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https://www.readbyqxmd.com/read/29046508/the-marcks-protein-amount-is-differently-regulated-by-calpain-during-toxic-effects-of-methylmercury-between-sh-sy5y-and-ea-hy926-cells
#1
Cuong Van Dao, Mitsuya Shiraishi, Atsushi Miyamoto
Methylmercury (MeHg) is an environmental pollutant that shows severe toxicity to humans and animals. However, the molecular mechanisms mediating MeHg toxicity are not completely understood. We have previously reported that the MARCKS protein is involved in the MeHg toxicity to SH-SY5Y neuroblastoma and EA.hy926 vascular endothelial cell lines. In addition, calpain, a Ca(2+)-dependent protease, is suggested to be associated with the MeHg toxicity. Because MARCKS is known as a substrate of calpain, we studied the relation between calpain activation and cleavage of MARCKS and its role in MeHg toxicity...
October 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29039083/myristoylated-alanine-rich-c-kinase-substrate-marcks-a-multirole-signaling-protein-in-cancers
#2
REVIEW
Lon Wolf R Fong, David C Yang, Ching-Hsien Chen
Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is tethered to the plasma membrane but can shuttle between the cytosol and plasma membrane via the myristoyl-electrostatic switch. Phosphorylation of MARCKS by PKC leads to its translocation from the plasma membrane to the cytosol where it functions in actin cytoskeletal remodeling, Ca(2+) signaling through binding to calmodulin, and regulation of exocytic vesicle release in secretory cells such as neurons and airway goblet cells...
October 16, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29022719/preferential-enrichment-of-a-range-of-proteins-distinguishes-the-corona-of-pegylated-poly-glycidyl-methacrylate-nanoparticles
#3
Priya S R Naidu, Marck Norret, Nicole M Smith, Sarah A Dunlop, Nicolas L Taylor, Melinda Fitzgerald, K Swaminathan Iyer
Composition of the protein corona formed on poly(ethylene glycol)-functionalised (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for 'stealth' functionality, we demonstrate preferential enrichment of specific serum proteins of varied biological functions in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona...
October 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29020306/lithium-and-tamoxifen-modulate-behavior-and-protein-kinase-c-activity-in-the-animal-model-of-mania-induced-by-ouabain-behavior-and-pkc-activity-in-animal-model
#4
Samira S Valvassori, Gustavo C Dal-Pont, Wilson R Resende, Roger B Varela, Bruna R Peterle, Fernanda F Gava, Franciele G Mina, José H Cararo, André F Carvalho, João Quevedo
Background: The intracerebroventricular (ICV) injection of ouabain, a specific inhibitor of the Na+/K+-adenosine-triphosphatase (Na+/K+-ATPase) enzyme, induces hyperactivity in rats in a putative animal model of mania. Several evidences have suggested that protein kinase C (PKC) signaling pathway is involved in bipolar disorder (BD). In addition, it is known that protein kinase C (PKC) inhibitors, such as lithium (Li) and tamoxifen (TMX), are effective in treating acute mania. Methods: In the present study, we investigated the effects of Li and TMX on PKC signaling pathway in the frontal cortex and hippocampus of rats submitted to the animal model of mania induced by ouabain...
