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Campylobacter jejuni

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https://www.readbyqxmd.com/read/28646425/hydroxylamine-induced-oxidation-of-ferrous-carbonylated-truncated-hemoglobins-from-mycobacterium-tuberculosis-and-campylobacter-jejuni-is-limited-by-carbon-monoxide-dissociation
#1
Paolo Ascenzi, Chiara Ciaccio, Tecla Gasperi, Alessandra Pesce, Lucia Caporaso, Massimo Coletta
Hydroxylamine (HA) is an oxidant of ferrous globins and its action has been reported to be inhibited by CO, even though this mechanism has not been clarified. Here, kinetics of the HA-mediated oxidation of ferrous carbonylated Mycobacterium tuberculosis truncated hemoglobin N and O (Mt-trHbN(II)-CO and Mt-trHbO(II)-CO, respectively) and Campylobacter jejuni truncated hemoglobin P (Cj-trHbP(II)-CO), at pH 7.2 and 20.0 °C, are reported. Mixing Mt-trHbN(II)-CO, Mt-trHbO(II)-CO, and Cj-trHbP(II)-CO solution with the HA solution brings about absorption spectral changes reflecting the disappearance of the ferrous carbonylated derivatives with the concomitant formation of the ferric species...
June 23, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28642840/cytolethal-distending-toxin-enhances-radiosensitivity-in-prostate-cancer-cells-by-regulating-autophagy
#2
Hwai-Jeng Lin, Hsin-Ho Liu, Chia-Der Lin, Min-Chuan Kao, Yu-An Chen, Chuan Chiang-Ni, Zhi-Pei Jiang, Mei-Zi Huang, Chun-Jung Lin, U-Ging Lo, Li-Chiung Lin, Cheng-Kuo Lai, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Chih-Ho Lai
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Radiation therapy is an effective modality for the treatment of localized prostate cancer (PCa). However, patients often develop radioresistance. Owing to its particular biochemical properties, we previously employed CdtB as a therapeutic agent for sensitizing radioresistant PCa cells to ionizing radiation (IR)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28640123/recurrent-campylobacter-jejuni-bacteremia-in-a-patient-with-hypogammaglobulinemia-a-case-report
#3
Youie Kim, Ju Ae Shin, Seung Beom Han, Bin Cho, Dae Chul Jeong, Jin Han Kang
RATIONALE: Although some cases of recurrent bacteremia due to Campylobacter jejuni have been reported in immunocompromised patients, antibiotic treatment strategies to eradicate C. jejuni and prevent recurrent infections in immunocompromised patients have not been established. Authors' experience of such rare cases should be shared for improving patients' outcomes. PATIENT CONCERNS: An 18-year-old boy with hypogammaglobulinemia, who received intravenous immunoglobulin replacement therapy every 3 weeks, was admitted to hospital repeatedly due to recurrent diarrhea and cellulitis of the leg...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28636341/biochemical-characterization-of-wbkc-an-n-formyltransferase-from-brucella-melitensis
#4
Alexander S Riegert, Daniel P Chantigian, James B Thoden, Peter A Tipton, Hazel M Holden
It has become increasingly apparent within the last several years that unusual N-formylated sugars are often found on the O-antigens of such Gram negative pathogenic organisms as Francisella tularensis, Campylobacter jejuni, and Providencia alcalifaciens, amongst others. Indeed, in some species of Brucella, for example, the O-antigen contains 1,2-linked 4-formamido-4,6-dideoxy-alpha-D-mannosyl groups. These sugars, often referred to as N-formylperosamine, are synthesized in pathways initiating with GDP-mannose...
