keyword
https://read.qxmd.com/read/32796823/distinct-fibroblast-subsets-regulate-lacteal-integrity-through-yap-taz-induced-vegf-c-in-intestinal-villi
#21
JOURNAL ARTICLE
Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H Adams, Kari Alitalo, Daesik Lim, Gou Young Koh
Emerging evidence suggests that intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. However, the extent of heterogeneity within the villi stromal compartment and how IntSCs regulate the structure and function of specialized intestinal lymphatic capillary called lacteal remain elusive. Here we show that selective hyperactivation or depletion of YAP/TAZ in PDGFRβ+ IntSCs leads to lacteal sprouting or regression with junctional disintegration and impaired dietary fat uptake...
August 14, 2020: Nature Communications
https://read.qxmd.com/read/32765055/the-interaction-between-spinal-pdgfr%C3%AE-and-%C3%AE-opioid-receptor-in-the-activation-of-microglia-in-morphine-tolerant-rats
#22
JOURNAL ARTICLE
Zheng Li, Xiaoqian Jia, Xiaoling Peng, Feng Gao
Purpose: Opioid tolerance remains a challenging problem, which limits prolonged drug usage in clinics. Previous studies have shown a fundamental role of platelet-derived growth factor receptor β submit (PDGFRβ) in morphine tolerance. The aim of this study was to investigate the mechanisms of spinal PDGFRβ activation in morphine tolerance. Methods: Rats were treated with morphine for 7 days and the effect of drug was evaluated by tail-flick latency test. By using Western blot and real-time PCR, the interaction between μ opioid receptor (MOR) and PDGFRβ in microglia activation, as well as related signaling pathways during morphine tolerance were investigated...
2020: Journal of Pain Research
https://read.qxmd.com/read/32764293/attenuation-of-flightless-i-increases-human-pericyte-proliferation-migration-and-angiogenic-functions-and-improves-healing-in-murine-diabetic-wounds
#23
JOURNAL ARTICLE
Hannah M Thomas, Parinaz Ahangar, Benjamin R Hofma, Xanthe L Strudwick, Robert Fitridge, Stuart J Mills, Allison J Cowin
Pericytes are peri-vascular mural cells which have an important role in the homeostatic regulation of inflammatory and angiogenic processes. Flightless I (Flii) is a cytoskeletal protein involved in regulating cellular functions, but its involvement in pericyte activities during wound healing is unknown. Exacerbated inflammation and reduced angiogenesis are hallmarks of impaired diabetic healing responses, and strategies aimed at regulating these processes are vital for improving healing outcomes. To determine the effect of altering Flii expression on pericyte function, in vitro and in vivo studies were performed to assess the effect on healing, inflammation and angiogenesis in diabetic wounds...
August 5, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32756477/uveal-melanoma-cells-elicit-retinal-pericyte-phenotypical-and-biochemical-changes-in-an-in-vitro-model-of-coculture
#24
JOURNAL ARTICLE
Carmelina Daniela Anfuso, Anna Longo, Alfio Distefano, Angela Maria Amorini, Mario Salmeri, Guido Zanghì, Cesarina Giallongo, Giovanni Giurdanella, Gabriella Lupo
Vascular pericytes are an important cellular component in the tumor microenvironment, however, their role in supporting cancer invasion is poorly understood. We hypothesized that PDGF-BB could be involved in the transition of human retinal pericytes (HRPC) in cancer-activated fibroblasts (CAF), induced by the 92.1 uveal melanoma (UM) cell line. In our model system, HRPC were conditioned by co-culturing with 92.1UM for 6 days (cHRPC), in the presence or absence of imatinib, to block PDGF receptor-β (PDGFRβ)...
August 3, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32751200/novel-histone-based-dna-carrier-targeting-cancer-associated-fibroblasts
#25
JOURNAL ARTICLE
Alexey Kuzmich, Olga Rakitina, Dmitry Didych, Victor Potapov, Marina Zinovyeva, Irina Alekseenko, Eugene Sverdlov
Nuclear proteins, like histone H2A, are promising non-viral carriers for gene delivery since they are biocompatible, biodegradable, bear intrinsic nuclear localization signal, and are easy to modify. The addition of surface-protein-binding ligand to histone H2A may increase its DNA delivery efficiency. Tumor microenvironment (TME) is a promising target for gene therapy since its surface protein repertoire is more stable than that of cancer cells. Cancer-associated fibroblasts (CAFs) are important components of TME, and one of their surface markers is beta-type platelet-derived growth factor receptor (PDGFRβ)...
