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https://www.readbyqxmd.com/read/28912572/follistatin-n-terminus-differentially-regulates-muscle-size-and-fat-in-vivo
#1
Hui Zheng, Chunping Qiao, Ruhang Tang, Jianbin Li, Karen Bulaklak, Zhenhua Huang, Chunxia Zhao, Yi Dai, Juan Li, Xiao Xiao
Delivery of follistatin (FST) represents a promising strategy for both muscular dystrophies and diabetes, as FST is a robust antagonist of myostatin and activin, which are critical regulators of skeletal muscle and adipose tissues. FST is a multi-domain protein, and deciphering the function of different domains will facilitate novel designs for FST-based therapy. Our study aims to investigate the role of the N-terminal domain (ND) of FST in regulating muscle and fat mass in vivo. Different FST constructs were created and packaged into the adeno-associated viral vector (AAV)...
September 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28881838/prognostic-value-of-molecular-events-from-negative-surgical-margin-of-non-small-cell-lung-cancer
#2
Bangrong Cao, Lin Feng, Dan Lu, Yan Liu, Yu Liu, Suping Guo, Naijun Han, Xiangyang Liu, Yousheng Mao, Jie He, Shujun Cheng, Yanning Gao, Kaitai Zhang
It is hypothesized that the molecular status in negative surgical margin (NSM) is associated with prognosis of cancer patients. In this study, the prognostic relevance of Epithelial-to-Mesenchymal Transition (EMT) molecular events in NSMs in patients with NSCLC was investigated. EMT model was developed, in which the mesenchymal transition of human immortalized bronchial epithelial cell line was induced by TGF-beta1. Gene expression of EMT-induced cells and NSMs from 60 lung squamous cell carcinoma (SCC) patients was profiled by microarray and validated by quantitative RT-PCR...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28860038/functional-complement-activity-is-decisive-for-the-development-of-chronic-synovitis-osteophyte-formation-and-processes-of-cell-senescence-in-zymosan-induced-arthritis
#3
Petya Ganova, Valeriya Gyurkovska, Lyudmila Belenska-Todorova, Nina Ivanovska
Synovial inflammation plays a critical role in the symptoms and structural progression of arthritis which leads to irreversible damage of the adjacent cartilage and bone. Activation of complement system is strongly implicated as a factor in the pathogenesis of chronic synovitis in human rheumatoid arthritis (RA). In this study, we show that the depletion of functional complement activity at the time of the initiation of zymosan-induced arthritis, significantly reduced the expression of TGF-beta1/3, BMP2 and pSmad2 and decreased the number of Sudan Black B positive cells in the synovium...
August 30, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28835018/effect-of-fgf-2-tgf-%C3%AE-1-and-bmps-on-teno-ligamentogenesis-and-osteo-cementogenesis-of-human-periodontal-ligament-stem-cells
#4
Sun-Yi Hyun, Ji-Hye Lee, Kyung-Jung Kang, Young-Joo Jang
The periodontal ligament (PDL) is the connective tissue between tooth root and alveolar bone containing mesenchymal stem cells (MSC). It has been suggested that human periodontal ligament stem cells (hPDLSCs) differentiate into osteo/cementoblast and ligament progenitor cells. The periodontitis is a representative oral disease where the PDL tissue is collapsed, and regeneration of this tissue is important in periodontitis therapy. Fibroblast growth factor-2 (FGF-2) stimulates proliferation and differentiation of fibroblastic MSCs into various cell lineages...
