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Apocynin

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https://www.readbyqxmd.com/read/29348119/cigarette-smoke-initiates-oxidative-stress-induced-cellular-phenotypic-modulation-leading-to-cerebral-aneurysm-pathogenesis
#1
Robert M Starke, John W Thompson, Muhammad S Ali, Crissey L Pascale, Alejandra Martinez Lege, Dale Ding, Nohra Chalouhi, David M Hasan, Pascal Jabbour, Gary K Owens, Michal Toborek, Joshua M Hare, Aaron S Dumont
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on vascular smooth muscle cell (VSMC) phenotypic modulation and pathogenesis of CAs is unknown. The goal of this study was to investigate whether CSE activates a NOX (NAPDH oxidase)-dependent pathway leading to VSMC phenotypic modulation and CA formation and rupture...
January 18, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29343259/influence-of-apocynin-on-cardiac-remodeling-in-rats-with-streptozotocin-induced-diabetes-mellitus
#2
R Gimenes, C Gimenes, C M Rosa, N P Xavier, D H S Campos, A A H Fernandes, M D M Cezar, G N Guirado, L U Pagan, I D Chaer, D C Fernandes, F R Laurindo, A C Cicogna, M P Okoshi, K Okoshi
BACKGROUND: Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered an antioxidant agent by inhibiting NADPH oxidase activity and improving ROS scavenging. This study analyzed the influence of apocynin on cardiac remodeling in diabetic rats. METHODS: Six-month-old male Wistar rats were assigned into 4 groups: control (CTL, n = 15), control + apocynin (CTL + APO, n = 20), diabetes (DM, n = 20), and diabetes + apocynin (DM + APO, n = 20)...
January 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29299955/apocynin-combined-with-drugs-as-coadjuvant-could-be-employed-to-prevent-and-or-treat-the-chronic-kidney-disease
#3
Jorge Osvaldo Montes-Rivera, Feliciano Tamay-Cach, Julio César Quintana-Pérez, Juan Alberto Guevara-Salazar, José Guadalupe Trujillo-Ferrara, Leonardo Del Valle-Mondragón, Mónica Griselda Arellano-Mendoza
A worldwide public health problem is chronic kidney disease (CKD) presenting alarming epidemiological data. It currently affects about 10% of the adult population worldwide and has a high mortality rate. It is now known that oxidative stress represents one of the most important mechanisms in its pathophysiology, from the early stages to the terminal phase. Oxidation increases inflammation and reduces the capacity of NO• to relax vascular smooth muscle, in part by decreasing bioavailability of tetrahydrobiopterin (BH4), leading to endothelial dysfunction and high blood pressure, and due to the limited effectiveness of existing treatments, new drugs are needed to prevent and/or treat these mechanisms...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29289409/corrigendum-to-combined-nadph-and-the-nox-inhibitor-apocynin-provides-greater-anti-inflammatory-and-neuroprotective-effects-in-a-mouse-model-of-stroke-free-radic-biol-med-104-2017-333-345
#4
Yuan-Yuan Qin, Mei Li, Xing Feng, Jian Wang, Lijuan Cao, Xi-Kui Shen, Jieyu Chen, Meiling Sun, Rui Sheng, Feng Han, Zheng-Hong Qin
No abstract text is available yet for this article.
December 27, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29277696/oxidative-burst-activity-in-haemocytes-of-the-freshwater-prawn-macrobrachium-rosenbergii
#5
Jian-An Xian, Xiu-Xia Zhang, An-Li Wang, Jun-Tao Li, Pei-Hua Zheng, Yao-Peng Lu, Dong-Mei Wang, Jian-Min Ye
Oxidative burst, release of reactive oxygen species/reactive nitrogen species (ROS/RNS) contributed to microorganisms killing, is a vital immune response of crustacean haemocyte. Three morphologic haemocyte types (hyaline cells, HC; semigranular cells, SGC; granular cells, GC) have been defined in crustaceans, and found to play different roles in immune defense. However, oxidative burst activities of different haemocyte subpopulations in crustaceans are currently not documented. In the present study, we investigated the oxidative burst activities of the three haemocyte types in the freshwater prawn Macrobrachium rosenbergii using the common ROS fluorescent probe dichlorofluorescin-diacetate (DCFH-DA)...
