Eric M Schauberger, Susan L Ewart, Syed H Arshad, Marianne Huebner, Wilfried Karmaus, John W Holloway, Karen H Friderici, Julie T Ziegler, Hongmei Zhang, Matthew J Rose-Zerilli, Sheila J Barton, Stephen T Holgate, Jeffrey R Kilpatrick, John B Harley, Stephane Lajoie-Kadoch, Isaac T W Harley, Qutayba Hamid, Ramesh J Kurukulaaratchy, Max A Seibold, Pedro C Avila, William Rodriguez-Cintrón, Jose R Rodriguez-Santana, Donglei Hu, Christopher Gignoux, Isabelle Romieu, Stephanie J London, Esteban G Burchard, Carl D Langefeld, Marsha Wills-Karp
BACKGROUND: Asthma is a common disease of children with a complex genetic origin. Understanding the genetic basis of asthma susceptibility will allow disease prediction and risk stratification. OBJECTIVE: We sought to identify asthma susceptibility genes in children. METHODS: A nested case-control genetic association study of children of Caucasian European ancestry from a birth cohort was conducted. Single nucleotide polymorphisms (SNPs, n = 116,024) were genotyped in pools of DNA samples from cohort children with physician-diagnosed asthma (n = 112) and normal controls (n = 165)...
October 2011: Journal of Allergy and Clinical Immunology