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azoxymethane

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https://www.readbyqxmd.com/read/28810912/inhibition-of-trpm7-suppresses-cell-proliferation-of-colon-adenocarcinoma-in-vitro-and-induces-hypomagnesemia-in-vivo-without-affecting-azoxymethane-induced-early-colon-cancer-in-mice
#1
Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, F Kelly Galbraith Kawabata, David Horgen, Toshihiko Kawamori, Reinhold Penner, Andrea Fleig
BACKGROUND: Magnesium (Mg(2+)) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg(2+) homeostasis. Abnormal expression of TRPM7 is found in numerous cancers, including colon, implicating TRPM7 in this process. METHODS: To establish a possible link between systemic magnesium (Mg(2+)) status, the Mg(2+) conducting channel TRPM7 in colon epithelial cells, and colon carcinogenesis, in vitro whole-cell patch clamp electrophysiology, qPCR, and pharmacological tools were used probing human colorectal adenocarcinoma HT-29 as well as normal primary mouse colon epithelial cells...
August 15, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28808878/role-of-intestinal-microbiome-in-american-ginseng-mediated-colon-cancer-protection-in-high-fat-diet-fed-aom-dss-mice
#2
C-Z Wang, W-H Huang, C-F Zhang, J-Y Wan, Y Wang, C Yu, S Williams, T-C He, W Du, M W Musch, E B Chang, C-S Yuan
OBJECTIVE: Chronic intestinal inflammation is a risk factor for colorectal cancer (CRC) initiation and development. Diets that are rich in Western style fats have been shown to promote CRC. This study was conducted to investigate the role of intestinal microbiome in American ginseng-mediated CRC chemoprevention in a mouse model. The population and diversity of enteric microbiome were evaluated after the ginseng treatment. METHODS: Using an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced gut inflammation and tumorigenesis mouse model, the effects of oral American ginseng on high fat diet-associated enteric pathology were determined...
August 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28808375/chemopreventive-and-antioxidant-effect-of-polyphenol-free-spirulina-maxima-and-its-hydrolyzed-protein-content-investigation-on-azoxymethane-treated-mice
#3
Nikte Y Martínez-Palma, Gloria Dávila-Ortiz, Cristian Jiménez-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González
BACKGROUND: Spirulina maxima (Sm) is known to have nutritive value as well as a number of potentially useful biomedical properties. OBJECTIVES: The initial purpose of this report was to evaluate the inhibitory effect of the alga (without its polyphenol content), on the induction of azoxymethane (AOM)-induced colon aberrant crypts (AC) in mouse. Besides, we hydrolyzed the protein content of such mixture. Our second aim was to determine the inhibitory potential of this last plant mixture on the AOM-induced colon AC in mouse...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28800083/effect-of-angelica-sinensis-root-extract-on-cancer-prevention-in-different-stages-of-an-aom-dss-mouse-model
#4
Bochen Zhao, Qian Kang, Yu Peng, Yuanping Xie, Cheng Chen, Bingshao Li, Qing Wu
Angelica sinensis root (ASR) extract was obtained to investigate its effects on colorectal carcinogenesis in different stages of an Azoxymethane/Dextran sodium sulphate (AOM/DSS) model. In this study, we showed that ASR extract administration in the initial stage of the AOM/DSS model had cancer preventive effects with decreasing tumor incidence and a high-grade of intraepithelial neoplasia incidence. With respect to DNA damage, the amounts of 8-oxoguanine and γ-H2AX were suppressed in colon tissue. The balance of apoptosis and proliferation was approaching the normal state...
August 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28795969/e-cadherin-mediates-the-preventive-effect-of-vitamin-d3-in-colitis-associated-carcinogenesis
#5
Yu Xin, Longmei He, Zijian Luan, Hong Lv, Hong Yang, Ying Zhou, Xinhua Zhao, Weixun Zhou, Songlin Yu, Bei Tan, Hongying Wang, Jiaming Qian
Vitamin D3 is beneficial in ameliorating or preventing inflammation and carcinogenesis. Here, we evaluated if vitamin D3 has a preventive effect on colitis-associated carcinogenesis. Administration of azoxymethane (AOM), followed with dextran sulfate sodium (DSS), was used to simulate colitis-associated colon cancer in mice. The supplement of vitamin D3 at different dosages (15, 30, 60 IU·g·w), started before AOM or immediately after DSS treatment (post 60), was sustained to the end of the experiment. Dietary vitamin D3 significantly reduced the number of tumors and tumor burden in a dose-dependent manner...