July 29, 2020: Polymers
https://read.qxmd.com/read/32737287/vegfr2-signaling-drives-meningeal-vascular-regeneration-upon-head-injury
#26
JOURNAL ARTICLE
Bong Ihn Koh, Hyuek Jong Lee, Pil Ae Kwak, Myung Jin Yang, Ju-Hee Kim, Hyung-Seok Kim, Gou Young Koh, Injune Kim
Upon severe head injury (HI), blood vessels of the meninges and brain parenchyma are inevitably damaged. While limited vascular regeneration of the injured brain has been studied extensively, our understanding of meningeal vascular regeneration following head injury is quite limited. Here, we identify key pathways governing meningeal vascular regeneration following HI. Rapid and complete vascular regeneration in the meninges is predominantly driven by VEGFR2 signaling. Substantial increase of VEGFR2 is observed in both human patients and mouse models of HI, and endothelial cell-specific deletion of Vegfr2 in the latter inhibits meningeal vascular regeneration...
July 31, 2020: Nature Communications
https://read.qxmd.com/read/32736577/the-role-of-the-oncostatin-m-osm-receptor-%C3%AE-axis-in-activating-dermal-microvascular-endothelial-cells-in-systemic-sclerosis
#27
JOURNAL ARTICLE
G Marden, Q Wan, J Wilks, K Nevin, M Feeney, N Wisniacki, M Trojanowski, A Bujor, L Stawski, M Trojanowska
BACKGROUND: Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a significant player in various stages of fibrosis. The goal of this study was to assess the contribution of the OSM/OSMRβ pathway to endothelial cell (EC) injury and activation in SSc. METHODS: IHC and IF were used to assess the distribution of OSM and OSMRβ in SSc (n = 14) and healthy control (n = 7) skin biopsies...
July 31, 2020: Arthritis Research & Therapy
https://read.qxmd.com/read/32736067/life-long-dietary-pesticides-cocktail-induces-astrogliosis-along-with-behavioral-adaptations-and-activates-p450-metabolic-pathways
#28
JOURNAL ARTICLE
Wendy Klement, Fabiana Oliviero, Giuseppe Gangarossa, Emma Zub, Frederic De Bock, Isabel Forner, Marine Blaquiere, Frederic Lasserre, Jean-Marc Pascussi, Tangui Maurice, Etienne Audinat, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Laila Mselli-Lakhal, Nicola Marchi
Exposure to environmental contaminants is a public health concern. However, pre-clinical studies examining the impact of pesticides at low-dose and their long-term consequences are uncommon. Here, C57BL6/j male and female mice were daily fed from weaning and up to 12 months, corresponding to early-childhood into middle-age in humans, using chow pellets containing a cocktail of pesticides and exposing them to the tolerable daily intake level for each pesticide. We found that 12 months of dietary exposure to pesticides was associated with a moderate astrogliosis in the hippocampus...
July 28, 2020: Neuroscience
https://read.qxmd.com/read/32732288/tgf%C3%AE-acts-through-pdgfr%C3%AE-to-activate-mtorc1-via-the-akt-pras40-axis-and-causes-glomerular-mesangial-cell-hypertrophy-and-matrix-protein-expression
#29
JOURNAL ARTICLE
Soumya Maity, Falguni Das, Balakuntalam S Kasinath, Nandini Ghosh-Choudhury, Goutam Ghosh Choudhury
Interaction of transforming growth factor-β (TGFβ)-induced canonical signaling with the noncanonical kinase cascades regulates glomerular hypertrophy and matrix protein deposition, which are early features of glomerulosclerosis. However, the specific target downstream of the TGFβ receptor involved in the noncanonical signaling is unknown. Here, we show that TGFβ increased the catalytic loop phosphorylation of platelet-derived growth factor receptor β (PDGFRβ), a receptor tyrosine kinase expressed abundantly in glomerular mesangial cells...
October 16, 2020: Journal of Biological Chemistry
https://read.qxmd.com/read/32709869/therapeutic-paradigm-of-dual-targeting-vegf-and-pdgf-for-effectively-treating-fgf-2-off-target-tumors
#30
JOURNAL ARTICLE
Kayoko Hosaka, Yunlong Yang, Takahiro Seki, Qiqiao Du, Xu Jing, Xingkang He, Jieyu Wu, Yin Zhang, Hiromasa Morikawa, Masaki Nakamura, Martin Scherzer, Xiaoting Sun, Yuanfu Xu, Tao Cheng, Xuri Li, Xialin Liu, Qi Li, Yizhi Liu, An Hong, Yuguo Chen, Yihai Cao
FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating FGF-2+ tumors are unavailable. Here we show that FGF-2 modulates tumor vessels by recruiting NG2+ pricytes onto tumor microvessels through a PDGFRβ-dependent mechanism. FGF-2+ tumors are intrinsically resistant to clinically available drugs targeting VEGF and PDGF. Surprisingly, dual targeting the VEGF and PDGF signaling produces a superior antitumor effect in FGF-2+ breast cancer and fibrosarcoma models...
