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https://www.readbyqxmd.com/read/28709641/glucocest-magnetic-resonance-imaging-in%C3%A2-vivo-may-be-diagnostic-of-acute-renal-allograft-rejection
#1
Dominik Kentrup, Philipp Bovenkamp, Annika Busch, Katharina Schuette-Nuetgen, Helga Pawelski, Hermann Pavenstädt, Eberhard Schlatter, Karl-Heinz Herrmann, Jürgen R Reichenbach, Bettina Löffler, Barbara Heitplatz, Veerle Van Marck, Nirbhay N Yadav, Guanshu Liu, Peter C M van Zijl, Stefan Reuter, Verena Hoerr
Acute cellular renal allograft rejection (AR) frequently occurs after kidney transplantations. It is a sterile T-cell mediated inflammation leading to increased local glucose metabolism. Here we demonstrate in an allogeneic model of Brown Norway rat kidneys transplanted into uninephrectomized Lewis rats the successful implementation of the recently developed glucose chemical exchange saturation transfer (glucoCEST) magnetic resonance imaging. This technique is a novel method to assess and differentiate AR...
July 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28699898/marcks-promotes-invasion-and-is-associated-with-biochemical-recurrence-in-prostate-cancer
#2
Emma Dorris, Amanda O'Neill, Karen Hanrahan, Ann Treacy, R William Watson
BACKGROUND: Overtreatment of low-grade prostate cancer is a recognised problem for clinicians and patients. However, under-treatment runs the risk of missing the opportunity for cure in those who could benefit. Identification of new biomarkers of disease progression, including metastases, is required to better stratify and appropriately treat these patients. The ability to predict if prostate cancer will recur is an important clinical question that would impact treatment options for patients...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28686298/predatory-birds-and-ants-partition-caterpillar-prey-by-body-size-and-diet-breadth
#3
M S Singer, R E Clark, I H Lichter-Marck, E R Johnson, K A Mooney
1.The effects of predator assemblages on herbivores are predicted to depend critically on predator-predator interactions and the extent to which predators partition prey resources. The role of prey heterogeneity in generating such multiple predator effects has received limited attention. 2.Vertebrate and arthropod insectivores constitute two co-dominant predatory taxa in many ecosystems, and the emergent properties of their joint effects on insect herbivores inform theory on multiple predator effects as well as biological control of insect herbivores...
July 7, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28655899/peptides-derived-from-marcks-block-coagulation-complex-assembly-on-phosphatidylserine
#4
Noah Kastelowitz, Ryo Tamura, Abimbola Onasoga, Timothy J Stalker, Ormacinda R White, Peter N Brown, Gary L Brodsky, Lawrence F Brass, Brian R Branchford, Jorge Di Paola, Hang Yin
Blood coagulation involves activation of platelets and coagulation factors. At the interface of these two processes resides the lipid phosphatidylserine. Activated platelets expose phosphatidylserine on their outer membrane leaflet and activated clotting factors assemble into enzymatically active complexes on the exposed lipid, ultimately leading to the formation of fibrin. Here, we describe how small peptide and peptidomimetic probes derived from the lipid binding domain of the protein myristoylated alanine-rich C-kinase substrate (MARCKS) bind to phosphatidylserine exposed on activated platelets and thereby inhibit fibrin formation...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28638804/pkc-%C3%AE-marcks-signaling-promotes-intracellular-survival-of-unopsonized-burkholderia-thailandensis
#5
Sofiya N Micheva-Viteva, Yulin Shou, Kumkum Ganguly, Terry H Wu, Elizabeth Hong-Geller
Pathogenic Burkholderia rely on host factors for efficient intracellular replication and are highly refractory to antibiotic treatment. To identify host genes that are required by Burkholderia spp. during infection, we performed a RNA interference (RNAi) screen of the human kinome and identified 35 host kinases that facilitated Burkholderia thailandensis intracellular survival in human monocytic THP-1 cells. We validated a selection of host kinases using imaging flow cytometry to assess efficiency of B. thailandensis survival in the host upon siRNA-mediated knockdown...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28624269/-technical-information-the-so-called-camille-bernard-lower-lip-reconstruction-an-eponymous-confusion-clarified
#6
K W Marck, D Martin
The use of eponyms honours those who have contributed to the development of medicine and facilitates communication between colleagues. Eponyms are based on historical knowledge to know who was the first to use a given technique. In the previous century, two different operative procedures have been attached to the 'so called' Bernard lower lip reconstruction. This historical literature on lip reconstruction with a focus on the years 1853-1855 elucidates the roles of Bernard, Saeman, Desgranges and Burow, and gives suggestions for eponyms that do justice to the innovating surgeons Bernard, Burow and Desgranges...
