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miR-22

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https://www.readbyqxmd.com/read/28314781/sex-specific-reciprocal-regulation-of-er%C3%AE-and-mir-22-controls-muscle-lipid-metabolism-in-male-mice
#1
Judith Schweisgut, Christian Schutt, Stas Wüst, Astrid Wietelmann, Bart Ghesquière, Peter Carmeliet, Stefan Dröse, Kenneth S Korach, Thomas Braun, Thomas Boettger
Control of energy homeostasis and metabolism is achieved by integrating numerous pathways, and miRNAs are involved in this process by regulating expression of multiple target genes. However, relatively little is known about the posttranscriptional processing of miRNAs and a potential role for the precursors they derive from. Here, we demonstrate that mature miRNA-22 is more abundant in muscle from male mice relative to females and that this enables sex-specific regulation of muscular lipid metabolism and body weight by repressing estrogen receptor alpha (ERα) expression...
March 17, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28296904/differentially-expressed-mirnas-in-sepsis-induced-acute-kidney-injury-target-oxidative-stress-and-mitochondrial-dysfunction-pathways
#2
Qin-Min Ge, Chun-Mei Huang, Xiang-Yang Zhu, Fan Bian, Shu-Ming Pan
OBJECTIVE: To identify specific miRNAs involved in sepsis-induced AKI and to explore their targeting pathways. METHODS: The expression profiles of miRNAs in serum from patients with sepsis-induced AKI (n = 6), sepsis-non AKI (n = 6), and healthy volunteers (n = 3) were investigated by microarray assay and validated by quantitative PCR (qPCR). The targets of the differentially expressed miRNAs were predicted by Target Scan, mirbase and Miranda. Then the significant functions and involvement in signaling pathways of gene ontology (GO) and KEGG pathways were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28294194/phosphodiesterase-5-inhibition-preserves-renal-hemodynamics-and-function-in-mice-with-diabetic-kidney-disease-by-modulating-mir-22-and-bmp7
#3
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M Isidori, Mary Anna Venneri
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P < 0.001), the increase of urine albumin creatinine ratio (P < 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288414/butyrate-induces-ros-mediated-apoptosis-by-modulating-mir-22-sirt-1-pathway-in-hepatic-cancer-cells
#4
Kishor Pant, Ajay K Yadav, Parul Gupta, Rakibul Islam, Anoop Saraya, Senthil K Venugopal
Butyrate is one of the short chain fatty acids, produced by the gut microbiota during anaerobic fermentation of dietary fibres. It has been shown that it can inhibit tumor progression via suppressing histone deacetylase and can induce apoptosis in cancer cells. However, the comprehensive pathway by which butyrate mediates apoptosis and growth arrest in cancer cells still remains unclear. In this study, the role of miR-22 in butyrate-mediated ROS release and induction of apoptosis was determined in hepatic cells...
March 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28274577/serially-measured-circulating-mir-22-3p-is-a-biomarker-for-adverse-clinical-outcome-in-patients-with-chronic-heart-failure-the-bio-shift-study
#5
Nick van Boven, K Martijn Akkerhuis, Sharda S Anroedh, Dimitris Rizopoulos, Yigal Pinto, Linda C Battes, Hans L Hillege, Kadir C Caliskan, Tjeerd Germans, Olivier C Manintveld, Jan-Hein Cornel, Alina A Constantinescu, Eric Boersma, Victor A Umans, Isabella Kardys
BACKGROUND: Several studies have suggested circulating microRNAs (miRs) are associated with heart failure, but these studies were small, and limited to single miR measurements. We examined 7 miRs which were previously linked to heart failure, and tested whether their temporal expression level predicts prognosis in a prospective cohort of chronic heart failure (CHF) patients. METHODS AND RESULTS: In 2011-2013, 263 CHF patients were included. At inclusion and subsequently every 3months, we measured 7miRs...