August 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28992142/researching-safety-culture-deliberative-dialogue-with-a-restorative-lens
#5
Elisiane Lorenzini, Nelly D Oelke, Patricia Beryl Marck, Clarice Maria Dall'agnol
Safety culture is a key component of patient safety. Many patient safety strategies in health care have been adapted from high-reliability organizations (HRO) such as aviation. However, to date, attempts to transform the cultures of health care settings through HRO approaches have had mixed results. We propose a methodological approach for safety culture research, which integrates the theory and practice of restoration science with the principles and methods of deliberative dialogue to support active engagement in critical reflection and collective debate...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28928713/pain-in-people-with-multiple-sclerosis-associations-with-modifiable-lifestyle-factors-fatigue-depression-anxiety-and-mental-health-quality-of-life
#6
Claudia H Marck, Alysha M De Livera, Tracey J Weiland, Pia L Jelinek, Sandra L Neate, Chelsea R Brown, Keryn L Taylor, Fary Khan, George A Jelinek
BACKGROUND: People with multiple sclerosis (MS) often experience pain, which can interfere with mobility, employment, and quality of life (QOL). METHODS: This cross-sectional study explored associations between pain, demographic, disease, and modifiable lifestyle factors in an international sample of people with MS recruited online. RESULTS: Substantial pain, of moderate/severe intensity and interfering at least moderately with work/household or enjoyment of life in the past 4 weeks, was reported by 682/2,362 (28...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28866462/a-spectroscopic-sensing-platform-for-marcks-protein-monolayers
#7
Joaquín Klug, María Fernanda Torresan, Florencia Lurgo, Graciela Borioli, Gabriela I Lacconi
We developed a highly sensitive silicon platform, suitable to assess the molecular organization of protein samples. Prototype platforms were obtained using different electrochemical protocols for the electrodeposition of Ag-nanoparticles onto the hydrogenated silicon surface. A platform with high Surface Enhanced Raman Scattering efficiency was selected based on the surface coverage and the number density of particles size distribution. The performance of the platform was determined by studying the interaction of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) protein with the substrate according to its molecular organization...
August 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28844963/novel-direct-factor-xa-inhibitory-compounds-from-tenebrio-molitor-with-anti-platelet-aggregation-activity
#8
Wonhwa Lee, Mi-Ae Kim, InWha Park, Jae Sam Hwang, MinKyun Na, Jong-Sup Bae
Tenebrio molitor is an edible insect that has antimicrobial, anticancer, and antihypertensive effects. The aim of this study was to identify the unreported bioactive compounds from T. molitor larvae with inhibitory activities against factor Xa (FXa) and platelet aggregation. Isolated compounds were evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity, and thrombus formation. A diketopiperazine (1, cyclo(L-Pro-L-Tyr)) and a phenylethanoid (2, N-acetyltyramine) were isolated and inhibited the catalytic activity of FXa in a mixed inhibition model and inhibited platelet aggregation induced by adenosine diphosphate (ADP) and U46619...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28819302/generation-and-intracellular-trafficking-of-a-polysialic-acid-carrying-fragment-of-the-neural-cell-adhesion-molecule-ncam-to-the-cell-nucleus
#9
Nina Westphal, Gabriele Loers, David Lutz, Thomas Theis, Ralf Kleene, Melitta Schachner
Polysialic acid (PSA) and its major protein carrier, the neural cell adhesion molecule NCAM, play important roles in many nervous system functions during development and in adulthood. Here, we show that a PSA-carrying NCAM fragment is generated at the plasma membrane by matrix metalloproteases and transferred to the cell nucleus via endosomes and the cytoplasm. Generation and nuclear import of this fragment in cultured cerebellar neurons is induced by a function-triggering NCAM antibody and a peptide comprising the effector domain (ED) of myristoylated alanine-rich C kinase substrate (MARCKS) which interacts with PSA within the plane of the plasma membrane...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783747/comprehensive-investigation-of-cask-mutations-and-other-genetic-etiologies-in-41-patients-with-intellectual-disability-and-microcephaly-with-pontine-and-cerebellar-hypoplasia-micpch
#10
Shin Hayashi, Daniela Tiaki Uehara, Kousuke Tanimoto, Seiji Mizuno, Yasutsugu Chinen, Shinobu Fukumura, Jun-Ichi Takanashi, Hitoshi Osaka, Nobuhiko Okamoto, Johji Inazawa
The CASK gene (Xp11.4) is highly expressed in the mammalian nervous system and plays several roles in neural development and synaptic function. Loss-of-function mutations of CASK are associated with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH), especially in females. Here, we present a comprehensive investigation of 41 MICPCH patients, analyzed by mutational search of CASK and screening of candidate genes using an SNP array, targeted resequencing and whole-exome sequencing (WES)...
