Weiyu Dai, Linjie Hong, Wushuang Xiao, Luyu Zhang, Weihong Sha, Zhen Yu, Xuehua Liu, Side Liu, Yizhi Xiao, Ping Yang, Ying Peng, Jieming Zhang, Jianjiao Lin, Xiaosheng Wu, Weimei Tang, Zhizhao Lin, Li Xiang, Jiaying Li, Miaomiao Pei, Jide Wang
Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous miR-3913-5p expression weakens the CRC cells growth, migration and invasion. Mechanistically, miR-3913-5p directly targets the 3'UTR of CREB5. Overexpression of CREB5 reverses the suppression of CRC cells proliferation, migration and invasion induced by miR-3913-5p...
October 10, 2023: Communications Biology