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CALCIUM OXALATE STONES

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https://www.readbyqxmd.com/read/28528955/potential-therapeutic-activity-of-phlogacanthus-thyrsiformis-hardow-mabb-flower-extract-and-its-biofabricated-silver-nanoparticles-against-chemically-induced-urolithiasis-in-male-wistar-rats
#1
Poppy Das, Kiran Kumar, Arunai Nambiraj, Reshma Rajan, Rajendra Awasthi, Kamal Dua, Himaja M
Urolithiasis is a painful disorder in which stones are formed in the kidney, bladder or urethra. There are no proper therapeutic treatments available for kidney stones and people suffering from larger stones have to undergo surgery which has many side effects. A natural remedy with therapeutic effects that can dissipate and remove even the larger stones would eliminate the need of a surgery and the risks associated with it. The flowers of Phlogacanthus thyrsiformis used in culinary recipes in the north eastern India are also widely used as a folklore medicine for the treatment of kidney stones and liver disorders...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28526618/24-hour-urine-metabolic-differences-between-solitary-and-multiple-stone-formers-results-of-the-collaboration-on-urolithiasis-in-pediatrics-cup-working-group
#2
Theodore R Saitz, Solange Mongoue-Tchokote, Cynthia Sharadin, Dana W Giel, Sean Corbett, Larisa Kovacevic, Aaron P Bayne
INTRODUCTION: Specific factors associated with the risk of developing pediatric urinary stone disease remain unclear, especially those that may be associated with recurrent stone disease. OBJECTIVE: We compared the results of 24-h urine collections in children with a solitary stone episode to those with multiple stone episodes to determine if there is a difference that may be associated with multiple stone formation in children. STUDY DESIGN: A multi-institutional retrospective analysis was completed to assess 24-h urinary metabolic profiles in children with urolithiasis aged 2-18 years old...
April 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28496123/systematic-evaluation-for-effects-of-urine-ph-on-calcium-oxalate-crystallization-crystal-cell-adhesion-and-internalization-into-renal-tubular-cells
#3
Juthatip Manissorn, Kedsarin Fong-Ngern, Paleerath Peerapen, Visith Thongboonkerd
Urine pH has been thought to be an important factor that can modulate kidney stone formation. Nevertheless, there was no systematic evaluation of such pH effect. Our present study thus addressed effects of differential urine pH (4.0-8.0) on calcium oxalate (CaOx) crystallization, crystal-cell adhesion, crystal internalization into renal tubular cells, and binding of apical membrane proteins to the crystals. Microscopic examination revealed that CaOx monohydrate (COM), the pathogenic form, was crystallized with greatest size, number and total mass at pH 4...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28492152/effect-of-stone-composition-on-the-outcomes-of-semi-rigid-ureteroscopy-using-holmium-yttrium-aluminum-garnet-laser-or-pneumatic-lithotripsy
#4
Mustafa Kadihasanoglu, Ugur Yucetas, Mehmet Gokhan Culha, Erkan Erkan, Mahmut Gokhan Toktas
OBJECTIVE: To compare the effectiveness of laser lithotripsy (LL) and pneumatic lithotripters (PL) in calcium oxalate (CaOx) and calcium phosphate (CaP) stones and assess whether these stone compositions affect the outcomes of LL and PL. STUDY DESIGN: Comparative, descriptive study. PLACE AND DURATION OF STUDY: Istanbul Training and Research Hospital, Turkey, from August 2010 to August 2015. METHODOLOGY: A total of 114 patients underwent ureteroscopy using LL and PL...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28480748/effect-of-fruit-extract-on-renal-stone-formation-and-kidney-injury-in-rats
#5
Nasrin Partovi, Mohammad Reza Ebadzadeh, S Jamilaldin Fatemi, Mohammad Khaksari
This study investigated the effect of oral administration of Cactus fruit extracts on calcium oxalate deposition, malondialdehyde (MDA) and superoxide dismutase (SOD) activity in rat model. About 42 rats were used for the study. The animals were divided into seven groups. Control group maintained on regular rat food and drinking water throughout the study period, whereas in other groups nephrolithiasis was induced by ethylene glycol. Rats in kidney stone group were sacrificed after 28 days and all remaining groups after 58 days...
