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EDITORIAL
Benjamin P Keepers, Brian C Jensen
No abstract text is available yet for this article.
October 2023: JACC. Basic to Translational Science
#22
JOURNAL ARTICLE
Barbara Calabrese, Shelley Halpain
Myristoylated, alanine-rich C-kinase substrate (MARCKS) is an F-actin and phospholipid binding protein implicated in numerous cellular activities, including the regulation of morphology in neuronal dendrites and dendritic spines. MARCKS contains a lysine-rich effector domain that mediates its binding to plasma membrane phosphatidylinositol-4,5-biphosphate (PI(4,5)P2 ) in a manner controlled by PKC and calcium/calmodulin. In neurons, manipulations of MARCKS concentration and membrane targeting strongly affect the numbers, shapes, and F-actin properties of dendritic spines, but the mechanisms remain unclear...
December 13, 2023: Molecular Biology of the Cell
#23
JOURNAL ARTICLE
Y C Learmonth, B Galna, L L Laslett, I van der Mei, C H Marck
PURPOSE: The COVID-19 pandemic impacted healthcare delivery, especially for people with chronic disease. We investigated telehealth use by persons with multiple sclerosis (MS) during the COVID-19 pandemic and their suggestions to improve their telehealth experience. METHODS: From persons with MS, we collected data on demographic, disease-related and social determinants of health, telehealth use during the COVID-19 pandemic, satisfaction with telehealth, and suggestions to improve telehealth...
December 13, 2023: Disability and Rehabilitation
#24
Chenguang Xu, Yan Fang, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu, Wanli Liu
No abstract text is available yet for this article.
December 1, 2023: Leukemia
#25
JOURNAL ARTICLE
Marie-Hélène Disatnik, Stéphane C Boutet, Wilfred Pacio, Annie Y Chan, Lindsey B Ross, Christine H Lee, Thomas A Rando
No abstract text is available yet for this article.
November 15, 2023: Journal of Cell Science
#26
JOURNAL ARTICLE
Marie-Hélène Disatnik, Stéphane C Boutet, Christine H Lee, Daria Mochly-Rosen, Thomas A Rando
No abstract text is available yet for this article.
November 15, 2023: Journal of Cell Science
#27
JOURNAL ARTICLE
Chin-Meng Ko, Chee-Kin Then, Yu-Ming Kuo, Yen-Kuang Lin, Shing-Chuan Shen
Far-infrared (FIR), characterized by its specific electromagnetic wavelengths, has emerged as an adjunctive therapeutic strategy for various diseases, particularly in ameliorating manifestations associated with renal disorders. Although FIR was confirmed to possess antioxidative and anti-inflammatory attributes, the intricate cellular mechanisms through which FIR mitigates lead (Pb)-induced nephrotoxicity remain enigmatic. In this study, we investigated the effects of FIR on Pb-induced renal damage using in vitro and in vivo approaches...
