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Rothia mucilaginosa

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https://www.readbyqxmd.com/read/29149111/-bilateral-bronchopneumonia-due-to-rothia-mucilaginosa
#1
B De Escalante Yangüela, A Gracia Gutiérrez, B C Gracia Tello, V A Alastrué Del Castaño, E Bueno Juana, S Algárate Cajo
Rothia mucilaginosa (R. mucilaginosa), formerly named Stomatococcus mucilaginosus, is a facultatively anaerobic, encapsulated gram-positive coccus, which forms part of the normal oropharyngeal and is rarely considered to be a pathogen in immunocompetent patients, although it can produce, on rare occasions, serious infections like bacteremia, endocarditis and respiratory infections; such as pneumonia, pleural empyema or superinfection of bronchiectasis. We present the case of a 74-year-old male diagnosed with right basal pneumonia of torpid evolution with a poor initial response to different antibiotics, with clinical and radiological worsening and the appearance of bilateral bronchopneumonia with pseudonodular images...
November 17, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29121069/developing-selective-media-for-quantification-of-multispecies-biofilms-following-antibiotic-treatment
#2
Eva Vandeplassche, Tom Coenye, Aurélie Crabbé
The lungs of cystic fibrosis (CF) patients are chronically colonized by a polymicrobial biofilm community, leading to difficult-to-treat infections. To combat these infections, CF patients are commonly treated with a variety of antibiotics. Understanding the dynamics of polymicrobial community composition in response to antibiotic therapy is essential in the search for novel therapies. Culture-dependent quantification of individual bacteria from defined multispecies biofilms is frequently carried out by plating on selective media...
2017: PloS One
https://www.readbyqxmd.com/read/28740343/distinct-gut-microbiota-profiles-in-patients-with-primary-sclerosing-cholangitis-and-ulcerative-colitis
#3
Lukas Bajer, Miloslav Kverka, Martin Kostovcik, Peter Macinga, Jiri Dvorak, Zuzana Stehlikova, Jan Brezina, Pavel Wohl, Julius Spicak, Pavel Drastich
AIM: To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). METHODS: Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with (n = 32) or without (n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16S ribosomal RNA gene were sequenced on Illumina MiSeq platform to cover low taxonomic levels...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28500338/inflammatory-bacteriome-featuring-fusobacterium-nucleatum-and-pseudomonas-aeruginosa-identified-in-association-with-oral-squamous-cell-carcinoma
#4
Nezar Noor Al-Hebshi, Akram Thabet Nasher, Mohamed Yousef Maryoud, Husham E Homeida, Tsute Chen, Ali Mohamed Idris, Newell W Johnson
Studies on the possible association between bacteria and oral squamous cell carcinoma (OSCC) remain inconclusive, largely due to methodological variations/limitations. The objective of this study was to characterize the species composition as well as functional potential of the bacteriome associated with OSCC. DNA obtained from 20 fresh OSCC biopsies (cases) and 20 deep-epithelium swabs (matched control subjects) was sequenced for the V1-V3 region using Illumina's 2 × 300 bp chemistry. High quality, non-chimeric merged reads were classified to species level using a prioritized BLASTN-algorithm...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28480145/insights-of-the-dental-calculi-microbiome-of-pre-columbian-inhabitants-from-puerto-rico
#5
Tasha M Santiago-Rodriguez, Yvonne Narganes-Storde, Luis Chanlatte-Baik, Gary A Toranzos, Raul J Cano
BACKGROUND: The study of ancient microorganisms in mineralized dental plaque or calculi is providing insights into microbial evolution, as well as lifestyles and disease states of extinct cultures; yet, little is still known about the oral microbial community structure and function of pre-Columbian Caribbean cultures. In the present study, we investigated the dental calculi microbiome and predicted function of one of these cultures, known as the Saladoid. The Saladoids were horticulturalists that emphasized root-crop production...
