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https://www.readbyqxmd.com/read/28343376/ruthenium-106-brachytherapy-with-or-without-additional-local-therapy-showed-favorable-outcome-for-variable-sized-choroidal-melanomas-in-korean-patients
#1
Yeona Cho, Jee Suk Chang, Jin Sook Yoon, Sung Chul Lee, Yong Bae Kim, Joo Ho Kim, Ki Chang Keum
Purpose: To report clinical outcomes of ruthenium-106 (Ru-106) brachytherapy with or without additional local therapy for choroidal melanomas in Korean patients. Materials and Methods: A total of 88 patients diagnosed with choroidal melanomas were treated with Ru-106 brachytherapy between 2006 and 2012. Patients were divided into two groups according to their tumor height: a large group (≥6 mm, n=50) and a small group (<6 mm, n=38). Most patients in the large group received combined therapy with local excision and/or transpupillary thermotherapy...
March 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28343375/foxo1-suppression-is-a-determinant-of-acquired-lapatinib-resistance-in-her2-positive-gastric-cancer-cells-through-met-upregulation
#2
Jinju Park, Yiseul Choi, Young San Ko, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Min A Kim, Jae-Seon Lee, Mee Soo Chang, Jong-Wan Park, Byung Lan Lee
Purpose: Lapatinib is a candidate drug for treatment of trastuzumab-resistant, HER2-positive gastric cancer (GC). Unfortunately, lapatinib resistance renders this drug ineffective. The present study investigated the implication of forkhead box protein O1 (FOXO1) signaling in the acquired lapatinib resistance in HER2-positive GC cells. Materials and Methods: Lapatinib-resistant GC cell lines (SNU-216 LR2-8) were generated in vitro by chronic exposure of lapatinib-sensitive, HER2-positive SNU-216 cells to lapatinib...
March 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28343367/magnetic-resonance-imaging-features-of-leukoaraiosis-in-elderly-dogs
#3
Elena Scarpante, Giunio Bruto Cherubini, Alberta de Stefani, Olivier Taeymans
Leukoaraiosis is a descriptive term used to designate bilateral, symmetrical, white matter lesions identified in brains of elderly human patients. These lesions are isointense to normal in magnetic resonance imaging (MRI) T1-weighted pulse sequences, non-contrast enhancing, and hyperintense in T2-weighted and FLAIR pulse sequences. Pathophysiologic mechanisms for leukoaraiosis remain incompletely understood; however, an ischemic origin is currently being favored. Age-related changes, such as brain atrophy, ventricular enlargement, and well-demarcated sulci, have also been previously described in dogs over 9 years of age...
March 26, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28343366/motor-learning-in-animal-models-of-parkinson-s-disease-aberrant-synaptic-plasticity-in-the-motor-cortex
#4
REVIEW
Tonghui Xu, Shaofang Wang, Rupa R Lalchandani, Jun B Ding
In Parkinson's disease (PD), dopamine depletion causes major changes in the brain, resulting in the typical cardinal motor features of the disease. PD neuropathology has been restricted to postmortem examinations, which are limited to only a single time of PD progression. Models of PD in which dopamine tone in the brain is chemically or physically disrupted are valuable tools in understanding the mechanisms of the disease. The basal ganglia have been well studied in the context of PD, and circuit changes in response to dopamine loss have been linked to the motor dysfunctions in PD...
March 25, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28343364/comparison-between-the-effect-of-6-weeks-of-morning-or-evening-aerobic-exercise-on-appetite-and-anthropometric-indices-a-randomized-controlled-trial
#5
Z Alizadeh, S Younespour, M Rajabian Tabesh, S Haghravan
Several studies have shown that exercise is directly related to creating negative energy balance and changes in appetite. However, few studies have examined the effect of exercise time during the day on these factors. The aim of the present study was to demonstrate the effect of 6 weeks of morning and evening aerobic exercise on appetite and anthropometric indices. A total of 48 overweight females were recruited to this clinical trial. By the time of exercise, they were divided into two groups (morning or evening) and performed 6 weeks of exercise with a target heart rate on the ventilatory threshold...
