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CALCIUM OXALATE STONES

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https://www.readbyqxmd.com/read/29777258/development-of-a-two-stage-in-vitro-model-system-to-investigate-the-mineralization-mechanisms-involved-in-idiopathic-stone-formation-stage-1-biomimetic-randall-s-plaque-using-decellularized-porcine-kidneys
#1
Archana C Lovett, Saeed R Khan, Laurie B Gower
Idiopathic calcium oxalate (CaOx) stone formers form stones that are commonly attached to calcium phosphate (CaP) deposits in the renal tissue, known as Randall's plaques (RP). Plaques are suggested to originate in the renal tubular basement membrane, where they exhibit a morphology of concentrically laminated apatitic spherules, while in the interstitial regions, the collagen fibrils and vesicles become mineralized. We hypothesize that these minerals might form by non-classical crystallization mechanisms, such as via amorphous precursors, some of which might originate from a polymer-induced liquid-precursor (PILP) process...
May 18, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29761226/renal-stone-composition-does-not-affect-the-outcome-of-percutaneous-nephrolithotomy-in-children
#2
Onur Kaygısız, Fethi Ahmet Türegün, Nihat Satar, Ender Özen, Serdar Toksöz, Hasan Serkan Doğan, Mehmet Mesut Pişkin, Volkan İzol, Şaban Sarıkaya, Hakan Kılıçarslan, Tufan Çiçek, Ahmet Öztürk, Serdar Tekgül, Bülent Önal
PURPOSE: We sought to investigate the association between renal stone composition and percutaneous nephrolithotomy outcomes in pediatric patients and define the characterization of the stone composition. METHODS: The data of 1157 children who underwent percutaneous nephrolithotomy between 1991 and 2012 were retrieved from the multicenter database of the Turkish Pediatric Urology Society. The study population comprised 359 children (160 girls, 199 boys) with stone analyses...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29750296/hyperoside-protects-human-kidney%C3%A2-2-cells-against-oxidative-damage-induced-by-oxalic-acid
#3
Yongliang Chen, Lihong Ye, Wangjian Li, Dongzhang Li, Feng Li
The majority of renal calculi (kidney stones) are calcium stones. Oxidative damage to renal tubular epithelial cells induced by reactive oxygen species (ROS) is the predominant cause of calcium oxalate stone formation. Hyperoside (Hyp) is a flavonol glycoside extracted from medicinal plants and appears to exhibit potent antioxidant activity in various cells. The aim of the present study was to investigate the protective effect of Hyp on renal cells exposed to oxidative stress simulated by oxalic acid (OA), and to determine whether the underlying mechanism involves the nuclear factor E2‑related factor2 (Nrf2)‑antioxidative response element signaling pathway...
May 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29747780/comparison-of-miniaturized-percutaneous-nephrolithotomy-and-flexible-ureterorenoscopy-for-moderate-size-renal-stones-in-elderly-patients
#4
Faruk Ozgor, Fatih Yanaral, Metin Savun, Harun Ozdemir, Ufuk Caglar, Omer Sarilar
Life expectancy has become longer, thus the number of elderly people who require treatment for nephrolithiasis has increased. We aimed to analyze the efficacy of flexible ureterorenoscopy (f-URS) and miniaturized percutaneous nephrolithotomy (mPNL) in the management of 10 and 30 mm renal stones in patients aged >60 years. In prospective non-randomized series, the data of patients who underwent f-URS or mPNL for kidney stones between July 2013 and July 2016 were analyzed. The procedure was accepted as successful if the patient was achieved complete stone clearance according to CT imaging between 1-3 months postoperatively...