July 24, 2020: Nature Communications
https://read.qxmd.com/read/32699964/stromal-cell-derived-factor-1-sdf1-attenuates-platelet-derived-growth-factor-b-pdgf-b-induced-vascular-remodeling-for-adipose-tissue-expansion-in-obesity
#31
JOURNAL ARTICLE
Eri Watanabe, Tsutomu Wada, Akira Okekawa, Fuka Kitamura, Go Komatsu, Yasuhiro Onogi, Seiji Yamamoto, Masakiyo Sasahara, Munehiro Kitada, Daisuke Koya, Hiroshi Tsuneki, Toshiyasu Sasaoka
Platelet-derived growth factor-B (PDGF-B) is a main factor to promote adipose tissue angiogenesis, which is responsible for the tissue expansion in obesity. In this process, PDGF-B induces the dissociation of pericytes from blood vessels; however, its regulatory mechanism remains unclear. In the present study, we found that stromal cell-derived factor 1 (SDF1) plays an essential role in this regulatory mechanism. SDF1 mRNA was increased in epididymal white adipose tissue (eWAT) of obese mice. Ex vivo pharmacological analyses using cultured adipose tissue demonstrated that physiological concentrations (1-100 pg/mL) of SDF1 inhibited the PDGF-B-induced pericyte dissociation from vessels via two cognate SDF1 receptors, CXCR4 and CXCR7...
July 22, 2020: Angiogenesis
https://read.qxmd.com/read/32691170/gint4-t-modified-dna-tetrahedrons-loaded-with-doxorubicin-inhibits-glioma-cell-proliferation-by-targeting-pdgfr%C3%AE
#32
JOURNAL ARTICLE
Feng Wang, Yanghao Zhou, Si Cheng, Jinhe Lou, Xiang Zhang, Qiuguang He, Ning Huang, Yuan Cheng
Glioma is one of the deadliest intrinsic brain tumours due to its invasive growth. The effect of glioma treatment is poor because of the presence of the blood-brain barrier and blood tumour barrier and insufficient drug targeting. DNA tetrahedrons (TDN) show great potential for drug delivery and may be a novel therapeutic strategy for glioma. In this study, we used TDN to deliver doxorubicin (DOX) for the glioma therapy. Gint4.T, an aptamer that could recognize platelet-derived growth factor receptor β on tumour cell, was used to modify TDN (Apt-TDN) for targeted drug delivery...
July 20, 2020: Nanoscale Research Letters
https://read.qxmd.com/read/32683952/knockout-of-sulfatase-2-is-associated-with-decreased-steatohepatitis-and-fibrosis-in-a-mouse-model-of-nonalcoholic-fatty-liver-disease
#33
JOURNAL ARTICLE
Tae Hyo Kim, Bubu A Banini, Faizal Z Asumda, Nellie A Campbell, Chunling Hu, Catherine D Moser, Abdirashid M Shire, Shaoshan Han, Chenchao Ma, Anuradha Krishnan, Taofic Mounajjed, Thomas A White, Gregory J Gores, Nathan K LeBrasseur, Michael P Charlton, Lewis Rowland Roberts
Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes. We used a murine model of diet-induced steatohepatitis to assess the effect of SULF2 down-regulation on the development of nonalcoholic steatohepatitis (NASH) and liver fibrosis. Wildtype B6;129 mice (WT) and Sulf2-knockout B6;129P2-SULF2Gt(PST111)Byg mice (Sulf2-KO) were fed a fast food diet (FFD) rich in saturated fats, cholesterol and fructose or a standard chow diet (SC) ad libitum for 9 months...
July 20, 2020: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/32647861/periostin-is-expressed-by-pericytes-and-is-crucial-for-angiogenesis-in-glioma
#34
JOURNAL ARTICLE
Karin Huizer, Changbin Zhu, Ihsan Chirifi, Bart Krist, Denise Zorgman, Marcel van der Weiden, Thierry P P van den Bosch, Jasper Dumas, Caroline Cheng, Johan M Kros, Dana A Mustafa
The expression of the matricellular protein periostin has been associated with glioma progression. In previous work we found an association of periostin with glioma angiogenesis. Here, we screen gliomas for POSTN expression and identify the cells that express periostin in human gliomas. In addition, we study the role of periostin in an in vitro model for angiogenesis. The expression of periostin was investigated by RT-PCR and by immunohistochemistry. In addition, we used double labeling and in situ RNA techniques to identify the expressing cells...