March 26, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28343340/a-lake-centric-geospatial-database-to-guide-research-and-inform-management-decisions-in-an-arctic-watershed-in-northern-alaska-experiencing-climate-and-land-use-changes
#6
Benjamin M Jones, Christopher D Arp, Matthew S Whitman, Debora Nigro, Ingmar Nitze, John Beaver, Anne Gädeke, Callie Zuck, Anna Liljedahl, Ronald Daanen, Eric Torvinen, Stacey Fritz, Guido Grosse
Lakes are dominant and diverse landscape features in the Arctic, but conventional land cover classification schemes typically map them as a single uniform class. Here, we present a detailed lake-centric geospatial database for an Arctic watershed in northern Alaska. We developed a GIS dataset consisting of 4362 lakes that provides information on lake morphometry, hydrologic connectivity, surface area dynamics, surrounding terrestrial ecotypes, and other important conditions describing Arctic lakes. Analyzing the geospatial database relative to fish and bird survey data shows relations to lake depth and hydrologic connectivity, which are being used to guide research and aid in the management of aquatic resources in the National Petroleum Reserve in Alaska...
March 25, 2017: Ambio
https://www.readbyqxmd.com/read/28343339/bound-pahs-in-sediment-and-related-environmental-significance
#7
Jian-Yang Guo, Jing-An Chen, Jing-Fu Wang, Feng-Chang Wu
Extractable polycyclic aromatic hydrocarbons (EPAHs) and bound PAHs (BPAHs) were measured in a sediment core using conventional Soxhlet extraction and a more astringent extraction method, with the objectives of determining the influence of BPAHs on the historical reconstruction of PAHs and exploring the formation of BPAHs and long-term behaviors of PAHs in sediment. The results indicated that the formation of BPAHs was clearly sediment-depth and molecular-size dependent. BPAHs represents an important portion of PAHs in sediment and cannot be extracted by conventional Soxhlet extraction...
March 25, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28343334/design-and-test-of-a-microsoft-kinect-based-system-for-delivering-adaptive-visual-feedback-to-stroke-patients-during-training-of-upper-limb-movement
#8
Daniel Simonsen, Mirjana B Popovic, Erika G Spaich, Ole Kæseler Andersen
The present paper describes the design and test of a low-cost Microsoft Kinect-based system for delivering adaptive visual feedback to stroke patients during the execution of an upper limb exercise. Eleven sub-acute stroke patients with varying degrees of upper limb function were recruited. Each subject participated in a control session (repeated twice) and a feedback session (repeated twice). In each session, the subjects were presented with a rectangular pattern displayed on a vertical mounted monitor embedded in the table in front of the patient...
March 25, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28343332/posterior-elements-disruption-with-hybrid-constructs-in-ais-patients-is-there-an-impact-on-proximal-junctional-kyphosis
#9
S Ghailane, Sebastien Pesenti, E Peltier, E Choufani, B Blondel, J L Jouve
PURPOSE: Proximal junctional kyphosis (PJK) is a frequent proximal adjacent segment disease following spinal fusion in adolescent idiopathic scoliosis (AIS) and its rate has been estimated to 28% in the literature. The etiology is multifactorial, and risk factors associated with PJK are controversial. The aim of this study was to demonstrate that the disruption of muscular and bony tissue above the upper instrumented vertebra (UIV) during surgery does not increase the rate of PJK in patients undergoing posterior fusion for adolescent idiopathic scoliosis...
March 25, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28343331/economic-and-public-health-consequences-of-delayed-access-to-medical-care-for-migrants-living-with-hiv-in-france
#10
Marlène Guillon, Michel Celse, Pierre-Yves Geoffard
In 2013, migrants accounted for 46% of newly diagnosed cases of HIV (human immunodeficiency virus) infection in France. These populations meet with specific obstacles leading to late diagnosis and access to medical care. Delayed access to care (ATC) for HIV-infected migrants reduces their life expectancy and quality of life. Given the reduction of infectivity under antiretroviral (ARV) treatment, delayed ATC for HIV-infected migrants may also hinder the control of the HIV epidemic. The objective of this study is to measure the public health and economic consequences of delayed ATC for migrants living with HIV in France...