May 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28480348/antiurolithic-effect-of-olive-oil-in-a-mouse-model-of-ethylene-glycol-induced-urolithiasis
#6
Mohammed Alenzi, Shaik Rahiman, Bilal Ahmad Tantry
PURPOSE: At present, commercially available antiurolithic drugs have more adverse effects than potential therapeutic or preventive effects with chronic use. With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-induced urolithiasis. MATERIALS AND METHODS: Adult albino mice were divided into 6 groups. Group I was fed the vehicle only. Group II was supplemented with 0.75% EG alone in drinking water during the experimental period to initiate deposition of calcium oxalate in kidneys, which leads to urolithiasis in animals...
May 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28467511/urinary-metals-in-a-spontaneous-canine-model-of-calcium-oxalate-urolithiasis
#7
Eva Furrow, Molly E McCue, Jody P Lulich
Calcium oxalate urolithiasis is a common and painful condition in people. The pathogenesis of this disease is complex and poorly understood. Laboratory animal and in vitro studies have demonstrated an effect of multiple trace metals in the crystallization process, and studies in humans have reported relationships between urinary metal concentrations and stone risk. Dogs are a spontaneous model of calcium oxalate urolithiasis, and the metal content of canine calcium oxalate stones mirrors that of human stones...
2017: PloS One
https://www.readbyqxmd.com/read/28465866/kidney-stones-after-bariatric-surgery-risk-assessment-and-mitigation
#8
REVIEW
Pedro Mario Espino-Grosso, Benjamin Kirk Canales
Obesity is rampant across the spectrum of age, gender, and race in the Unites States. Paralleling this epidemic, kidney stone prevalence is also rising, affecting nearly 1 in 11 individuals. Bariatric surgical procedures, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), are the most effective weight loss options for morbidly obese or severely obese individuals with comorbidities. A number of studies have linked kidney stone development to bariatric surgical history, particularly RYGB, which portends up to a threefold increase in calcium oxalate stone risk compared with age-matched, obese controls...
March 1, 2017: Bariatric Surgical Practice and Patient Care
https://www.readbyqxmd.com/read/28460910/organic-acids-in-kakadu-plum-terminalia-ferdinandiana-the-good-ellagic-the-bad-oxalic-and-the-uncertain-ascorbic
#9
David J Williams, David Edwards, Sharon Pun, Mridusmita Chaliha, Brian Burren, Ujang Tinggi, Yasmina Sultanbawa
The phenolic ellagic acid (EA) is receiving increasing attention for its nutritional and pharmacological potential as an antioxidant and antimicrobial agent. The Australian native Kakadu plum (Terminalia ferdinandiana) fruit is an abundant source of this phytochemical. The fruit also contains large amounts of vitamin C (mainly as ascorbic acid, AA) and possibly the undesirable oxalic acid (OA). Regular consumption of high oxalate foods poses a variety of health risks in humans including interference with calcium absorption and kidney stone formation...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28458443/renal-stone-characterization-using-high-resolution-imaging-mode-on-a-photon-counting-detector-ct-system
#10
A Ferrero, R Gutjahr, A Henning, S Kappler, A Halaweish, D Abdurakhimova, Z Peterson, J Montoya, S Leng, C McCollough
In addition to the standard-resolution (SR) acquisition mode, a high-resolution (HR) mode is available on a research photon-counting-detector (PCD) whole-body CT system. In the HR mode each detector consists of a 2x2 array of 0.225 mm × 0.225 mm subpixel elements. This is in contrast to the SR mode that consists of a 4x4 array of the same sub-elements, and results in 0.25 mm isotropic resolution at iso-center for the HR mode. In this study, we quantified ex vivo the capabilities of the HR mode to characterize renal stones in terms of morphology and mineral composition...
