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Lucas Goedert, Cristiano G Pereira, Jason Roszik, Jessica R Pla├ža, Cibele Cardoso, Guo Chen, Wanleng Deng, Vashisht Gopal Yennu-Nanda, Wilson A Silva, Michael A Davies, Enilza M Espreafico
Previous work identified RMEL3 as a lncRNA with enriched expression in melanoma. Analysis of The Cancer Genome Atlas (TCGA) data confirmed RMEL3 enriched expression in melanoma and demonstrated its association with the presence of BRAFV600E. RMEL3 siRNA-mediated silencing markedly reduced (95%) colony formation in different BRAFV600E melanoma cell lines. Multiple genes of the MAPK and PI3K pathways found to be correlated with RMEL3 in TCGA samples were experimentally confirmed. RMEL3 knockdown led to downregulation of activators or effectors of these pathways, including FGF2, FGF3, DUSP6, ITGB3 and GNG2...
May 4, 2016: Oncotarget
Josane F Sousa, Raul Torrieri, Rodrigo R Silva, Cristiano G Pereira, Valeria Valente, Erico Torrieri, Kamila C Peronni, Waleska Martins, Nair Muto, Guilherme Francisco, Carla Abdo Brohem, Carlos G Carlotti, Silvya S Maria-Engler, Roger Chammas, Enilza M Espreafico
Melanoma is a highly aggressive and therapy resistant tumor for which the identification of specific markers and therapeutic targets is highly desirable. We describe here the development and use of a bioinformatic pipeline tool, made publicly available under the name of EST2TSE, for the in silico detection of candidate genes with tissue-specific expression. Using this tool we mined the human EST (Expressed Sequence Tag) database for sequences derived exclusively from melanoma. We found 29 UniGene clusters of multiple ESTs with the potential to predict novel genes with melanoma-specific expression...
2010: PloS One
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