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https://www.readbyqxmd.com/read/29777724/novel-mirna-biomarkers-for-genotoxicity-screening-in-mouse
#1
Hiroyuki Oka, Koichi Masuno, Takeki Uehara, Toru Okamoto, Yoshiharu Matsuura, Toru Nakano, Shinpei Yamaguchi
The genotoxic potential of drugs is a serious problem, and its evaluation is one of the most critical processes of drug development. Although the comet assay of compound-exposed tissue is a frequently used genotoxicity test, its high false-positive rate is a major complication, and we consistently obtained false-positive results using the comet assay of mouse liver for nine hepatotoxic non-genotoxins (NGTXs). To identify novel genotoxin (GTX)-specific biomarkers, we screened the expression of 750 microRNAs (miRNAs) in the livers of mice treated with GTXs or NGTXs...
May 16, 2018: Toxicology
https://www.readbyqxmd.com/read/29734428/characterization-of-mirnas-modulated-by-torpor-in-the-hibernating-ground-squirrel-ictidomys-tridecemlineatus-liver-by-next-generation-sequencing
#2
M D Morin, D Lang-Ouellette, P J Lyons, N Crapoulet, P Morin
BACKGROUND: Mammalian hibernation is a fascinating phenomenon that involves multiple molecular and biochemical changes to proceed. While the molecular picture associated with torpor has become clearer in recent years, the function of non-coding RNAs, and especially of microRNAs, solicited during this process is not well understood. OBJECTIVE: To better characterize a signature of cold torpor-associated miRNAs in the hibernating thirteen-lined ground squirrel Ictidomys tridecemlineatus...
July 2017: Cryo Letters
https://www.readbyqxmd.com/read/29716630/serum-mir-22-as-potential-non-invasive-predictor-of-poor-clinical-outcome-in-newly-diagnosed-uniformly-treated-patients-with-diffuse-large-b-cell-lymphoma-an-explorative-pilot-study
#3
Francesco Marchesi, Giulia Regazzo, Francesca Palombi, Irene Terrenato, Andrea Sacconi, Manuela Spagnuolo, Sara Donzelli, Mirella Marino, Cristiana Ercolani, Anna Di Benedetto, Giovanni Blandino, Gennaro Ciliberto, Andrea Mengarelli, Maria Giulia Rizzo
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of tumors, with aggressive clinical course that renders prognostication and choice of treatment strategy difficult. Chemo-immunotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) is the current first-line treatment. MicroRNAs (miRNAs) are under investigation as novel diagnostic and prognostic biomarkers in several malignancies, including malignant lymphomas. While tissue miRNAs in DLBCL patients have been extensively studied as biomarkers, only few reports to date have evaluated the role of circulating/serum miRNAs as potential prognostic factors...
May 2, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29709471/mm9_circ_009056-enhances-osteogenesis-by-targeting-bmp7-via-cgrp-mediated-mir-22-3p
#4
Caijuan Wu, Zhichao Zheng, Wen Ren, Tian Deng, Yuanjing Li, Lan Yang, Jingwen Wu, Zhu Huang, Zhengmao Li, Lvhua Guo
Circular RNAs (circRNAs) are noncoding RNAs that can function as miRNA sponges, post-transcriptionally regulating the expression of genes. Here, we report a novel positive function of mm9_circ_009056 during osteogenesis in regulating bone morphogenetic protein 7 (BMP7) through miR-22-3p. First, we found that calcitonin gene-related peptide (CGRP) had great osteogenesis function on MC3T3 cells. Then aberrant expression of mm9_circ_009056 were confirmed in CGRP-induced cells. Furthermore, the expression of mm9_circ_009056 was up-regulated in the CGRP-induced cells, whereas miR-22-3p was obviously decreased...