2017: PeerJ
https://www.readbyqxmd.com/read/28293681/community-level-differences-in-the-microbiome-of-healthy-wild-mallards-and-those-infected-by-influenza-a-viruses
#6
Holly H Ganz, Ladan Doroud, Alana J Firl, Sarah M Hird, Jonathan A Eisen, Walter M Boyce
Waterfowl, especially ducks and geese, are primary reservoirs for influenza A viruses (IAVs) that evolve and emerge as important pathogens in domestic animals and humans. In contrast to humans, where IAVs infect the respiratory tract and cause significant morbidity and mortality, IAVs infect the gastrointestinal tract of waterfowl and cause little or no pathology and are spread by fecal-oral transmission. For this reason, we examined whether IAV infection is associated with differences in the cloacal microbiome of mallards (Anas platyrhyncos), an important host of IAVs in North America and Eurasia...
January 2017: MSystems
https://www.readbyqxmd.com/read/28194750/differential-responses-of-human-dendritic-cells-to-metabolites-from-the-oral-airway-microbiome
#7
K Whiteson, S Agrawal, A Agrawal
Small molecule metabolites that are produced or altered by host-associated microbial communities are emerging as significant immune response modifiers. However, there is a key gap in our knowledge of how oral microbial metabolites affect the immune response. Here, we examined the effects of metabolites from five bacterial strains found commonly in the oral/airway microbial communities of humans. The five strains, each isolated from cystic fibrosis patient sputum, were Pseudomonas aeruginosa FLR01 non-mucoid (P1) and FLR02 mucoid (P2) forms, Streptococcus pneumoniae (Sp), S...
June 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28070022/stable-isotope-profiles-reveal-active-production-of-vocs-from-human-associated-microbes
#8
Joann Phan, Simone Meinardi, Barbara Barletta, Donald R Blake, Katrine Whiteson
Volatile organic compounds (VOCs) measured from exhaled breath have great promise for the diagnosis of bacterial infections. However, determining human or microbial origin of VOCs detected in breath remains a great challenge. For example, the microbial fermentation product 2,3-butanedione was recently found in the breath of Cystic Fibrosis (CF) patients; parallel culture-independent metagenomic sequencing of the same samples revealed that Streptococcus and Rothia spp. have the genetic capacity to produce 2,3-butanedione...
February 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/27606659/bacteremia-caused-by-rothia-mucilaginosa-after-pneumonia-in-a-patient-with-hematopoietic-stem-cell-transplantation
#9
Cihangül Bayhan, Eda Karadag Oncel, Ali B Cengiz, Ayça B Oksüz, Güzide B Aydin
Rothia muciloginosa is a member of normal flora and rarely causes invasive disease. Immunosupressed patients have increased risk for severe infection. Here, we report a male patient with relapsed neuroblastoma hospitalized for pneumonia. After clinical improvement, patient's respiratory symptoms worsened again. Rothia muciloginosa was isolated from blood culture. The worsening of respiratory symptoms can be explained by hematogenous spread of bacteria. He was successfully treated with meropenem and vancomycin for 14 days...