June 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29745818/novel-insights-into-renal-mineralization-and-stone-formation-through-advanced-imaging-modalities
#5
Scott V Wiener, Ling Chen, Alex R Shimotake, Misun Kang, Marshall L Stoller, Sunita P Ho
Purpose/Aim: The most common kidney stone composed of calcium oxalate forms on interstitial calcium phosphate mineral known as a Randall's plaque (RP). Due to limited information about events leading to the initial deposition of nanometer size interstitial calcium phosphate pre-clusters, there continues to be a debate on the initial site of calcium phosphate deposition and factors leading to stone formation. MATERIALS AND METHODS: High-resolution X-ray micro-computed tomography (CT), and light and electron microscopy techniques were used to characterize human renal pyramids and five representative kidney stones with identifiable stems...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29738031/influence-of-nutritional-status-laboratory-parameters-and-dietary-patterns-upon-urinary-acid-excretion-in-calcium-stone-formers
#6
Carolini Zanette Warmling Tessaro, Christiane Ishikawa Ramos, Ita Pfeferman Heilberg
INTRODUCTION: Obesity and Metabolic Syndrome (MS) are associated with low urinary pH and represent risk factors for nephrolithiasis, especially composed by uric acid. Acidogenic diets may also contribute to a reduction of urinary pH. Propensity for calcium oxalate precipitation has been shown to be higher with increasing features of the MS. OBJECTIVE: A retrospective evaluation of anthropometric and body composition parameters, MS criteria and the dietary patterns of overweight and obese calcium stone formers and their impact upon urinary pH and other lithogenic parameters was performed...
April 26, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29738024/urinary-ph-in-calcium-oxalate-stone-formers-does-it-matter
#7
EDITORIAL
Mauricio Carvalho
No abstract text is available yet for this article.
April 9, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29705728/understanding-the-gut-kidney-axis-in-nephrolithiasis-an-analysis-of-the-gut-microbiota-composition-and-functionality-of-stone-formers
#8
Andrea Ticinesi, Christian Milani, Angela Guerra, Franca Allegri, Fulvio Lauretani, Antonio Nouvenne, Leonardo Mancabelli, Gabriele Andrea Lugli, Francesca Turroni, Sabrina Duranti, Marta Mangifesta, Alice Viappiani, Chiara Ferrario, Rossella Dodi, Margherita Dall'Asta, Daniele Del Rio, Marco Ventura, Tiziana Meschi
OBJECTIVES: The involvement of the gut microbiota in the pathogenesis of calcium nephrolithiasis has been hypothesised since the discovery of the oxalate-degrading activity of Oxalobacter formigenes , but never comprehensively studied with metagenomics. The aim of this case-control study was to compare the faecal microbiota composition and functionality between recurrent idiopathic calcium stone formers (SFs) and controls. DESIGN: Faecal samples were collected from 52 SFs and 48 controls (mean age 48±11)...
April 28, 2018: Gut
https://www.readbyqxmd.com/read/29692509/spectrum-of-urinary-stone-composition-in-northwestern-rajasthan-using-fourier-transform-infrared-spectroscopy
#9
Amilal Bhat, Vikash Singh, Mahakshit Bhat, Vinay Kumar, Akshita Bhat
Introduction: The aim of this study was to evaluate the chemical composition of urinary stones and pattern of changes according to the patient's age in Northwestern Rajasthan using Fourier transform infrared (FTIR) spectroscopy. Materials and Methods: A prospective study of 1005 urolithiasis patients was carried out in two tertiary care centers from September 2012 to September 2016. Chemical composition of urinary stones was analyzed using FTIR spectroscopy, and a subgroup study based on the patient's age was done (8-12 years - Group A, 13-18 years - Group B, and >18 years - Group C)...
April 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29691640/thermal-effects-of-ho-yag-laser-lithotripsy-real-time-evaluation-in-an-in-vitro-model
#10
Simon Hein, Ralf Petzold, Martin Schoenthaler, Ulrich Wetterauer, Arkadiusz Miernik
PURPOSE: To evaluate the thermal effect of Ho:YAG laser lithotripsy in a standardized in vitro model via real-time temperature measurement. METHODS: Our model comprised a 20 ml test tube simulating the renal pelvis that was immersed in a 37 °C water bath. Two different laser fibers [FlexiFib (15-45 W), RigiFib 1000 (45-100 W), LISA laser products OHG, Katlenburg-Lindau, Germany] were placed in the test tube. An Ho:YAG 100 W laser was used in all experiments (LISA)...
