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azoxymethane

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https://www.readbyqxmd.com/read/29331105/dietary-factors-modulate-colonic-tumorigenesis-through-the-interaction-of-gut-microbiota-and-host-chloride-channels
#1
Yong Zhang, Chao Kang, Xiao-Lan Wang, Min Zhou, Meng-Ting Chen, Xiao-Hui Zhu, Kai Liu, Bin Wang, Qian-Yong Zhang, Jun-Dong Zhu, Man-Tian Mi
SCOPE: In recent decades, the association between diet, gut microbiota and the risk of colorectal cancer (CRC) has been established. Gut microbiota and associated metabolites, such as bile acids and butyrate, are now known to play a key role in CRC development. The aim of this study was to identify the progression to CRC is influenced by cholic acid, sodium butyrate, a high-fat diet or different dose of dihydromyricetin (DMY) interacted with gut microbiota. METHODS AND RESULTS: An AOM/DSS (azoxymethan/dextran sodium sulfate) model was established to study the gut microbiota compsition before and after tumor formation during colitis-induced tumorigenesis...
January 13, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29290650/structural-shift-of-gut-microbiota-during-chemo-preventive-effects-of-epigallocatechin-gallate-on-colorectal-carcinogenesis-in-mice
#2
Xin Wang, Tao Ye, Wen-Jie Chen, You Lv, Zong Hao, Jun Chen, Jia-Ying Zhao, Hui-Peng Wang, Yuan-Kun Cai
AIM: To investigate the effect of epigallocatechin gallate (EGCG) on structural changes of gut microbiota in colorectal carcinogenesis. METHODS: An azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis mouse model was established. Forty-two female FVB/N mice were randomly divided into the following three groups: group 1 (10 mice, negative control) was treated with vehicle, group 2 (16 mice, positive control) was treated with AOM plus vehicle, and group 3 (16 mice, EG) was treated with AOM plus EGCG...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29288512/pretreatment-of-probiotic-bifico-ameliorates-colitis-associated-cancer-in-mice-transcriptome-and-gut-flora-profiling
#3
Huan Song, Weiyi Wang, Bo Shen, Hao Jia, Zhaoyuan Hou, Ping Chen, Yunwei Sun
Individuals with inflammatory bowel disease (IBD) are at a high risk for developing colitis-associated cancer (CAC). Strategies to block the process from IBD to CAC should be considered. In the experiment, we aim to explore the chemopreventive efficacy of the probiotic cocktail Bifico and its potential mechanism in azoxymethane (AOM) and dextran sodium sulphate (DSS) induced colitis-associated cancer in mice. Oral pretreatment of Bifico was adopted to evaluate its protective effect. The colorectums of thirty-five C57BL/6 mice were collected and examined for degree of inflammation and tumorigenesis...
December 30, 2017: Cancer Science
https://www.readbyqxmd.com/read/29275305/inhibition-of-formation-of-azoxymethane-induced-colonic-aberrant-crypt-foci-in-rats-by-edible-green-algae-capsosiphon-fulvescens-and-brown-algae-hizikia-fusiforme
#4
Young-Sook Son, H M Arif Ullah, Ahmed K Elfadl, Soong-Gu Ghim, Myung-Jin Chung, Yong Deuk Kim, Eun-Joo Lee, Kyung-Ku Kang, Kyu-Shik Jeong
Capsosiphon fulvescens (green seaweed) and Hizikia fusiforme (brown seaweed) are marine algae consumed as food supplements, especially in Japan, China and Korea, and are considered traditional medicinal tonics for certain ailments. The aim of this study was to investigate the possible inhibitory effects of dietary C. fulvescens and H. fusiforme on azoxymethane (AOM)-induced colorectal cancer (CRC) in rats. F344 male rats (5 weeks, 150 g) were divided into six groups as follows. Group 1: Injected with normal saline solution and fed control diet (untreated control)...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29259703/prostaglandin-e2-ep2-signaling-as-a-node-of-chronic-inflammation-in-the-colon-tumor-microenvironment
#5
REVIEW
Tomohiro Aoki, Shuh Narumiya
Background: Colorectal cancer is the third most common cancer. Involvement of prostaglandin (PG) system in the pathogenesis of colorectal cancer has been suggested from clinical studies demonstrating therapeutic effect of NSAIDs including aspirin or selective COX-2 inhibitors. However, mechanisms on how PG regulates inflammatory responses leading to colorectal cancer development remain obscure. Further, careful attention is needed to use these drugs for a long time because of adverse effects due to non-specific inhibition of physiological PG production in addition to pathological one, making the development of alternatives to aspirin important...