December 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29277598/deletion-of-rap1-disrupts-redox-balance-and-impairs-endothelium-dependent-relaxations
#6
Kenneth H K Wong, Yin Cai, Fan Ying, Xinyi Chen, Paul M Vanhoutte, Eva H C Tang
AIMS: Repressor activator protein 1 (Rap1) is conventionally known as a static structural component of the telomere, but recent evidence indicates that it exerts functions within and outside the nucleus taking part in metabolic regulation and promoting inflammatory responses. The present study investigated whether or not Rap1 deletion affects oxidative stress and nitric oxide (NO) bioavailability in the vascular wall, thus modulating endothelial function. METHODS AND RESULTS: Vascular responsiveness was studied in wire myographs in aortae from Rap1 wildtype and knockout mice...
December 22, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29260383/oxidative-stress-in-granulosa-cells-contributes-to-poor-oocyte-quality-and-ivf-et-outcomes-in-women-with-polycystic-ovary-syndrome
#7
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared the in vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P < 0...
December 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29259041/paeonol-attenuates-lps-induced-endothelial-dysfunction-and-apoptosis-by-inhibiting-bmp4-and-tlr4-signalling-simultaneously-but-independently
#8
Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Paul M Vanhoutte, Mohd Rais Mustafa
Inflammatory injury of the endothelium leads to apoptosis and endothelial dysfunction. The current study explored the effect and mechanisms of paeonol in inflammation-induced apoptosis and endothelial dysfunction induced by lipopolysaccharides (LPS). The effects of paeonol on LPS-induced inflammatory injury were assessed by Western blotting, flow cytometry and reactive oxygen species (ROS) measurement in human umbilical vein endothelial cells (HUVECs) and C57BL/6J mice. Vascular reactivity of isolated mouse aortae was examined using wire myographs...
December 19, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29229746/inhibition-of-nadph-oxidase-dependent-oxidative-stress-in-the-rostral-ventrolateral-medulla-mediates-the-antihypertensive-effects-of-acupuncture-in-spontaneously-hypertensive-rats
#9
Xue-Rui Wang, Jing-Wen Yang, Cai-Shuo Ji, Xiang-Hong Zeng, Guang-Xia Shi, Marc Fisher, Cun-Zhi Liu
Oxidative stress in the rostral ventrolateral medulla (RVLM), where the sympathetic nervous control center is located, contributes to neural mechanisms of hypertension. Acupuncture was previously reported to favorably affect high blood pressure. However, little is known about the effect of acupuncture on oxidative stress-modulated mechanisms in hypertension. This study was designed to evaluate the hypothesis that acupuncture exerts an antihypertensive effect via ameliorating oxidative stress and the redox-sensitive pathway in the RVLM of spontaneously hypertensive rats...
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29208022/role-of-endoplasmic-reticulum-stress-in-the-protective-effects-of-ppar%C3%AE-%C3%AE-activation-on-endothelial-dysfunction-induced-by-plasma-from-patients%C3%A2-with-lupus
#10
Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio, Juan Duarte
BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. METHODS: A total of 12 non-pregnant women with lupus and 5 non-pregnant healthy women (controls) participated in the study. Cytokines and double-stranded DNA autoantibodies (anti-dsDNA) were tested in plasma samples...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29206487/role-of-catechins-on-et-1-induced-stimulation-of-pld-and-nadph-oxidase-activities-in-pulmonary-smooth-muscle-cells-determination-of-the-probable-mechanism-by-molecular-docking-studies
#11
Sajal Chakraborti, Jaganmay Sarkar, Rajabrata Bhuyan, Tapati Chakraborti
Treatment of human pulmonary artery smooth muscle cells with ET-1 stimulated PLD and NADPH oxidase activities, which were inhibited upon pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor) and EGCG & ECG (catechins having galloyl group), but not EGC & EC (catechins devoid of galloyl group). Herein, we determined the probable mechanism by which the galloyl group containing catechins inhibit ET-1 induced stimulation of PLD activity by molecular docking analyses based on our biochemical studies...
