keyword
MENU ▼
Read by QxMD icon Read
search

MARCKS

keyword
https://www.readbyqxmd.com/read/29620148/carnosic-acid-protects-mice-from-high-fat-diet-induced-nafld-by-regulating-marcks
#1
Hong-Mao Song, Xiang Li, Yuan-Yuan Liu, Wei-Ping Lu, Zhao-Hui Cui, Li Zhou, Di Yao, Hong-Man Zhang
Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage characterized by abnormal hepatic fat accumulation and inflammatory response. Although the molecular mechanisms responsible for the disease are not yet fully understood, the pathogenesis of NAFLD likely involves multiple signals. The identification of effective therapeutic strategies to target these signals is of utmost importance. Carnosic acid (CA), as a phenolic diterpene with anticancer, anti-bacterial, anti-diabetic and neuroprotective properties, is produced by many species of the Lamiaceae family...
March 27, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29603589/marcks-phosphorylation-by-pkc-strongly-impairs-cell-polarity-in-the-chick-neural-plate
#2
Gonzalo Aparicio, Cristina Arruti, Flavio R Zolessi
Neurulation involves a complex coordination of cellular movements that are in great part based on the modulation of the actin cytoskeleton. MARCKS, an F-actin-binding protein and the major substrate for PKC, is necessary for gastrulation and neurulation morphogenetic movements in mice, frogs and fish. We previously showed that this protein accumulates at the apical region of the closing neural plate in chick embryos, and here further explore its role in this process and how it is regulated by PKC phosphorylation...
March 30, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29588366/the-long-noncoding-rna-lnczic2-drives-the-self-renewal-of-liver-tumor-initiating-cells-via-the-protein-kinase-c-substrates-marcks-and-marcksl1
#3
Zhenzhen Chen, Yating Liu, Lintong Yao, Shiying Guo, Yanfeng Gao, Pingping Zhu
Liver tumor-initiating cells (TICs) form small subsets of cells in hepatocellular tumors and account for tumorigenesis, metastasis, recurrence, and drug resistance. Recently, we found that the transcription factor Zic family member 2 (ZIC2) is highly expressed in liver TICs and required for their self-renewal. However, the molecular mechanisms underlying self-renewal of liver TICs remains unclear. Here, using expression profiling and CRISPR-interference assays with clinical samples of human liver cancers, we identified a long noncoding RNA (lncRNA), lncZic2, that is located near the ZIC2 locus and was highly expressed in liver cancer and liver TICs...
March 27, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29557637/bridging-multiple-dementias
#4
Hitoshi Okazawa
Tau phosphorylation has come into the limelight again, this time as a critical player in the earliest stages of dementia pathology. Mislocalization of phosphorylated tau to dendritic spines and the resultant degeneration of synapses are observed across multiple neurodegenerative diseases, even in the absence of tau aggregation. Moreover, other molecules phosphorylated by the same kinases, such as MARCKS, might contribute to ultra-early phase pathology by promoting synapse dysfunction.
March 20, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29553873/activation-function-and-content-of-platelets-in-burn-patients
#5
Roos E Marck, Ivo van der Bijl, Herbert Korsten, Jos Lorinser, Dirk de Korte, Esther Middelkoop
Burn injury has severe impact on the physiologic homeostasis. Platelet counts show a distinct course post-burn injury, with a nadir at day 3 followed by a thrombocytotic period with at peak at day 15, with a gradual return to normal. So far, it is unknown how the functionality and activational status of platelets develop post burn. In this study, we investigated if the function, activation and growth factor content of platelets of burn patients are affected and how this evolves in time. Six burn patients with over 15% total burned surface area were followed during 1 month...
March 19, 2018: Platelets
https://www.readbyqxmd.com/read/29546593/marcks-is-necessary-for-netrin-dcc-signaling-and-corpus-callosum-formation
#6
J J Brudvig, J T Cain, G G Schmidt-Grimminger, D J Stumpo, K J Roux, P J Blackshear, J M Weimer
Axons of the corpus callosum (CC), the white matter tract that connects the left and right hemispheres of the brain, receive instruction from a number of chemoattractant and chemorepulsant cues during their initial navigation towards and across the midline. While it has long been known that the CC is malformed in the absence of Myristoylated alanine-rich C-kinase substrate (MARCKS), evidence for a direct role of MARCKS in axon navigation has been lacking. Here, we show that MARCKS is necessary for Netrin-1 (NTN1) signaling through the DCC receptor, which is critical for axon guidance decisions...
March 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29529183/identification-of-influencing-factors-and-strategies-to-improve-communication-between-general-practitioners-and-community-nurses-a-qualitative-focus-group-study
#7
Minke S Nieuwboer, Marieke Perry, Rob van der Sande, Irma T H M Maassen, Marcel G M Olde Rikkert, Marjolein A van der Marck
Background: As the number of patients with complex healthcare needs grows, inter-professional collaboration between primary care professionals must be constantly optimized. General practitioners (GPs) and community nurses (CNs) are key professions in primary care; however, poor GP-CN communication is common, and research into the factors influencing its quality is limited. Objective: To explore patient-related GP-CN communication and facilitating and hindering factors, and to identify strategies to enhance this communication...
