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azoxymethane

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https://www.readbyqxmd.com/read/29786668/scf-c-kit-signaling-increased-mucin2-production-by-maintaining-atoh1-expression-in-mucinous-colorectal-adenocarcinoma
#1
Ping Shen, Shu Yang, Haimei Sun, Guilan Li, Bo Wu, Fengqing Ji, Tingyi Sun, Deshan Zhou
Mucinous colorectal adenocarcinoma (MCA) patients often a show high risk of malignant potential and a poorer survival rate. Given that the pathological feature and oncobiological characteristics of MCA are correlated with its abundant extracellular mucin2 (MUC2), we paid interest toward investigating the key factor that promotes MUC2 production exposure to highly-activated stem cell factor (SCF)/c-KIT signaling, which we believed to contribute to MCA formation. Long-term azoxymethane and dextran sodium sulfate treatment successfully induced MCA only in wild-type (WT) mice at week 37 and 43, while all c-kit loss-of-function mutant mice (Wadsm/m ) developed non-MCA...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29778535/lysophosphatidic-acid-receptor-lpa-6-regulates-endothelial-blood-brain-barrier-function-implication-of-hepatic-encephalopathy
#2
Kayo Masago, Yasuyuki Kihara, Keisuke Yanagida, Fumie Hamano, Shinsuke Nakagawa, Masami Niwa, Takao Shimizu
Cerebral edema is a life-threatening neurological condition characterized by brain swelling due to accumulation of excess fluid both intracellularly and extracellularly. Fulminant hepatic failure (FHF) develops cerebral edema by disrupting blood brain barrier (BBB). However, the mechanisms by which mediator induces brain edema in FHF remain to be elucidated. Here, we assessed a linkage between brain edema and lysophosphatidic acid (LPA) signaling by utilizing an animal model of FHF and in vitro BBB model. Azoxymethane-treated mice developed FHF and hepatic encephalopathy, associated with higher autotaxin (ATX) activities in serum than controls...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29772253/interstitial-ion-homeostasis-and-acid-base-balance-are-maintained-in-oedematous-brain-of-mice-with-acute-toxic-liver-failure
#3
Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
Acute toxic liver failure (ATLF) rapidly leads to brain oedema and neurological decline. We evaluated the ability of ATLF-affected brain to control the ionic composition and acid-base balance of the interstitial fluid. ATLF was induced in 10-12 weeks old male C57Bl mice by single intraperitoneal (i.p.) injection of 100 μg/g azoxymethane (AOM). Analyses were carried out in cerebral cortex of precomatous mice 20-24 h after AOM administration. Brain fluid status was evaluated by measuring apparent diffusion coefficient [ADC] using NMR spectroscopy, Evans Blue extravasation, and accumulation of an intracisternally-injected fluorescent tracer...
May 14, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29760543/microbiota-modification-by-probiotic-supplementation-reduces-colitis-associated-colon-cancer-in-mice
#4
Maria Carolina S Mendes, Daiane Sm Paulino, Sandra R Brambilla, Juliana A Camargo, Gabriela F Persinoti, José Barreto C Carvalheira
AIM: To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer (CAC). METHODS: C57BL/6 mice received an intraperitoneal injection of azoxymethane (10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water (5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus , Lactobacillus rhamnosus and Bifidobacterium bifidum . Microbiota composition was assessed by 16S rRNA Illumina HiSeq sequencing...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29757351/m10-a-novel-derivative-of-myricetin-prevents-ulcerative-colitis-and-colorectal-tumor-through-attenuating-robust-endoplasmic-reticulum-stress
#5
Feng Wang, Zhi-Yu Song, Xian-Jun Qu, Feng Li, Liang Zhang, Wen-Bao Li, Shu-Xiang Cui
Chronic gut inflammation disposes to an increased risk of colitis-associated cancer (CAC). Chemoprevention is an attractive complementary strategy. We aimed to evaluate the chemopreventive effects of M10, a novel derivative of Myricetin, in the murine azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Oral administration of M10 at 50-100 mg/kg once a day for consecutive 12 weeks significantly prevented ulcerative colitis and colorectal tumor. Pathological analysis of intestines showed that M10 reduced the degree of chronic inflammation and prevented the progression of colorectal tumorigenesis...
