-apoptotic and anti-inflammatory properties. MLT is safe for administration during pregnancy or to the newborn after birth, and can reduce white matter brain injury under conditions of chronic fetal hypoxia. Accordingly, in the current study, we examined whether an intermediate dose of MLT could restore white matter brain development when administered after an acute hypoxic ischemic (HI) insult in preterm fetal sheep...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29017609/effects-of-intra-arterial-transplantation-of-adipose-derived-stem-cells-on-the-expression-of-netrin-1-and-its-receptor-dcc-in-the-peri-infarct-cortex-after-experimental-stroke
#5
Huan Huang, Fan Lin, Jingjing Jiang, Yan Chen, Ainong Mei, Pengli Zhu
BACKGROUND: Stem cell transplantation has been documented to promote functional recovery in animal models of stroke; however, the underlying mechanisms are not yet fully understood. As netrin-1 and its receptor deleted in colorectal cancer (DCC) are important regulators in neuronal and vascular activities, the present study attempted to explore whether netrin-1 and DCC are involved in the neuroprotection of stem cell-based therapies in a rat ischemic stroke model. METHODS: Adult male Sprague-Dawley rats were subjected to a transient middle cerebral artery occlusion (MCAO) and subsequently received an intra-arterial injection of 2 × 10(6) PKH26-labeled adipose-derived stem cells (ADSCs) or saline 24 h later...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29016715/matrix-metalloproteinase-2-knockout-prevents-angiotensin-ii-induced-vascular-injury
#6
Tlili Barhoumi, Julio C Fraulob-Aquino, Muhammad Oneeb Rehman Mian, Sofiane Ouerd, Noureddine Idris-Khodja, Ku-Geng Huo, Asia Rehman, Antoine Caillon, Bianca Dancose-Giambattisto, Talin Ebrahimian, Stéphanie Lehoux, Pierre Paradis, Ernesto L Schiffrin
Aims: Matrix metalloproteinases (MMPs) have been implicated in the development of hypertension in animal models and humans. Mmp2 deletion did not change Ang II-induced blood pressure (BP) rise. However, whether Mmp2 knockout affects angiotensin (Ang) II-induced vascular injury has not been tested. We sought to determine whether Mmp2 knockout will prevent Ang II-induced vascular injury. Methods and results: A fourteen-day Ang II infusion (1000 ng/kg/min, SC) increased systolic BP, decreased vasodilatory responses to acetylcholine, induced mesenteric artery (MA) hypertrophic remodelling, and enhanced MA stiffness in wild-type (WT) mice...
July 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28993725/laser-speckle-imaging-of-rat-pial-microvasculature-during-hypoperfusion-reperfusion-damage
#7
Teresa Mastantuono, Noemy Starita, Laura Battiloro, Martina Di Maro, Martina Chiurazzi, Gilda Nasti, Espedita Muscariello, Mario Cesarelli, Luigi Iuppariello, Gianni D'Addio, Alexander Gorbach, Antonio Colantuoni, Dominga Lapi
The present study was aimed to in vivo assess the blood flow oscillatory patterns in rat pial microvessels during 30 min bilateral common carotid artery occlusion (BCCAO) and 60 min reperfusion by laser speckle imaging (LSI). Pial microcirculation was visualized by fluorescence microscopy. The blood flow oscillations of single microvessels were recorded by LSI; spectral analysis was performed by Wavelet transform. Under baseline conditions, arterioles and venules were characterized by blood flow oscillations in the frequency ranges 0...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28991897/the-influence-of-different-diets-on-metabolism-and-atherosclerosis-processes-a-porcine-model-blood-serum-urine-and-tissues-1h-nmr-metabolomics-targeted-analysis
#8
Adam Zabek, Robert Paslawski, Urszula Paslawska, Wojciech Wojtowicz, Katarzyna Drozdz, Sergio Polakof, Marzena Podhorska, Piotr Dziegiel, Piotr Mlynarz, Andrzej Szuba
The global epidemic of cardiovascular diseases leads to increased morbidity and mortality caused mainly by myocardial infarction and stroke. Atherosclerosis is the major pathological process behind this epidemic. We designed a novel model of atherosclerosis in swine. Briefly, the first group (11 pigs) received normal pig feed (balanced diet group-BDG) for 12 months, the second group (9 pigs) was fed a Western high-calorie diet (unbalanced diet group-UDG) for 12 months, the third group (8 pigs) received a Western type high-calorie diet for 9 months later replaced by a normal diet for 3 months (regression group-RG)...