February 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28272709/expression-of-microrna-122-and-microrna-22-in-hbv-related-liver-cancer-and-the-correlation-with-clinical-features
#6
D-D Qiao, J Yang, X-F Lei, G-L Mi, S-L Li, K Li, C-Q Xu, H-L Yang
OBJECTIVE: MicroRNAs (miR) participate in cell proliferation, apoptosis and transformation, as they can regulate gene expression and intracellular signal transduction for various physiological processes. MiR-122 and miR-22 are known to be related with occurrence and progression of hepatitis B virus (HBV)-related hepatocellular cancer (HCC). This study recruited HBV-related HCC patients, whose expression levels of miR-122 and miR-22 were determined to analyze the correlation with clinical and pathological indexes...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28253725/predicative-values-of-serum-microrna-22-and-microrna-126-levels-for-non-small-cell-lung-cancer-development-and-metastasis-a-case-control-study
#7
A Q Shang, Y N Xie, J Wang, L Sun, J Wei, W Y Lu, J Y Lan, W W Wang, L Wang, L L Wang
Presented study aims to explore the predictive values of serum microRNA-22 (miR-22) and miR-126 levels for non-small cell lung cancer (NSCLC) development and metastasis.A total of 127 NSCLC patients who were admitted in the First People's Hospital of Yancheng City from May, 2013 to May, 2015 were selected as the case group, including 71 cases of adenocarcinoma and 56 cases of squamous cell carcinoma. There were 112 healthy individuals selected as the control group. The qRT-PCR was performed to testify the serum miR-22 and miR-126 levels...
March 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28251131/how-to-be-young-at-heart-mir-22-as-a-potential-therapeutic-target-to-boost-autophagy-and-protect-the-old-myocardium
#8
EDITORIAL
Sebastiano Sciarretta, Elena De Falco, Giacomo Frati, Junichi Sadoshima
No abstract text is available yet for this article.
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28195408/microrna-22-promoted-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-by-targeting-hdac6
#9
Guang-Qi Yan, Xue Wang, Fan Yang, Min-Liang Yang, Guo-Kun Wang, Qing Zhou
Stem cells transplantation is a promising therapy strategy for accelerating periodontal regeneration and reconstruction. Genetic modification could induce stem cells directional differentiation to facilitate recovery of physiological functions. In this study, we investigated the role and mechanism of miR-22 on human periodontal ligament stem cells (PDLSCs). Firstly, a cellular model of osteogenic differentiation was first established by osteogenic inductive cocktail. Real-time PCR determined that expression of miR-22 was significantly increased during PDLSCs osteogenic differentiation...
February 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28193709/testosterone-represses-estrogen-signaling-by-upregulating-mir-22-a-mechanism-for-imbalanced-steroid-hormone-production-in-preeclampsia
#10
Xuan Shao, Yanlei Liu, Ming Liu, Yongqing Wang, Liying Yan, Hao Wang, Liyang Ma, Yu-Xia Li, Yangyu Zhao, Yan-Ling Wang
Preeclampsia, a multisystem syndrome occurring during mid- to late gestation in humans, is a leading cause of maternal and perinatal morbidity and mortality. Patients usually present with high circulating testosterone and reduced estradiol production, but the mechanisms remain unclear. Revealing the mechanism that modulating the imbalance of testosterone and estradiol in preeclampsia is of great value in understanding the cause of the disease. The placenta is the predominant source of steroid hormone production during gestation, and we observed markedly increased 17β-HSD3 (17β-hydroxysteroid dehydrogenase 3) levels and downregulated aromatase expression, the key enzymes responsible for synthesis of testosterone and estradiol, respectively, in preeclamptic placentas compared with controls...