October 31, 2023: International Journal of Molecular Sciences
#28
JOURNAL ARTICLE
Rauan Kaiyrzhanov, Aboulfazl Rad, Sheng-Jia Lin, Aida Bertoli-Avella, Wouter W Kallemeijn, Annie Godwin, Maha S Zaki, Kevin Huang, Tracy Lau, Cassidy Petree, Stephanie Efthymiou, Ehsan Ghayoor Karimiani, Maja Hempel, Elizabeth A Normand, Sabine Rudnik-Schöneborn, Ulrich A Schatz, Marc P Baggelaar, Muhammad Ilyas, Tipu Sultan, Javeria Raza Alvi, Manizha Ganieva, Ben Fowler, Ruxandra Aanicai, Gulsen Akay Tayfun, Abdulaziz Al Saman, Abdulrahman Alswaid, Nafise Amiri, Nilufar Asilova, Vorasuk Shotelersuk, Patra Yeetong, Matloob Azam, Meisam Babaei, Gholamreza Bahrami Monajemi, Pouria Mohammadi, Saeed Samie, Selina Husna Banu, Jorge Pinto Basto, Fanny Kortüm, Mislen Bauer, Peter Bauer, Christian Beetz, Masoud Garshasbi, Awatif Hameed Issa, Wafaa Eyaid, Hind Ahmed, Narges Hashemi, Kazem Hassanpour, Isabella Herman, Sherozjon Ibrohimov, Ban A Abdul-Majeed, Maria Imdad, Maksudjon Isrofilov, Qassem Kaiyal, Suliman Khan, Brian Kirmse, Janet Koster, Charles Marques Lourenço, Tadahiro Mitani, Oana Moldovan, David Murphy, Maryam Najafi, Davut Pehlivan, Maria Eugenia Rocha, Vincenzo Salpietro, Miriam Schmidts, Adel Shalata, Mohammad Mahroum, Jawabreh Kassem Talbeya, Robert W Taylor, Dayana Vazquez, Annalisa Vetro, Hans R Waterham, Mashaya Zaman, Tina A Schrader, Wendy K Chung, Renzo Guerrini, James R Lupski, Joseph Gleeson, Mohnish Suri, Yalda Jamshidi, Kailash P Bhatia, Barbara Vona, Michael Schrader, Mariasavina Severino, Matthew Guille, Edward W Tate, Gaurav K Varshney, Henry Houlden, Reza Maroofian
The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the consequence of ACBD6 defects on human pathophysiology. Utilizing exome sequencing and extensive international data sharing efforts, we identified 45 affected individuals from 28 unrelated families (consanguinity 93%) with bi-allelic pathogenic, predominantly loss-of-function (18/20) variants in ACBD6...
November 10, 2023: Brain
#29
JOURNAL ARTICLE
Jiraphorn Issara-Amphorn, Virginie H Sjoelund, Margery Smelkinson, Sebastian Montalvo, Sung Hwan Yoon, Nathan P Manes, Aleksandra Nita-Lazar
MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation. LPS (lipopolysaccharide) triggers inflammation via TLR4 (toll-like receptor 4).The presence of MARCKS and the formation of phospho-MARCKS in various cell types have been described, but the role(s) of MARCKS in regulating macrophage functions remain unclear. We investigated the role of MARCKS in inflammation...
November 10, 2023: Scientific Reports
#30
JOURNAL ARTICLE
Natasha Honoré, Athenaïs van der Elst, Anne Dietz, Cédric van Marcke, Raphael Helaers, Antonella Mendola, Hajar Dahou, Etienne Marbaix, Renaud Poncin, Emanuel Seront, Sandra Schmitz, Nisha Limaye, Rachel Galot, Jean-Pascal Machiels
BACKGROUND: Only 15-20% of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) patients derive long-term benefit from nivolumab or pembrolizumab. We developed a circulating tumour DNA (ctDNA) tumour-agnostic assay aimed at the early prediction of single agent programmed cell death 1 (PD1) inhibitor efficacy in R/M SCCHN. PATIENTS AND METHODS: Our tumour-agnostic assay included 37 genes frequently mutated in R/M SCCHN and two HPV16 genes...
October 9, 2023: European Journal of Cancer
#31
JOURNAL ARTICLE
Yvonne C Learmonth, Matthew P Herring, Daniel I Russell, Lara A Pilutti, Sandra Day, Claudia H Marck, Bryan Chan, Alexandra P Metse, Robert W Motl
BACKGROUND: A review of the safety profile of exercise training in multiple sclerosis (MS) has not been conducted since 2013. OBJECTIVE: We undertook a systematic review and meta-analysis of randomised controlled trials (RCTs) of exercise training published since 2013 and quantified estimated population risks of clinical relapse, adverse events (AE) and serious adverse event (SAE). METHODS: Articles reporting safety outcomes from comparisons of exercise training with non-exercise among persons with MS were identified...
