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Chlorophyllin

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https://www.readbyqxmd.com/read/27719668/chlorophylls-and-their-derivatives-used-in-food-industry-and-medicine
#1
Beata Mysliwa-Kurdziel, Katalin Solymosi
Thylakoids and chloroplasts harbor several vital metabolic processes, but are most importantly associated with photosynthesis. The undisturbed functioning of this process necessitates the ceaseless synthesis of photosynthetic pigments, including closed tetrapyrroles such as chlorophylls (Chls). Chls probably represent the most abundant natural pigment molecules which are via photosynthesis not only crucial for the autotrophic production of food sources for heterotrophic organisms but have also contributed to oxygen production essential for aerobic metabolism...
October 4, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27690001/sodium-copper-chlorophyllin-immobilization-onto-hippospongia-communis-marine-demosponge-skeleton-and-its-antibacterial-activity
#2
Małgorzata Norman, Przemysław Bartczak, Jakub Zdarta, Wiktor Tomala, Barbara Żurańska, Anna Dobrowolska, Adam Piasecki, Katarzyna Czaczyk, Hermann Ehrlich, Teofil Jesionowski
In this study, Hippospongia communis marine demosponge skeleton was used as an adsorbent for sodium copper chlorophyllin (SCC). Obtained results indicate the high sorption capacity of this biomaterial with respect to SCC. Batch experiments were performed under different conditions and kinetic and isotherms properties were investigated. Acidic pH and the addition of sodium chloride increased SCC adsorption. The experimental data were well described by a pseudo-second order kinetic model. Equilibrium adsorption isotherms were determined and the experimental data were analyzed using both Langmuir and Freundlich isotherms...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27688849/toxicity-of-chlorophyllin-against-lymnaea-acuminata-at-different-wavelengths-of-visible-light
#3
Divya Chaturvedi, Vinay Kumar Singh
Fasciolosis is a water and food-borne disease caused by the liver fluke Fasciola hepatica and Fasciola gigantica. This disease is widespread in different parts of the world. Lymnaeidae and Planorbidae snails are the intermediate hosts of these flukes. Snail population management is a good tool to control fasciolosis because gastropods represent the weakest link in the life-cycle of trematodes. Chlorophyll can be extracted from any green plant. Chlorophyllin was prepared from spinach in 100% ethanol by using different types of chemicals...
August 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27618070/a-saponification-method-for-chlorophyll-removal-from-microalgae-biomass-as-oil-feedstock
#4
Tao Li, Jin Xu, Hualian Wu, Guanghua Wang, Shikun Dai, Jiewei Fan, Hui He, Wenzhou Xiang
Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a preprocessing method of algae oil feedstock (Scenedesmus) to remove chlorophyll by saponification. The results showed that 96% of chlorophyll in biomass was removed. High quality orange transparent oil could be extracted from the chlorophyll reduced biomass...
September 7, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27524916/ability-of-sodium-copper-chlorophyllin-complex-to-repair-photoaged-skin-by-stimulation-of-biomarkers-in-human-extracellular-matrix
#5
John P McCook, Thomas J Stephens, Lily I Jiang, Robert M Law, Vincent Gotz
PURPOSE: To examine the effect of sodium copper chlorophyllin complex on the expression of biomarkers of photoaged dermal extracellular matrix indicative of skin repair. PATIENTS AND METHODS: Following a previously published 12-day clinical assessment model, skin biopsy samples from the forearms of four healthy females with signs of photoaged skin were obtained and samples were analyzed by immunohistochemistry for key biomarkers of aging skin after each subject was treated with a test material consisting of a gel containing a liposomal dispersion of sodium copper chlorophyllin complex 0...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27458703/nano-encapsulated-chlorophyllin-significantly-delays-progression-of-lung-cancer-both-in-in-vitro-and-in-vivo-models-through-activation-of-mitochondrial-signaling-cascades-and-drug-dna-interaction
#6
Jayeeta Das, Asmita Samadder, Jesmin Mondal, Suresh K Abraham, Anisur Rahman Khuda-Bukhsh
Chlorophyllin (CHL), a sodium-copper-salt derived from chlorophyll, has been widely used as a food-dye, also reportedly having some anti-cancer effect. We tested if PLGA-loaded CHL (NCHL) could have additional protective abilities through its faster and targeted drug delivery in cancer cells. Physico-chemical characterization of NCHL was done through atomic-force microscopy and UV-spectroscopy. NCHL demonstrated greater ability of drug uptake and strong anti-cancer potentials in non-small cell lung cancer cells, A549, as revealed from data of% cell viability, generation of reactive-oxygen-species and expression of bax, bcl2, caspase3, p53 and cytochrome c proteins...