May 11, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29756208/impact-of-loss-of-function-mutations-at-the-rnf43-locus-on-colorectal-cancer-development-and-progression
#6
Tsugio Eto, Keisuke Miyake, Katsuhiko Nosho, Masaki Ohmuraya, Yu Imamura, Kota Arima, Shinichi Kanno, Lingfeng Fu, Yuki Kiyozumi, Daisuke Izumi, Hidetaka Sugihara, Yukiharu Hiyoshi, Yuji Miyamoto, Hiroshi Sawayama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Toru Furukawa, Kimi Araki, Hideo Baba, Takatsugu Ishimoto
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. Here, we investigated the clinical significance of RNF43 mutations in a large Japanese cohort and the role of RNF43 at various stages of colorectal cancer development and progression. Mutation analysis of the RNF43 gene locus using pyrosequencing technology detected RNF43 hotspot mutations in 1 (0.88%) of 113 colorectal polyp cases and 30 (6.45%) of 465 colorectal cancer cases. Moreover, patients with colorectal cancer harboring mutated RNF43 experienced a higher recurrence rate than those harboring non-mutated RNF43...
May 13, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29748582/usp49-participates-in-the-dna-damage-response-by-forming-a-positive-feedback-loop-with-p53
#7
Rongfu Tu, Wenqian Kang, Xuefei Yang, Qi Zhang, Xiaoyu Xie, Wenbin Liu, Jinxiang Zhang, Xiao-Dong Zhang, Hui Wang, Run-Lei Du
The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB) for p53 from a library consisting of 80 DUBs and found that USP49 has a positive effect on p53 transcriptional activity and protein stability. Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination. Furthermore, USP49 rendered HCT116 cells more sensitive to etoposide (Eto)-induced DNA damage and was upregulated in response to several types of cell stress, including DNA damage...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29744610/walnut-phenolic-extract-inhibits-nuclear-factor-kappab-signaling-in-intestinal-epithelial-cells-and-ameliorates-experimental-colitis-and-colitis-associated-colon-cancer-in-mice
#8
Seong-Joon Koh, Youn-I Choi, Yuri Kim, Yoo-Sun Kim, Sang Woon Choi, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee
PURPOSE: Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS: COLO205 cells were pretreated with WPE and then stimulated with tumor necrosis factor (TNF)-α. In the acute colitis model, wild type mice (C57BL/6) were administered 4% dextran sulfate sodium (DSS) for 5 days. In the chronic colitis model, interleukin (IL)-10-/- mice were administered with either the vehicle or WPE (20 mg/kg) by oral gavage daily for 2 weeks...
May 9, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29736317/klf5-mediates-the-hyper-proliferative-phenotype-of-the-intestinal-epithelium-in-mice-with-intestine-specific-endogenous-k-ras-g12d-expression
#9
Mandayam O Nandan, Agnieszka B Bialkowska, Vincent W Yang
Oncogenic K-Ras activation is a common mutational event in colorectal cancer. We previously showed that transcription factor, Krüppel-like factor 5 (KLF5), contributes to intestinal polyposis in mice with K-Ras activation. At 14 months of age, Villin-Cre/LSL-K-RasG12D mice developed small intestinal and colonic hyperplastic polyps while LSL-K-RasG12D had none. The intestinal crypts of Villin-Cre/LSL-K-RasG12D mice contained a higher number of mitotic figures and increased crypt heights compared to controls...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29730197/heat-shock-factor-1-epigenetically-stimulates-glutaminase-1-dependent-mtor-activation-to-promote-colorectal-carcinogenesis
#10
Jiaqiu Li, Ping Song, Tingting Jiang, Dongjun Dai, Hanying Wang, Jie Sun, Liyuan Zhu, Wenxia Xu, Lifeng Feng, Vivian Y Shin, Helen Morrison, Xian Wang, Hongchuan Jin
Heat shock factor 1 (HSF1) generally exhibits its properties under stress conditions. In tumors, HSF1 has a pleiotropic feature in regulating growth, survival, and aggressiveness of cancer cells. In this study, we found HSF1 was increased in colorectal cancer (CRC) and had a positive correlation with shorter disease-free survival (DFS). Knockdown of HSF1 in CRC cells attenuated their growth while inhibiting mTOR activation and glutamine metabolism. HSF1 inhibited the expression of microRNA137 (MIR137), which targeted GLS1 (glutaminase 1), thus stimulating GLS1 protein expression to promote glutaminolysis and mTOR activation...