August 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28748762/post-cardiovascular-surgery-atrial-fibrillation-biomarkers-determining-prognosis
#5
Olivia Manfrini, Edina Cenko, Beatrice Ricci, Raffaele Bugiardini
New onset of atrial fibrillation (AF) after cardiovascular surgery is associated with increased risk of complications and length of hospital stay. Identification of patients at high risk of post cardiovascular surgery AF may help to act with preventive strategies having clinical and economic relevance. Many factors such as cardiac remodelling, changes in atrial pressure, surgery trauma, inflammation, oxidative stress, and sympathetic/parasympathetic activation have been implicated in the development of post cardiovascular surgery...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28614933/-study-on-the-establishment-of-hmld-model-and-the-expression-of-kl-6-tgf-beta-in-rat
#6
Z S Zhang, Y F Zhao, L Tang, H K Xie, D Y Sun
Objective: To establish an animal model of hard metal lung disease (HMLD) in rats, and to screen the indications for diagnosis of HMLD. Methods: The rats were randomly divided into 5 groups, each group included 8 rats: saline group, pure cobalt group, pure tungsten carbide group, silica group and hard metal (HM) group. 10 mg subjects were administered in each group by using the pulmonary endotracheal tube. After 8 week, the lung CT scan and lung tissue pathology were observed, the serum and bronchoalveolar lavage fluid (BALF) were collected for KL-6, TGF-beta1 and TGF-beta2...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28424263/the-kielin-chordin-like-protein-kcp-attenuates-high-fat-diet-induced-obesity-and-metabolic-syndrome-in-mice
#7
Abdul Soofi, Katherine I Wolf, Margo P Emont, Nathan Qi, Gabriel Martinez-Santibanez, Edward Grimley, Wesam Ostwani, Gregory R Dressler
Obesity and its associated complications such as insulin resistance and non-alcoholic fatty liver disease are reaching epidemic proportions. In mice, the TGF-β superfamily is implicated in the regulation of white and brown adipose tissue differentiation. The kielin/chordin-like protein (KCP) is a secreted regulator of the TGF-β superfamily pathways that can inhibit both TGF-β and activin signals while enhancing bone morphogenetic protein (BMP) signaling. However, KCP's effects on metabolism and obesity have not been studied in animal models...
June 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28399671/substance-p-increases-ccn2-dependent-on-tgf-beta-yet-collagen-type-i-via-tgf-beta1-dependent-and-independent-pathways-in-tenocytes
#8
Nagat Frara, Paul W Fisher, Yingjie Zhao, Joseph T Tarr, Mamta Amin, Steven N Popoff, Mary F Barbe
Transforming growth factor beta 1 (TGFbeta-1) and connective tissue growth factor (CCN2) are important mediators of tissue repair and fibrosis, with CCN2 functioning as a downstream mediator of TGFβ-1. Substance P (SP) is also linked to collagen production in tenocytes. A link between SP, TGFbeta-1 and CCN2 has yet to be established in tenocytes or fibrogenic processes. We sought to determine whether SP induces tenocyte proliferation, CCN2, or collagen production via TGFbeta-1 signaling or independently in rat primary tenocytes...
March 1, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28065853/sitagliptin-inhibit-human-lymphocytes-proliferation-and-th1-th17-differentiation-in-vitro
#9
Marcelo Maia Pinheiro, Caroline Lais Stoppa, Claudete Justina Valduga, Cristina Eunice Okuyama, Renata Gorjão, Regina Mara Silva Pereira, Susana Nogueira Diniz
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti-diabetic agents that are widely used in clinical practice to improve glycemic control in patients with type 2 diabetes. DPP-4 is also known as lymphocyte cell surface protein, CD26, and plays an important role in T-cell immunity. Recent studies suggest that DPP-4 inhibitors improve beta-cell function and attenuate autoimmunity in type 1 diabetic mouse models. To investigate the direct effect of DPP4 in immune response, human peripheral blood mononuclear cells (PBMC) from healthy volunteers were obtained by Ficoll gradient and cultivated in the absence (control) or presence of phytohemagglutinin (PHA), or stimulated with PHA and treated with sitagliptin...
March 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27814572/tgf-beta1-wnt-and-shh-signaling-in-tumor-progression-and-in-fibrotic-diseases
#10
REVIEW
Maria D Castellone, Mikko O Laukkanen
Activation of resting fibroblasts to myofibroblasts characterizes several physiological and pathological conditions, from wound healing to aggressive metastatic cancers. In tissue damage, including wound healing, fibroblasts are activated in response to injury for a limited period of time to stimulate the healing process. Similar biological mechanisms are maintained in pathological conditions, e.g., scleroderma and cancer, where myofibroblasts persist in producing cytokines and growth factors to drive the development of fibrosis and the progression of disease...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27624777/inhibition-of-s-adenosylmethionine-dependent-methyltransferase-attenuates-tgf%C3%AE-1-induced-emt-and-metastasis-in-pancreatic-cancer-putative-roles-of-mir-663a-and-mir-4787-5p
#11
Hardik R Mody, Sau Wai Hung, Mohammad AlSaggar, Jazmine Griffin, Rajgopal Govindarajan
The identification of epigenetic reversal agents for use in combination chemotherapies to treat human pancreatic ductal adenocarcinomas (PDAC) remains an unmet clinical need. Pharmacologic inhibitors of Enhancer of Zeste Homolog 2 (EZH2) are emerging as potential histone methylation reversal agents for the treatment of various solid tumors and leukemia; however, the surprisingly small set of mRNA targets identified with EZH2 knockdown suggests novel mechanisms contribute to their antitumorigenic effects. Here, 3-deazaneplanocin-A (DZNep), an inhibitor of S-adenosyl-L-homocysteine hydrolase and EZH2 histone lysine-N-methyltransferase, significantly reprograms noncoding microRNA (miRNA) expression and dampens TGFβ1-induced epithelial-to-mesenchymal (EMT) signals in pancreatic cancer...