June 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/28634541/campylobacter-jejuni-myocarditis-a-journey-from-the-gut-to-the-heart
#5
M Toba Obafemi, Homeyra Douglas
OBJECTIVES: Campylobacter jejuni is an unusual cause of myocarditis and could easily be missed. METHODS: We describe a case of a 25 year old man, who presented with 3 day history of vomiting and diarrhoea, followed by chest pain and significant high sensitive troponin rise. RESULTS: The patient's profuse diarrhoea was accompanied by raised inflammatory markers, electrocardiogram changes and evidence of cardiomyopathy on transthoracic echocardiogram...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28619796/draft-genome-sequence-of-campylobacter-jejuni-cam970-and-c-%C3%A2-coli-cam962-associated-with-a-large-outbreak-of-foodborne-illness-in-fukuoka-japan-in-2016
#6
Hiroshi Asakura, Naoto Takahashi, Shiori Yamamoto, Hiroyuki Maruyama
Here, we report the draft genome sequences of Campylobacter jejuni CAM970 and C. coli CAM962, which were associated with a large outbreak of foodborne illness originating from undercooked chicken sushi in Fukuoka, Japan, in May 2016. Their genome sizes were 1,690,901 and 1,704,736 bp, with 22 and 23 rRNAs, 9 and 9 tRNAs, and 411× and 419× coverage for C. jejuni CAM970 and C. coli CAM962, respectively.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28619636/isolation-and-characterization-of-a-non-specific-lipid-transfer-protein-from-chelidonium-majus-l-latex
#7
Robert Nawrot, Damian Józefiak, Anna Sip, Dorota Kuźma, Oskar Musidlak, Anna Goździcka-Józefiak
Plant non-specific lipid transfer proteins (nsLTPs) are small basic proteins, which mostly play a role in intracellular lipid transport and antimicrobial defense. Recently it was shown using shotgun proteomic approach that the whole plant extract of Chelidonium majus L. (Papaveraceae) contains relatively abundant nsLTPs. Therefore the aim of the work was to isolate and characterize nsLTP from C. majus latex. Results obtained using PCR approach with degenerate primers showed the presence of nsLTP protein in C...
June 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28619013/mlst-genotypes-of-campylobacter-jejuni-isolated-from-broiler-products-dairy-cattle-and-human-campylobacteriosis-cases-in-lithuania
#8
Sigita Ramonaite, Egle Tamuleviciene, Thomas Alter, Neringa Kasnauskyte, Mindaugas Malakauskas
BACKGROUND: Campylobacter (C.) jejuni is the leading cause of human campylobacteriosis worldwide. We performed a molecular epidemiological study to investigate the genetic relationship among C. jejuni strains isolated from human diarrhoeal patients, broiler products and dairy cattle in Lithuania. METHODS: The C. jejuni isolates from human clinical cases, dairy cattle and broiler products were genotyped using multilocus sequence typing (MLST). Allele numbers for each housekeeping gene, sequence type (ST), and clonal complex (CC) were assigned by submitting the DNA sequences to the C...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28611753/differential-survival-of-hyper-aerotolerant-campylobacter-jejuni-under-different-gas-conditions
#9
Euna Oh, Lynn M McMullen, Linda Chui, Byeonghwa Jeon
Campylobacter jejuni accounts for a significant number of foodborne illnesses around the world. C. jejuni is microaerophilic and typically does not survive efficiently in oxygen-rich conditions. We recently reported that hyper-aerotolerant (HAT) C. jejuni are highly prevalent in retail poultry meat. To assess the capabilities of HAT C. jejuni in foodborne transmission and infection, in this study, we investigated the prevalence of virulence genes in HAT C. jejuni and the survival in poultry meat in atmosphere at a refrigeration temperature...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28611744/rnaseq-reveals-complex-response-of-campylobacter-jejuni-to-ovine-bile-and-in-vivo-gallbladder-environment
#10
Amanda J Kreuder, Jennifer A Schleining, Michael Yaeger, Qijing Zhang, Paul J Plummer
Colonization of the gallbladder by enteric pathogens such as Salmonella typhi, Listeria monocytogenes, and Campylobacter jejuni is thought to play a key role in transmission and persistence of these important zoonotic agents; however, little is known about the molecular mechanisms that allow for bacterial survival within this harsh environment. Recently, a highly virulent C. jejuni sheep abortion (SA) clone represented by the clinical isolate IA3902 has emerged as the dominant cause for sheep abortion in the United States...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28608661/campylobacter-jejuni-bacteremia-in-a-liver-cirrhosis-patient-and-review-of-literature-a-case-study
#11
Jin Gu Yoon, Saem Na Lee, Hak Jun Hyun, Min Joo Choi, Ji Ho Jeon, Eunju Jung, Seonghui Kang, Jeeyong Kim, Ji Yun Noh, Won Suk Choi, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
Campylobacter infection causes gastrointestinal symptoms such as abdominal pain or diarrhea. Occasionally, Campylobacter bacteremia affects immunocompromised patients; however, serious outcomes are known to be rare. Here, we present a case of a patient with Campylobacter bacteremia who had underlying liver cirrhosis. The patient had fever and diarrhea. These symptoms subsided after treatment with cefotaxime. Campylobacter jejuni was isolated in the blood culture after 10 days. In addition, previously reported cases of Campylobacter bacteremia in Asian countries were reviewed with respect to antimicrobial sensitivities...