2017: PloS One
https://www.readbyqxmd.com/read/28780556/evaluation-of-dementianet-a-network-based-primary-care-innovation-for-community-dwelling-patients-with-dementia-protocol-for-a-longitudinal-mixed-methods-multiple-case-study
#11
Anke Richters, Minke S Nieuwboer, Marieke Perry, Marcel G M Olde Rikkert, Rene J F Melis, Marjolein A van der Marck
INTRODUCTION: Primary healthcare professionals will increasingly be required to manage and optimise their treatment for patients with dementia. With DementiaNet, we aim to reduce the burden of dementia on healthcare services and society through implementation and facilitation of integrated network-based care with increased dementia expertise. DementiaNet is designed as a stepwise approach including clinical leadership, quality improvement cycles and interprofessional training, which are tailor-made to the local context...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28765579/inhibition-of-akt1-signaling-promotes-invasion-and-metastasis-of-non-small-cell-lung-cancer-cells-with-k-ras-or-egfr-mutations
#12
Guanhua Rao, Mariaelena Pierobon, In-Kyu Kim, Wei-Hsun Hsu, Jianghong Deng, Yong-Wha Moon, Emanuel F Petricoin, Yu-Wen Zhang, Yisong Wang, Giuseppe Giaccone
Accumulating evidence supports a role of the PI3K-AKT pathway in the regulation of cell motility, invasion and metastasis. AKT activation is known to promote metastasis, however under certain circumstances, it also shows an inhibitory activity on metastatic processes, and the cause of such conflicting results is largely unclear. Here we found that AKT1 is an important regulator of metastasis and down-regulation of its activity is associated with increased metastatic potential of A549 cells. Inhibition of AKT1 enhanced migration and invasion in KRAS- or EGFR-mutant non-small cell lung cancer (NSCLC) cells...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709641/glucocest-magnetic-resonance-imaging-in%C3%A2-vivo-may-be-diagnostic-of-acute-renal-allograft-rejection
#13
Dominik Kentrup, Philipp Bovenkamp, Annika Busch, Katharina Schuette-Nuetgen, Helga Pawelski, Hermann Pavenstädt, Eberhard Schlatter, Karl-Heinz Herrmann, Jürgen R Reichenbach, Bettina Löffler, Barbara Heitplatz, Veerle Van Marck, Nirbhay N Yadav, Guanshu Liu, Peter C M van Zijl, Stefan Reuter, Verena Hoerr
Acute cellular renal allograft rejection (AR) frequently occurs after kidney transplantations. It is a sterile T-cell mediated inflammation leading to increased local glucose metabolism. Here we demonstrate in an allogeneic model of Brown Norway rat kidneys transplanted into uninephrectomized Lewis rats the successful implementation of the recently developed glucose chemical exchange saturation transfer (glucoCEST) magnetic resonance imaging. This technique is a novel method to assess and differentiate AR...
September 2017: Kidney International
https://www.readbyqxmd.com/read/28699898/marcks-promotes-invasion-and-is-associated-with-biochemical-recurrence-in-prostate-cancer
#14
Emma Dorris, Amanda O'Neill, Karen Hanrahan, Ann Treacy, R William Watson
BACKGROUND: Overtreatment of low-grade prostate cancer is a recognised problem for clinicians and patients. However, under-treatment runs the risk of missing the opportunity for cure in those who could benefit. Identification of new biomarkers of disease progression, including metastases, is required to better stratify and appropriately treat these patients. The ability to predict if prostate cancer will recur is an important clinical question that would impact treatment options for patients...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28686298/predatory-birds-and-ants-partition-caterpillar-prey-by-body-size-and-diet-breadth
#15
Michael S Singer, Robert E Clark, Issac H Lichter-Marck, Emily R Johnson, Kailen A Mooney
The effects of predator assemblages on herbivores are predicted to depend critically on predator-predator interactions and the extent to which predators partition prey resources. The role of prey heterogeneity in generating such multiple predator effects has received limited attention. Vertebrate and arthropod insectivores constitute two co-dominant predatory taxa in many ecosystems, and the emergent properties of their joint effects on insect herbivores inform theory on multiple predator effects as well as biological control of insect herbivores...
