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Amit D Gujar, Hiroko Yano, Albert H Kim
Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20-anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.
May 2016: Molecular & Cellular Oncology
Kamesh Dhamodaran, Murali Subramani, Nallathambi Jeyabalan, Murugeswari Ponnalagu, Priyanka Chevour, Reshma Shetty, Himanshu Matalia, Rohit Shetty, Sabina Evan Prince, Debashish Das
PURPOSE: Limbal epithelial stem cell deficiency is caused by exposure of the cornea to thermal, chemical, or radiation burns or by diseases (aniridia and Stevens-Johnson syndrome). Autologous cell transplantation is a widely used therapeutic modality for restoring the corneal surface in such pathological conditions. Ex vivo cultured limbal, conjunctival, and oral biopsies have been widely used to reconstruct the corneal surface with variable outcomes. Culture characterization of the ex vivo cultured cells would provide insight and clues into the underlying signaling mechanisms that would aid in determining the probable transplantation outcome...
2015: Molecular Vision
Diane D Mao, Amit D Gujar, Tatenda Mahlokozera, Ishita Chen, Yanchun Pan, Jingqin Luo, Taylor Brost, Elizabeth A Thompson, Alice Turski, Eric C Leuthardt, Gavin P Dunn, Michael R Chicoine, Keith M Rich, Joshua L Dowling, Gregory J Zipfel, Ralph G Dacey, Samuel Achilefu, David D Tran, Hiroko Yano, Albert H Kim
Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs...
June 23, 2015: Cell Reports
Christian Ra Regenbrecht, Marc Jung, Hans Lehrach, James Adjaye
BACKGROUND: Genistein is an isoflavonoid present in soybeans that exhibits anti-carcinogenic properties. The issue of genistein as a potential anti-cancer drug has been addressed in some papers, but comprehensive genomic analysis to elucidate the molecular mechanisms underlying the effect elicited by genistein on cancer cells have not been performed on primary cancer cells, but rather on transformed cell lines. In the present study, we treated primary glioblastoma, rhabdomyosarcoma, hepatocellular carcinoma and human embryonic carcinoma cells (NCCIT) with mu-molar concentrations of genistein and assessed mitotic index, cell morphology, global gene expression, and specific cell-cycle regulating genes...
2008: BMC Medical Genomics
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