April 14, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29720595/cytoglobin-affects-tumorigenesis-and-the-expression-of-ulcerative-colitis-associated-genes-under-chemically-induced-colitis-in-mice
#11
Mohammad Yassin, Hannelouise Kissow, Ben Vainer, Philomeena Daphne Joseph, Anders Hay-Schmidt, Jørgen Olsen, Anders Elm Pedersen
Cytoglobin (Cygb) is a member of the hemoglobin family and is thought to protect against cellular hypoxia and oxidative stress. These functions may be particularly important in inflammation-induced cancer, e.g., in patients with ulcerative colitis (UC). In this study, we investigated the development of inflammation and tumors in a murine model of inflammation-induced colorectal cancer using a combined treatment of azoxymethane and dextran sulfate sodium. A bioinformatics analysis of genome-wide expression data revealed increased colonic inflammation at the molecular level accompanied by enhanced macroscopic tumor development in Cygb-deficient mice...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29702174/beneficial-effects-of-extracellular-polysaccharide-from-rhizopus-nigricans-on-the-intestinal-immunity-of-colorectal-cancer-mice
#12
Zhidan Yu, Ge Song, Jing Liu, Jiayue Wang, Pengying Zhang, Kaoshan Chen
An extracellular polysaccharide (EPS1-1) extracted from the fermentation broth of Rhizopus nigricans has been proved to enhance the immunity of immunosuppressed mice. The purpose of this study was to investigate the beneficial effects of EPS1-1 on the intestinal immunity of mice with colorectal cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). The results showed that EPS1-1 could resist hydrolysis in an artificial stomach. Oral EPS1-1 modulated gut microbiota and increased the concentration of total short-chain fatty acids (SCFAs) in the feces of colorectal cancer mice compared with the AOM/DSS only-treated mice...
April 24, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29696632/parabacteroides-distasonis-attenuates-toll-like-receptor-4-signaling-and-akt-activation-and-blocks-colon-tumor-formation-in-high-fat-diet-fed-azoxymethane-treated-mice
#13
Gar Yee Koh, Anne Kane, Kyongbum Lee, Qiaobing Xu, Xian Wu, Jatin Roper, Joel B Mason, Jimmy W Crott
Gut dysbiosis may play an etiological role in colorectal tumorigenesis. We previously observed that the abundance of Parabacteroides distasonis (Pd) in stool was inversely associated with intestinal tumor burden and IL-1β concentrations in mice. Here, we assessed the anti-inflammatory capacity of Pd membrane fraction (PdMb) in colon cancer cell lines. In addition, we tested whether Pd could suppress colon tumorigenesis in mice. Six-week old male A/J mice were fed a low-fat diet (LF), high-fat diet (HF), or HF+ whole freeze-dried Pd (HF+Pd, 0...
April 26, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29694938/short-chain-fatty-acids-administration-is-protective-in-colitis-associated-colorectal-cancer-development
#14
Yun Tian, Qing Xu, Liqun Sun, Ying Ye, Guozhong Ji
Reduced short-chain fatty acids (SCFAs) have been reported in patients with ulcerative colitis, and increased intake of dietary fiber has shown to be clinically beneficial for colitis. Whether SCFAs suppress tumorigenesis in colitis-associated colorectal cancer remains unknown. The chemopreventive effect of SCFAs in colitis-associated colorectal cancer was evaluated in this study. Model of colitis-associated colorectal cancer in male BALB/c mice was induced by azoxymethane (AOM) and dextran sodium sulfate (DSS)...
March 17, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29688249/prolyl-hydroxylase-2-is-dispensable-for-homeostasis-of-intestinal-epithelium-in-mice
#15
Yinghui Xie, Tanglong Yuan, Yanqing Qin, Zhonghui Weng, Jing Fang
Prolyl hydroxylases (PHD1-3) hydroxylate hypoxia inducible factor α (HIFα), leading to HIFα ubiquitination and degradation. Recent studies indicated that administration of generic inhibitors of PHDs improved mice colitis, suggesting that suppression of PHD activity by these inhibitors may be a potential strategy for the treatment of inflammatory bowel diseases. However, the exact role of each member of PHD family in homeostasis of intestinal epithelium remains elusive. The aim of this work is to study the possible role of PHD2 by using mice with genetic ablation of Phd2 in intestinal epithelial cells (IECs)...