2017: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29242607/the-impact-of-stromal-hic-5-on-the-tumorigenesis-of-colorectal-cancer-through-lysyl-oxidase-induction-and-stromal-remodeling
#6
Tomokatsu Omoto, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-Ei Kudo, Shogo Haraguchi, Takuro Miyazaki, Akira Miyazaki
Carcinoma-associated fibroblasts (CAFs) influence tumor initiation, progression, and metastasis within the tumor-associated stroma. This suggests that CAFs would be a potential target for tumor therapy. Here we found that Hydrogen peroxide-inducible clone-5 (Hic-5), also named transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1), was strongly induced in CAFs found in human colorectal cancer. To investigate the role of Hic-5 in CAFs, we isolated CAFs and the control counterpart normal fibroblasts (NFs) from human colorectal cancer and non-cancerous regions, respectively...
December 15, 2017: Oncogene
https://www.readbyqxmd.com/read/29238715/chemopreventive-potential-of-2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucoside-on-the-formation-of-aberrant-crypt-foci-in-azoxymethane-induced-colorectal-cancer-in-rats
#7
Chien-Liang Lin, Jiiang-Huei Jeng, Chih-Chung Wu, Shu-Ling Hsieh, Guan-Cheng Huang, Wan Leung, Chining-Ting Lee, Chung-Yi Chen, Chien-Hsing Lee
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) has been shown to have antioxidative and anti-inflammatory effects. Oxidative and inflammatory reactions are related to the development of colorectal carcinoma (CRC). In the present study, we characterized the preventive activities of THSG on colon carcinogenesis using the azoxymethane- (AOM-) mediated rat colon carcinogenesis model. F344 male rats were randomly divided into 5 groups (untreated and AOM model rats treated with or without THSG at 30, 150, or 250 mg/kg) after which the numbers of aberrant crypt foci (ACF) were assessed in the colon tissues of all rats...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29235493/small-molecules-related-to-adrenomedullin-reduce-tumor-burden-in-a-mouse-model-of-colitis-associated-colon-cancer
#8
Laura Ochoa-Callejero, Josune García-Sanmartín, Sonia Martínez-Herrero, Susana Rubio-Mediavilla, Judit Narro-Íñiguez, Alfredo Martínez
To investigate the contribution of adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), to the progression and potential treatment of colon cancer we studied the effects of four small molecules (SM) related to AM and PAMP on a mouse model of colon cancer. For each SM, four experimental groups of male mice were used: (i) Control group; (ii) SM group; (iii) DSS group (injected with azoxymethane [AOM] and drank dextran sulfate sodium [DSS]); and (iv) DSS + SM group (treated with AOM, DSS, and the SM)...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233556/contribution-of-atoh1-cells-to-the-homeostasis-repair-and-tumorigenesis-of-the-colonic-epithelium
#9
Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto
ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal epithelial cells (IECs). However, the comprehensive contribution of ATOH1+ secretory lineage IECs to the homeostasis, repair, and tumorigenesis of the intestinal epithelium remains uncertain. Through our ATOH1+ cell-lineage tracing, we show here that a definite number of ATOH1+ IECs retain stem cell properties and can form ATOH1+IEC-derived clonal ribbons (ATOH1+ICRs) under completely homeostatic conditions. Interestingly, colonic ATOH1+ IECs appeared to exhibit their stem cell function more frequently compared with those of the small intestine...
December 1, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29228136/cd177-neutrophils-suppress-epithelial-cell-tumourigenesis-in-colitis-associated-cancer-and-predict-good-prognosis-in-colorectal-cancer
#10
Guangxi Zhou, Kangsheng Peng, Yang Song, Wenjing Yang, Weigang Shu, Tianming Yu, Lin Yu, Moubin Lin, Qing Wei, Chunqiu Chen, Lu Yin, Yingzi Cong, Zhanju Liu
Neutrophils are found to be infiltrated in tumour tissues of patients with colitis-associated cancer (CAC) and colorectal cancer (CRC), and CD177 is mainly expressed in neutrophils. In our study, expression of CD177 in tumour tissues from patients with CAC or CRC was analysed by qRT-PCR, flow cytometry, and immunohistochemistry. We recruited 378 patients with CRC, determined CD177 expression in tumours, and examined its correlation with clinicopathological features. Moreover, CAC model was induced in wild type (WT) and CD177-/- mice by azoxymethane (AOM)/dextran sodium sulfate (DSS)...
