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https://www.readbyqxmd.com/read/29222109/marcks-related-protein-regulates-cytoskeletal-organization-at-cell-cell-and-cell-substrate-contacts-in-epithelial-cells
#1
Christina M Van Itallie, Amber Jean Tietgens, Angel Aponte, Marjan Gucek, Alexander X Cartagena-Rivera, Richard S Chadwick, James M Anderson
MARCKS-related protein (MRP) is tagged by biotin ligase fused to occludin and the level of tagging increases ∼20-fold following IFN/TNF treatment. GFP-MRP is focused at the lateral cell membrane and its overexpression potentiates the physiological response of the tight junction barrier to cytokines. However, deletion of MRP does not abrogate cytokine responses, suggesting that MRP is not required in the occludin-dependent IFN/TNF response. Instead, our results reveal a key role for MRP in epithelial cells in control of multiple actin-based structures, likely by regulation of integrin signaling...
December 8, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29192063/mechanism-of-inhibition-of-taurolithocholate-induced-retrieval-of-plasma-membrane-mrp2-by-cyclic-amp-and-tauroursodeoxycholate
#2
Se Won Park, Cynthia R L Webster, Mohammed S Anwer
Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC-induced cholestasis by inhibiting TLC-induced retrieval of MRP2. However, cellular mechanisms for this reversal are incompletely understood. Recently, we reported that TLC decreases PM-MRP2 by activating PKCε followed by phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS). Thus, cAMP and TUDC may reverse TLC-induced cholestasis by inhibiting the TLC/PKCε/MARCKS phosphorylation pathway...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29130378/the-experiences-of-patients-with-advanced-cancer-and-caregivers-presenting-to-emergency-departments-a-qualitative-study
#3
Jennifer Philip, Cheryl Remedios, Sibilah Breen, Tracey Weiland, Lisa Willenberg, Mark Boughey, George Jelinek, Heather Lane, Claudia Marck, Jennifer Weil
BACKGROUND: Despite being a common event in the course of an advanced cancer illness, there is little understanding of patients' perceptions of hospital Emergency Department presentations. AIM: To explore the experiences and perceptions of Emergency Departments held by patients with advanced cancer and their informal caregivers. DESIGN: Cross-sectional study involving semi-structured interviews with advanced cancer patients and their informal caregivers...
October 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29123486/are-we-reaching-the-limits-of-homo-sapiens
#4
REVIEW
Adrien Marck, Juliana Antero, Geoffroy Berthelot, Guillaume Saulière, Jean-Marc Jancovici, Valérie Masson-Delmotte, Gilles Boeuf, Michael Spedding, Éric Le Bourg, Jean-François Toussaint
Echoing scientific and industrial progress, the Twentieth century was an unprecedented period of improvement for human capabilities and performances, with a significant increase in lifespan, adult height, and maximal physiological performance. Analyses of historical data show a major slow down occurring in the most recent years. This triggered large and passionate debates in the academic scene within multiple disciplines; as such an observation could be interpreted as our upper biological limits. Such a new phase of human history may be related to structural and functional limits determined by long term evolutionary constraints, and the interaction between complex systems and their environment...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29116649/wwc-proteins-regulate-hepatic-cell-differentiation-and-tumorigenesis-via-the-hippo-signaling-pathway
#5
Anke Hermann, Dirk Oliver Wennmann, Sascha Gromnitza, Maria Edeling, Veerle Van Marck, Marius Sudol, Liliana Schaefer, Kerstin Duning, Thomas Weide, Hermann Pavenstädt, Joachim Kremerskothen
The Hippo pathway regulates cell differentiation, proliferation and apoptosis. Upon activation, it inhibits the import of the transcriptional co-activator YAP into the nucleus, thus suppressing transcription of pro-proliferative genes. Hence, dynamic and precise control of the Hippo pathway is crucial for organ size control and the prevention of tumor formation. Hippo signaling is controlled by a growing number of upstream regulators - including WWC proteins - which trigger a serine/threonine kinase pathway...
November 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29079957/-guideline-on-medical-research-in-older-persons
#6
Marjolein A van der Marck, Marcel G M Olde Rikkert
This paper describes the development of a guideline on medical research with older subjects. Although our society is aging, evidence on health care for older persons is lacking on many topics, because these subjects are underrepresented in most drug and non-drug trials, while these services are used many older persons, and result in many adverse reactions and unplanned hospitalisation. Part of the reasons for this underrepresentation is the multimorbidity, often leading to exclusion, but also the lack of appropriate research methods plays a major role...
October 27, 2017: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/29073717/effective-excision-of-cutaneous-squamous-cell-carcinoma-of-the-face-using-analysis-of-intra-operative-frozen-sections-from-the-whole-specimen
#7
Kor H Hutting, Paul G Bos, Robby E Kibbelaar, Nic J G M Veeger, Klaas W Marck, Chantal M Mouës
BACKGROUND AND OBJECTIVES: We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra-operative frozen section analysis of the margins in an optimized bread-loafing fashion (WIFSA). METHODS: Medical records were reviewed of 160 cSCCs of the face that were treated by surgical excision with WIFSA between April 2007 and January 2013. The accuracy of WIFSA was verified by comparing results with postoperative formalin-fixed paraffin-embedded (FFPE) sections...