May 26, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28598346/application-of-long-amplicon-propidium-monoazide-pcr-to-assess-the-effects-of-temperature-and-background-microbiota-on-pathogens-in-river-water
#12
Avid Banihashemi, Michele I Van Dyke, Peter M Huck
The decay rates of enteric waterborne pathogens were evaluated following the introduction of Yersinia enterocolitica, Salmonella enterica, Campylobacter jejuni and Arcobacter butzleri into river water at different temperatures (5, 15 and 25°C) for a period of 28 days. To improve the accuracy of the results a molecular viability assay, long amplicon propidium monoazide-polymerase chain reaction (PMA-PCR), was used to quantify the viable cell concentration and results from PCR with and without PMA were compared...
June 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28597819/phage-exposure-causes-dynamic-shifts-in-the-expression-states-of-specific-phase-variable-genes-of-campylobacter-jejuni
#13
Jack Aidley, Martine C Holst Sørensen, Christopher D Bayliss, Lone Brøndsted
Phase variation (PV) creates phenotypic heterogeneity at high frequencies and in a reversible manner. This phenomenon allows bacteria to adapt to a variety of different environments and selective pressures. In Campylobacterjejuni this reversible adaptive process is mediated by mutations in homopolymeric G/C tracts. Many C. jejuni-specific phages are dependent on phase-variable surface structures for successful infection. We previously identified the capsular polysaccharide (CPS) moiety, MeOPN-GalfNAc, as a receptor for phage F336 and showed that phase-variable expression of the transferase for this CPS modification, cj1421, and two other phase-variable CPS genes generated phage resistance in C...
June 8, 2017: Microbiology
https://www.readbyqxmd.com/read/28595575/towards-diagnostic-metagenomics-of-campylobacter-in-fecal-samples
#14
Sandra Christine Andersen, Kristoffer Kiil, Christoffer Bugge Harder, Mathilde Hasseldam Josefsen, Søren Persson, Eva Møller Nielsen, Jeffrey Hoorfar
BACKGROUND: The development of diagnostic metagenomics is driven by the need for universal, culture-independent methods for detection and characterization of pathogens to substitute the time-consuming, organism-specific, and often culture-based laboratory procedures for epidemiological source-tracing. Some of the challenges in diagnostic metagenomics are, that it requires a great next-generation sequencing depth and unautomated data analysis. RESULTS: DNA from human fecal samples spiked with 7...
June 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28592996/immune-responses-upon-campylobacter-jejuni-infection-of-secondary-abiotic-mice-lacking-nucleotide-oligomerization-domain-2
#15
Stefan Bereswill, Ursula Grundmann, Marie E Alutis, André Fischer, Anja A Kühl, Markus M Heimesaat
BACKGROUND: Campylobacter jejuni infections are of rising importance worldwide. Given that innate immune receptors including nucleotide-oligomerization-domain-2 (Nod2) are essentially involved in combating enteropathogenic infections, we here surveyed the impact of Nod2 in murine campylobacteriosis. METHODS AND RESULTS: In order to overcome physiological colonization resistance preventing from C. jejuni infection, we generated secondary abiotic Nod2(-/-) and wildtype (WT) mice by broad-spectrum antibiotic treatment...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28586527/generation-of-the-membrane-potential-and-its-impact-on-the-motility-atp-production-and-growth-in-campylobacter-jejuni
#16
Anne-Xander van der Stel, Fred C Boogerd, Steven Huynh, Craig T Parker, Linda van Dijk, Jos P M van Putten, Marc M S M Wösten
The generation of a membrane potential (Δψ), the major constituent of the proton motive force (pmf), is crucial for ATP synthesis, transport of nutrients and flagellar rotation. Campylobacter jejuni harbors a branched electron transport chain, enabling respiration with different electron donors and acceptors. Here, we demonstrate that a relatively high Δψ is only generated in the presence of either formate as electron donor or oxygen as electron acceptor, in combination with an acceptor/donor, respectively...