June 14, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28623606/marcks-is-necessary-for-oligodendrocyte-precursor-cell-maturation
#7
Zhao-Huan Zhang, Fan-Fei Ma, Hui Zhang, Xiao-Hui Xu
Oligodendrocyte precursor cell (OPC) development into myelinated oligodendrocytes demands vigorous membrane addition. Since myristoylated alanine-rich C-kinase substrate (MARCKS) reportedly contributes to Ras-associated protein (Rab)-10-associated vesicle insertion into neuronal membranes, we investigated the role of MARCKS in OPC maturation. We found that either knockdown of MARCKS or interruption of its interaction with Rab10 would cause a decrease of the cell membrane area during OPC development. Enhanced MARCKS phosphorylation by Nogo66 or myelin debris treatment inhibited OPC maturation, while its dephosphorylation by protein phosphatase 2 A activator D-erythro-sphingosine promoted OPC development in the presence of myelin debris...
June 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28620343/international-differences-in-multiple-sclerosis-health-outcomes-and-associated-factors-in-a-cross-sectional-survey
#8
Grace D Reilly, Awng Shar Mahkawnghta, Pia L Jelinek, Alysha M De Livera, Tracey J Weiland, Chelsea R Brown, Keryn L Taylor, Sandra L Neate, George A Jelinek, Claudia H Marck
Multiple sclerosis (MS) is a major cause of disability and poor quality of life (QOL). Previous studies have shown differences in MS health outcomes between countries. This study aimed to examine the associations between international regions and health outcomes in people with MS. Self-reported data were taken from the Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis online survey collected in 2012. The 2,401 participants from 37 countries were categorized into three regions: Australasia, Europe, and North America...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28614432/characteristics-of-nursing-professionals-and-the-practice-of-ecologically-sustainable-actions-in-the-medication-processes
#9
Patricia de Oliveira Furukawa, Isabel Cristina Kowal Olm Cunha, Mavilde da Luz Gonçalves Pedreira, Patricia Beryl Marck
Objectives: to verify the correlation between the characteristics of professionals and the practice of sustainable actions in the medication processes in an ICU, and to determine if interventions such as training and awareness can promote sustainable practices performed by nursing staff in the hospital. Methods: before-and-after design study using Lean Six Sigma methodology, applied in an intensive care unit. Nursing staff were observed regarding the practice of ecologically sustainable actions during medication processes (n = 324 cases for each group (pre and post-intervention)) through a data collection instrument...