October 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29069765/marcks-promotes-invasion-and-is-associated-with-biochemical-recurrence-in-prostate-cancer
#8
Emma Dorris, Amanda O'Neill, Karen Hanrahan, Ann Treacy, R William Watson
BACKGROUND: Overtreatment of low-grade prostate cancer is a recognised problem for clinicians and patients. However, under-treatment runs the risk of missing the opportunity for cure in those who could benefit. Identification of new biomarkers of disease progression, including metastases, is required to better stratify and appropriately treat these patients. The ability to predict if prostate cancer will recur is an important clinical question that would impact treatment options for patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29064846/pre-and-post-conditioning-by-cardiac-glycosides-in-the-mouse-heart
#9
Qiming Duan, Yunhui Xu, Pauline Marck, Jennifer Kalisz, Eric E Morgan, Sandrine V Pierre
Ouabain preconditioning (OPC) initiated by low concentrations of the cardiac glycoside (CG) ouabain binding to Na/K-ATPase is relayed by a unique intracellular signaling and protects cardiac myocytes against ischemia/reperfusion (IR) injury. To explore more clinically applicable protocols based on CG properties, we tested whether the FDA-approved CG digoxin could trigger cardioprotective effects comparable to those of ouabain using PC and PostC protocols in the Langendorff-perfused mouse heart subjected to global ischemia and reperfusion...
October 23, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29046508/the-marcks-protein-amount-is-differently-regulated-by-calpain-during-toxic-effects-of-methylmercury-between-sh-sy5y-and-ea-hy926-cells
#10
Cuong Van Dao, Mitsuya Shiraishi, Atsushi Miyamoto
Methylmercury (MeHg) is an environmental pollutant that shows severe toxicity to humans and animals. However, the molecular mechanisms mediating MeHg toxicity are not completely understood. We have previously reported that the MARCKS protein is involved in the MeHg toxicity to SH-SY5Y neuroblastoma and EA.hy926 vascular endothelial cell lines. In addition, calpain, a Ca(2+)-dependent protease, is suggested to be associated with the MeHg toxicity. Because MARCKS is known as a substrate of calpain, we studied the relation between calpain activation and cleavage of MARCKS and its role in MeHg toxicity...
October 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29039083/myristoylated-alanine-rich-c-kinase-substrate-marcks-a-multirole-signaling-protein-in-cancers
#11
REVIEW
Lon Wolf R Fong, David C Yang, Ching-Hsien Chen
Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is tethered to the plasma membrane but can shuttle between the cytosol and plasma membrane via the myristoyl-electrostatic switch. Phosphorylation of MARCKS by PKC leads to its translocation from the plasma membrane to the cytosol where it functions in actin cytoskeletal remodeling, Ca(2+) signaling through binding to calmodulin, and regulation of exocytic vesicle release in secretory cells such as neurons and airway goblet cells...
October 16, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29022719/the-protein-corona-of-pegylated-pgma-based-nanoparticles-is-preferentially-enriched-with-specific-serum-proteins-of-varied-biological-function
#12
Priya S R Naidu, Marck Norret, Nicole M Smith, Sarah A Dunlop, Nicolas L Taylor, Melinda Fitzgerald, K Swaminathan Iyer
The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona...
October 30, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29020306/lithium-and-tamoxifen-modulate-behavior-and-protein-kinase-c-activity-in-the-animal-model-of-mania-induced-by-ouabain
#13
Samira S Valvassori, Gustavo C Dal-Pont, Wilson R Resende, Roger B Varela, Bruna R Peterle, Fernanda F Gava, Francielle G Mina, José H Cararo, André F Carvalho, João Quevedo
Background: The intracerebroventricular injection of ouabain, a specific inhibitor of the Na+/K+-adenosine-triphosphatase (Na+/K+-ATPase) enzyme, induces hyperactivity in rats in a putative animal model of mania. Several evidences have suggested that the protein kinase C signaling pathway is involved in bipolar disorder. In addition, it is known that protein kinase C inhibitors, such as lithium and tamoxifen, are effective in treating acute mania. Methods: In the present study, we investigated the effects of lithium and tamoxifen on the protein kinase C signaling pathway in the frontal cortex and hippocampus of rats submitted to the animal model of mania induced by ouabain...
