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Maria Brüggemann, Arabella Gromes, Mirjam Poss, Doris Schmidt, Niklas Klümper, Yuri Tolkach, Dimo Dietrich, Glen Kristiansen, Stefan C Müller, Jörg Ellinger
Mitochondrial dysfunction is common in cancer and the mitochondrial electron transport chain is often affected in carcinogenesis. To date, little is known about the expression of the ATP synthase subunits in clear cell renal cell carcinoma (ccRCC). The NextBio database was used to determine an expression profile of the ATP synthase subunits based on published microarray studies. We observed down-regulation of 23 out of 29 subunits of the ATP synthase. Differential expression was validated exemplarily for 12 genes (ATP5A1, ATP5B, ATPAF1, ATP5C1, ATP5D, ATP5O, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5I, ATP5S; screening cohort ccRCC n=18 and normal renal tissue n=10) using real-time PCR...
August 2017: Translational Oncology
William J Smiles, Evelyn B Parr, Vernon G Coffey, Orly Lacham-Kaplan, John A Hawley, Donny M Camera
Alcohol ingestion decreases postexercise rates of muscle protein synthesis, but the mechanism(s) (e.g., increased protein breakdown) underlying this observation is unknown. Autophagy is an intracellular "recycling" system required for homeostatic substrate and organelle turnover; its dysregulation may provoke apoptosis and lead to muscle atrophy. We investigated the acute effects of alcohol ingestion on autophagic cell signaling responses to a bout of concurrent (combined resistance- and endurance-based) exercise...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
Jamaji C Nwanaji-Enwerem, Elena Colicino, Letizia Trevisi, Itai Kloog, Allan C Just, Jincheng Shen, Kasey Brennan, Alexandra Dereix, Lifang Hou, Pantel Vokonas, Joel Schwartz, Andrea A Baccarelli
BACKGROUND: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based predictor of chronological age. OBJECTIVE: We examined the relationship of DNAm-age with fine particulate matter (PM2.5), a measure of total inhalable particle mass, and black carbon (BC), a measure of particles from vehicular traffic. METHODS: We used validated spatiotemporal models to generate 1-year PM2...
April 2016: Environmental Epigenetics
Eric M Schauberger, Susan L Ewart, Syed H Arshad, Marianne Huebner, Wilfried Karmaus, John W Holloway, Karen H Friderici, Julie T Ziegler, Hongmei Zhang, Matthew J Rose-Zerilli, Sheila J Barton, Stephen T Holgate, Jeffrey R Kilpatrick, John B Harley, Stephane Lajoie-Kadoch, Isaac T W Harley, Qutayba Hamid, Ramesh J Kurukulaaratchy, Max A Seibold, Pedro C Avila, William Rodriguez-Cintrón, Jose R Rodriguez-Santana, Donglei Hu, Christopher Gignoux, Isabelle Romieu, Stephanie J London, Esteban G Burchard, Carl D Langefeld, Marsha Wills-Karp
BACKGROUND: Asthma is a common disease of children with a complex genetic origin. Understanding the genetic basis of asthma susceptibility will allow disease prediction and risk stratification. OBJECTIVE: We sought to identify asthma susceptibility genes in children. METHODS: A nested case-control genetic association study of children of Caucasian European ancestry from a birth cohort was conducted. Single nucleotide polymorphisms (SNPs, n = 116,024) were genotyped in pools of DNA samples from cohort children with physician-diagnosed asthma (n = 112) and normal controls (n = 165)...
October 2011: Journal of Allergy and Clinical Immunology
Ken Saito, Noritaka Adachi, Hideki Koyama, Masayuki Matsushita
The 2-oxoglutarate and iron dependent dioxygenase family are crucial for cellular adaptation to changes in oxygen concentration. We found that cells with OGFOD1 gene silencing in this family showed resistance to cell death under ischemia, and cDNA microarray analysis of OGFOD1 knockout human cells revealed downregulation of ATPAF1. Although reintroduction of the OGFOD1 wild-type gene to OGFOD1 KO cells restored ATPAF1 mRNA levels, the catalytically inactive OGFOD1 mutants did not. Furthermore, introduction of ATPAF1 gene to OGFOD1 KO cells induced ischemic cell death...
August 4, 2010: FEBS Letters
Andrea Picková, Jan Paul, Vittoria Petruzzella, Josef Houstek
Atp11p (Atpaf1p; F(1)-ATPase assembly factor 1) and Atp12p (Atpaf2p; F(1)-ATPase assembly factor 2) are proteins required for the assembly of beta (F(1)-beta) and alpha (F(1)-alpha) subunits into the mitochondrial ATPase. Here we report about 100 times lower levels of ATPAF1 and ATPAF2 transcripts in relation to the mRNA levels of F(1)-alpha and F(1)-beta in a range of mouse tissues. Quantitative reverse-transcription polymerase chain reaction revealed nearly constant ATPAF1 expression in all tissues in both adult and 5-day-old mice (up to two-fold differences), indicating that ATPAF1 rather behaves like a maintenance gene...
September 11, 2003: FEBS Letters
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