Keiichi Sumida, Prabin Shrestha, Yamini Mallisetty, Satya Surbhi, Fridtjof Thomas, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
OBJECTIVE: To investigate the association of incident use of diuretics with subsequent risk of incident bone fractures. PATIENTS AND METHODS: In a nationwide cohort of 863,339 US veterans receiving care from the VA health care system between October 1, 2004, and September 30, 2006, with follow-up through June 30, 2018, we examined the association of incident diuretic use (overall, and separately by thiazide, loop, and potassium-sparing diuretics) with subsequent risk of incident bone fractures using multivariable Cox regression models while minimizing confounding by indication using a target trial emulation approach...
April 3, 2024: Mayo Clinic Proceedings