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Russell I Heigh, Tracy C Yab, William R Taylor, Fareeda T N Hussain, Thomas C Smyrk, Douglas W Mahoney, Michael J Domanico, Barry M Berger, Graham P Lidgard, David A Ahlquist
OBJECTIVES: Precursors to 1/3 of colorectal cancer (CRC), serrated polyps have been under-detected by screening due to their inconspicuous, non-hemorrhagic, and proximal nature. A new multi-target stool DNA test (multi-target sDNA) shows high sensitivity for both CRC and advanced adenomas. Screen detection of serrated polyps by this approach requires further validation. We sought to assess and compare noninvasive detection of sessile serrated polyps (SSP) ≥ 1 cm by sDNA and an occult blood fecal immunochemical test (FIT)...
2014: PloS One
Roberto Flores, Jianxin Shi, Mitchell H Gail, Pawel Gajer, Jacques Ravel, James J Goedert
BACKGROUND: We conducted a pilot study of reproducibility and associations of microbial diversity and composition in faecal microbial DNA. METHODS AND RESULTS: Participants (25 men and 26 women, aged 17-65 years) provided questionnaire data and multiple samples of one stool collected with two Polymedco and two Sarstedt devices preloaded with RNAlater. 16S rRNA genes in each faecal DNA aliquot were amplified, sequenced (Roche/454 Life Sciences) and assigned to taxa...
August 2012: European Journal of Clinical Investigation
Bharathi Vennapusa, Laura De La Cruz, Hemangini Shah, Veronica Michalski, Qian-Yun Zhang
The erythrocyte sedimentation rate (ESR) is a nonspecific indicator of disease activity and is often used by clinicians in assisting diagnosis and follow-up of many inflammatory disorders. The Westergren method is considered the standard method for measuring ESR. Recently, many automated instruments have become available to address laboratory safety and time efficiency. We validated the Streck ESR-Auto Plus instrument (Streck, Omaha, NE) using the Sediplast (Polymedco, Cortlandt Manor, NY) Westergren method as the reference method...
March 2011: American Journal of Clinical Pathology
Lorne I Budman, Wassim Kassouf, Jordan R Steinberg
INTRODUCTION: Bladder cancer is the fourth most common cancer in men and the ninth most common cancer in women in Canada. Early detection of tumours is essential for improved prognosis and long-term survival. The standard method for detection and surveillance is cystoscopy together with urine cytology. Cystoscopy is relatively sensitive but is expensive and invasive. Urinary cytology is a noninvasive method that has poor sensitivity but high specificity; it is relied on for the detection of carcinoma in situ...
June 2008: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Suresh G Shelat, Deborah Chacosky, Susan Shibutani
The erythrocyte sedimentation rate (ESR) is a nonspecific screening test to assess elevations of acute phase proteins that occur in various acute and chronic diseases. The recommended method is based on the Westergren method. Other technologies to measure ESR have been developed, including centrifugation-based methods. We compared a centrifugation method (ESR STAT PLUS, Hema Technologies, Lebanon, NJ) with the current Westergren method (Sediplast ESR system, Polymedco, Cortlandt Manor, NY) at 3 ESR levels (0-20, 21-60, and >60 mm/h) in a pediatric population and found correlation coefficients of r=0...
July 2008: American Journal of Clinical Pathology
Afina S Glas, Daphne Roos, Marije Deutekom, Aeilko H Zwinderman, Patrick M Bossuyt, Karl H Kurth
PURPOSE: We systematically reviewed the available evidence, and obtained and compared summary estimates of the sensitivity and specificity of cytology and the urine based markers bladder tumor antigen, BTA stat (Polymedco, Redmond, Washington), BTA TRAK (Polymedco), NMP22 (Matritech, Cambridge, Massachusetts), telomerase and fibrin degradation product in detecting primary bladder cancer. MATERIALS AND METHODS: Studies on the diagnosis of primary bladder cancer published from 1990 through November 2001 in English and German were retrieved from MEDLINE and EMBASE data bases...
June 2003: Journal of Urology
Karen A Flessland, Helen R Landicho, Kimberlee K Borden, Harry E Prince
Conventional screening for circulating antinuclear antibodies (ANA) is generally performed by immunofluorescent (IF) microscopy with a 1:40 dilution of serum. Intensity of IF staining is then semiquantitated by using twofold serial dilutions, where the highest dilution in which staining intensity equals the endpoint control is expressed as an endpoint titer. The PolyTiter Immunofluorescent Titration system (Polymedco, Inc.) facilitates ANA-IF assay (IFA) testing by relating the intensity of IF staining to reference calibrators (defined in PolyTiter units), providing an endpoint titer directly from a 1:40 dilution...
March 2002: Clinical and Diagnostic Laboratory Immunology
A J Peters, L J Zaneveld, R S Jeyendran
OBJECTIVE: To provide a simple, universally applicable method of quality assurance for sperm counting, thereby reducing intercounting chamber variation. DESIGN: By using a known concentration of latex beads, the sperm:bead ratio can be used to calculate the actual sperm count. MAIN OUTCOME MEASURES: The mean sperm and bead counts were determined in both a Spot-lite hemocytometer (Baxter Diagnostics, McGaw Park, IL) and a Makler chamber (Polymedco Inc...
October 1993: Fertility and Sterility
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