November 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27588388/hyaluronan-oligosaccharides-promote-diabetic-wound-healing-by-increasing-angiogenesis
#12
Yi Wang, Guanying Han, Bin Guo, Jianhua Huang
BACKGROUND: Hyaluronan (also known as hyaluronic acid) oligosaccharides (O-HA) can promote angiogenesis and wound healing; however, there are few reports on whether O-HA also plays a role in healing wounds of diabetic patients. METHODS: In this study, we prepared a special ointment containing a mixture of hyaluronan fragments from 2 to 10 disaccharide units and investigated its effects on healing the wounds of diabetic rats. RESULTS: We found that O-HA significantly increases proliferation, migration, and tube formation of endothelial cells under high glucose conditions, and topical administration of O-HA ointment promotes wound healing by increasing angiogenesis in the wounded area of the skin...
December 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27566588/role-of-rbbp5-and-h3k4me3-in-the-vicinity-of-snail-transcription-start-site-during-epithelial-mesenchymal-transition-in-prostate-cancer-cell
#13
Dong Li, Hui Sun, Wen-Jing Sun, Hong-Bo Bao, Shu-Han Si, Jia-Lin Fan, Ping Lin, Rong-Jun Cui, Yu-Jia Pan, Si-Min Wen, Xiu-Lan Zheng, Xiao-Guang Yu
EMT (epithelial-mesenchymal transition) occurs in a wide range of tumor types, and has been shown to be crucial for metastasis. Epigenetic modifications of histones contribute to chromatin structure and result in the alterations in gene expression. Tri-methylation of histone H3 lysine 4 (H3K4me3) is associated with the promoters of actively transcribed genes and can serve as a transcriptional on/off switch. RbBP5 is a component of the COMPASS/ -like complex, which catalyzes H3K4me3 formation. In this study, we found that in the process of TGF-Beta1 induced EMT in the prostate cancer cell line DU145, H3K4me3 enrichment and RbBP5 binding increased in the vicinity of Snail (SNAI1) transcription start site...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27486775/prognostic-value-of-molecular-events-from-negative-surgical-margin-of-non-small-cell-lung-cancer
#14
Bangrong Cao, Lin Feng, Dan Lu, Yan Liu, Yu Liu, Suping Guo, Naijun Han, Xiangyang Liu, Yousheng Mao, Jie He, Shujun Cheng, Yanning Gao, Kaitai Zhang
It is hypothesized that the molecular status in negative surgical margin (NSM) is associated with prognosis of cancer patients. In this study, the prognostic relevance of Epithelial-to-Mesenchymal Transition (EMT) molecular events in NSMs in patients with NSCLC was investigated. EMT model was developed, in which the mesenchymal transition of human immortalized bronchial epithelial cell line was induced by TGF-beta1. Gene expression of EMT-induced cells and NSMs from 60 lung squamous cell carcinoma (SCC) patients was profiled by microarray and validated by quantitative RT-PCR...
July 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27466990/the-effect-of-sequential-transcatheter-arterial-chemoembolization-tace-and-portal-venous-embolizations-pve-vs-tace-or-pve-alone-on-rabbit-vx2-liver-carcinoma-and-on-liver-regeneration
#15
W-C Guo, X-F He, Y-H Li, Z-H Li, Q-L Mei, Y Chen
OBJECTIVE: This study aimed to build VX2 liver tumor model in rabbits and to investigate the sequential transcatheter arterial chemoembolization (TACE) and portal vein embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and liver regeneration. MATERIALS AND METHODS: VX2 liver tumor models were built in the rabbit. Rabbits carrying VX2 liver tumors were divided into four groups, including TACE+PVE, TACE, PVE and Sham groups respectively. Hematoxylin and eosin (HE) staining was performed to visualize the structures of tumor tissues...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27429124/the-role-of-cytokines-tgf-beta1-and-fgf-1-in-the-expression-of-characteristic-markers-of-rat-liver-myofibroblasts-cultured-in-three-dimensional-collagen-gel
#16
COMPARATIVE STUDY
E Peterová, A Mrkvicová, L Podmolíková, M Řezáčová, J Kanta
Rat liver myofibroblasts (MFB) are the key cells involved in the deposition of extracellular matrix in fibrotic liver. They were isolated by repeated passaging of non-parenchymal cell fraction and cultured in 3-dimensional (3D) collagen gel mimicking tissue. The transfer of MFB from plastic dishes to collagen resulted in the change in their shape from large and spread to slender with long extensions. The expression of transforming growth factor-beta1 (TGF-beta1) and of MFB markers, alpha-smooth muscle actin (alpha-SMA) and cellular fibronectin (EDA-FN), on protein level was significantly decreased in collagen gel...