October 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27469368/identification-of-food-grade-subtilisins-as-gluten-degrading-enzymes-to-treat-celiac-disease
#10
Guoxian Wei, Na Tian, Roland Siezen, Detlef Schuppan, Eva J Helmerhorst
Gluten are proline- and glutamine-rich proteins present in wheat, barley, and rye and contain the immunogenic sequences that drive celiac disease (CD). Rothia mucilaginosa, an oral microbial colonizer, can cleave these gluten epitopes. The aim was to isolate and identify the enzymes and evaluate their potential as novel enzyme therapeutics for CD. The membrane-associated R. mucilaginosa proteins were extracted and separated by DEAE chromatography. Enzyme activities were monitored with paranitroanilide-derivatized and fluorescence resonance energy transfer (FRET) peptide substrates, and by gliadin zymography...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27193835/species-level-core-oral-bacteriome-identified-by-16s-rrna-pyrosequencing-in-a-healthy-young-arab-population
#11
Nezar Noor Al-Hebshi, Ahmed Abdulhaq, Ahmed Albarrag, Vinod Kumar Basode, Tsute Chen
BACKGROUND: Reports on the composition of oral bacteriome in Arabs are lacking. In addition, the majority of previous studies on other ethnic groups have been limited by low-resolution taxonomic assignment of next-generation sequencing reads. Furthermore, there has been a conflict about the existence of a 'core' bacteriome. OBJECTIVE: The objective of this study was to characterize the healthy core oral bacteriome in a young Arab population at the species level...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27103973/first-report-of-acute-postoperative-endophthalmitis-caused-by-rothia-mucilaginosa-after-phacoemulsification
#12
Pablo Álvarez-Ramos, Amparo Del Moral-Ariza, José M Alonso-Maroto, Pilar Marín-Casanova, José M Calandria-Amigueti, Manuel Rodríguez-Iglesias, Enrique Rodríguez de la Rúa
We aimed at reporting the first case of rapidly progressive acute postoperative endophthalmitis after phacoemulsification cataract surgery in an immunocompetent patient caused by Rothia mucilaginosa. An immunocompetent patient manifested endophthalmitis signs 48 hours after an uncomplicated cataract surgery by phacoemulsification. A bacteria of the family Micrococcaceae was cultured in the vitreous biopsy, namely R. mucilaginosa. The patient did not show a favorable clinical response after vitrectomy and systemic, intravitreal, and topical fortified antibiotics...
March 21, 2016: Infectious Disease Reports
https://www.readbyqxmd.com/read/27008920/case-of-late-onset-bleb-associated-endophthalmitis-caused-by-rothia-mucilaginosa
#13
Shinya Oie, Kiyofumi Mochizuki, Kyoko Ishida, Asami Nakayama, Kiyofumi Ohkusu
Rothia mucilaginosa is a gram-positive coagulase-negative coccus of the family Micrococcaceae. Although R. mucilaginosa forms part of the oropharyngeal microflora, it has only recently been isolated in ocular infections. We report a case of a 41-year-old man who developed late-onset bleb-related endophthalmitis (BRE). He had undergone glaucoma surgery 21 years earlier and had a thin-walled cystic bleb prior to the development of endophthalmitis in his right eye. He immediately received intravitreal injections of ceftazidime and vancomycin, topical levofloxacin and cefmenoxime, and intravenous cefozopran...
September 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26607938/dietary-nitrate-improves-vascular-function-in-patients-with-hypercholesterolemia-a-randomized-double-blind-placebo-controlled-study
#14
RANDOMIZED CONTROLLED TRIAL
Shanti Velmurugan, Jasmine Ming Gan, Krishnaraj S Rathod, Rayomand S Khambata, Suborno M Ghosh, Amy Hartley, Sven Van Eijl, Virag Sagi-Kiss, Tahseen A Chowdhury, Mike Curtis, Gunter G C Kuhnle, William G Wade, Amrita Ahluwalia
BACKGROUND: The beneficial cardiovascular effects of vegetables may be underpinned by their high inorganic nitrate content. OBJECTIVE: We sought to examine the effects of a 6-wk once-daily intake of dietary nitrate (nitrate-rich beetroot juice) compared with placebo intake (nitrate-depleted beetroot juice) on vascular and platelet function in untreated hypercholesterolemics. DESIGN: A total of 69 subjects were recruited in this randomized, double-blind, placebo-controlled parallel study...
January 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26484045/a-case-of-peritoneal-dialysis-associated-peritonitis-by-rothia-mucilaginosa
#15
Byeong Gwan Kim, A Young Cho, Sang Sun Kim, Seong Hee Lee, Hong Shik Shin, Hyun Ju Yoon, Jeong Gwan Kim, In O Sun, Kwang Young Lee
Rothia muciliaginosa (R. mucilaginosa) is a facultative, Gram-positive coccus that is considered to be part of the normal flora of the mouth and respiratory tract. There are sporadic reports of the organism causing endocarditis in patients with heart valve abnormalities, as well as meningitis, septicemia, and pneumonia associated with intravenous drug abuse. However, it is an unusual pathogen in cases of peritoneal dialysis (PD)-associated peritonitis. Although R. mucilaginosa is generally susceptible to penicillin, ampicillin, cefotaxime, imipenem, rifampicin, and glycopeptides, there are no guidelines for the treatment of PD-associated peritonitis...