February 26, 2018: Family Practice
https://www.readbyqxmd.com/read/29524139/non-viral-methodology-for-efficient-co-transfection
#8
Jessica A Kretzmann, Cameron W Evans, Marck Norret, Pilar Blancafort, K Swaminathan Iyer
The potential impact of CRISPR/Cas9, TALE, and zinc finger technology is immense, both with respect to their use as tools for understanding the roles and functions of the genomic elements and epigenome modifications in an endogenous context and as new methods for treatment of diseases. Application of such technologies has drawn attention, however, to the prevailing lack of effective delivery methods. Promising viral and non-viral methods both currently fall short when the efficient delivery of large plasmids or multiple plasmids is required...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29419572/preconditioning-and-postconditioning-by-cardiac-glycosides-in-the-mouse-heart
#9
Qiming Duan, Yunhui Xu, Pauline V Marck, Jennifer Kalisz, Eric E Morgan, Sandrine V Pierre
Ouabain preconditioning (OPC) initiated by low concentrations of the cardiac glycoside (CG) ouabain binding to Na/K-ATPase is relayed by a unique intracellular signaling and protects cardiac myocytes against ischemia/reperfusion injury. To explore more clinically applicable protocols based on CG properties, we tested whether the FDA-approved CG digoxin could trigger cardioprotective effects comparable with those of ouabain using PC, preconditioning and PostC, postconditioning protocols in the Langendorff-perfused mouse heart subjected to global ischemia and reperfusion...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29371906/profile-of-epigenetic-mechanisms-in-lung-tumors-of-patients-with-underlying-chronic-respiratory-conditions
#10
Mercè Mateu-Jimenez, Víctor Curull, Alberto Rodríguez-Fuster, Rafael Aguiló, Albert Sánchez-Font, Lara Pijuan, Joaquim Gea, Esther Barreiro
Background: Chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and epigenetic events underlie lung cancer (LC) development. The study objective was that lung tumor expression levels of specific microRNAs and their downstream biomarkers may be differentially regulated in patients with and without COPD. Methods: In lung specimens (tumor and non-tumor), microRNAs known to be involved in lung tumorigenesis (miR-21, miR-200b, miR-126, miR-451, miR-210, miR-let7c, miR-30a-30p, miR-155 and miR-let7a, qRT-PCR), DNA methylation, and downstream biomarkers were determined (qRT-PCR and immunoblotting) in 40 patients with LC (prospective study, subdivided into LC-COPD and LC, N = 20/group)...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29341352/misregulation-of-membrane-trafficking-processes-in-human-nonalcoholic-steatohepatitis
#11
Anika L Dzierlenga, Nathan J Cherrington
Nonalcoholic steatohepatitis (NASH) remodels the expression and function of genes and proteins that are critical for drug disposition. This study sought to determine whether disruption of membrane protein trafficking pathways in human NASH contributes to altered localization of multidrug resistance-associated protein 2 (MRP2). A comprehensive immunoblot analysis assessed the phosphorylation, membrane translocation, and expression of transporter membrane insertion regulators, including several protein kinases (PK), radixin, MARCKS, and Rab11...
January 17, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29295532/stromal-expression-of-marcks-protein-in-ovarian-carcinomas-has-unfavorable-prognostic-value
#12
Raoudha Doghri, Maroua Manai, Pascal Finetti, Maha Driss, Emilie Agavnian, Marc Lopez, Meriam Elghardallou, Emmanuelle Charafe-Jauffret, Mohamed Manai, Max Chaffanet, Daniel Birnbaum, Karima Mrad, François Bertucci
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Identification of new therapeutic targets is crucial. MARCKS, myristoylated alanine-rich C-kinase substrate, has been implicated in aggressiveness of several cancers and MARCKS inhibitors are in development. Using immunohistochemistry (IHC), we retrospectively assessed MARCKS expression in epithelial and stromal cells of 118 pre-chemotherapy EOC samples and 40 normal ovarian samples from patients treated at Salah Azaiez Institute. We compared MARCKS expression in normal versus cancer samples, and searched for correlations with clinicopathological features, including overall survival (OS)...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29274834/espen-guideline-clinical-nutrition-in-neurology
#13
Rosa Burgos, Irene Bretón, Emanuele Cereda, Jean Claude Desport, Rainer Dziewas, Laurence Genton, Filomena Gomes, Pierre Jésus, Andreas Leischker, Maurizio Muscaritoli, Kalliopi-Anna Poulia, Jean Charles Preiser, Marjolein Van der Marck, Rainer Wirth, Pierre Singer, Stephan C Bischoff
Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may be involved in the pathogenesis of neurological diseases. Multiple causes for the development of malnutrition in patients with neurological diseases are known including oropharyngeal dysphagia, impaired consciousness, perception deficits, cognitive dysfunction, and increased needs...