November 8, 2016: Physiological Research
https://www.readbyqxmd.com/read/27352556/spag9-promotes-endometrial-carcinoma-cell-invasion-through-regulation-of-genes-related-to-the-epithelial-mesenchymal-transition
#17
L Zhang, L Yan, M Cao, H Zhang, C Li, Y Bai, P Yu, M Li, X Zhao
OBJECTIVE: To investigate the impact of sperm-associated antigen 9 (SPAG9) on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in endometrial cancer. MATERIALS AND METHODS: The present authors' previous study demonstrated that SPAG9 is highly expressed in endometrial cancer tissues. They analyzed correlation between the levels of SPAG9 and mRNA of EMT-related genes in endometrial carcinoma tissue by using quantitative real-time PCR...
2016: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/27329669/effect-of-tgf-beta1-on-mmp-timp-and-tgf-beta1-receptors-in-great-saphenous-veins-and-its-significance-on-chronic-venous-insufficiency
#18
Pedro Serralheiro, Elisa Cairrão, Cláudio J Maia, Marina João, Carlos M Costa Almeida, Ignacio Verde
OBJECTIVES: Transforming growth factor-beta1 (TGF-β1) may participate in local chronic inflammatory processes in varicose veins and in venous wall structure modifications through regulation of matrix metalloproteinases (MMP) and their inhibitors (tissue inhibitor of metalloproteinase (TIMP)). The aim of this study was to analyze the effect of TGF-β1 in the vein wall, namely on the gene expression of selected MMP, TIMP and TGF-β1 receptors. METHODS: Healthy vein samples were harvested from eight subjects who underwent coronary bypass graft surgery with great saphenous vein...
June 20, 2016: Phlebology
https://www.readbyqxmd.com/read/27306062/assessment-of-il-17a-il-10-and-tgf-beta1-serum-titers-in-rrms-patients-treated-with-avonex-possible-biomarkers-for-treatment-response
#19
Rodica Bălaşa, Smaranda Maier, Septimiu Voidăzan, Adina Huţanu, Zoltán Bajkó, Anca Moţăţăianu, Brindusa Tilea, Cristina Tiu
Individual response to interferon beta (IFN-β) 1a treatment is heterogeneous in multiple sclerosis (MS). Our objective was to find a connection between serum levels of interleukin (IL)-10, IL-17 and transforming growth factor beta (TGF-β)1 in MS patients treated with IFN-β in order to identify the nonresponders (NR). MATERIAL AND METHODS: We included in the study 32 healthy subjects and 32 MS patients: 10 naive, 10 early treated and 12 late treated with INF-β1a. Serum determination of cytokines and brain MRI were performed at the beginning of the study, after 6 and 12 months...
June 15, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27276822/-experimental-research-of-differentiation-of-human-amniotic-mesenchymal-stem-cells-into-ligament-cells-in-vitro
#20
Ying Jin, Yuwan Li, Chenghao Zhang, Shuhong Wu, Daixiong Cheng, Yi Liu
OBJECTIVE: To discuss whether human amniotic mesenchymal stem cells (hAMSCs) possesses the characteristic of mesenchymal stem cells, and could differentiate into ligament cells in vitro after induction. METHODS: The hAMSCs were separated through enzyme digestion, and the phenotypic characteristics of hAMSCs were tested through flow cytometry. The cells at passage 3 were cultured with L-DMEM/F12 medium containing transforming growth factor beta1 (TGF-beta1) + basic fibroblast growth factor (bFGF) (group A), containing hyaluronic acid (HA) (group B), containing TGF-beta1+bFGF+HA (group C), and simple L-DMEM/F12 medium (group D) as control group...
February 2016: Chinese Journal of Reparative and Reconstructive Surgery
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