September 2015: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/26430041/complete-genome-sequence-of-rothia-mucilaginosa-strain-num-rm6536-isolated-from-a-human-oral-cavity
#16
Takayuki Nambu, Osamu Tsuzukibashi, Satoshi Uchibori, Chiho Mashimo
Here, we present the complete genome sequence of Rothia mucilaginosa NUM-Rm6536, a strain isolated from the tongue plaque of a healthy human adult. This strain is amenable to genetic manipulation by transformation and so provides a useful foundation for more detailed investigation of this species.
2015: Genome Announcements
https://www.readbyqxmd.com/read/26256880/-bacteremia-due-to-rothia-mucilaginosa-after-chemotherapy-for-myeloid-malignancies
#17
REVIEW
Sumiko Kohashi, Takehiko Mori, Yuya Koda, Taku Kikuchi, Jun Kato, Takayuki Shimizu, Kayoko Sugita, Naoki Hasegawa, Mitsuru Murata, Shinichiro Okamoto
The number of reported cases of bacteremia due to Rothia mucilaginosa (R. mucilaginosa), a component of the normal flora of human gastrointestinal tract mucosa, is limited. We encountered three cases of bacteremia due to R. mucilaginosa during neutropenia after chemotherapy for myeloid malignancies. Although all three patients were successfully treated with antimicrobial agents, one patient developed disseminated lesions in the lungs and soft tissue. The portal of R. mucilaginosa bacteremia is reportedly mucositis or dental disorders; however, no such complications were identified in our patients...
June 2015: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/26191508/exploring-salivary-microbiota-in-aids-patients-with-different-periodontal-statuses-using-454-gs-flx-titanium-pyrosequencing
#18
Fang Zhang, Shenghua He, Jieqi Jin, Guangyan Dong, Hongkun Wu
Patients with acquired immunodeficiency syndrome (AIDS) are at high risk of opportunistic infections. Oral manifestations have been associated with the level of immunosuppression, these include periodontal diseases, and understanding the microbial populations in the oral cavity is crucial for clinical management. The aim of this study was to examine the salivary bacterial diversity in patients newly admitted to the AIDS ward of the Public Health Clinical Center (China). Saliva samples were collected from 15 patients with AIDS who were randomly recruited between December 2013 and March 2014...
2015: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/26120454/peritonitis-from-rothia-mucilaginosa-in-a-chronic-peritoneal-dialysis-patient
#19
Aileen B Cielo, Michael E Ullian
No abstract text is available yet for this article.
October 2013: Clinical Kidney Journal
https://www.readbyqxmd.com/read/25898134/changes-in-cystic-fibrosis-airway-microbial-community-associated-with-a-severe-decline-in-lung-function
#20
Patrizia Paganin, Ersilia Vita Fiscarelli, Vanessa Tuccio, Manuela Chiancianesi, Giovanni Bacci, Patrizia Morelli, Daniela Dolce, Claudia Dalmastri, Alessandra De Alessandri, Vincenzina Lucidi, Giovanni Taccetti, Alessio Mengoni, Annamaria Bevivino
Cystic fibrosis (CF) is a genetic disease resulting in chronic polymicrobial infections of the airways and progressive decline in lung function. To gain insight into the underlying causes of severe lung diseases, we aimed at comparing the airway microbiota detected in sputum of CF patients with stable lung function (S) versus those with a substantial decline in lung function (SD). Microbiota composition was investigated by using culture-based and culture-independent methods, and by performing multivariate and statistical analyses...
2015: PloS One
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