February 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29222109/marcks-related-protein-regulates-cytoskeletal-organization-at-cell-cell-and-cell-substrate-contacts-in-epithelial-cells
#14
Christina M Van Itallie, Amber Jean Tietgens, Angel Aponte, Marjan Gucek, Alexander X Cartagena-Rivera, Richard S Chadwick, James M Anderson
Treatment of epithelial cells with interferon-γ and TNF-α (IFN/TNF) results in increased paracellular permeability. To identify relevant proteins mediating barrier disruption, we performed proximity-dependent biotinylation (BioID) of occludin and found that tagging of MARCKS-related protein (MRP; also known as MARCKSL1) increased ∼20-fold following IFN/TNF administration. GFP-MRP was focused at the lateral cell membrane and its overexpression potentiated the physiological response of the tight junction barrier to cytokines...
February 2, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29192063/mechanism-of-inhibition-of-taurolithocholate-induced-retrieval-of-plasma-membrane-mrp2-by-cyclic-amp-and-tauroursodeoxycholate
#15
Se Won Park, Cynthia R L Webster, Mohammed S Anwer
Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC-induced cholestasis by inhibiting TLC-induced retrieval of MRP2. However, cellular mechanisms for this reversal are incompletely understood. Recently, we reported that TLC decreases PM-MRP2 by activating PKCε followed by phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS). Thus, cAMP and TUDC may reverse TLC-induced cholestasis by inhibiting the TLC/PKC ε /MARCKS phosphorylation pathway...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29130378/the-experiences-of-patients-with-advanced-cancer-and-caregivers-presenting-to-emergency-departments-a-qualitative-study
#16
Jennifer Philip, Cheryl Remedios, Sibilah Breen, Tracey Weiland, Lisa Willenberg, Mark Boughey, George Jelinek, Heather Lane, Claudia Marck, Jennifer Weil
BACKGROUND: Despite being a common event in the course of an advanced cancer illness, there is little understanding of patients' perceptions of hospital Emergency Department presentations. AIM: To explore the experiences and perceptions of Emergency Departments held by patients with advanced cancer and their informal caregivers. DESIGN: Cross-sectional study involving semi-structured interviews with advanced cancer patients and their informal caregivers...
October 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29123486/are-we-reaching-the-limits-of-homo-sapiens
#17
REVIEW
Adrien Marck, Juliana Antero, Geoffroy Berthelot, Guillaume Saulière, Jean-Marc Jancovici, Valérie Masson-Delmotte, Gilles Boeuf, Michael Spedding, Éric Le Bourg, Jean-François Toussaint
Echoing scientific and industrial progress, the Twentieth century was an unprecedented period of improvement for human capabilities and performances, with a significant increase in lifespan, adult height, and maximal physiological performance. Analyses of historical data show a major slow down occurring in the most recent years. This triggered large and passionate debates in the academic scene within multiple disciplines; as such an observation could be interpreted as our upper biological limits. Such a new phase of human history may be related to structural and functional limits determined by long term evolutionary constraints, and the interaction between complex systems and their environment...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29116649/wwc-proteins-regulate-hepatic-cell-differentiation-and-tumorigenesis-via-the-hippo-signaling-pathway
#18
Anke Hermann, Dirk Oliver Wennmann, Sascha Gromnitza, Maria Edeling, Veerle Van Marck, Marius Sudol, Liliana Schaefer, Kerstin Duning, Thomas Weide, Hermann Pavenstädt, Joachim Kremerskothen
The Hippo pathway regulates cell differentiation, proliferation and apoptosis. Upon activation, it inhibits the import of the transcriptional co-activator YAP into the nucleus, thus suppressing transcription of pro-proliferative genes. Hence, dynamic and precise control of the Hippo pathway is crucial for organ size control and the prevention of tumor formation. Hippo signaling is controlled by a growing number of upstream regulators - including WWC proteins - which trigger a serine/threonine kinase pathway...
November 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29079957/-guideline-on-medical-research-in-older-persons
#19
Marjolein A van der Marck, Marcel G M Olde Rikkert
This paper describes the development of a guideline on medical research with older subjects. Although our society is aging, evidence on health care for older persons is lacking on many topics, because these subjects are underrepresented in most drug and non-drug trials, while these services are used many older persons, and result in many adverse reactions and unplanned hospitalisation. Part of the reasons for this underrepresentation is the multimorbidity, often leading to exclusion, but also the lack of appropriate research methods plays a major role...
December 2017: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/29073717/effective-excision-of-cutaneous-squamous-cell-carcinoma-of-the-face-using-analysis-of-intra-operative-frozen-sections-from-the-whole-specimen
#20
Kor H Hutting, Paul G Bos, Robby E Kibbelaar, Nic J G M Veeger, Klaas W Marck, Chantal M Mouës
BACKGROUND AND OBJECTIVES: We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra-operative frozen section analysis of the margins in an optimized bread-loafing fashion (WIFSA). METHODS: Medical records were reviewed of 160 cSCCs of the face that were treated by surgical excision with WIFSA between April 2007 and January 2013. The accuracy of WIFSA was verified by comparing results with postoperative formalin-fixed paraffin-embedded (FFPE) sections...
October 26, 2017: Journal of Surgical Oncology
keyword
keyword
119498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"