March 9, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28457074/nephrolithiasis-in-israel-epidemiological-characteristics-of-return-patients-in-a-tertiary-care-center
#11
Yasmin Abu-Ghanem, Nir Kleinmann, Harry Z Winkler, Dorit E Zilberman
BACKGROUND: The prevalence and etiology of nephrolithiasis vary, depending on geography, gender and ethnicity. OBJECTIVES: To analyze the demographic data of return nephrolithiasis patients in a tertiary care center. METHODS: We retrospectively reviewed our prospective registry database of return patients seen at our outpatient clinic for nephrolithiasis. Data included gender, age at first visit, age at first stone event, body mass index (BMI), self-reported hypertension, diabetes mellitus (DM), and hyperlipidemia...
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28446830/bryophyllum-pinnatum-leaf-extracts-prevent-formation-of-renal-calculi-in-lithiatic-rats
#12
Mahendra Yadav, Vijay D Gulkari, Manish M Wanjari
BACKGROUND: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. AIM: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. MATERIALS AND METHODS: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28442375/implication-of-hyperoxaluria-on-osteopontin-and-er-stress-mediated-apoptosis-in-renal-tissue-of-rats
#13
Rishi Bhardwaj, Ankita Bhardwaj, Chanderdeep Tandon, Devinder K Dhawan, Rakesh Kumar Bijarnia, Tanzeer Kaur
Hyperoxaluria is a stress that leads to calcium oxalate crystal deposition which further causes inflammation and renal cell necroptosis. Many studies have linked osteopontin expression with apoptosis and inflammation but so far its association with apoptosis with regard to hyperoxaluria is undiscovered. Moreover, a recent report has suggested that osteopontin induces endoplasmic reticulum stress and subsequently apoptosis in myocytes. In this study, the impact of hyperoxaluria on the modulation of osteopontin expression and endoplasmic reticulum (ER) stress mediated apoptosis in rats is explored...
April 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28427913/predicting-the-stone-composition-of-children-preoperatively-by-hounsfield-unit-detection-on-non-contrast-computed-tomography
#14
Mesut Altan, Burak Çitamak, Ali Cansu Bozaci, Altan Güneş, Hasan Serkan Doğan, Mithat Haliloğlu, Serdar Tekgül
INTRODUCTION: Many studies have been performed on adult patients to reveal the relationship between Hounsfield unit (HU) value and composition of stone, but none have focused on childhood. OBJECTIVE: We aimed to predict stone composition by HU properties in pre-intervention non-contrast computed tomography (NCCT) in children. This could help to orient patients towards more successful interventions. MATERIALS AND METHODS: Data of 94 children, whose pre-intervention NCCT and post-interventional stone analysis were available were included...
March 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28427449/urolithiasis-analysis-in-a-multiethnic-population-at-a-tertiary-hospital-in-nairobi-kenya
#15
Francis K Wathigo, Alfred Hayombe, Daniel Maina
BACKGROUND: Urolithiasis is a global problem whose incidence is reported to be on the rise across the world. Previously, urolithiasis was reported as being rare among the indigenous African population but recent data suggest otherwise. This study reviewed the demographic and clinical characteristics of patients with urolithiasis seen at the Aga Khan University hospital Nairobi (AKUHN) as well as the chemical composition of the stones and the modalities of therapy used. METHODS: This was a retrospective study which utilized patients' clinical and laboratory records from 2013 to 2014...