November 2023: Multiple Sclerosis: Clinical and Laboratory Research
#32
JOURNAL ARTICLE
Robert W Motl, Blathin Casey, Yvonne Charlotte Learmonth, Amy Latimer-Cheung, Dominique L Kinnett-Hopkins, Claudia H Marck, Johannes Carl, Klaus Pfeifer, Karin Riemann-Lorenz, Christoph Heesen, Susan Coote
We know very little about exercise adherence, compliance and sustainability in multiple sclerosis (MS), yet adherence is seemingly important for yielding immediate and sustained health benefits. This paper is focused on exercise adherence, compliance and sustainability in the context of informing research and practice involving MS. This focus is critical for clarifying terminology for future research and providing a roadmap guiding clinical research and practice. Our objective was accomplished through a narrative summary of the literature by a panel of experts on exercise adherence from the Moving Exercise Research in Multiple Sclerosis Forward (MoXFo) initiative and a concluding summary of the state of the literature and future research directions...
October 26, 2023: Multiple Sclerosis: Clinical and Laboratory Research
#33
JOURNAL ARTICLE
N Honoré, C van Marcke, R Galot, R Helaers, J Ambroise, A van Maanen, A Mendola, H Dahou, E Marbaix, P Van Eeckhout, E Longton, M Magremanne, S Schmitz, N Limaye, J-P Machiels
BACKGROUND: Forty to fifty percent of patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) relapse despite multimodal treatment. Circulating tumor DNA (ctDNA) has the potential to detect minimal residual disease (MRD) after curative-intent therapy and to identify earlier which patients will progress. We developed a tumor-agnostic plasma ctDNA assay to detect MRD in unselected LA SCCHN with the aim of predicting progression-free survival (PFS) and overall survival without the need for tumor sequencing...
December 2023: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#34
JOURNAL ARTICLE
Juliana A Camargo, Nayara I Viana, Ruan Pimenta, Vanessa R Guimarães, Gabriel A Dos Santos, Patrícia Candido, Vitória Ghazarian, Poliana Romão, Iran A Silva, Alexander Birbrair, Miguel Srougi, William C Nahas, Kátia R Leite, Ericka B Trarbach, Sabrina T Reis
Prostate cancer (PCa) has a high prevalence and represents an important health problem, with an increased risk of metastasis. With the advance of CRISPR-Cas9 genome editing, new possibilities have been created for investigating PCa. The technique is effective in knockout oncogenes, reducing tumor resistance. MMP9 and miR-21 target genes are associated with PCa progression; therefore, we evaluated the MMP-9 and miR-21 targets in PCa using the CRISPR-Cas9 system. Single guide RNAs (sgRNAs) of MMP9 and miR-21 sequences were inserted into a PX-330 plasmid, and transfected in DU145 and PC-3 PCa cell lines...
October 3, 2023: International Journal of Molecular Sciences
#35
Jiraphorn Issara-Amphorn, Virginie Sjoelund, Margery Smelkinson, Sung Hwan Yoon, Nathan P Manes, Aleksandra Nita-Lazar
MARCKS (Myristoylated Alanine-rich C-kinase Substrate) is a membrane protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation. LPS (lipopolysaccharide) triggers inflammation via TLR4 (Toll-like receptor 4). The presence of MARCKS and the formation of phospho-MARCKS in macrophages have been described, but the role(s) of MARCKS in regulating macrophage functions remain unclear. To investigate the role of MARCKS during inflammation, we activated macrophages using LPS with or without the addition of a PKC inhibitor...
July 10, 2023: Research Square
#36
JOURNAL ARTICLE
Christine M Lim, Alicia González Díaz, Monika Fuxreiter, Frank W Pun, Alex Zhavoronkov, Michele Vendruscolo
The phenomenon of protein phase separation (PPS) underlies a wide range of cellular functions. Correspondingly, the dysregulation of the PPS process has been associated with numerous human diseases. To enable therapeutic interventions based on the regulation of this association, possible targets should be identified. For this purpose, we present an approach that combines the multiomic PandaOmics platform with the FuzDrop method to identify PPS-prone disease-associated proteins. Using this approach, we prioritize candidates with high PandaOmics and FuzDrop scores using a profiling method that accounts for a wide range of parameters relevant for disease mechanism and pharmacological intervention...