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28184176/the-inhibition-role-of-mir-22-in-hepatocellular-carcinoma-cell-migration-and-invasion-via-targeting-cd147
#11
Ling-Juan Luo, Li-Ping Zhang, Chun-Yan Duan, Bei Wang, Na-Na He, Patima Abulimiti, Yan Lin
BACKGROUND: Recently, miR-22 is identified as a tumor-suppressing microRNA in many human cancers. CD147 is a novel cancer-associated biomarker that plays an important role in the invasion and metastasis of malignant tumor. However, the involvement of miR-22 in CD147 regulation and hepatocellular carcinoma (HCC) progression and metastasis has not been investigated. METHODS: We measured miR-22 expression level in 34 paired of HCC and matched normal tissues, HCC cell lines by real-time quantitative RT-PCR...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28179883/new-microrna-biomarkers-for-drug-induced-steatosis-and-their-potential-to-predict-the-contribution-of-drugs-to-non-alcoholic-fatty-liver-disease
#12
Mireia López-Riera, Isabel Conde, Laia Tolosa, Ángela Zaragoza, José V Castell, María J Gómez-Lechón, Ramiro Jover
Background and Aims: Drug-induced steatosis is a major reason for drug failure in clinical trials and post-marketing withdrawal; and therefore, predictive biomarkers are essential. These could be particularly relevant in non-alcoholic fatty liver disease (NAFLD), where most patients show features of the metabolic syndrome and are prescribed with combined chronic therapies, which can contribute to fatty liver. However, specific biomarkers to assess the contribution of drugs to NAFLD are lacking. We aimed to find microRNAs (miRNAs) responsive to steatotic drugs and to investigate if they could become circulating biomarkers for drug-induced steatosis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28164492/significance-of-serum-micrornas-in-the-auxiliary-diagnosis-of-non-small-cell-lung-cancer
#13
Guang-Li Shi, Yan Chen, Yong Sun, Yan-Jun Yin, Chang-Xing Song
BACKGROUND: The lack of effective means for the early diagnosis of non-small cell lung cancer (NSCLC) is the leading cause of the high mortality associated with this form of lung cancer. This study aims to explore the potential significance of serum miRNA in the auxiliary diagnosis of NSCLC. METHODS: The relative serum levels of 10 miRNAs in 120 patients with NSCLC, 45 patients with benign lung diseases, and 45 healthy controls were detected using real-time quantitative polymerase chain reaction (PCR)...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28161397/mir-22-contributes-to-endosulfan-induced-endothelial-dysfunction-by-targeting-srf-in-huvecs
#14
Dan Xu, Yubing Guo, Tong Liu, Shuai Li, Yeqing Sun
microRNAs (miRNAs) function in the posttranscriptional gene regulation, providing new insights into the epigenetic mechanism of toxicity induced by environmental pollutants. miR-22 was discovered to regulate cell proliferation and apoptosis in response to environmental toxicants. We have reported that endosulfan can cause endothelial toxicity in human umbilical vein endothelial cells (HUVECs). In the present study, we investigated the involvement of miR-22 in endosulfan-induced endothelial dysfunction. The expression level of miR-22 was increased in a dose-dependent manner by endosulfan exposure...
March 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28123428/key-genes-expressed-in-different-stages-of-spinal-cord-ischemia-reperfusion-injury
#15
Jian-An Li, Chun-Fang Zan, Peng Xia, Chang-Jun Zheng, Zhi-Ping Qi, Chun-Xu Li, Zhi-Gang Liu, Ting-Ting Hou, Xiao-Yu Yang
The temporal expression of microRNA after spinal cord ischemia/reperfusion injury is not yet fully understood. In the present study, we established a model of spinal cord ischemia in Sprague-Dawley rats by clamping the abdominal aorta for 90 minutes, before allowing reperfusion for 24 or 48 hours. A sham-operated group underwent surgery but the aorta was not clamped. The damaged spinal cord was removed for hematoxylin-eosin staining and RNA extraction. Neuronal degeneration and tissue edema were the most severe in the 24-hour reperfusion group, and milder in the 48-hour reperfusion group...