April 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28422036/physicochemical-factors-of-the-urine-of-children-with-hypercalciuria
#16
Mercedes Ubetagoyena-Arrieta, Jorge Martínez Sáenz de Jubera, María Nieves Corera-Casty, Eduardo González Pérez-Yarza, Irati García-Albizua
OBJECTIVE: Hypercalciuria is a common lithogenic risk factor. The aim of this study was, first, to study the characteristics of urine biochemical factors of children with hypercalciuria (HC) and compare them with those of children without hypercalciuria. Second, to analyze the differences between children with HC and lithiasis (HCL) and children with HC and no lithiasis (HCNL). METHODS: The sample was composed by 111 cases with HC, divided into 2 groups: HCNL group, consisting of 93 cases with no personal history of kidney stones, and HCL group, 18 cases with personal history of kidney stones...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28410252/molecular-modifiers-of-kidney-stones
#17
Bryan G Alamani, Jeffrey D Rimer
PURPOSE OF REVIEW: This review discusses the role of molecular modifiers as inhibitors of kidney stone formation, drawing largely from in-vitro evidence while also citing relevant in-vivo studies. An emphasis is placed on physical observations of crystal growth inhibition, including mechanisms of action that focus predominantly on the literature of calcium oxalate and L-cystine. RECENT FINDINGS: The last decade has witnessed several breakthroughs in the identification of molecules with promise to curb kidney stone formation, as well as discoveries of the mechanisms by which these molecules (or combinations thereof) function as inhibitors of pathological crystal growth...
April 13, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28394535/-metaphylaxis-of-urolithiasis-new-look-modern-approach-implementation-in-a-mobile-application
#18
N K Gadzhiev, S S Brovkin, V E Grigorev, V V Dmitriev, V A Malkhasyan, D D Shkarupa, A V Pisarev, D A Mazurenko, V M Obidnyak, I N Orlov, S V Popov, N S Tagirov, S V Petrov
AIM: To analyze the sub-segment of mHealth devoted to assessing of the risk of recurrent stone formation and metaphylaxis of stone formation. To design a smartphone application (app.) in Russian language for urolithiasis patients. MATERIALS AND METHODS: Three working groups of urologists from three St. Petersburg clinics searched for downloadable medical applications relevant to the above requirements. After searching and analyzing existing medical applications, the most acceptable design and structure of our own application were identified...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28392511/combination-of-vitamin-e-and-vitamin-c-alleviates-renal-function-in-hyperoxaluric-rats-via-antioxidant-activity
#19
Orapun Jaturakan, Thasinas Dissayabutra, Narongsak Chaiyabutr, Anusak Kijtawornrat, Piyaratana Tosukhowong, Anudep Rungsipipat, Thumnoon Nhujak, Chollada Buranakarl
Hyperoxaluria and oxidative stress are risk factors in calcium oxalate (CaOx) stone formation. Supplement with antioxidant could be effective in prevention of recurrent stone formation. The present study aims to evaluate the protective effects of vitamin E and vitamin C in hyperoxaluric rat. The experiment was performed in rats for 21 days. Rats were divided into 5 groups as follows: control (group 1, n=8), hyperoxaluric rats (group 2, n=8), hyperoxaluric rats with vitamin E supplement (group 3, n=7), hyperoxaluric rats with vitamin C supplement (group 4, n=7) and hyperoxaluric rats with vitamin E and C supplement (group 5, n=7)...
April 8, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28384169/serum-concentrations-of-symmetric-dimethylarginine-and-creatinine-in-cats-with-kidney-stones
#20
Jean A Hall, Maha Yerramilli, Edward Obare, Jun Li, Murthy Yerramilli, Dennis E Jewell
Serum concentrations of symmetric dimethylarginine (SDMA) correlate with renal function in cats and SDMA has been shown to be a more reliable and earlier marker for chronic kidney disease (CKD) compared with serum creatinine (Cr). Calcium oxalate uroliths tend to develop in mid-to-older aged cats and kidney stones may cause a reduction in renal function with increased SDMA, but normal serum Cr. The purpose of this retrospective study was to determine if cats with kidney stones had increased serum SDMA concentrations, and whether SDMA increased earlier than serum creatinine concentrations...
2017: PloS One
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