April 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29707120/mirna-based-signatures-in-cerebrospinal-fluid-as-potential-diagnostic-tools-for-early-stage-parkinson-s-disease
#5
Marcia Cristina T Dos Santos, Miguel Arturo Barreto-Sanz, Bruna Renata S Correia, Rosie Bell, Catherine Widnall, Luis Tosar Perez, Caroline Berteau, Claudia Schulte, Dieter Scheller, Daniela Berg, Walter Maetzler, Pedro A F Galante, Andre Nogueira da Costa
Parkinson's Disease is the second most common neurodegenerative disorder, affecting 1-2% of the elderly population. Its diagnosis is still based on the identification of motor symptoms when a considerable number of dopaminergic neurons are already lost. The development of translatable biomarkers for accurate diagnosis at the earliest stages of PD is of extreme interest. Several microRNAs have been associated with PD pathophysiology. Consequently, microRNAs are emerging as potential biomarkers, especially due to their presence in Cerebrospinal Fluid and peripheral circulation...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29685931/mir-22-in-smooth-muscle-cells-a-potential-therapy-for-cardiovascular-disease
#6
EDITORIAL
Zhan-Peng Huang, Da-Zhi Wang
No abstract text is available yet for this article.
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29684772/identification-of-mir-22-3p-mir-92a-3p-and-mir-137-in-peripheral-blood-as-biomarker-for-schizophrenia
#7
Jie Ma, Shanshan Shang, Jihan Wang, Tianbu Zhang, Fayi Nie, Xiaobin Song, Heping Zhao, Chunhui Zhu, Rui Zhang, Dingjun Hao
MicroRNAs (miRNAs) are a class of endogenous and non-coding single-stranded RNAs with length of about 22 nucleotides, and many are evolutionarily conserved. Although postmortem brain samples provide direct evidence of miRNA dysregulation within the brain, peripheral tissue samples can be obtained from living subjects and have the potential to yield biomarkers that could be used as diagnostic tools. To verify and detect additional miRNAs differentially expressed in peripheral blood and further explore their diagnostic value and function for schizophrenia, we performed a next-generation sequencing approach in combination with a literature search to select appropriate miRNAs...
April 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29665181/mir-193a-3p-functions-as-a-tumour-suppressor-in-human-aldosterone-producing-adrenocortical-adenoma-by-down-regulating-cyp11b2
#8
Guoxi Zhang, Xiaofeng Zou, Quanliang Liu, Tianpeng Xie, Ruohui Huang, Huan Kang, Changfu Lai, Jiaxing Zhu
The mechanism of aldosterone-producing adrenocortical adenoma (APA) pathogenesis and the role of microRNAs (miRNAs) in APA pathogenesis have not been completely clarified. We examined the expression and function of miR-140-3p, miR-193a-3p and miR-22-3p, which have binding sites in CYP11B2. Expression of miRNAs and CYP11B2 mRNA was measured by quantitative reverse transcription PCR (qRT-PCR). Cell proliferation was monitored by colorimetric analysis, and cell apoptosis and cell cycle progression were analysed by flow cytometry...
April 17, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29663359/lncrna-dgcr5-contributes-to-csc-like-properties-via-modulating-mir-330-5p-cd44-in-nsclc
#9
Ren Wang, Hui-Xing Dong, Jian Zeng, Jing Pan, Xiao-Yan Jin
Non-coding RNAs can exert significant roles various cancers, including NSCLC. Previously, we indicated that lncRNA DGCR5 can promote lung cancer progression through inhibiting hsa-mir-22-3p. In our current study, we investigated the role of DGCR5 in cancer stem cell-like properties of NSCLC. CSCs have been recognized as the frequent cause of tumor metastasis, tumor recurrence, and chemotherapy resistance. Here, lung cancer stem cells were successfully enriched from the parental NSCLC A549, H460, and H1299 cells by using tumor sphere formation assays and side population (SP) assays...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29620229/mir%C3%A2-22%C3%A2-3p-enhances-multi%C3%A2-chemoresistance-by-targeting-net1-in-bladder-cancer-cells
#10
Jun Xiao, Sanqiang Niu, Jiahong Zhu, Lei Lv, Hui Deng, Daqing Pan, Deyun Shen, Congyun Xu, Zhou Shen, Tao Tao
With the discovery of new chemotherapeutic drugs, chemotherapy becomes increasingly valuable. However, the resistance of tumor cells to chemotherapeutic agents significantly limits the effectiveness and causes chemotherapy failure. MicroRNAs have been shown to regulate drug resistance in many types of cancer. In the present study, we measured the chemosensitivity of five bladder cancer (BCa) cell lines to seven commonly used chemotherapeutic drugs by Vita‑Blue assay. We then identified the most sensitive (5637) and most tolerant cell lines (H‑bc) and conducted a multi‑group test...