April 23, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29686976/microsatellite-instability-in-mouse-models-of-colorectal-cancer
#16
Nicola Currey, Joseph J Daniel, Dessislava N Mladenova, Jane E Dahlstrom, Maija R J Kohonen-Corish
Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an important prognostic and predictive biomarker in colorectal cancer but relatively few studies have exploited mouse models in the study of its clinical utility. Furthermore, most previous studies have looked at MSI in the small intestine rather than the colon of mismatch repair deficient Msh2 -knockout (KO) mice. Here we compared Msh2 -KO, p53 -KO, and wild type (WT) mice that were treated with the carcinogen azoxymethane (AOM) and the nonsteroidal anti-inflammatory drug sulindac or received no treatment...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29683343/allicin-inhibits-mouse-colorectal-tumorigenesis-through-suppressing-the-activation-of-stat3-signaling-pathway
#17
Xiang Li, Jiahui Ni, Yixin Tang, Xu Wang, Huanhuan Tang, Haidong Li, Sulin Zhang, Xiaoyan Shen
Allicin is the major biologically active compounds of freshly crushed garlic. It has been reported to inhibit the proliferation and promote the apoptosis of multiple colorectal cancer cells. However, the anti-colorectal cancer effect of Allicin has not been verified by in vivo studies. In the present study, we investigated the effect of Allicin on azoxymethane/dextran sodium sulfate (AOM/DSS) colorectal cancer mouse model and explore the underlying possible mechanism. Our result showed that Allicin could inhibit colonic tumorigenesis of AOM/DSS mice in vivo...
April 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29682678/more-protection-of-lactobacillus-acidophilus-than-bifidobacterium-bifidum-probiotics-on-azoxymethane-induced-mouse-colon-cancer
#18
Shahram Agah, Ali Mohammad Alizadeh, Maryam Mosavi, Peyman Ranji, Hossein Khavari-Daneshvar, Farnaz Ghasemian, Sahar Bahmani, Abbas Tavassoli
Based on the ability of the probiotics in the gut microflora modification, they can have the beneficial effects on diseases in the short and/or the long term. In previous study, we revealed that unlike Bifidobacterium bifidum, the amount of Lactobacillus acidophilus remained almost unchanged in mice gut microflora in the long term, indicating more stability of L. acidophilus than B. bifidum which can be used to prevent some incurable diseases such as cancer. Thirty-eight male BALB/c mice were divided into four groups, control, azoxymethane (AOM), L...
April 22, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29656647/tea-polysaccharides-inhibits-colitis-associated-colorectal-cancer-via-interleukin-6-stat3-pathway
#19
Li-Qiao Liu, Mingyue Shen, Shao-Ping Nie, Jie-Lun Hu, Qiang Yu, Deming Gong, Ming-Yong Xie
The interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)-3 signaling pathway regulates survival and proliferation of intestinal epithelial cells, and has profound impact on the tumorigenesis of colitis-associated cancer (CAC). Tea polysaccharides (TPS) is the major nutraceutical component isolated from tea-leaves and is known to possess antioxidant, anti-inflammatory and antitumor bi-oactivities. Here, we investigated the antitumor activities of TPS on CAC using the azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model and IL-6-induced colorectal cancer cell line (CT26), and determined whether TPS exerted its antitumor effects through the IL-6/STAT3 pathway...
April 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29655682/pristimerin-a-naturally-occurring-triterpenoid-attenuates-tumorigenesis-in-experimental-colitis-associated-colon-cancer
#20
Ju-Hyung Park, Jin-Kyung Kim
BACKGROUND: Pristimerin is a quinonemethide triterpenoid with anti-cancer, anti-angiogenic, anti-inflammatory and anti-protozoal activity. However, the therapeutic role of pristimerin in colitis-associated colorectal carcinogenesis is unknown. PURPOSE: We sought to examine the therapeutic effects of pristimerin on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS). The goal was to identify the potential mechanism of action underlying the pharmacological activity of pristimerin...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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