June 8, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28589100/microrna-21-limits-uptake-of-listeria-monocytogenes-by-macrophages-to-reduce-the-intracellular-niche-and-control-infection
#10
Daniel G W Johnston, Jay Kearney, Zbigniew Zasłona, Michelle A Williams, Luke A J O'Neill, Sinéad C Corr
MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of infections. We investigated the influence of miR-21 on macrophage responses during infection with Listeria monocytogenes, which establishes an intracellular niche within macrophages. MiR-21 is induced following infection of bone marrow-derived macrophages (BMDMs) with Listeria. MiR-21(-/-) macrophages display an increased bacterial burden with Listeria at 30 min and 2 h post-infection...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28588270/maternal-placental-fetal-biodistribution-of-multimodal-polymeric-nanoparticles-in-a-pregnant-rat-model-in-mid-and-late-gestation
#11
Diwei Ho, Joan W Leong, Rachael C Crew, Marck Norret, Michael J House, Peter J Mark, Brendan J Waddell, K Swaminathan Iyer, Jeffrey A Keelan
Multimodal polymeric nanoparticles have many exciting diagnostic and therapeutic applications, yet their uptake and passage by the placenta, and applications in the treatment of pregnancy complications have not been thoroughly investigated. In this work, the maternal-fetal-placental biodistribution of anionic and cationic multimodal poly(glycidyl methacrylate) (PGMA) nanoparticles in pregnant rats at mid (ED10) and late (ED20) gestation was examined. Fluorescently-labelled and superparamagnetic PGMA nanoparticles functionalized with/without poly(ethyleneimine) (PEI) were administered to pregnant rats at a clinically-relevant dose and biodistribution and tissue uptake assessed...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28554819/interstitial-lung-fluid-balance-in-healthy-lowlanders-exposed-to-high-altitude
#12
Bryan J Taylor, Glenn M Stewart, Jan W Marck, Douglas T Summerfield, Amine N Issa, Bruce D Johnson
We aimed to assess lung fluid balance before and after gradual ascent to 5150m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11±10%) and Day 9 (10±9%) vs...
September 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28505308/diagnostic-performance-of-ultrasound-guided-fine-needle-aspiration-of-nonpalpable-breast-lesions-in-a-multidisciplinary-setting-the-institut-curie-s-experience
#13
Josep A Farras Roca, Anne Tardivon, Fabienne Thibault, Carl El Khoury, Séverine Alran, Virginie Fourchotte, Véronique Marck, Bernard Alépée, Birigitte Sigal, Yann de Rycke, Roman Rouzier, Jerzy Klijanienko
Objectives: To assess the diagnostic performance of ultrasound-guided fine-needle aspiration (USFNA) in nonpalpable breast lesions (NPBLs) in a multidisciplinary setting. Methods: In total, 2,601 NPBLs underwent USFNA by a radiologist-pathologist team. Gold-standard diagnosis was based on surgery, core-needle biopsy, or 1-year imaging follow-up. USFNA's diagnostic performance was analyzed in different clinical and imaging subgroups. Results: USFNA's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were, respectively, 92...
June 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28468944/enac-activity-is-regulated-by-calpain-2-proteolysis-of-marcks-proteins
#14
Darrice S Montgomery, Ling Yu, Zinah M Ghazi, Tiffany L Thai, Otor Al-Khalili, He-Ping Ma, Douglas C Eaton, Abdel A Alli
We previously demonstrated a role for the myristoylated alanine-rich C kinase substrate (MARCKS) to serve as an adaptor protein in the anionic phospholipid phosphate-dependent regulation of the epithelial sodium channel (ENaC). Both MARCKS and ENaC are regulated by proteolysis. Calpains are a family of ubiquitously expressed intracellular Ca(2+)-dependent cysteine proteases involved in signal transduction. Here we examine the role of calpain-2 in regulating MARCKS and ENaC in cultured renal epithelial cells and in the mouse kidney...
