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calcium channel pumps

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https://www.readbyqxmd.com/read/29351458/differences-in-l-type-calcium-channel-activity-partially-underlie-the-regional-dichotomy-in-pumping-behavior-by-murine-peripheral-and-visceral-lymphatic-vessels
#1
Scott D Zawieja, Jorge A Castorena-Gonzalez, Joshua Scallan, Michael J Davis
We identified a regional dichotomy in murine lymphatic contractile function with regard to vessel location within either the periphery or visceral cavity. All vessels isolated from peripheral regions; cervical, popliteal, inguinal, axillary, and inter-nodal inguinal axillary (Ing-Ax) developed robust contractions with maximal ejection fractions (EFs) of 50-80% in our ex vivo isobaric myograph experiments. Conversely, vessels isolated from the visceral cavity (mesenteric, TD, and iliac) demonstrated maximal EFs below 15%...
January 5, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29251738/nm23-proteins-innocent-bystanders-or-local-energy-boosters-for-cftr
#2
Richmond Muimo, Hani Mm Alothaid, Anil Mehta
NM23 proteins NDPK-A and -B bind to the cystic fibrosis (CF) protein CFTR in different ways from kinases such as PKA, CK2 and AMPK or linkers to cell calcium such as calmodulin and annexins. NDPK-A (not -B) interacts with CFTR through reciprocal AMPK binding/control, whereas NDPK-B (not -A) binds directly to CFTR. NDPK-B can activate G proteins without ligand-receptor coupling, so perhaps NDPK-B's binding influences energy supply local to a nucleotide-binding site (NBD1) needed for CFTR to function. Curiously, CFTR (ABC-C7) is a member of the ATP-binding cassette (ABC) protein family that does not obey 'clan rules'; CFTR channels anions and is not a pump, regulates disparate processes, is itself regulated by multiple means and is so pleiotropic that it acts as a hub that orchestrates calcium signaling through its consorts such as calmodulin/annexins...
December 18, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29180009/regulation-of-the-plasma-membrane-calcium-atpases-by-the-actin-cytoskeleton
#3
Marianela G Dalghi, Mariela Ferreira-Gomes, Juan Pablo Rossi
Associations between the cortical cytoskeleton and the components of the plasma membrane are no longer considered to be merely of structural and mechanical nature but are nowadays recognized as dynamic interactions that modulate a plethora of cellular responses. Reorganization of actin filaments upon diverse stimuli - among which is the rise in cytosolic Ca2+ - is involved in cell motility and adhesion, phagocytosis, cytokinesis, and secretion. Actin dynamics also participates in the regulation of ion transport across the membranes where it not only plays a key role in the delivery and stabilization of channels and transporters in the plasma membrane but also in the regulation of their activity...
November 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29163059/oxygen-and-glucose-deprivation-induces-bergmann-glia-membrane-depolarization-and-ca-2-rises-mainly-mediated-by-k-and-atp-increases-in-the-extracellular-space
#4
Romain Helleringer, Oana Chever, Hervé Daniel, Micaela Galante
During brain ischemia, intense energy deficiency induces a complex succession of events including pump failure, acidosis and exacerbated glutamate release. In the cerebellum, glutamate is the principal mediator of Purkinje neuron anoxic depolarization during episodes of oxygen and glucose deprivation (OGD). Here, the impact of OGD is studied in Bergmann glia, specialized astrocytes closely associated to Purkinje neurons. Patch clamp experiments reveal that during OGD Bergmann glial cells develop a large depolarizing current that is not mediated by glutamate and purinergic receptors but is mainly due to the accumulation of K(+) in the extracellular space...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29157865/peptide-yy-3-36-modulates-intracellular-calcium-through-activation-of-the-phosphatidylinositol-pathway-in-hippocampal-neurons
#5
Michelle Flores Domingues, Dênis Reis de Assis, Angela Regina Piovesan, Cháriston André Dal Belo, Jaderson Costa da Costa
Peptide YY (PYY) belongs to the neuropeptide Y (NPY) family, which also includes the pancreatic polypeptide (PP) and NPY. PYY is secreted by the intestinal L cells, being present in the blood stream in two active forms capable of crossing the blood brain barrier, PYY (1-36) and its cleavage product, PYY (3-36). PYY is a selective agonist for the Y2 receptor (Y2R) and these receptors are abundant in the hippocampus. Here we investigated the mechanisms by which PYY (3-36) regulates intracellular Ca(2+) concentrations ([Ca(2+)]i) in hippocampal neurons by employing a calcium imaging technique in hippocampal cultures...