April 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29602299/identification-of-human-skeletal-muscle-mirna-related-to-strength-by-high-throughput-sequencing
#11
Cameron J Mitchell, Randall F D'Souza, William Schierding, Nina Zeng, Farha Ramzan, Justin M O'Sullivan, Sally D Poppitt, David Cameron-Smith
The loss of muscle size, strength and quality with ageing is a major determinant of morbidity and mortality in the elderly. The regulatory pathways that impact on the muscle phenotype include the translational regulation maintained by microRNAs (miRNA). Yet the miRNAs that are expressed in human skeletal muscle and relationship to muscle size, strength and quality are unknown. Using next-generation sequencing, the 50 most abundantly expressed miRNAs were selected and then analysed in m. vastus lateralis, obtained by biopsy from middle-aged males (n=48; 50...
March 30, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29588073/mir-22-regulates-c2c12-myoblast-proliferation-and-differentiation-by-targeting-tgfbr1
#12
Han Wang, Qian Zhang, BinBin Wang, WangJun Wu, Julong Wei, Pinghua Li, Ruihua Huang
Recently, miR-22 was found to be differentially expressed in different skeletal muscle growth period, indicated that it might have function in skeletal muscle myogenesis. In this study, we found that the expression of miR-22 was the most in skeletal muscle and was gradually up-regulated during mouse myoblast cell (C2C12 myoblast cell line) differentiation. Overexpression of miR-22 repressed C2C12 myoblast proliferation and promoted myoblast differentiation into myotubes, whereas inhibition of miR-22 showed the opposite results...
March 21, 2018: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29568877/microrna%C3%A2-22-inhibits-the-proliferation-and-migration-and-increases-the-cisplatin-sensitivity-of-osteosarcoma-cells
#13
Xiang Zhou, Dimple Natino, Xu Zhai, Zhongyang Gao, Xijing He
Osteosarcoma (OS) is the major type of primary bone tumor and is associated with a poor prognosis due to chemotherapy resistance. Accumulating evidence indicates that microRNAs (miRNAs/miRs) may influence the tumor progression of OS and cell sensitivity to chemotherapy. In the present study, a total of 7 patients with OS and 7 healthy volunteers were recruited. Reverse transcription‑quantitative polymerase chain reaction and ELISA were performed to determine the expression of miRNAs and mRNAs in the serum of participants...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29534065/microrna-signatures-for-circulating-cd133-positive-cells-in-hepatocellular-carcinoma-with-hcv-infection
#14
Abdel-Rahman N Zekri, Enas Reda El-Sisi, Amira Salah El-Din Youssef, Mahmoud M Kamel, Auhood Nassar, Ola Sayed Ahmed, Mohamed El Kassas, Ahmed Barakat Barakat, Alaa Ismail Abd El-Motaleb, Abeer A Bahnassy
AIM: Molecular characterization of the CD133+ stem cells associated with hepatocarinogensis through identifying the expression patterns of specific microRNAs (miRNAs). METHODS: We investigated the expression pattern of 13 miRNAs in purified CD133+ cells separated from the peripheral blood of healthy volunteers, chronic hepatitis C (CHC), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients a long with bone marrow samples from the healthy volunteers and the LC patients using custom miScript miRNA PCR array...
2018: PloS One
https://www.readbyqxmd.com/read/29520849/lncrna-h19-targets-mir-22-to-modulate-h-2-o-2-induced-deregulation-in-nucleus-pulposus-cell-senescence-proliferation-and-ecm-synthesis-through-wnt-signaling
#15
Xiaobin Wang, Mingxiang Zou, Jing Li, Bing Wang, Qianshi Zhang, Fubin Liu, Guohua Lü
Intervertebral disc (IVD) degeneration (IDD) is a major contributor to low back pain. During IDD progression, ROS can be produced in the form of H2 O2 in nucleus pulposus cells (NPCs) in response to elevated cytokines, leading to subsequent alternations of cell fate and metabolic processes. Genetic factors are considered as main contributors to IDD pathopoiesis. Herein, we investigated the detailed function and mechanism of H19, one of the most up-regulated lncRNAs in IDD specimens, in H2 O2 -induced cell senescence model in NPCs...