July 1, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28454237/marcks-phosphorylation-is-modulated-by-a-peptide-mimetic-of-marcks-effector-domain-leading-to-increased-radiation-sensitivity-in-lung-cancer-cell-lines
#15
Timothy D Rohrbach, Robert B Jones, Patricia H Hicks, Alice N Weaver, Tiffiny S Cooper, Nicholas J Eustace, Eddy S Yang, John S Jarboe, Joshua C Anderson, Christopher D Willey
Lung cancer is the leading cause of cancer-associated mortality in the United States. Kinase hyperactivation is a known mechanism of tumorigenesis. The phosphorylation status of the plasma membrane-associated protein myristoylated alanine rich C-kinase substrate (MARCKS) effector domain (ED) was previously established as being important in the sensitivity of lung cancer to radiation. Specifically, when MARCKS ED was in a non-phosphorylated state, lung cancer cells were more susceptible to ionizing radiation and experienced prolonged double-strand DNA breaks...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451358/synthetically-controlling-dendrimer-flexibility-improves-delivery-of-large-plasmid-dna
#16
Jessica A Kretzmann, Diwei Ho, Cameron W Evans, Janice H C Plani-Lam, Benjamin Garcia-Bloj, A Elaaf Mohamed, Megan L O'Mara, Ethan Ford, Dennis E K Tan, Ryan Lister, Pilar Blancafort, Marck Norret, K Swaminathan Iyer
Tools for editing the genome and epigenome have revolutionised the field of molecular biology and represent a new frontier in targeted therapeutic intervention. Although efficiencies and specificities of genome editing technologies have improved with the development of TALEs and CRISPR platforms, intracellular delivery of these larger constructs still remains a challenge using existing delivery agents. Viral vectors, including lentiviruses and adeno-associated viruses, as well as some non-viral strategies, such as cationic polymers and liposomes, are limited by packaging capacity, poor delivery, toxicity, and immunogenicity...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28414123/anti-factor-xa-activities-of-zingerone-with-anti-platelet-aggregation-activity
#17
Wonhwa Lee, Sae-Kwang Ku, Mi-Ae Kim, Jong-Sup Bae
Zingerone (ZGR), a phenolic alkanone found in Zingiber officinale, has been reported to have various pharmacological activities such as anti-inflammatory, anti-apoptotic, and protecting myocardial infarction and irritable bowel disorder. The aim was to identify the unreported bioactive anti-factor Xa (FXa) and anti-platelet activities of ZGR. ZGR was evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity and production, and thrombus formation...
July 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28389510/association-of-tissue-abiraterone-levels-and-slco-genotype-with-intraprostatic-steroids-and-pathologic-response-in-men-with-high-risk-localized-prostate-cancer
#18
Elahe A Mostaghel, Eunpi Cho, Ailin Zhang, Mohammad Alyamani, Arja Kaipainen, Sean Green, Brett Marck, Nima Sharifi, Jonathan L Wright, Roman Gulati, Lawrence D True, Massimo Loda, Alvin M Matsumoto, Daniel Tamae, Trevor N Penning, Steven P Balk, Philip W Kantoff, Peter S Nelson, Mary-Ellen Taplin, Bruce Montgomery
Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer (PCa) outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo SLCO-mediated transport and that SLCO gene variation may influence intracellular abiraterone levels and outcomes.<br /><br />Experimental Design: Steroid and abiraterone levels were measured by mass spectrometry in serum and tissue from 58 men with localized PCa in a clinical trial of LHRH agonist plus abiraterone acetate plus prednisone for 24 weeks prior to prostatectomy...
April 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28372581/perseverance-time-of-informal-caregivers-for-people-with-dementia-construct-validity-responsiveness-and-predictive-validity
#19
Anke Richters, René J F Melis, N Job van Exel, Marcel G M Olde Rikkert, Marjolein A van der Marck
BACKGROUND: Informal care is essential for many people with dementia (PwD), but it often results in a considerable burden for the caregiver. The perseverance time instrument integrates the aspect of perceived burden with the caregiver's capacity to cope with the burden, in contrast to most available instruments, which measure solely the burden of caregiving. The aim of this study was to extend insight into psychometric properties of the perseverance time instrument, specifically the construct validity, responsiveness, and predictive validity, within the population of informal caregivers for PwD...
April 4, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28370068/dose-response-effects-of-sex-hormone-concentrations-on-body-composition-and-adipokines-in-medically-castrated-healthy-men-administered-graded-doses-of-testosterone-gel
#20
Arthi Thirumalai, Katya B Rubinow, Lori A Cooper, John K Amory, Brett T Marck, Alvin M Matsumoto, Stephanie T Page
OBJECTIVE: Serum sex steroid concentrations may alter body composition and glucose homoeostasis in men in a dose-response manner. We evaluated these end-points in healthy men rendered medically castrate through use of a gonadotrophin-releasing hormone antagonist (acyline) with incremental doses of exogenous testosterone (T) gel. DESIGN: Subjects (n=6-9 per group) were randomly assigned to injections of acyline every 2 weeks plus transdermal T gel (1.25 g, 2.5 g, 5...
March 30, 2017: Clinical Endocrinology
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