November 7, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29150934/the-current-status-and-perspectives-regarding-the-clinical-implication-of-intracellular-calcium-in-breast-cancer
#6
REVIEW
Amir Tajbakhsh, Alireza Pasdar, Mehdi Rezaee, Mostafa Fazeli, Saman Soleimanpour, Seyed Mahdi Hassanian, Zahra FarshchiyanYazdi, Tayebe Younesi Rad, Gordon A Ferns, Amir Avan
Calcium ions (Ca2+ ) act as second messengers in intracellular signaling. Ca2+ pumps, channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular Ca2+ as a key regulator of important cellular processes such as gene expression, proliferation, differentiation, DNA repair, apoptosis, metastasis, and hormone secretion. Intracellular Ca2+ also influences the functions of several organelles, that include: the endoplasmic reticulum, mitochondria, the Golgi, and cell membrane both in normal and breast cancer cells...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29114587/reduction-of-calcium-flux-from-the-extracellular-region-and-endoplasmic-reticulum-by-amorphous-nano-silica-particles-owing-to-carboxy-group-addition-on-their-surface
#7
Akira Onodera, Katsutoshi Yayama, Hideto Morosawa, Yukina Ishii, Yasuo Tsutsumi, Yuichi Kawai
Several studies have reported that amorphous nano-silica particles (nano-SPs) modulate calcium flux, although the mechanism remains incompletely understood. We thus analyzed the relationship between calcium flux and particle surface properties and determined the calcium flux route. Treatment of Balb/c 3T3 fibroblasts with nano-SPs with a diameter of 70 nm (nSP70) increased cytosolic calcium concentration, but that with SPs with a diameter of 300 or 1000 nm did not. Surface modification of nSP70 with a carboxy group also did not modulate calcium flux...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29110957/a-protease-activated-receptor-1-antagonist-protects-against-podocyte-injury-in-a-mouse-model-of-nephropathy
#8
Yu Guan, Daisuke Nakano, Yifan Zhang, Lei Li, Wenhua Liu, Motohiro Nishida, Takashige Kuwabara, Asahiro Morishita, Hirofumi Hitomi, Kiyoshi Mori, Masashi Mukoyama, Tsutomu Masaki, Katsuya Hirano, Akira Nishiyama
The kidney expresses protease-activated receptor-1 (PAR-1). PAR-1 is known as a thrombin receptor, but its role in kidney injury is not well understood. In this study, we examined the contribution of PAR-1 to kidney glomerular injury and the effects of its inhibition on development of nephropathy. Mice were divided into 3 groups: control, doxorubicin + vehicle (15 mg/kg doxorubicin and saline) and doxorubicin + Q94 (doxorubicin at 15 mg/kg and the PAR-1 antagonist Q94 at 5 mg/kg/d) groups. Where indicated, doxorubicin was administered intravenously and PAR-1 antagonist or saline vehicle by subcutaneous osmotic mini-pump...
September 14, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28990197/pollen-tube-growth-and-guidance-occam-s-razor-sharpened-on-a-molecular-arabinogalactan-glycoprotein-rosetta-stone
#9
Derek T A Lamport, Li Tan, Michael Held, Marcia J Kieliszewski
Occam's Razor suggests a new model of pollen tube tip growth based on a novel Hechtian oscillator that integrates a periplasmic arabinogalactan glycoprotein-calcium (AGP-Ca(2+) ) capacitor with tip-localized AGPs as the source of tip-focussed cytosolic Ca(2+) oscillations: Hechtian adhesion between the plasma membrane and the cell wall of the growing tip acts as a piconewton force transducer that couples the internal stress of a rapidly growing wall to the plasma membrane. Such Hechtian transduction opens stretch-activated Ca(2+) channels and activates H(+) -ATPase proton pump efflux that dissociates periplasmic AGP-Ca(2+) resulting in a Ca(2+) influx that activates exocytosis of wall precursors...