March 25, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28343327/osteolytic-variant-poems-syndrome-an-uncommon-presentation-of-osteosclerotic-myeloma
#11
Michael S Clark, Benjamin M Howe, Katrina N Glazebrook, Michelle L Mauermann, Stephen M Broski
Polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome, a form of osteosclerotic myeloma, is a multisystem disease related to a monoclonal plasma cell proliferative disorder. Osseous lesions are most commonly sclerotic on radiographs and computed tomography (CT), demonstrate low T1 and T2 signal intensity on magnetic resonance imaging (MRI), and have variable degrees of avidity on positon emission tomography (PET) imaging using 18-fluorodeoxyglucose ((18)F-FDG). We present three cases of POEMS syndrome manifesting as osteolytic lesions with indolent features, including well-defined thin sclerotic rims, no cortical disruption or periosteal reaction, no associated soft-tissue mass, and a periarticular location, all features that could lead to misinterpretation as benign bone lesions...
March 25, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28343320/allergic-airway-inflammation-induces-migration-of-mast-cell-populations-into-the-mouse-airway
#12
David Schmit, Duc Dung Le, Sebastian Heck, Markus Bischoff, Thomas Tschernig, Christian Herr, Christoph Beisswenger, Peter Kobelt, Phillipp Moritz Lepper, Kian Fan Chung, Robert Bals, Quoc Thai Dinh
Mast cells (MCs) and airway nerves play an important role in allergic asthma. However, little is known about the MCs and their interaction with airway nerves during allergic airway inflammation. This study aims to investigate the distribution and proliferation of MC populations in different lung compartments, along with the association of mast cells with nerve endings, using a house dust mite (HDM) model for allergic airway inflammation. BALB/c mice were exposed to HDM extract intranasally (25 μg/50 μl) for 5 consecutive days a week over 7 weeks...
March 25, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28343296/ibuprofen-protects-from-cypermethrin-induced-changes-in-the-striatal-dendritic-length-and-spine-density
#13
Pratibha Tripathi, Ashish Singh, Lakshmi Bala, Devendra Kumar Patel, Mahendra Pratap Singh
Microgliosis and inflammation are major wrongdoers in cypermethrin-induced Parkinsonism along with oxidative stress, mitochondrial dysfunction and α-synuclein aggregation. Dopamine depletion could alter dendritic morphology, length and spine number in the striatum. Present study investigated the effect of ibuprofen on the dendritic morphology, length and spine density in cypermethrin PD model. Male pups were treated intraperitoneally with cypermethrin during postnatal days followed by adulthood to induce Parkinsonism using standard procedure along with controls...
March 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28343293/pharmacokinetic-and-pharmacodynamic-considerations-in-the-treatment-of-chronic-lymphocytic-leukemia-ibrutinib-idelalisib-and-venetoclax
#14
REVIEW
Madeline Waldron, Allison Winter, Brian T Hill
Management of chronic lymphocytic leukemia has changed markedly over the last several years with the emergence of several novel oral agents targeting B-cell receptor and Bcl-2 signaling pathways. For patients requiring treatment, ibrutinib, idelalisib, and venetoclax offer unique clinical benefits with a different set of therapeutic considerations compared with traditional parenteral therapy. Despite the conveniences afforded by oral therapy, these agents also carry unique logistical obstacles. Drug interactions with agents that are metabolized via the cytochrome P450 3A4 pathway are possible with all three agents...
March 25, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28343292/psychometric-validation-of-the-heart-failure-caregiver-questionnaire-hf-cq-%C3%A2
#15
Anna Strömberg, Nicola Bonner, Laura Grant, Bryan Bennett, Misook L Chung, Tiny Jaarsma, Marie Louise Luttik, Eldrin F Lewis, Frederico Calado, Celine Deschaseaux
BACKGROUND: The Heart Failure Caregiver Questionnaire (HF-CQ(®)) was developed to assess subjective outcomes of heart failure caregivers. The HF-CQ(®) comprises 21 questions on three domains, namely physical, emotional/psychological and lifestyle. The objective of this study was to evaluate the psychometric properties of the HF-CQ(®). METHODS: Patients (n = 150) with heart failure and their primary caregivers (n = 150) were recruited from 11 sites in USA...