August 8, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28780076/bmi1-and-mel18-promote-colitis-associated-cancer-in-mice-via-reg3b-and-stat3
#6
Xicheng Liu, Wendi Wei, Xiaowei Li, Pengcheng Shen, Dapeng Ju, Zhen Wang, Rukui Zhang, Fu Yang, Chunyan Chen, Kun Cao, Guoli Zhu, Hongyan Chen, Liang Chen, Jianhua Sui, Erquan Zhang, Kaichun Wu, Fengchao Wang, Liping Zhao, Rongwen Xi
BACKGROUND & AIMS: Polycomb group proteins are epigenetic factors that silence gene expression; they are dysregulated in cancer cells and contribute to carcinogenesis by unclear mechanisms. We investigated whether BMI1 proto-oncogene, polycomb ring finger (BMI1) and polycomb group ring finger 2 (PCGF2, also called MEL18) are involved in initiation and progression of colitis-associated cancer (CAC) in mice. METHODS: We generated mice containing floxed alleles of Bmi1 and/or Mel18 and/or Reg3b using the villin-Cre promoter (called Bmi1(ΔIEC), Mel18(ΔIEC), DKO, and TKO mice)...
August 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28765774/increase-in-dietary-protein-content-exacerbates-colonic-inflammation-and-tumorigenesis-in-azoxymethane-induced-mouse-colon-carcinogenesis
#7
Ka-Hee Tak, Eunyeong Ahn, Eunjung Kim
BACKGROUND/OBJECTIVE: The incidence of colorectal cancer (CRC) has been attributed to higher intake of fat and protein. However, reports on the relationship between protein intake and CRC are inconsistent, possibly due to the complexity of diet composition. In this study, we addressed a question whether alteration of protein intake is independently associated with colonic inflammation and colon carcinogenesis. MATERIALS/METHODS: Balb/c mice were randomly divided into 4 experimental groups: 20% protein (control, 20P, 20% casein/kg diet), 10% protein (10P, 10% casein/kg diet), 30% protein (30P, 30% casein/kg diet), and 50% protein (50P, 50% casein/kg diet) diet groups and were subjected to azoxymethane-dextran sodium sulfate induced colon carcinogenesis...
August 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28751809/intake-of-mulberry-1-deoxynojirimycin-prevents-colorectal-cancer-in-mice
#8
Shuang E, Kazushi Yamamoto, Yu Sakamoto, Yui Mizowaki, Yui Iwagaki, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa, Tsuyoshi Tsuduki
The effect of 1-deoxynojirimycin, a caloric restriction mimetic, was examined in ICR mice with azoxymethane dextran sodium sulfate-induced colorectal cancer. Azoxymethane is a carcinogen (10 mg/kg body weight), and 2% dextran sodium sulfate (w/v) used as a colitis-inducing agent. Mice were separated into 5 groups: a group without colorectal cancer fed a normal diet (CO- group), and groups with colorectal cancer fed a normal diet (CO+ group), a calorie-restricted diet (caloric restriction group), and diets including 0...
July 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28747791/molecular-imaging-of-aberrant-crypt-foci-in-the-human-colon-targeting-glutathione-s-transferase-p1-1
#9
Naoki Muguruma, Koichi Okamoto, Tadahiko Nakagawa, Katsutaka Sannomiya, Shota Fujimoto, Yasuhiro Mitsui, Tetsuo Kimura, Hiroshi Miyamoto, Jun Higashijima, Mitsuo Shimada, Yoko Horino, Shinya Matsumoto, Kenjiro Hanaoka, Tetsuo Nagano, Makoto Shibutani, Tetsuji Takayama
Aberrant crypt foci (ACF), the earliest precursor lesion of colorectal cancers (CRCs), are a good surrogate marker for CRC risk stratification and chemoprevention. However, the conventional ACF detection method with dye-spraying by magnifying colonoscopy is labor- and skill-intensive. We sought to identify rat and human ACF using a fluorescent imaging technique that targets a molecule specific for ACF. We found that glutathione S-transferase (GST) P1-1 was overexpressed in ACF tissues in a screening experiment...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747693/expression-profile-of-intestinal-stem-cell-markers-in-colitis-associated-carcinogenesis
#10
Hye Sung Kim, Cheol Lee, Woo Ho Kim, Young Hee Maeng, Bo Gun Jang
The intestinal epithelium has two distinct two stem cell populations, namely, crypt base columnar (CBC) cells and +4 cells. Several specific markers have been identified for each stem cell population. In this study, we examined the expression profiles of these markers in colitis-associated carcinogenesis (CAC) to investigate whether they can be used as biomarkers for the early detection of dysplasia. The expression of intestinal stem cell (ISC) markers was measured by real-time polymerase chain reaction during CAC that was induced by azoxymethane and dextran sodium sulfate treatment...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745498/curcumin-and-salsalate-suppresses-colonic-inflammation-and-procarcinogenic-signaling-in-high-fat-fed-azoxymethane-treated-mice
#11
Xian Wu, Anna C Pfalzer, Gar Yee Koh, Sanyuan Tang, Jimmy W Crott, Michael J Thomas, Mohsen Meydani, Joel B Mason
High-fat diets (HFDs) and excess adiposity increase proinflammatory cytokines in the colon, altering gene expression in a manner that promotes the development of colorectal cancer (CRC). Thus, compounds that reduce this biochemical inflammation are potential chemopreventive agents. Curcumin (CUR), a dietary polyphenol, and salsalate (SAL), a non-steroidal anti-inflammatory drug, are both anti-inflammatories. We investigated the inhibitory effects of CUR with or without SAL on inflammatory cytokines and procarcinogenic signaling in azoxymethane (AOM)-treated A/J mice...