November 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28081132/the-janus-faced-nature-of-mir-22-in-hematopoiesis-is-it-an-oncogenic-tumor-suppressor-or-rather-a-tumor-suppressive-oncogene
#16
Alexander Arthur Wurm, Daniel G Tenen, Gerhard Behre
No abstract text is available yet for this article.
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28045918/response-of-mirna-22-3p-and-mirna-149-5p-to-folate-deficiency-and-the-differential-regulation-of-mthfr-expression-in-normal-and-cancerous-human-hepatocytes
#17
Chao Li, Juan Ni, Yao-Xian Liu, Han Wang, Zi-Qing Liang, Xu Wang
BACKGROUND/AIMS: Folic acid (FA) is a core micronutrient involved in DNA synthesis/methylation, and the metabolism of FA is responsible for genomic stability. MicroRNAs may affect gene expression during folate metabolism when cellular homeostasis is changed. This study aimed to reveal the relationship between FA deficiency and the expression of miR-22-p/miR-149-5p and the targeted regulation of miR-22-3p/miR-149-5p on the key folate metabolic gene Methylenetetrahydrofolate reductase (MTHFR)...
2017: PloS One
https://www.readbyqxmd.com/read/28035913/microrna-137-chemosensitizes-colon-cancer-cells-to-the-chemotherapeutic-drug-oxaliplatin-oxa-by-targeting-ybx1
#18
Yunsheng Guo, Yan Pang, Xia Gao, Min Zhao, Xin Zhang, Hao Zhang, Bing Xuan, Yimin Wang
The mechanisms underlying oxaliplatin (OXA) resistance in colon cancer cells are not fully understood. MicroRNAs (miRNAs) play important roles in tumorigenesis and drug resistance. However, the relationship between miRNA and OXA resistance in colon cancer cells has not been previously explored. In this study, we utilized microRNA microarray analysis and real-time PCR to verify that miR-93, miR-191, miR-137, miR-181 and miR-491-3p were significantly down-regulated and that miR-96, miR-21, miR-22, miR-15b and miR-92 were up-regulated in both HCT-15/OXA and SW480/OXA cell lines...
2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28000852/molecular-mechanisms-and-clinical-applications-of-mir-22-in-regulating-malignant-progression-in-human-cancer-review
#19
Jingyu Wang, Yuan Li, Meiman Ding, Honghe Zhang, Xiaoming Xu, Jinlong Tang
miRNAs (microRNAs) have been validated to play fateful roles in the occurrence and development of cancers by post-transcriptionally targeting 3'-untranslated regions of the downstream gene mRNAs to repress mRNA expression. Mounting investigations forcefully document that not only does miR‑22 biologically impinge on the processes of senescence, energy supply, angiogenesis, EMT (epithelial-mesenchymal transition), proliferation, migration, invasion, metastasis and apoptosis, but also it genetically or epigenetically exerts dual (inhibitory/promoting cancer) effects in various cancers via CNAs (copy number alterations), SNPs (single nucleotide polymorphisms), methylation, acetylation and even more momentously hydroxymethylation...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27997889/mir-22-may-suppress-fibrogenesis-by-targeting-tgf%C3%AE-r-i-in-cardiac-fibroblasts
#20
Yuan Hong, Huaming Cao, Qiang Wang, Jianlin Ye, Lijun Sui, Jinhua Feng, Xiaojun Cai, Huizhu Song, Xiuhong Zhang, Xichuang Chen
BACKGROUND/AIMS: Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure, but the mechanisms undelying cardiac fibrosis remained unknown. microRNAs (miRNAs) are novel mechanisms leading to fibrotic diseases, including cardiac fibrosis. Previous studies revealed that miR-22 might be a potential target. However, the roles and mechanisms of miR-22 in cardiac fibrosis remained ill defined. The present study thus addressed the impact of miR-22 in cardiac fibrosis...
2016: Cellular Physiology and Biochemistry
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