2017: PloS One
https://www.readbyqxmd.com/read/28989072/pentoxifylline-treatment-enhances-antihypertensive-activity-of-captopril-through-hemorheological-improvement-in-spontaneously-hypertensive-rats-during-development-of-arterial-hypertension
#9
Mark B Plotnikov, Alexander Y Shamanaev, Oleg I Aliev, Anastasia V Sidekhmenova, Anna M Anishchenko, Alexander M Arkhipov
The rheological properties of blood play a significant role in the onset and progression of arterial hypertension. The aim of our work was to evaluate the effect of the angiotensin-converting enzyme inhibitor captopril (20 mg/kg/d), pentoxifylline (PTX; 100 mg/kg/d), and the combination of captopril + PTX (20 + 100 mg/kg/d) on the hemodynamic and hemorheological parameters in spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. In the group of animals that received captopril, the mean arterial pressure (MAP) was significantly lower by 30% due to a decrease in cardiac output of 23% and in total peripheral resistance (TPR) of 26% compared with the control group, whereas blood viscosity did not change significantly...
September 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28985762/a-study-of-epstein-barr-virus-infection-in-the-chinese-tree-shrew-tupaia-belangeri-chinensis
#10
Zhi Wang, Xiang Yi, Long Du, Hong Wang, Jie Tang, Menglin Wang, Chenglin Qi, Heng Li, Yongjing Lai, Wei Xia, Anzhou Tang
BACKGROUND: Epstein-Barr virus (EBV) is closely associated with many human diseases, including a variety of deadly human malignant tumours. However, due to the lack of ideal animal models,the biological characteristics of EBV, particularly its function in tumourigenesis, have not been determined. Chinese tree shrews (Tupaia belangeri chinensis), which are similar to primates, have been used to establish a variety of animal models and have recently received much attention. Here, we established tree shrews as a model for EBV infection by intravenous injection...
October 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28980339/prorenin-receptor-mediates-inflammation-in-renal-ischemia
#11
Syed S Quadri, Silas Culver, Helmy M Siragy
We hypothesized that PRR contributes to renal inflammation in the 2-kidney, 1-clip (2K1C) renal ischemia model. Male Sprague-Dawley rats were fed normal sodium diet. BP was obtained on day 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%. Renal expression of TNF-α, COX-2, NF-κB, IL-1β, MCP-1 and collagen type I were assessed in sham and 2K1C rats with or without left renal administration of scramble or PRR shRNA. At baseline, there were no differences in BP. Compared to sham, MAP significantly increased in clipped animals (sham: 102± 1...
October 5, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28980297/remote-ischemic-preconditioning-of-human-myocardium-ripe-study-protocol-for-a-double-blinded-randomized-controlled-trial
#12
Marek A Deja, Ryszard Wiaderkiewicz, Piotr Czekaj, Ewa Czech, Marcin Malinowski, Leszek Machej, Andrzej Węglarzy, Adam Kowalówka, Magda Piekarska, Bartosz Szurlej, Tomasz Latusek
BACKGROUND: Remote preconditioning was showed to be a potent protective phenomenon in many animals. Several studies aimed to demonstrate it was feasible in humans by trying to show its protective effect during cardiac surgery. Of these studies some small studies and one bigger trial were positive while two other bigger studies showed no effectiveness of remote preconditioning as assessed by levels of postoperatively released cardiac markers. Recently two large clinical trials also failed to prove the benefit of remote preconditioning in cardiac surgery...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28978533/non-invasive-measurement-of-renal-blood-flow-by-magnetic-resonance-imaging-mri-in-rats
#13
Cesar A Romero, Glauber Cabral, Robert A Knight, Guangliang Ding, Edward L Peterson, Oscar A Carretero
Renal blood flow (RBF) provides important information regarding renal physiology and nephropathies. Arterial spin labeling-magnetic resonance imaging (ASL-MRI) is a non-invasive method of measuring blood flow without exogenous contrast media. However, low signal/noise ratio and respiratory motion artifacts are challenges for RBF measurements in small animals. Our objective was to evaluate the feasibility and reproducibility of RBF measures by ASL-MRI using respiratory-gating and navigator correction methods to reduce motion artifacts...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28975436/unraveling-pancreatic-segmentation
#14
REVIEW
Yohann Renard, Louis de Mestier, Manuela Perez, Claude Avisse, Philippe Lévy, Reza Kianmanesh
BACKGROUND: Limited pancreatic resections are increasingly performed, but the rate of postoperative fistula is higher than after classical resections. Pancreatic segmentation, anatomically and radiologically identifiable, may theoretically help the surgeon removing selected anatomical portions with their own segmental pancreatic duct and thus might decrease the postoperative fistula rate. We aimed at systematically and comprehensively reviewing the previously proposed pancreatic segmentations and discuss their relevance and limitations...