April 24, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29680902/contamination-of-soil-and-the-medicinal-plant-phyllanthus-niruri-linn-with-cadmium-in-ceramic-industrial-areas
#11
Vanessa Santana Vieira Santos, Karen Magalhães Arantes, Ester Luiza Gonçalves, Carlos Fernando Campos, Edimar Olegário de Campos Júnior, Antônio Marcos Machado de Oliveira, Boscolli Barbosa Pereira
Phyllanthus niruri is a plant that is used to prevent calcium oxalate crystallisation and to block the stone formation in urolithiasis. Contaminants in the environment can be readily taken up by medicinal plants due to their ability to absorb chemicals into their tissues. If contaminated plants are ingested, they have the potential to negatively affect human and environmental health. The aim of this study was to assess contamination in the soil and the medicinal plant P. niruri by cadmium (Cd) in ceramic industrial areas of Monte Carmelo, Brazil...
April 22, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29676375/bone-marrow-oxalosis-an-unusual-cause-of-cytopenia-in-end-stage-renal-disease-report-of-two-cases
#12
Seema Sharma, Ram Nawal Rao, Krushna Chandra Pani, Paramita Paul
Systemic oxalosis can be either primary or secondary hyperoxaluria. Oxalosis is a phenomenon in which calcium oxalate crystals deposit in various visceral organs leading to bone marrow (BM) failure and recurrent renal stones. We describe two rare cases of BM oxalosis. Hyperoxaluria is strongly associated with nephrolithiasis and nephrocalcinosis. Both the patients presented with recurrent renal stones and a variable degree of BM failure. BM oxalosis should be considered as a possible diagnosis in patients in recurrent nephrolithiasis and cytopenia...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676347/dual-energy-computed-tomography-a-reliable-and-established-tool-for-in-vivo-differentiation-of-uric-acid-from-nonuric-acid-renal-stones
#13
Mohd Ilyas, Ghanshyam Dev, Anchal Gupta, Tameem Ahmad Bhat, Shwait Sharma
Background: Dual-energy computed tomography (DECT) utilises the technique of simultaneous image acquisition of a body part at two different energy levels of the X-ray tubes. We used the DECT in this project to study its accuracy in non-invasive in vivo differentiation of uric acid (UA) calculi from non-UA calculi using the 3rd generation dual-source computed tomography (CT) scanner. Materials and Methods: The DECT ratios of the various stones were noted and compared with the postextraction analysis of stones for composition...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29660680/phase-composition-and-morphological-characterization-of-human-kidney-stones-using-ir-spectroscopy-scanning-electron-microscopy-and-x-ray-rietveld-analysis
#14
Paramita Chatterjee, Arup Chakraborty, Alok K Mukherjee
Pathological calcification in human urinary tract (kidney stones) is a common problem affecting an increasing number of people around the world. Analysis of such minerals or compounds is of fundamental importance for understanding their etiology and for the development of prophylactic measures. In the present study, structural characterization, phase quantification and morphological behaviour of thirty three (33) human kidney stones from eastern India have been carried out using IR spectroscopy (FT-IR), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)...
April 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29653411/autophagy-inhibition-attenuates-hyperoxaluria-induced-renal-tubular-oxidative-injury-and-calcium-oxalate-crystal-depositions-in-the-rat-kidney
#15
Xiaolu Duan, Zhenzhen Kong, Xin Mai, Yu Lan, Yang Liu, Zhou Yang, Zhijian Zhao, Tuo Deng, Tao Zeng, Chao Cai, Shujue Li, Wen Zhong, Wenqi Wu, Guohua Zeng
Hyperoxaluria-induced oxidative injury of renal tubular epithelial cell is a casual and essential factor in kidney calcium oxalate (CaOx) stone formation. Autophagy has been shown to be critical for the regulation of oxidative stress-induced renal tubular injury; however, little is known about its role in kidney CaOx stone formation. In the present study, we found that the autophagy antagonist chloroquine could significantly attenuate oxalate-induced autophagy activation, oxidative injury and mitochondrial damage of renal tubular cells in vitro and in vivo, as well as hyperoxaluria-induced CaOx crystals depositions in rat kidney, whereas the autophagy agonist rapamycin exerted contrasting effects...