October 9, 2017: New Phytologist
https://www.readbyqxmd.com/read/28951477/a-novel-calcium-uptake-transporter-of-uncharacterized-p-type-atpase-family-supplies-calcium-for-cell-surface-integrity-in-mycobacterium-smegmatis
#10
Hemant Kumar Gupta, Shruti Shrivastava, Rakesh Sharma
Ca(2+) plays an important role in the physiology of bacteria. Intracellular Ca(2+) concentrations are tightly maintained in the nanomolar range. Molecular mechanisms of Ca(2+) uptake in bacteria remain elusive. Here we show that CtpE is responsible for Ca(2+) uptake in Mycobacterium smegmatis It represents a previously uncharacterized P-type ATPase family in bacteria. Disruption of ctpE in M. smegmatis resulted in a mutant with impaired growth under Ca(2+)-deficient conditions. The growth defect of the mutant could be rescued by Ca(2+) or by ectopic expression of ctpE from M...
September 26, 2017: MBio
https://www.readbyqxmd.com/read/28900924/tissue-specificity-store-operated-ca-2-entry-in-cardiac-myocytes
#11
Martin D Bootman, Katja Rietdorf
Calcium (Ca(2+)) is a key regulator of cardiomyocyte contraction. The Ca(2+) channels, pumps, and exchangers responsible for the cyclical cytosolic Ca(2+) signals that underlie contraction are well known. In addition to those Ca(2+) signaling components responsible for contraction, it has been proposed that cardiomyocytes express channels that promote the influx of Ca(2+) from the extracellular milieu to the cytosol in response to depletion of intracellular Ca(2+) stores. With non-excitable cells, this store-operated Ca(2+) entry (SOCE) is usually easily demonstrated and is essential for prolonging cellular Ca(2+) signaling and for refilling depleted Ca(2+) stores...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28872107/soft-lithographic-procedure-for-producing-plastic-microfluidic-devices-with-view-ports-transparent-to-visible-and-infrared-light
#12
Mona Suryana, Jegan V Shanmugarajah, Sivakumar M Maniam, Gianluca Grenci
Infrared (IR) spectro-microscopy of living biological samples is hampered by the absorption of water in the mid-IR range and by the lack of suitable microfluidic devices. Here, a protocol for the fabrication of plastic microfluidic devices is demonstrated, where soft lithographic techniques are used to embed transparent Calcium Fluoride (CaF2) view-ports in connection with observation chamber(s). The method is based on a replica casting approach, where a polydimethylsiloxane (PDMS) mold is produced through standard lithographic procedures and then used as the template to produce a plastic device...
August 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28795720/restoring-calcium-homeostasis-in-diabetic-cardiomyocytes-an-investigation-through-mathematical-modelling
#13
Phonindra Nath Das, Ajay Kumar, Nandadulal Bairagi, Samrat Chatterjee
Calcium homeostasis is a key factor in the regulation of cardiac excitation-contraction coupling. Calcium dynamics in cardiomyocytes is governed by ATP which depends on insulin dependent glucose concentration, via the glucose transporter type 4 (GLUT4) transporter. It would therefore be interesting to see how calcium dynamics changes in a cardiomyocyte under diabetic conditions. We proposed and analysed a four dimensional ordinary differential equation (ODE) model to capture the interdependency of calcium dynamics on glucose uptake and ATP generation...
September 26, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28792496/stabilization-of-diastolic-calcium-signal-via-calcium-pump-regulation-of-complex-local-calcium-releases-and-transient-decay-in-a-computational-model-of-cardiac-pacemaker-cell-with-individual-release-channels
#14
Alexander V Maltsev, Victor A Maltsev, Michael D Stern
Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker cell function by activation of electrogenic Na/Ca exchanger (NCX) during diastole. Prior studies demonstrated the existence of powerful compensatory mechanisms of LCR regulation via a complex local cross-talk of Ca pump, release and NCX. One major obstacle to study these mechanisms is that LCR exhibit complex Ca release propagation patterns (including merges and separations) that have not been characterized. Here we developed new terminology, classification, and computer algorithms for automatic detection of numerically simulated LCRs and examined LCR regulation by SR Ca pumping rate (Pup) that provides a major contribution to fight-or-flight response...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28768356/-singultus-diagnostic-workup-and-therapy
#15
Ohlrich Marcus, Georg Royl
A hiccup is a reflex movement with diffusely distributed afferents and efferents in the thorax; its functional relevance is controversial. In its physiological form, it is mostly a minor complaint that stops spontaneously and rarely leads to medical consultation. However, prolonged agonizing hiccups represent serious deterioration of quality of life. Chronic hiccups by definition last for more than 48 h, with gastroesophageal reflux being the frequent underlying disease. Various other causes affect multiple organ systems, some with serious underlying diseases...