June 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29515098/lncrna-hcp5-promotes-follicular-thyroid-carcinoma-progression-via-mirnas-sponge
#16
Leilei Liang, Jingchao Xu, Meng Wang, Gaoran Xu, Ning Zhang, Guangzhi Wang, Yongfu Zhao
Long non-coding RNAs (lncRNAs), which are important functional regulators in cancer, have received increased attention in recent years. In this study, next-generation sequencing technology was used to identify aberrantly expressed lncRNAs in follicular thyroid carcinoma (FTC). The long non-coding RNA-HLA complex P5 (HCP5) was found to be overexpressed in FTC. The results of the qPCR analysis were consistent with the sequencing results. In addition, functional experiments showed that overexpression of HCP5 can promote the proliferation, migration, invasiveness and angiogenic ability of FTC cells...
March 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29506076/altered-microrna-profile-in-osteoporosis-caused-by-impaired-wnt-signaling
#17
Riikka E Mäkitie, Matthias Hackl, Riitta Niinimäki, Sakari Kakko, Johannes Grillari, Outi Mäkitie
Context: WNT signaling is fundamental to bone health, and its aberrant activation leads to skeletal pathologies. The heterozygous missense mutation p.C218G in WNT1, a key WNT pathway ligand, leads to severe early-onset and progressive osteoporosis with multiple peripheral and spinal fractures. Despite the severe skeletal manifestations, conventional bone turnover markers are normal in mutation-positive patients. Objective: This study sought to explore the circulating microRNA (miRNA) pattern in patients with impaired WNT signaling...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29486470/abnormal-downregulation-of-caveolin-3-mediates-the-pro-fibrotic-action-of-microrna-22-in-a-model-of-myocardial-infarction
#18
Lu Zhang, Hongli Yin, Lei Jiao, Tianyi Liu, Yuqiu Gao, Yingchun Shao, Yuanyuan Zhang, Hongli Shan, Ying Zhang, Baofeng Yang
BACKGROUND/AIMS: Cardiac fibrosis is an important cardiac remodeling event that can ultimately lead to the development of severe arrhythmia and heart failure. MicroRNAs (miRNAs) are involved in the pathogenesis of many cardiovascular diseases. Here, we aimed to investigate the effects of caveolin-3 (Cav3) on the pathogenesis of cardiac fibrosis and the underlying molecular mechanisms. METHODS: Cav3 expression was decreased in cardiac fibrosis in vivo and in vitro model...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29434190/mir-22-suppresses-epithelial-mesenchymal-transition-in-bladder-cancer-by-inhibiting-snail-and-mapk1-slug-vimentin-feedback-loop
#19
Mingjie Xu, Jiangfeng Li, Xiao Wang, Shuai Meng, Jiaying Shen, Song Wang, Xin Xu, Bo Xie, Ben Liu, Liping Xie
MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of bladder cancer (BCa). MiR-22 was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in BCa remain unclear. Here, we find that miR-22 is frequently downregulated in BCa tissues compared with adjacent non-cancerous tissues. Overexpression of miR-22 significantly inhibits proliferation, migration, and invasion of BCa cells both in vitro and in vivo...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29429995/mir-125b-5p-and-mir-99a-5p-downregulate-human-%C3%AE-%C3%AE-t-cell-activation-and-cytotoxicity
#20
Yuli Zhu, Siya Zhang, Zinan Li, Huaishan Wang, Zhen Li, Yu Hu, Hui Chen, Xuan Zhang, Lianxian Cui, Jianmin Zhang, Wei He
As an important component of innate immunity, human circulating γδ T cells function in rapid responses to infections and tumorigenesis. MicroRNAs (miRNAs) play a critical regulatory role in multiple biological processes and diseases. Therefore, how the functions of circulating human γδ T cells are regulated by miRNAs merits investigation. In this study, we profiled the miRNA expression patterns in human peripheral γδ T cells from 21 healthy donors and identified 14 miRNAs that were differentially expressed between peripheral αβ T cells and γδ T cells...
February 12, 2018: Cellular & Molecular Immunology
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