August 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28744216/nuclear-magnetic-resonance-based-metabolomics-approach-to-evaluate-the-prevention-effect-of-camellia-nitidissima-chi-on-colitis-associated-carcinogenesis
#12
Ming-Hui Li, Hong-Zhi Du, Gui-Ju Kong, Li-Bao Liu, Xin-Xin Li, Sen-Sen Lin, Ai-Qun Jia, Sheng-Tao Yuan, Li Sun, Jun-Song Wang
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, occurring in the colon or rectum portion of large intestine. With marked antioxidant, anti-inflammation and anti-tumor activities, Camellia nitidissima Chi has been used as an effective treatment of cancer. The azoxymethane/dextran sodium sulfate (AOM/DSS) induced CRC mice model was established and the prevention effect of C. nitidissima Chi extracts on the evolving of CRC was evaluated by examination of neoplastic lesions, histopathological inspection, serum biochemistry analysis, combined with nuclear magnetic resonance (NMR)-based metabolomics and correlation network analysis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28725670/fatty-acid-and-lipidomic-data-in-normal-and-tumor-colon-tissues-of-rats-fed-diets-with-and-without-fish-oil
#13
Zora Djuric, Muhammad Nadeem Aslam, Becky R Simon, Ananda Sen, Yan Jiang, Jianwei Ren, Rena Chan, Tanu Soni, Thekkelnaycke M Rajendiran, William L Smith, Dean E Brenner
Data is provided to show the detailed fatty acid and lipidomic composition of normal and tumor rat colon tissues. Rats were fed either a Western fat diet or a fish oil diet, and half the rats from each diet group were treated with chemical carcinogens that induce colon cancer (azoxymethane and dextran sodium sulfate). The data show total fatty acid profiles of sera and of all the colon tissues, namely normal tissue from control rats and both normal and tumor tissues from carcinogen-treated rats, as obtained by gas chromatography with mass spectral detection...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28725183/bile-acid-mediated-sphingosine-1-phosphate-receptor-2-signaling-promotes-neuroinflammation-during-hepatic-encephalopathy-in-mice
#14
Matthew McMillin, Gabriel Frampton, Stephanie Grant, Shamyal Khan, Juan Diocares, Anca Petrescu, Amy Wyatt, Jessica Kain, Brandi Jefferson, Sharon DeMorrow
Hepatic encephalopathy (HE) is a neuropsychiatric complication that occurs due to deteriorating hepatic function and this syndrome influences patient quality of life, clinical management strategies and survival. During acute liver failure, circulating bile acids increase due to a disruption of the enterohepatic circulation. We previously identified that bile acid-mediated signaling occurs in the brain during HE and contributes to cognitive impairment. However, the influences of bile acids and their downstream signaling pathways on HE-induced neuroinflammation have not been assessed...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28718722/anticarcinogenic-effects-of-dried-citrus-peel-in-colon-carcinogenesis-due-to-inhibition-of-oxidative-stress
#15
Wakana Onuma, Daichi Asai, Susumu Tomono, Shingo Miyamoto, Gen Fujii, Takahiro Hamoya, Aya Nagano, Satoru Takahashi, Shoji Masumori, Noriyuki Miyoshi, Keiji Wakabayashi, Michihiro Mutoh
Colorectal cancer is one of the leading causes of death worldwide. Reactive oxygen species produce oxidative stress and contribute to colorectal carcinogenesis. Because dietary citrus has been shown to reduce oxidative stress, we investigated the effects of citrus peel extract at dilutions of 1/200-1/500 on the activity of oxidative-stress-related transcription factors, including AP-1, NF-κB, NRF2, p53, and STAT3, in human colon cancer cell line HCT116 cells using a luciferase reporter gene assay. NRF2 transcriptional activities were 1...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28711947/repression-of-intestinal-transporters-and-fxr-fgf15-signaling-explains-bile-acids-dysregulation-in-experimental-colitis-associated-colon-cancer
#16
Lijuan Cao, Yuan Che, Tuo Meng, Shanshan Deng, Jun Zhang, Min Zhao, Wanfeng Xu, Dandan Wang, Zhichen Pu, Guangji Wang, Haiping Hao