December 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29223827/colonic-aberrant-crypt-formation-accompanies-an-increase-of-opportunistic-pathogenic-bacteria-in-c57bl-6-mice-fed-a-high-fat-diet
#11
Huawei Zeng, Suzanne L Ishaq, Zhenhua Liu, Michael R Bukowski
The increasing worldwide incidence of colon cancer has been linked to obesity and consumption of a high-fat Western diet. To test the hypothesis that a high-fat diet (HFD) promotes colonic aberrant crypt (AC) formation in a manner associated with gut bacterial dysbiosis, we examined the susceptibility to azoxymethane (AOM)-induced colonic AC and microbiome composition in C57/BL6 mice fed a modified AIN93G diet (AIN, 16% fat, energy) or an HFD (45% fat, energy) for 14 weeks. Mice receiving the HFD exhibited increased plasma leptin, body weight, body fat composition and inflammatory cell infiltration in the ileum compared with those in the AIN group...
November 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29214422/emu-oil-improves-clinical-indicators-of-disease-in-a-mouse-model-of-colitis-associated-colorectal-cancer
#12
Lauren C Chartier, Gordon S Howarth, Ian C Lawrance, Debbie Trinder, Scott J Barker, Suzanne Mashtoub
BACKGROUND/AIMS: Ulcerative colitis is a remitting and relapsing inflammatory bowel disorder. Current treatments are limited, and if poorly controlled, colitis may progress to colorectal cancer. Previously, Emu Oil protected the intestine in experimental models of gut damage. We aimed to determine whether Emu Oil could reduce the severity of chronic colitis and prevent the onset of neoplasia in a mouse model of colitis-associated colorectal cancer. METHODS: Female C57BL/6 mice were injected (day 0) with azoxymethane, followed by ad libitum access to three dextran sulfate sodium/water cycles (7 days of dextran sulfate sodium and 14 days of water)...
December 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29209314/probiotic-strain-lactobacillus-casei-bl23-prevents-colitis-associated-colorectal-cancer
#13
Elsa Jacouton, Florian Chain, Harry Sokol, Philippe Langella, Luis G Bermúdez-Humarán
The gut microbiota plays a major role in intestinal health, and an imbalance in its composition can lead to chronic gut inflammation and a predisposition to developing colorectal cancer (CRC). Currently, the use of probiotic bacteria represents an emerging alternative to treat and prevent cancer. Moreover, consumption of these beneficial bacteria may also favorably modulate the composition of the gut microbiota, which has been described in several studies to play an important role in CRC carcinogenesis. In this context, the aim of this study was to assess the protective effect of oral treatment with Lactobacillus casei BL23, a probiotic strain well known for its anti-inflammatory and anticancer properties...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29203393/pyrin-inflammasome-regulates-tight-junction-integrity-to-restrict-colitis-and-tumorigenesis
#14
Deepika Sharma, Ankit Malik, Clifford S Guy, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti
BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) increase risk for colorectal cancer. Mutations in the Mediterranean fever gene (MEFV or pyrin) are associated with hereditary autoinflammatory disease and severe IBD. Expression of MEFV, a sensor protein that the initiates assembly of the inflammasome complex, is increased in colon biopsies from patients with IBD. We investigated the role of pyrin in intestinal homeostasis in mice. METHODS: Mefv-/- mice and C57/BL6 mice (controls) were given azoxymethane followed by multiple rounds of dextran sodium sulfate (DSS) to induce colitis and tumorigenesis...
December 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29197088/inhibition-of-mk2-suppresses-il-1%C3%AE-il-6-and-tnf-%C3%AE-dependent-colorectal-cancer-growth
#15
Anita L Ray, Kiersten L Berggren, Sebastian Restrepo Cruz, Gregory N Gan, Ellen J Beswick
Colorectal cancer (CRC) development and progression is associated with chronic inflammation. We have identified the MAPK-activated protein kinase 2 (MK2) pathway as a primary mediator of inflammation in CRC. MK2 signaling promotes production of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. These cytokines have been implicated in tumor growth, invasion and metastasis. For the first time, we investigate whether MK2 inhibition can improve outcome in two mouse models of CRC. In our azoxymethane/dextran sodium sulfate (AOM/DSS) model of colitis-associated CRC, MK2 inhibitor treatment eliminated murine tumor development...