September 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27410300/surface-plasmon-resonance-prism-coupler-for-enhanced-circular-dichroism-sensing
#7
Quoc-Hung Phan, Yu-Lung Lo, Chih-Ling Huang
A novel method for enhanced circular dichroism (CD) detection is proposed based on a surface plasmon resonance (SPR) prism coupler and a polarization scanning ellipsometry technique. An analytical model is derived to extract the CD and degree of polarization (DOP) properties of optical samples with and without scattering effects, respectively. The validity of the analytical model is confirmed by means of numerical simulations. The simulation results show that the proposed detection method has a sensitivity of 10<sup>-5</sup>~10<sup>-6</sup> RIU (refractive index unit) for refractive indices in the range of 1...
June 13, 2016: Optics Express
https://www.readbyqxmd.com/read/27253741/anthelmintic-activity-of-chlorophyllin-against-different-larval-stages-of-fasciola-gigantica
#8
Divya Jyoti Singh, Dinesh Kumar Singh
Fasciolosis is a food borne zoonosis, caused by the digenetic trematode Fasciola. Freshwater lymnaeid snails are the intermediate host of the trematodes. Chlorophyllin, a semi-synthetic derivative of chlorophyll and its formulations obtained from freeze dried cow urine (FCU) had their toxicity tested against redia and cercaria larvae of F. gigantica. The larvicidal activity of chlorophyllin and its formulations were found to depend on both, time and concentration used against the larvae. Toxicity of chlorophyllin + FCU (1:1 ratio) in sunlight against redia larva (8 h LC50: 0...
2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27098305/roles-of-chlorophyllin-in-cell-proliferation-and-the-expression-of-apoptotic-and-cell-cycle-genes-in-hb4a-non-tumor-breast-cells
#9
Gláucia Fernanda Rocha D Epiro, Simone Cristine Semprebon, Andressa Megumi Niwa, Juliana Cristina Marcarini, Mário Sérgio Mantovani
Chlorophyllin (Chl) has attracted interest in the scientific community due to its chemopreventive and antimutagenic properties. However, the molecular mechanisms of action of Chl remain unclear. This study assesses the effects on cell proliferation and the expression of genes involved in apoptosis, and the cell cycle in HB4a cells treated with Chl. Chl was cytotoxic and induced apoptosis to HB4a cells at 400 μg/mL. Analysis of gene expression showed that there was a decrease in the mRNA level of BIRC5 and CCNA2 genes involved in apoptosis and cell cycle progression, respectively...
June 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27046952/in-vitro-inhibition-of-cytopathic-effect-of-influenza-virus-and-human-immunodeficiency-virus-by-bamboo-leaf-extract-solution-and-sodium-copper-chlorophyllin
#10
Akiko Ito, Akeno Tsuneki, Yu Yoshida, Kazuo Ryoke, Toshiyuki Kaidoh, Seiji Kageyama
BACKGROUND: Although the link between oral and oropharyngeal health status and susceptibility to infection has long been recognized, there is a limit to the selection of antiseptics for oral care. METHODS: Madin-Darby canine kidney (MDCK) cells were exposed to influenza virus and cultured in the presence or absence of test reagents: bamboo leaf extract solution and sodium copper chrolophyllin. MDCK cells were pre-incubated with the reagents to assess the inhibitory activity at adsorption (viral attachment)...