November 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28992142/researching-safety-culture-deliberative-dialogue-with-a-restorative-lens
#14
Elisiane Lorenzini, Nelly D Oelke, Patricia Beryl Marck, Clarice Maria Dall'agnol
Safety culture is a key component of patient safety. Many patient safety strategies in health care have been adapted from high-reliability organizations (HRO) such as aviation. However, to date, attempts to transform the cultures of health care settings through HRO approaches have had mixed results. We propose a methodological approach for safety culture research, which integrates the theory and practice of restoration science with the principles and methods of deliberative dialogue to support active engagement in critical reflection and collective debate...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28928713/pain-in-people-with-multiple-sclerosis-associations-with-modifiable-lifestyle-factors-fatigue-depression-anxiety-and-mental-health-quality-of-life
#15
Claudia H Marck, Alysha M De Livera, Tracey J Weiland, Pia L Jelinek, Sandra L Neate, Chelsea R Brown, Keryn L Taylor, Fary Khan, George A Jelinek
BACKGROUND: People with multiple sclerosis (MS) often experience pain, which can interfere with mobility, employment, and quality of life (QOL). METHODS: This cross-sectional study explored associations between pain, demographic, disease, and modifiable lifestyle factors in an international sample of people with MS recruited online. RESULTS: Substantial pain, of moderate/severe intensity and interfering at least moderately with work/household or enjoyment of life in the past 4 weeks, was reported by 682/2,362 (28...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28866462/a-spectroscopic-sensing-platform-for-marcks-protein-monolayers
#16
Joaquín Klug, María Fernanda Torresan, Florencia Lurgo, Graciela Borioli, Gabriela I Lacconi
We developed a highly sensitive silicon platform, suitable to assess the molecular organization of protein samples. Prototype platforms were obtained using different electrochemical protocols for the electrodeposition of Ag-nanoparticles onto the hydrogenated silicon surface. A platform with high Surface Enhanced Raman Scattering efficiency was selected based on the surface coverage and the number density of particles size distribution. The performance of the platform was determined by studying the interaction of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) protein with the substrate according to its molecular organization...
August 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28844963/novel-direct-factor-xa-inhibitory-compounds-from-tenebrio-molitor-with-anti-platelet-aggregation-activity
#17
Wonhwa Lee, Mi-Ae Kim, InWha Park, Jae Sam Hwang, MinKyun Na, Jong-Sup Bae
Tenebrio molitor is an edible insect that has antimicrobial, anticancer, and antihypertensive effects. The aim of this study was to identify the unreported bioactive compounds from T. molitor larvae with inhibitory activities against factor Xa (FXa) and platelet aggregation. Isolated compounds were evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity, and thrombus formation. A diketopiperazine (1, cyclo(L-Pro-L-Tyr)) and a phenylethanoid (2, N-acetyltyramine) were isolated and inhibited the catalytic activity of FXa in a mixed inhibition model and inhibited platelet aggregation induced by adenosine diphosphate (ADP) and U46619...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28819302/generation-and-intracellular-trafficking-of-a-polysialic-acid-carrying-fragment-of-the-neural-cell-adhesion-molecule-ncam-to-the-cell-nucleus
#18
Nina Westphal, Gabriele Loers, David Lutz, Thomas Theis, Ralf Kleene, Melitta Schachner
Polysialic acid (PSA) and its major protein carrier, the neural cell adhesion molecule NCAM, play important roles in many nervous system functions during development and in adulthood. Here, we show that a PSA-carrying NCAM fragment is generated at the plasma membrane by matrix metalloproteases and transferred to the cell nucleus via endosomes and the cytoplasm. Generation and nuclear import of this fragment in cultured cerebellar neurons is induced by a function-triggering NCAM antibody and a peptide comprising the effector domain (ED) of myristoylated alanine-rich C kinase substrate (MARCKS) which interacts with PSA within the plane of the plasma membrane...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783747/comprehensive-investigation-of-cask-mutations-and-other-genetic-etiologies-in-41-patients-with-intellectual-disability-and-microcephaly-with-pontine-and-cerebellar-hypoplasia-micpch
#19
Shin Hayashi, Daniela Tiaki Uehara, Kousuke Tanimoto, Seiji Mizuno, Yasutsugu Chinen, Shinobu Fukumura, Jun-Ichi Takanashi, Hitoshi Osaka, Nobuhiko Okamoto, Johji Inazawa
The CASK gene (Xp11.4) is highly expressed in the mammalian nervous system and plays several roles in neural development and synaptic function. Loss-of-function mutations of CASK are associated with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH), especially in females. Here, we present a comprehensive investigation of 41 MICPCH patients, analyzed by mutational search of CASK and screening of candidate genes using an SNP array, targeted resequencing and whole-exome sequencing (WES)...
2017: PloS One
https://www.readbyqxmd.com/read/28780556/evaluation-of-dementianet-a-network-based-primary-care-innovation-for-community-dwelling-patients-with-dementia-protocol-for-a-longitudinal-mixed-methods-multiple-case-study
#20
Anke Richters, Minke S Nieuwboer, Marieke Perry, Marcel G M Olde Rikkert, Rene J F Melis, Marjolein A van der Marck
INTRODUCTION: Primary healthcare professionals will increasingly be required to manage and optimise their treatment for patients with dementia. With DementiaNet, we aim to reduce the burden of dementia on healthcare services and society through implementation and facilitation of integrated network-based care with increased dementia expertise. DementiaNet is designed as a stepwise approach including clinical leadership, quality improvement cycles and interprofessional training, which are tailor-made to the local context...
August 4, 2017: BMJ Open
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