July 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28765761/simulation-of-ventricular-rate-control-during-atrial-fibrillation-using-ionic-channel-blockers
#16
Shin Inada, Nitaro Shibata Md PhD, Michiaki Iwata PhD, Ryo Haraguchi PhD, Takashi Ashihara Md PhD, Takanori Ikeda Md PhD, Kazuyuki Mitsui PhD, Halina Dobrzynski PhD, Mark R Boyett PhD, Kazuo Nakazawa PhD
BACKGROUND: The atrioventricular (AV) node is the only compartment that conducts an electrical impulse between the atria and the ventricles. The main role of the AV node is to facilitate efficient pumping by conducting excitation slowly between the two chambers as well as reduce the ventricular rate during atrial fibrillation (AF). METHODS: Using computer simulations, we investigated excitation conduction from the right atrium to the bundle of His during high-rate atrial excitation with or without partial blocking of the calcium or potassium ionic current...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28753475/presenilin-1-mutation-decreases-both-calcium-and-contractile-responses-in-cerebral-arteries
#17
Xavier Toussay, Jean-Luc Morel, Nathalie Biendon, Lolita Rotureau, François-Pierre Legeron, Marie-Charlotte Boutonnet, Yoon H Cho, Nathalie Macrez
Mutations or upregulation in presenilin 1 (PS1) gene are found in familial early-onset Alzheimer's disease or sporadic late-onset Alzheimer's disease, respectively. PS1 has been essentially studied in neurons and its mutation was shown to alter intracellular calcium (Ca(2+)) signals. Here, we showed that PS1 is expressed in smooth muscle cells (SMCs) of mouse cerebral arteries, and we assessed the effects of the deletion of exon 9 of PS1 (PS1dE9) on Ca(2+) signals and contractile responses of vascular SMC. Agonist-induced contraction of cerebral vessels was significantly decreased in PS1dE9 both in vivo and ex vivo...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28747251/serca-control-of-cell-death-and-survival
#18
REVIEW
Elie R Chemaly, Luca Troncone, Djamel Lebeche
Intracellular calcium (Ca(2+)) is a critical coordinator of various aspects of cellular physiology. It is increasingly apparent that changes in cellular Ca(2+) dynamics contribute to the regulation of normal and pathological signal transduction that controls cell growth and survival. Aberrant perturbations in Ca(2+) homeostasis have been implicated in a range of pathological conditions, such as cardiovascular diseases, diabetes, tumorigenesis and steatosis hepatitis. Intracellular Ca(2+) concentrations are therefore tightly regulated by a number of Ca(2+) handling enzymes, proteins, channels and transporters located in the plasma membrane and in Ca(2+) storage organelles, which work in concert to fine tune a temporally and spatially precise Ca(2+) signal...
July 12, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28745215/nitroxyl-anion-mediates-relaxation-in-mesenteric-arteries-from-angiotensin-ii-hypertensive-mice
#19
Brandi M Wynne, Hicham Labazi, Rita C Tostes, R Clinton Webb
AIMS: Nitroxyl anion (HNO) has recently become an emerging candidate in vascular regulation. NO- is a potent vasodilator of both conduit and small resistance vessels and mediates relaxation in a soluble guanylate cyclase-dependent manner. Interestingly, HNO activates voltage-dependent K+ (K+V) channels, whereas nitric oxide (NO) activates calcium-activated K+ channels. To date, there are few studies investigating the role of HNO in hypertension, and the possible mechanisms, which may be altered during this condition...
July 25, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28725634/ip3-receptor-mediated-calcium-signaling-and-its-role-in-autophagy-in-cancer
#20
REVIEW
Elzbieta Kania, Gemma Roest, Tim Vervliet, Jan B Parys, Geert Bultynck
Calcium ions (Ca(2+)) play a complex role in orchestrating diverse cellular processes, including cell death and survival. To trigger signaling cascades, intracellular Ca(2+) is shuffled between the cytoplasm and the major Ca(2+) stores, the endoplasmic reticulum (ER), the mitochondria, and the lysosomes. A key role in the control of Ca(2+) signals is attributed to the inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), the main Ca(2+)-release channels in the ER. IP3Rs can transfer Ca(2+) to the mitochondria, thereby not only stimulating core metabolic pathways but also increasing apoptosis sensitivity and inhibiting basal autophagy...
2017: Frontiers in Oncology
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