June 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28582978/detection-and-prevalence-of-antimicrobial-resistance-genes-in-i-campylobacter-i-spp-isolated-from-chickens-and-humans
#17
Samantha Reddy, Oliver T Zishiri
Campylobacter spp. are common pathogenic bacteria in both veterinary and human medicine. Infections caused by Campylobacter spp. are usually treated using antibiotics. However, the injudicious use of antibiotics has been proven to spearhead the emergence of antibiotic resistance. The purpose of this study was to detect the prevalence of antibiotic resistance genes in Campylobacter spp. isolated from chickens and human clinical cases in South Africa. One hundred and sixty one isolates of Campylobacter jejuni and Campylobacter coli were collected from chickens and human clinical cases and then screened for the presence of antimicrobial resistance genes...
May 29, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28578266/next-generation-sequencing-based-multigene-panel-for-high-throughput-detection-of-food-borne-pathogens
#18
Chiara Ferrario, Gabriele Andrea Lugli, Maria Cristina Ossiprandi, Francesca Turroni, Christian Milani, Sabrina Duranti, Leonardo Mancabelli, Marta Mangifesta, Giulia Alessandri, Douwe van Sinderen, Marco Ventura
Contamination of food by chemicals or pathogenic bacteria may cause particular illnesses that are linked to food consumption, commonly referred to as foodborne diseases. Bacteria are present in/on various foods products, such as fruits, vegetables and ready-to-eat products. Bacteria that cause foodborne diseases are known as foodborne pathogens (FBPs). Accurate detection methods that are able to reveal the presence of FBPs in food matrices are in constant demand, in order to ensure safe foods with a minimal risk of causing foodborne diseases...
May 3, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28574617/confirmed-identification-and-toxin-profiling-of-campylobacter-jejuni-using-a-thermostabilized-multiplex-pcr-formulation
#19
Nitya Ramachandran, Shylaja Ramlal, Harsh Vardhan Batra
Cytolethal distending toxin (CDT) producing Campylobacter jejuni species are one of the leading causes of human gastroenteritis worldwide. The main intent of the study was to develop a multiplex PCR assay for the confirmed identification and toxin profiling of C. jejuni. The genes targeted were rpo B as genus specific, hip O for species; cdt A, cdt B, cdt C encoding respective subunit proteins of CDT with Internal Amplification Control (IAC). To enhance its application as a pre-mixed ready-to-use format, the master mix of developed mPCR was dried by lyophilization and stability was assessed...
July 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28574503/pathogen-induced-ubiquitin-editing-enzyme-a20-bifunctionally-shuts-off-nf-%C3%AE%C2%BAb-and-caspase-8-dependent-apoptotic-cell-death
#20
Michelle C C Lim, Gunter Maubach, Olga Sokolova, Michael H Feige, Rolf Diezko, Jörn Buchbinder, Steffen Backert, Dirk Schlüter, Inna N Lavrik, Michael Naumann
The human pathogen Helicobacter pylori infects more than half of the world's population and is a paradigm for persistent yet asymptomatic infection but increases the risk for chronic gastritis and gastric adenocarcinoma. For successful colonization, H. pylori needs to subvert the host cell death response, which serves to confine pathogen infection by killing infected cells and preventing malignant transformation. Infection of gastric epithelial cells by H. pylori provokes direct and fast activation of the proinflammatory and survival factor NF-κB, which regulates target genes, such as CXCL8, BIRC3 and TNFAIP3...
June 2, 2017: Cell Death and Differentiation
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