October 3, 2023: Proceedings of the National Academy of Sciences of the United States of America
#37
JOURNAL ARTICLE
Monica Tschang, Suneel Kumar, Wise Young, Melitta Schachner, Thomas Theis
Myristoylated alanine-rich C-kinase substrate (MARCKS) is a critical member of a signaling cascade that influences disease-relevant neural functions such as neural growth and plasticity. The effector domain (ED) of MARCKS interacts with the extracellular glycan polysialic acid (PSA) through the cell membrane to stimulate neurite outgrowth in cell culture. We have shown that a synthetic ED peptide improves functional recovery after spinal cord injury in female but not male mice. However, peptides themselves are unstable in therapeutic applications, so we investigated more pharmacologically relevant small organic compounds that mimic the ED peptide to maximize therapeutic potential...
September 19, 2023: International Journal of Molecular Sciences
#38
JOURNAL ARTICLE
Yoshiaki Nakamura, Nobumasa Mizuno, Yu Sunakawa, Jean-Luc Canon, Matthew D Galsky, Erika Hamilton, Hidetoshi Hayashi, Guy Jerusalem, Seung Tae Kim, Keun-Wook Lee, Lionel Aurelien Kankeu Fonkoua, Bradley J Monk, Danny Nguyen, Do-Youn Oh, Alicia Okines, David M O'Malley, Paula Pohlmann, Martin Reck, Sang Joon Shin, Kazuki Sudo, Shunji Takahashi, Cedric Van Marcke, Evan Y Yu, Roman Groisberg, Jorge Ramos, Sherry Tan, Thomas E Stinchcombe, Tanios Bekaii-Saab
PURPOSE: To evaluate the efficacy and safety of tucatinib and trastuzumab in patients with previously treated human epidermal growth factor receptor 2-positive (HER2+) metastatic biliary tract cancer (mBTC). METHODS: SGNTUC-019 (ClinicalTrials.gov identifier: NCT04579380) is an open-label phase II basket study evaluating the efficacy and safety of tucatinib and trastuzumab in patients with HER2-altered solid tumors. In the biliary tract cancer cohort, patients had previously treated HER2 overexpressing or amplified (HER2+) tumors (identified with local testing) with no prior HER2-directed therapy...
December 20, 2023: Journal of Clinical Oncology
#39
JOURNAL ARTICLE
Jiaming Su, Jing Peng, Lin Wang, Huidi Xie, Ying Zhou, Haimin Chen, Yang Shi, Yan Guo, Yicheng Zheng, Yuxin Guo, Zhaoxi Dong, Xianhui Zhang, Hongfang Liu
BACKGROUNDS: Diabetes nephropathy (DN) is a growing public health concern worldwide. Renal dysfunction impairment in DN is intimately linked to ER stress and its related signaling pathways. Nonetheless, the underlying mechanism and biomarkers for this function of ER stress in the DN remain unknown. METHODS: Microarray datasets were retrieved from the Gene Expression Omnibus (GEO) database, and ER stress-related genes (ERSRGs) were downloaded from the MSigDB and GeneCards database...
2023: Frontiers in Endocrinology
#40
JOURNAL ARTICLE
Amy Orr, William Wickner
Yeast vacuolar HOPS tethers membranes, catalyzes trans -SNARE assembly between R- and Q-SNAREs, and shepherds SNAREs past early inhibition by Sec17. After partial SNARE zippering, fusion is driven slowly by either completion of SNARE zippering or by Sec17/Sec18, but rapid fusion needs zippering and Sec17/Sec18. Using reconstituted vacuolar fusion, we find that MARCKS Effector Domain (MED) peptide, a lipid ligand, blocks fusion reversibly at a late reaction stage. The MED fusion blockade is overcome by either salt extraction, inactivation with the MED ligand calmodulin, or addition of Sec17/Sec18...
September 6, 2023: Molecular Biology of the Cell
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