March 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/26947225/effective-photosensitization-based-inactivation-of-gram-food-pathogens-and-molds-using-the-chlorophyllin-chitosan-complex-towards-photoactive-edible-coatings-to-preserve-strawberries
#11
Irina Buchovec, Viktorija Lukseviciute, Arunas Marsalka, Ignas Reklaitis, Zivile Luksiene
This study is focused on the novel approaches to enhance the inactivation of the Gram (-) food pathogen Salmonella enterica and harmful molds in vitro and on the surface of strawberries using the chlorophyllin-chitosan complex. Salmonella enterica (∼1 × 10(7) CFU mL(-1)) was incubated with chlorophyllin 1.5 × 10(-5) M (Chl, food additive), chitosan 0.1% (CHS, food supplement) or the chlorophyllin-chitosan complex (1.5 × 10(-5) M Chl-0.1% CHS) and illuminated with visible light (λ = 405 nm, light dose 38 J cm(-2)) in vitro...
April 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/26936032/fighting-fish-parasites-with-photodynamically-active-chlorophyllin
#12
D-P Häder, J Schmidl, R Hilbig, M Oberle, H Wedekind, P Richter
Water-soluble chlorophyll (chlorophyllin) was used in a phototoxic reaction against a number of fish ectoparasites such as Ichtyobodo, Dactylogyrus, Trichodina, and Argulus. Chlorophyllin is applied to the water at concentrations of several micrograms per milliliter for a predefined incubation time, and afterwards, the parasites are exposed to simulated solar radiation. Application in the dark caused only little damage to the parasites; likewise, light exposure without the addition of the photosensitizer was ineffective...
June 2016: Parasitology Research
https://www.readbyqxmd.com/read/26925296/chlorophyllin-bait-formulation-and-exposure-to-different-spectrum-of-visible-light-on-the-reproduction-of-infected-uninfected-snail-lymnaea-acuminata
#13
Navneet Kumar, D K Singh, Vinay Kumar Singh
Fasciolosis is a waterborne disease, caused by Fasciola species. Snail Lymnaea acuminata is an intermediate host of these flukes. Control of snail population is major tool in reducing the incidences. Variation in light intensity and wavelength caused significant changes in reproduction pattern of snails. Maximum fecundity was noted with bait containing carbohydrate (starch, 468 ± 0.10/20 snails) or amino acid (serine, 319 ± 0.29/20 snails) as attractant. Sublethal feeding of chlorophyllin bait with starch or serine attractant to infected and uninfected snails caused significant reduction in fecundity, hatchability, and survivability...
2016: Scientifica
https://www.readbyqxmd.com/read/26693716/treatment-of-ichthyophthiriasis-with-photodynamically-active-chlorophyllin
#14
D-P Häder, J Schmidl, R Hilbig, M Oberle, H Wedekind, P R Richter
Water-soluble chlorophyll (chlorophyllin) exerts pronounced photodynamic activity on fish parasites. In order to determine its potential as a remedy against ectoparasites in fish carps were incubated in water with defined concentrations of chlorophyllin. The main focus of the experiments was on the ciliate Ichthyophthirius multifiliis (Fouquet) which is responsible for considerable losses in livestock in aquaculture. As malachite green, which in the past efficiently cured infected fishes, is banned because of its possible carcinogenicity; no effective remedy is presently available in aquaculture to treat ichthyophthiriasis...
April 2016: Parasitology Research
https://www.readbyqxmd.com/read/26602166/oxidative-stress-response-in-canine-in-vitro-liver-kidney-and-intestinal-models-with-seven-potential-dietary-ingredients
#15
Kyoungju Choi, Maria T Ortega, Brett Jeffery, Jim E Riviere, Nancy A Monteiro-Riviere
In vitro cell culture systems are a useful tool to rapidly assess the potential safety or toxicity of chemical constituents of food. Here, we investigated oxidative stress and organ-specific antioxidant responses by 7 potential dietary ingredients using canine in vitro culture of hepatocytes, proximal tubule cells (CPTC), bone marrow-derived mesenchymal stem cells (BMSC) and enterocyte-like cells (ELC). Cellular production of free radical species by denatonium benzoate (DB), epigallocatechin gallate (EPI), eucalyptol (EUC), green tea catechin extract (GTE) and sodium copper chlorophyllin (SCC), tetrahydroisohumulone (TRA) as well as xylitol (XYL) were continuously measured for reactive oxygen/nitrogen species (ROS/RNS) and superoxide (SO) for up to 24h...