June 2018: Redox Biology
https://www.readbyqxmd.com/read/29651290/anti-transforming-growth-factor-%C3%AE-igg-elicits-a-dual-effect-on-calcium-oxalate-crystallization-and-progressive-nephrocalcinosis-related-chronic-kidney-disease
#16
Stefanie Steiger, Julia Felicitas Grill, Qiuyue Ma, Tobias Bäuerle, Jutta Jordan, Michaela Smolle, Claudia Böhland, Maciej Lech, Hans-Joachim Anders
Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney stone disease or nephrocalcinosis-related chronic kidney disease (CKD). We hypothesized that immunoglobulins can modulate CaOx microcrystal formation and crystal growth and that therefore, biological IgG-based drugs designed to specifically target disease modifying proteins would elicit a dual effect on the outcome of CaOx-related crystallopathies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29625137/sensitivity-of-non-contrast-computed-tomography-for-small-renal-calculi-with-endoscopy-as-the-gold-standard
#17
Naeem Bhojani, Jessica E Paonessa, Marawan M El Tayeb, James C Williams, Tariq A Hameed, James E Lingeman
OBJECTIVES: To compare the sensitivity of non-contrast CT to endoscopy for detection of renal calculi. Imaging modalities for detection of nephrolithiasis have centered on abdominal x-ray (KUB), ultrasound (US), and non-contrast computed tomography (CT). Sensitivities of 58-62% (KUB), 45% (US), and 95-100% (CT) have been previously reported. However, these results have never been correlated with endoscopic findings. METHODS: Idiopathic calcium oxalate stone formers with symptomatic calculi requiring ureteroscopy (URS) were studied...
April 3, 2018: Urology
https://www.readbyqxmd.com/read/29617079/effect-of-phyllanthus-niruri-on-metabolic-parameters-of-patients-with-kidney-stone-a-perspective-for-disease-prevention
#18
Nidia D Pucci, Giovanni S Marchini, Eduardo Mazzucchi, Sabrina T Reis, Miguel Srougi, Denise Evazian, William C Nahas
Phyllanthus niruri (P.niruri) or stone breaker is a plant commonly used to reduce stone risk, however, clinical studies on this issue are lacking. OBJECTIVE: To prospectively evaluate the effect of P. niruri on the urinary metabolic parameters of patients with urinary lithiasis. MATERIALS AND METHODS: We studied 56 patients with kidney stones <10mm. Clinical, metabolic, and ultrasonography assessment was conducted before (baseline) the use of P. niruri infusion for 12-weeks (P...
March 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29607709/impact-of-food-quantity-and-quality-on-the-biochemical-risk-of-renal-stone-formation
#19
Francesco Esperto, Roberto Miano, Martino Marangella, Alberto Trinchieri
OBJECTIVE: This study evaluated the role of body mass index (BMI) and dietary potential renal acid load (PRAL) with urinary saturation for calcium oxalate (US-CaOx), calcium phosphate (US-CaP) and uric acid (US-UA) in renal stone formers. MATERIALS AND METHODS: A retrospective analysis was conducted of laboratory data collected on 442 renal stone-forming patients. Demographic information, BMI and 24 h urinary samples were collected from patients on their regular diets...
April 1, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29594505/urinary-stone-risk-factors-in-the-descendants-of-patients-with-kidney-stone-disease
#20
Thasinas Dissayabutra, Nuttiya Kalpongkul, Jakkhaphan Rattanaphan, Chanchai Boonla, Monpicha Srisa-Art, Wattanachai Ungjaroenwathana, Piyaratana Tosukhowong
BACKGROUND: Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population. METHODS: The 24-h urinary metabolic profile was studied for 28 calcium oxalate nephrolithiasis patients (NL) and 46 of their descendants (ND), as well as 40 non-stone-forming volunteers (V) and 34 of their descendants (VD)...
March 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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