March 25, 2017: Patient
https://www.readbyqxmd.com/read/28343279/the-independent-influences-of-heat-strain-and-dehydration-upon-cognition
#16
Anne M J van den Heuvel, Benjamin J Haberley, David J R Hoyle, Nigel A S Taylor, Rodney J Croft
PURPOSE: Many researchers have addressed the potential effects of hyperthermia and dehydration on cognition, often revealing contradictory outcomes. A possible reason for this inconsistency is that experiments may have been inadequately designed for such effects. In this study, the impact of hyperthermia, dehydration and their combination on cognition were evaluated in eight young males, after accounting for a range of experimental limitations. METHODS: Passive heating and thermal clamping at two mean body temperatures (36...
March 25, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28343272/effect-of-atra-and-ato-on-the-expression-of-tissue-factor-in-nb4-acute-promyelocytic-leukemia-cells-and-regulatory-function-of-the-inflammatory-cytokines-tnf-and-il-1%C3%AE
#17
Sylvie Dunoyer-Geindre, Anne-Sophie Rivier-Cordey, Olga Tsopra, Thomas Lecompte, Egbert K O Kruithof
The characteristic hemorrhages of acute promyelocytic leukemia (APL) are caused in part by the high expression of tissue factor (TF) on leukemic cells, which also produce TNF and IL-1β, proinflammatory cytokines known to increase TF in various cell types. Exposure of NB4 cells, an APL cell line, to all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) rapidly and strongly reduced TF mRNA. Both drugs also reduced TNF mRNA, but later, and moreover increased IL-1β mRNA. The effect on procoagulant activity of cells and microparticles, as measured with calibrated automated thrombography, was delayed and only partial at 24 h...
March 25, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28343270/magnetic-field-discrimination-learning-and-memory-in-the-yellow-stingray-urobatis-jamaicensis
#18
Kyle C Newton, Stephen M Kajiura
Elasmobranch fishes (sharks, skates, and rays) have been hypothesized to use the geomagnetic field as a cue for orienting and navigating across a wide range of spatial scales. Magnetoreception has been demonstrated in many invertebrate and vertebrate taxa, including elasmobranchs, but this sensory modality and the cognitive abilities of cartilaginous fishes are poorly studied. Wild caught yellow stingrays, Urobatis jamaicensis (N = 8), underwent conditioning to associate a magnetic stimulus with a food reward in order to elicit foraging behaviors...
March 25, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28343269/neophobia-is-negatively-related-to-reversal-learning-ability-in-females-of-a-generalist-bird-of-prey-the-chimango-caracara-milvago-chimango
#19
Jorgelina María Guido, Laura Marina Biondi, Aldo Ivan Vasallo, Rubén Nestor Muzio
In an ever-changing environment, the ability to adapt choices to new conditions is essential for daily living and ultimately, for survival. Behavioural flexibility allows animals to maximise survival and reproduction in novel settings by adjusting their behaviour based on specific information and feedback acquired in their current environments. However, a growing body of evidence indicates that an individual's personality type can limit the extent to which the individual might behave flexibly, by influencing the way an individual pays attention to novelty and how much information it collects and stores, which in turn affects the individual's decision-making and learning process...
March 25, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28343257/leaf-ontogeny-of-schinus-molle-l-plants-under-cadmium-contamination-the-meristematic-origin-of-leaf-structural-changes
#20
Marcio Paulo Pereira, Felipe Fogaroli Corrêa, Evaristo Mauro de Castro, Jean Paulo Vitor de Oliveira, Fabricio José Pereira
Previous works show the development of thicker leaves on tolerant plants growing under cadmium (Cd(2+)) contamination. The aim of this study was to evaluate the Cd(2+) effects on the leaf meristems of the tolerant species Schinus molle. Plants were grown in nutrient solution containing 0, 10, and 50 μM of Cd(2+). Anatomical analysis was performed on leaf primordia sampled at regular time intervals. Under the lowest Cd(2+) level (10 μM), increased ground meristem thickness, diameter of the cells, cell elongation rate, and leaf dry mass were found...
March 25, 2017: Protoplasma
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