December 5, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29183043/benzo-e-pyrene-inhibits-endothelium-dependent-no-mediated-dilation-of-retinal-arterioles-via-superoxide-production-and-endoplasmic-reticulum-stress
#12
Takayuki Kamiya, Taiji Nagaoka, Tsuneaki Omae, Shinji Ono, Shinichi Otani, Akitoshi Yoshida
Purpose: To investigate whether benzo(e)pyrene (B(e)P), a toxicant in cigarette smoke, affects the endothelium-dependent nitric oxide (NO)-induced vasodilation of the retinal arterioles, and whether oxidative stress, distinct protein kinase signaling pathways, and endoplasmic reticulum (ER) stress are associated with the B(e)P-induced effect on the retinal arterioles. Methods: In this in vitro study, porcine retinal arterioles were isolated, cannulated, and pressurized without flow...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29169992/hax-1-regulates-serca2a-oxidation-and-degradation
#13
Philip A Bidwell, Guan-Sheng Liu, Narayani Nagarajan, Chi Keung Lam, Kobra Haghighi, George Gardner, Wen-Feng Cai, Wen Zhao, Luke Mugge, Elizabeth Vafiadaki, Despina Sanoudou, Jack Rubinstein, Djamel Lebeche, Roger Hajjar, Junichi Sadoshima, Evangelia G Kranias
Ischemia/reperfusion injury is associated with contractile dysfunction and increased cardiomyocyte death. Overexpression of the hematopoietic lineage substrate-1-associated protein X-1 (HAX-1) has been shown to protect from cellular injury but the function of endogenous HAX-1 remains obscure due to early lethality of the knockout mouse. Herein we generated a cardiac-specific and inducible HAX-1 deficient model, which uncovered an unexpected role of HAX-1 in regulation of sarco/endoplasmic reticulum Ca-ATPase (SERCA2a) in ischemia/reperfusion injury...
November 21, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29154190/-epicatechin-protects-the-intestinal-barrier-from-high-fat-diet-induced-permeabilization-implications-for-steatosis-and-insulin-resistance
#14
Eleonora Cremonini, Ziwei Wang, Ahmed Bettaieb, Ana M Adamo, Elena Daveri, David A Mills, Karen M Kalanetra, Fawaz G Haj, Sidika Karakas, Patricia I Oteiza
Increased permeability of the intestinal barrier is proposed as an underlying factor for obesity-associated pathologies. Consumption of high fat diets (HFD) is associated with increased intestinal permeabilization and increased paracellular transport of endotoxins which can promote steatosis and insulin resistance. This study investigated whether dietary (-)-epicatechin (EC) supplementation can protect the intestinal barrier against HFD-induced permeabilization and endotoxemia, and mitigate liver damage and insulin resistance...
November 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/29106440/identification-of-pmn-released-mutagenic-factors-in-a-co-culture-model-for-colitis-associated-cancer
#15
Nicolas Granofszky, Michaela Lang, Vineeta Khare, Gerald Schmid, Theresa Scharl, Franziska Ferk, Kristine Jimenez, Siegfried Knasmüller, Christoph Campregher, Christoph Gasche
Microsatellite instability (MSI) is present in ulcerative colitis and colitis-associated colorectal cancers. Certain factors released by polymorphonuclear cells (PMN) may drive mucosal frameshift mutations resulting in MSI and cancer. Here, we applied a co-culture system with PMNs and colon epithelial cells to identify such culprit factors. Subjecting HCT116+chr3 and HCEC-1CT MSI-reporter cell lines harboring mono-, di- or tetranucleotide DNA repeats linked to EGFP to activated PMNs induced frameshift mutations within all repeats, as quantified by flow cytometry...