October 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28655899/peptides-derived-from-marcks-block-coagulation-complex-assembly-on-phosphatidylserine
#16
Noah Kastelowitz, Ryo Tamura, Abimbola Onasoga, Timothy J Stalker, Ormacinda R White, Peter N Brown, Gary L Brodsky, Lawrence F Brass, Brian R Branchford, Jorge Di Paola, Hang Yin
Blood coagulation involves activation of platelets and coagulation factors. At the interface of these two processes resides the lipid phosphatidylserine. Activated platelets expose phosphatidylserine on their outer membrane leaflet and activated clotting factors assemble into enzymatically active complexes on the exposed lipid, ultimately leading to the formation of fibrin. Here, we describe how small peptide and peptidomimetic probes derived from the lipid binding domain of the protein myristoylated alanine-rich C-kinase substrate (MARCKS) bind to phosphatidylserine exposed on activated platelets and thereby inhibit fibrin formation...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28638804/pkc-%C3%AE-marcks-signaling-promotes-intracellular-survival-of-unopsonized-burkholderia-thailandensis
#17
Sofiya N Micheva-Viteva, Yulin Shou, Kumkum Ganguly, Terry H Wu, Elizabeth Hong-Geller
Pathogenic Burkholderia rely on host factors for efficient intracellular replication and are highly refractory to antibiotic treatment. To identify host genes that are required by Burkholderia spp. during infection, we performed a RNA interference (RNAi) screen of the human kinome and identified 35 host kinases that facilitated Burkholderia thailandensis intracellular survival in human monocytic THP-1 cells. We validated a selection of host kinases using imaging flow cytometry to assess efficiency of B. thailandensis survival in the host upon siRNA-mediated knockdown...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28624269/-technical-information-the-so-called-camille-bernard-lower-lip-reconstruction-an-eponymous-confusion-clarified
#18
K W Marck, D Martin
The use of eponyms honours those who have contributed to the development of medicine and facilitates communication between colleagues. Eponyms are based on historical knowledge to know who was the first to use a given technique. In the previous century, two different operative procedures have been attached to the 'so called' Bernard lower lip reconstruction. This historical literature on lip reconstruction with a focus on the years 1853-1855 elucidates the roles of Bernard, Saeman, Desgranges and Burow, and gives suggestions for eponyms that do justice to the innovating surgeons Bernard, Burow and Desgranges...
June 14, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28623606/marcks-is-necessary-for-oligodendrocyte-precursor-cell-maturation
#19
Zhao-Huan Zhang, Fan-Fei Ma, Hui Zhang, Xiao-Hui Xu
Oligodendrocyte precursor cell (OPC) development into myelinated oligodendrocytes demands vigorous membrane addition. Since myristoylated alanine-rich C-kinase substrate (MARCKS) reportedly contributes to Ras-associated protein (Rab)-10-associated vesicle insertion into neuronal membranes, we investigated the role of MARCKS in OPC maturation. We found that either knockdown of MARCKS or interruption of its interaction with Rab10 would cause a decrease of the cell membrane area during OPC development. Enhanced MARCKS phosphorylation by Nogo66 or myelin debris treatment inhibited OPC maturation, while its dephosphorylation by protein phosphatase 2 A activator D-erythro-sphingosine promoted OPC development in the presence of myelin debris...
June 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28620343/international-differences-in-multiple-sclerosis-health-outcomes-and-associated-factors-in-a-cross-sectional-survey
#20
Grace D Reilly, Awng Shar Mahkawnghta, Pia L Jelinek, Alysha M De Livera, Tracey J Weiland, Chelsea R Brown, Keryn L Taylor, Sandra L Neate, George A Jelinek, Claudia H Marck
Multiple sclerosis (MS) is a major cause of disability and poor quality of life (QOL). Previous studies have shown differences in MS health outcomes between countries. This study aimed to examine the associations between international regions and health outcomes in people with MS. Self-reported data were taken from the Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis online survey collected in 2012. The 2,401 participants from 37 countries were categorized into three regions: Australasia, Europe, and North America...
2017: Frontiers in Neurology
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