October 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28972696/arterial-blood-supply-to-the-spinal-cord-in-animal-models-of-spinal-cord-injury-a-review
#15
REVIEW
David Mazensky, Slavka Flesarova, Igor Sulla
Animal models are used to examine the results of experimental spinal cord injury. Alterations in spinal cord blood supply caused by complex spinal cord injuries contribute significantly to the diversity and severity of the spinal cord damage, particularly ischemic changes. However, the literature has not completely clarified our knowledge of anatomy of the complex three-dimensional arterial system of the spinal cord in experimental animals, which can impede the translation of experimental results to human clinical applications...
October 3, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28971974/hypoxia-induced-changes-in-plasma-micrornas-correlate-with-pulmonary-artery-pressure-at-high-altitude
#16
Birgit Blissenbach, Christos T Nakas, Martin Krönke, Thomas Geiser, Tobias M Merz, Jacqueline Pichler Hefti
In vitro and animal studies revealed miRs to be involved in modulation of hypoxia-induced pulmonary hypertension (HPH). However, knowledge on circulating miRs in humans in the context of HPH is very limited. Since symptoms of HPH are non-specific and non-invasive diagnostic parameters do not exist, a disease-specific and hypoxemia-independent biomarker indicating HPH would be of clinical value. To examine whether plasma miR levels correlate with hypoxia-induced increase in pulmonary artery pressures, plasma miRs were assessed in a model of hypoxia-related pulmonary hypertension in humans exposed to extreme altitude...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28970059/structural-requirements-of-flavonoids-to-induce-heme-oxygenase-1-expression
#17
K D Croft, D Zhang, R Jiang, A Ayer, S Shengule, R J Payne, N C Ward, R Stocker
Population studies suggest cardiovascular health benefits of consuming fruits and vegetables rich in polyphenolic compounds such as flavonoids. We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role. The present study investigated the structural requirements of flavonoids to induce Hmox1 in human aortic endothelial cells (HAEC)...
September 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28969719/high-dose-enoxaparin-in-the-treatment-of-abdominal-angiostrongyliasis-in-swiss-mice
#18
A S S Sandri, R Rodriguez, M M Costa, S M Porto, D Schwingel, M I B Vieira
Abdominal angiostrongyliasis (AA) is caused by Angiostrongylus costaricensis, which inhabits mesenteric arteries. There is no drug treatment for AA, and since intestinal infarction due to thrombi is one of the main complications of the disease, the use of anticoagulants may be a treatment option. Thus, we aimed to assess the effect of high doses of enoxaparin on the prevention of ischaemic intestinal lesions and on the survival of mice infected with A. costaricensis. Twenty-four mice were infected with L3 of A...
October 3, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28966799/promoting-neurovascular-recovery-in-aged-mice-after-ischemic-stroke-prophylactic-effect-of-omega-3-polyunsaturated-fatty-acids
#19
Mengfei Cai, Wenting Zhang, Zhongfang Weng, R Anne Stetler, Xiaoyan Jiang, Yejie Shi, Yanqin Gao, Jun Chen
The aged population is among the highest at risk for ischemic stroke, yet most stroke patients of advanced ages (>80 years) are excluded from access to thrombolytic treatment by tissue plasminogen activator, the only FDA approved pharmacological therapy for stroke victims. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) robustly alleviate ischemic brain injury in young adult rodents, but have not yet been studied in aged animals. This study investigated whether chronic dietary supplementation of n-3 PUFAs protects aging brain against cerebral ischemia and improves long-term neurological outcomes...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28966635/modulation-of-valosin-containing-protein-by-kyoto-university-substances-kus-as-a-novel-therapeutic-strategy-for-ischemic-neuronal-diseases
#20
REVIEW
Masayuki Hata, Hanako Ohashi Ikeda
Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate (ATP) depletion and subsequent induced endoplasmic reticulum (ER) stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity...
August 2017: Neural Regeneration Research
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