November 2, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29106395/nadph-oxidase-4-promotes-cisplatin-induced-acute-kidney-injury-via-ros-mediated-programmed-cell-death-and-inflammation
#16
Xiao-Ming Meng, Gui-Ling Ren, Li Gao, Qin Yang, Hai-Di Li, Wei-Feng Wu, Cheng Huang, Lei Zhang, Xiong-Wen Lv, Jun Li
The goal of this study was to elucidate the functional role of Nox4 during acute kidney injury (AKI). NADPH oxidases are a major source of reactive oxygen species (ROS) in the kidney in normal and pathological conditions. Among NADPH oxidase isoforms, NADPH oxidase4 (Nox4) is highly expressed in the kidney and has an important role in kidney diseases, such as diabetic nephropathy and renal carcinoma. We previously found that Nox4 expression significantly increased in the toxic AKI model. However, its functional role and mechanism of action in AKI are still unknown...
November 6, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29101185/advanced-oxidation-protein-products-aggravate-cardiac-remodeling-via-cardiomyocyte-apoptosis-in-chronic-kidney-disease
#17
Weijing Feng, Kun Zhang, Yu Liu, Jie Chen, Qingqing Cai, Wanbing He He, Yinyin Zhang, Mong-Heng Wang, Jingfeng Wang, Hui Huang
Advanced oxidation protein products (AOPPs) are independent risk factor for various cardiovascular diseases. Cardiomyocyte apoptosis has been implicated as an important mechanism in cardiac remodeling in chronic kidney disease (CKD). However, whether AOPPs affect cardiomyocyte apoptosis and subsequent cardiac remodeling in CKD is still not very clear. Here, we assessed the role of AOPPs in cardiomyocyte apoptosis in CKD. H9C2 rat cardiomyoblast cells were exposed to AOPPs. The apoptotic cells were determined by TUNEL assay...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29091896/effect-of-the-nadph-oxidase-inhibitor-apocynin-on-ischemia-reperfusion-hippocampus-injury-in-rat-brain
#18
Monika Kapoor, Neha Sharma, Rajat Sandhir, Bimla Nehru
Blockage along with sudden restoration of blood following ischemia, results in several cascading events, such as a massive ROS production which plays an important role in the pathophysiology of ischemia. NADPH oxidase complex in mitochondria complex is believed to be the major source for ROS production. The present study explores the therapeutic potential of apocynin, an NADPH oxidase inhibitor in attenuating the ROS production, and the resultant neuroinflammation and mitochondrial injury during cerebral ischemia in rats...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29083257/a-combination-antioxidant-therapy-to-inhibit-nox2-and-activate-nrf2-decreases-secondary-brain-damage-and-improves-functional-recovery-after-traumatic-brain-injury
#19
Raghavendar Chandran, TaeHee Kim, Suresh L Mehta, Eshwar Udho, Vishal Chanana, Pelin Cengiz, HwuiWon Kim, Chanul Kim, Raghu Vemuganti
Uncontrolled oxidative stress contributes to the secondary neuronal death that promotes long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both NADPH oxidase 2 (NOX2) that increases and transcription factor Nrf2 that decreases reactive oxygen species (ROS) are induced after TBI. As the post-injury functional outcome depends on the balance of these opposing molecular pathways, we evaluated the effect of TBI on the motor and cognitive deficits and cortical contusion volume in NOX2 and Nrf2 knockout mice...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29079903/anti-oxidants-correct-disturbance-of-redox-enzymes-in-the-hearts-of-rat-fetuses-with-congenital-diaphragmatic-hernia
#20
Rosa Aras-López, L Almeida, V Andreu-Fernández, J Tovar, L Martínez
AIM: To evaluate if the redox system is unbalanced in the hearts of nitrofen-induced congenital diaphragmatic hernia  (CDH) animals and to study the possible preventive effects of two anti-oxidant treatments, apocynin and epigallocatechin-3-gallate (EGCG). METHODS: Adult rats were divided into four groups. Group 1: rats received only vehicle on day E9.5. Group 2: rats received 100 mg nitrofen on day E9.5. Group 3: 1 month before mating rats received apocynin 1...
October 27, 2017: Pediatric Surgery International
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