December 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29163827/fluorescence-contrast-enhanced-proliferative-lesion-imaging-by-enema-administration-of-indocyanine-green-in-a-rat-model-of-colon-carcinogenesis
#16
Nobuhiko Onda, Reiko Mizutani-Morita, Susumu Yamashita, Rei Nagahara, Shinya Matsumoto, Toshinori Yoshida, Makoto Shibutani
The fluorescent contrast agent indocyanine green (ICG) is approved by the Food and Drug Administration for clinical applications. We previously reported that cultured human colon tumor cells preferentially take up ICG by endocytic activity in association with disruption of their tight junctions. The present study explored ICG availability in fluorescence imaging of the colon to identify proliferative lesions during colonoscopy. The cellular uptake of ICG in cultured rat colon tumor cells was examined using live-cell imaging...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162930/chemopreventive-effects-of-ku-jin-tea-against-aom-induced-precancerous-colorectal-lesions-in-rats-and-metabolomic-analysis
#17
Wu Bi, Haibo Liu, Jie Shen, Ling-Hua Zhang, Pei Li, Bing Peng, Li Cao, Pengfei Zhang, Chunnian He, Peigen Xiao
Ku-jin tea (KJT) is a health beverage prepared from the leaves of the plant Acer tataricum subsp. ginnala that has been consumed in some regions of China for thousands of years. KJT contains high levels of anti-inflammatory and antioxidative compounds such as ginnalins, but little is known about the chemopreventive effect of KJT on colon cancer. In this study, we investigated the preventive effects of KJT on colon carcinogenesis using the azoxymethane (AOM)-induced precancerous colorectal lesion model in rats...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118162/does-mutated-k-ras-oncogene-attenuate-the-effect-of-sulindac-in-colon-cancer-chemoprevention
#18
Photini F S Rice, Kevin G Ehrichs, Mykella S Jones, Hwudarw Chen, Chiu-Hsieh Hsu, Edward R Abril, Raymond B Nagle, David G Besselsen, Jennifer K Barton, Natalia A Ignatenko
The non-steroidal anti-inflammatory drug (NSAID) Sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition, and also showed its efficacy in prevention of sporadic colon adenomas. At the same time, some experimental and clinical reports suggest that a mutant K-RAS oncogene may negate Sulindac anti-tumor efficacy. To directly assess Sulindac activity at suppressing premalignant lesions carrying K-RAS mutation, we utilized a novel mouse model with an inducible colon-specific expression of the mutant K-ras oncogene (K-ras G12D)...
November 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29070673/il-17a-induced-plet1-expression-contributes-to-tissue-repair-and-colon-tumorigenesis
#19
Jarod A Zepp, Junjie Zhao, Caini Liu, Katazyna Bulek, Ling Wu, Xing Chen, Yujun Hao, Zhenghe Wang, Xinxin Wang, Wenjun Ouyang, Matthew F Kalady, Julie Carman, Wen-Pin Yang, Jun Zhu, Clare Blackburn, Yina H Huang, Thomas A Hamilton, Bing Su, Xiaoxia Li
This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-associated cancer. A novel IL-17A target gene, PLET1 (a progenitor cell marker involved in wound healing), was highly induced in DSS-treated colon tissues and tumors in an IL-17RC-dependent manner. PLET1 expression was induced in LGR5(+) colon epithelial cells after DSS treatment...
October 25, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29069290/potent-suppression-of-both-spontaneous-and-carcinogen-induced-colitis-associated-colorectal-cancer-in-mice-by-dietary-celastrol-supplementation
#20
Emily C Barker, Byung-Gyu Kim, Ji Hee Yoon, Gregory P Tochtrop, John J Letterio, Sung Hee Choi
Celastrol is an anti-inflammatory natural triterpenoid, isolated from the herb Tripterygium wilfordii or thunder god vine. Here we define mechanisms mediating anti-inflammatory activity of celastrol and demonstrate efficacy of a dietary celastrol supplement for chemoprevention of inflammation-driven carcinogenesis in mice. Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6, and IL-1β...
October 21, 2017: Carcinogenesis
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