Liuyang Cai, Hengyan Zhu, Qianqian Mou, Po Yee Wong, Linlin Lan, Cherrie W K Ng, Pu Lei, Man Kit Cheung, Daijuanru Wang, Eddy W Y Wong, Eric H L Lau, Zenon W C Yeung, Ronald Lai, Katie Meehan, Sherwood Fung, Kwan Chee A Chan, Vivian W Y Lui, Alfred S L Cheng, Jun Yu, Paul K S Chan, Jason Y K Chan, Zigui Chen
Dysbiosis of the human oral microbiota has been reported to be associated with oral cavity squamous cell carcinoma (OSCC) while the host-microbiota interactions with respect to the potential impact of pathogenic bacteria on host genomic and epigenomic abnormalities remain poorly studied. In this study, the mucosal bacterial community, host genome-wide transcriptome and DNA CpG methylation were simultaneously profiled in tumors and their adjacent normal tissues of OSCC patients. Significant enrichment in the relative abundance of seven bacteria species (Fusobacterium nucleatum, Treponema medium, Peptostreptococcus stomatis, Gemella morbillorum, Catonella morbi, Peptoanaerobacter yurli and Peptococcus simiae) were observed in OSCC tumor microenvironment...
April 8, 2024: NPJ Biofilms and Microbiomes