January 22, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/26538799/the-effect-of-bamboo-leaf-extract-solution-and-sodium-copper-chlorophyllin-solution-on-growth-and-volatile-sulfur-compounds-production-of-oral-malodor-associated-some-anaerobic-periodontal-bacteria
#16
Abir Majbauddin, Isamu Kodani, Kazuo Ryoke
BACKGROUND: Bamboo leaf extract solution (BLES) and sodium copper chlorophyllin solution (SCCS) are known for their anti-oxidant activities. Oral malodor is often related with periodontal pathogens. The present study was undertaken to investigate the anti-bacterial effect of both BLES and SCCS on anaerobic periodontal bacteria producing oral malodorous volatile sulfur compounds (VSC). METHODS: Porphyromonas gingivalis W83 (PG), Prevotella intermidai TDC19B (PI), Fusobacterium nucleatum ATCC25586 (FN) and Prevotella nigrescence ATCC33563 (PN) were investigated as oral isolated bacteria...
September 2015: Yonago Acta Medica
https://www.readbyqxmd.com/read/26461829/%C3%AF-%C3%AF-topical-treatment-with-liposomal-sodium-copper-chlorophyllin-complex-in-subjects-with-facial-redness-and-erythematotelangiectatic-rosacea-case-studies
#17
David B Vasily
Physicians are often presented with patients complaining of facial redness and difficult to control rosacea. The water soluble sodium copper chlorophyllin complex has been shown to have anti-oxidant, anti-inflammatory, and anti-bacterial activities in vitro and anti-redness, pore reduction, and anti-acne activities in pilot clinical studies. In these case studies, the safety and efficacy of a topical gel containing a liposomal suspension of sodium copper chlorophyllin complex was assessed in subjects with facial redness and erythematotelangiectatic rosacea...
October 2015: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26300653/in-vitro-inhibition-of-hyaluronidase-by-sodium-copper-chlorophyllin-complex-and-chlorophyllin-analogs
#18
John P McCook, Peter L Dorogi, David B Vasily, Dustin R Cefalo
BACKGROUND: Inhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents. Sodium copper chlorophyllin complex is being used therapeutically as a component in anti-aging cosmeceuticals, and has been shown to have anti-hyaluronidase activity. In this study we evaluated various commercial lots of sodium copper chlorophyllin complex to identify the primary small molecule constituents, and to test various sodium copper chlorophyllin complexes and their small molecule analog compounds for hyaluronidase inhibitory activity in vitro...
2015: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/26091384/pilot-study-of-topical-copper-chlorophyllin-complex-in-subjects-with-facial-acne-and-large-pores
#19
Thomas J Stephens, John P McCook, James H Herndon
BACKGROUND: Acne vulgaris is one of the most common skin diseases treated by dermatologists. Salts of copper chlorophyllin complex are semi-synthetic naturally-derived compounds with antioxidant, anti-inflammatory and wound healing activity that have not been previously tested topically in the treatment of acne-prone skin with enlarged pores. OBJECTIVES: This single-center pilot study was conducted to assess the efficacy and safety of a liposomal dispersion of topically applied sodium copper chlorophyllin complex in subjects with mild-moderate acne and large, visible pores over a course of 3 weeks...
June 2015: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26062536/experimental-application-of-lactobacillus-fermentum-ccm-7421-in-combination-with-chlorophyllin-in-dogs
#20
Viola Strompfová, Ivana Kubašová, Jana Farbáková, Soňa Gancarčíková, Dagmar Mudroňová, Aladár Maďari, Andrea Lauková
Chlorophyll belongs in a larger class of phytochemical plant pigments currently receiving more attention as a physiologically active dietary component. Although most research has focused on its biological activities such as its antioxidant, antimutagenic, anti-inflammatory or apoptotic effects in humans or rodents, there is limited knowledge at this time about the combinative possibilities of chlorophyll with probiotic bacteria. Our aim was to test the growth characteristics of canine-derived probiotic strain Lactobacillus fermentum CCM 7421 in the presence of different concentrations of chlorophyllin in vitro...
October 2015: Applied Microbiology and Biotechnology
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