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Siddik Sarkar, Bridget A Quinn, Xue-Ning Shen, Rupesh Dash, Swadesh K Das, Luni Emdad, Alexander L Klibanov, Xiang-Yang Wang, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher
Despite recent advances, treatment options for advanced prostate cancer (CaP) remain limited. We are pioneering approaches to treat advanced CaP that employ conditionally replication-competent oncolytic adenoviruses that simultaneously produce a systemically active cancer-specific therapeutic cytokine, mda-7/IL-24, Cancer Terminator Viruses (CTV). A truncated version of the CCN1/CYR61 gene promoter, tCCN1-Prom, was more active than progression elevated gene-3 promoter (PEG-Prom) in regulating transformation-selective transgene expression in CaP and oncogene-transformed rat embryo cells...
May 10, 2015: Oncotarget
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