Bile acids (BAs) are important endogenous signaling molecules that play vital roles in the pathological development of various diseases including colitis-associated cancer (CAC). BAs were previously found dysregulated under conditions of CAC; however, the exact patterns and underlying molecular mechanisms remain largely elusive. Based on the development of a method for comprehensive analysis of BAs, this study aims to elucidate the dysregulation patterns and involved mechanisms in a typical CAC model induced by azoxymethane (AOM)/dextran sodium sulfate (DSS)...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28702433/korean-solar-salt-ameliorates-colon-carcinogenesis-in-an-aom-dss-induced-c57bl-6-mouse-model
#17
Jaehyun Ju, Yeung-Ju Kim, Eui Seong Park, Kun-Young Park
The effects of Korean solar salt on an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer C57BL/6 mouse model were studied. Korean solar salt samples (SS-S, solar salt from S salt field; SS-Yb, solar salt from Yb salt field), nine-time-baked bamboo salt (BS-9x, made from SS-Yb), purified salt (PS), and SS-G (solar salt from Guérande, France) were orally administered at a concentration of 1% during AOM/DSS colon cancer induction, and compared for their protective effects during colon carcinogenesis in C57BL/6 mice...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28692412/plant-sterol-esters-in-extruded-food-model-inhibits-colon-carcinogenesis-by-suppressing-inflammation-and-stimulating-apoptosis
#18
Nur Fathonah Sadek, Nancy Dewi Yuliana, Endang Prangdimurti, Bambang Pontjo Priosoeryanto, Slamet Budijanto
Plant sterols in their free forms are known to inhibit colon cancer. Whether these activities persist when compounds are incorporated into processed food is not reported yet. This study aimed to test the ability of plant sterol esters (PSE) incorporated into a nonpuffed extruded food (NPE) model to inhibit colon carcinogenesis. PSE was added into NPE at four concentrations (0.0%, 0.7%, 1.4%, and 2.1%). PSE-NPE activity was tested in azoxymethane/dextran sodium sulfate-induced Balb/c mice. The groups given PSE-NPE did not show any colon tumor formation...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28659405/fish-oil-contaminated-with-persistent-organic-pollutants-induces-colonic-aberrant-crypt-foci-formation-and-reduces-antioxidant-enzyme-gene-expression-in-rats
#19
Mee Young Hong, Eunha Hoh, Brian Kang, Rebecca DeHamer, Jin Young Kim, Jan Lumibao
Background: Epidemiologic, clinical, and experimental studies have suggested that fish oil (FO), a rich source of n-3 (ω-3) polyunsaturated fatty acids, protects against colon cancer. However, this message is confounded by the FDA's warning that the consumption of certain types of fish should be restricted because of contamination with persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs) and organochlorine pesticides.Objective: We examined FO contaminated with POPs (PCBs, dichlorodiphenyltrichloroethane, and chlordane) compared with unmodified FO on the risk factors of colon cancer development...
August 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28657468/cooked-chickpea-consumption-inhibits-colon-carcinogenesis-in-mice-induced-with-azoxymethane-and-dextran-sulfate-sodium
#20
Xariss M Sánchez Chino, Cristian Jiménez Martínez, Verónica R Vásquez Garzón, Isela Álvarez González, Saúl Villa Treviño, Eduardo Madrigal Bujaidar, Gloria Dávila Ortiz, Rafael Baltiérrez Hoyos
SCOPE: The objective of the study was to evaluate the effect of daily consumption of cooked chickpea (2% and 10%) in ICR male mice in which colon cancer was induced with azoxymethane and dextran sulfate sodium. METHODS AND RESULTS: The effect of consumption of 2% or 10% cooked chickpeas on carcinogenesis-induced colon azoxymethane (AOM)/dextran sulfate sodium (DSS) in ICR mice was determined. Protein oxidation and lipids were determined by colorimetric methods and oxidation of DNA through the identification of adducts 8-hydroxy-2'-desoxiguanosine and proliferation markers (proliferating cell nuclear antigen [PCNA], Ki-67, and β-catenin), and inflammation (cyclooxygenase [COX]-2 and inducible nitric oxide synthase [iNOS]) were identified by immunohistochemistry reactions...
July 2017: Journal of the American College of Nutrition
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