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1q31-32 CFH

Alexander P Reiner, Jaana Hartiala, Tanja Zeller, Joshua C Bis, Josée Dupuis, Myriam Fornage, Jens Baumert, Marcus E Kleber, Philipp S Wild, Stephan Baldus, Suzette J Bielinski, João D Fontes, Thomas Illig, Brendan J Keating, Leslie A Lange, Francisco Ojeda, Martina Müller-Nurasyid, Thomas F Munzel, Bruce M Psaty, Kenneth Rice, Jerome I Rotter, Renate B Schnabel, W H Wilson Tang, Barbara Thorand, Jeanette Erdmann, David R Jacobs, James G Wilson, Wolfgang Koenig, Russell P Tracy, Stefan Blankenberg, Winfried März, Myron D Gross, Emelia J Benjamin, Stanley L Hazen, Hooman Allayee
Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and African Americans (AAs). A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene was strongly associated with serum MPO levels in 9305 subjects of European ancestry (lead SNP rs800292; P = 4...
August 15, 2013: Human Molecular Genetics
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