July 10, 2020: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/32647179/tensile-force-induced-pdgf-bb-pdgfr%C3%AE-signals-in-periodontal-ligament-fibroblasts-activate-jak2-stat3-for-orthodontic-tooth-movement
#35
JOURNAL ARTICLE
Yuqin Jin, Liang Ding, Zhuang Ding, Yong Fu, Yuxian Song, Yue Jing, Qiang Li, Jianyun Zhang, Yanhong Ni, Qingang Hu
Orthodontic force-induced osteogenic differentiation and bone formation at tension side play a pivotal role in orthodontic tooth movement (OTM). Platelet-derived growth factor-BB (PDGF-BB) is a clinically proven growth factor during bone regeneration process with unclear mechanisms. Fibroblasts in periodontal ligament (PDL) are considered to be mechanosensitive under orthodontic force. Thus, we established OTM model to investigate the correlation between PDGF-BB and fibroblasts during bone regeneration at tension side...
July 9, 2020: Scientific Reports
https://read.qxmd.com/read/32642001/erratum-specific-targeting-of-pdgfr%C3%AE-in-the-stroma-inhibits-growth-and-angiogenesis-in-tumors-with-high-pdgf-bb-expression-erratum
#36
Maria Tsioumpekou, Sara I Cunha, Haisha Ma, Aive Åhgren, Jessica Cedervall, Anna-Karin Olsson, Carl-Henrik Heldin, Johan Lennartsson
[This corrects the article DOI: 10.7150/thno.37851.].
2020: Theranostics
https://read.qxmd.com/read/32634060/long-noncoding-rna-tykril-plays-a-role-in-pulmonary-hypertension-via-the-p53-mediated-regulation-of-pdgfr%C3%AE
#37
JOURNAL ARTICLE
Christoph M Zehendner, Chanil Valasarajan, Astrid Werner, Jes-Niels Boeckel, Florian C Bischoff, David John, Tyler Weirick, Simone F Glaser, Oliver Rossbach, Nicolas Jaé, Shemsi Demolli, Fatemeh Khassafi, Ke Yuan, Vinicio A de Jesus Perez, Katharina M Michalik, Wei Chen, Werner Seeger, Andreas Guenther, Roxana M Wasnick, Shizuka Uchida, Andreas M Zeiher, Stefanie Dimmeler, Soni S Pullamsetti
Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored. Objectives: To elucidate the role of TYKRIL (tyrosine kinase receptor-inducing lncRNA) as a regulator of p53/ PDGFRβ (platelet-derived growth factor receptor β) signaling pathway and to investigate its role in PAH. Methods: Pericytes and pulmonary arterial smooth muscle cells exposed to hypoxia and derived from patients with idiopathic PAH were analyzed with RNA sequencing...
November 15, 2020: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/32613760/engineered-perineural-vascular-plexus-for-modeling-developmental-toxicity
#38
JOURNAL ARTICLE
Gaurav Kaushik, Kartik Gupta, Victoria Harms, Elizabeth Torr, Jonathan Evans, Hunter J Johnson, Cheryl Soref, Suehelay Acevedo-Acevedo, Jessica Antosiewicz-Bourget, Daniel Mamott, Peyton Uhl, Brian P Johnson, Sean P Palecek, David J Beebe, James A Thomson, William T Daly, William L Murphy
There is a vital need to develop in vitro models of the developing human brain to recapitulate the biological effects that toxic compounds have on the brain. To model perineural vascular plexus (PNVP) in vitro, which is a key stage in embryonic development, human embryonic stem cells (hESC)-derived endothelial cells (ECs), neural progenitor cells, and microglia (MG) with primary pericytes (PCs) in synthetic hydrogels in a custom-designed microfluidics device are cocultured. The formation of a vascular plexus that includes networks of ECs (CD31+, VE-cadherin+), MG (IBA1+), and PCs (PDGFRβ+), and an overlying neuronal layer that includes differentiated neuronal cells (βIII Tubulin+, GFAP+) and radial glia (Nestin+, Notch2NL+), are characterized...
July 1, 2020: Advanced Healthcare Materials
https://read.qxmd.com/read/32613162/cell-populations-and-muscle-fiber-morphology-associated-with-acute-and-chronic-muscle-degeneration-in-lumbar-spine-pathology
#39
JOURNAL ARTICLE
Bahar Shahidi, Michael C Gibbons, Mary Esparza, Vinko Zlomislic, Richard Todd Allen, Steven R Garfin, Samuel R Ward
Many chronic musculoskeletal conditions are associated with loss of muscle volume and quality, resulting in functional decline. While atrophy has long been implicated as the mechanism of muscle loss in these conditions, recent evidence has emerged demonstrating a degenerative phenotype of muscle loss consisting of disrupted muscle fiber membranes, infiltration of cells into muscle fibers, and as previously describer, possible replacement of muscle fibers by adipose tissue. Here, we use human lumbar spine pathology as a model system to provide a more comprehensive analysis of the morphological features of this mode of muscle loss between early and late stages of disease, including an analysis of the cell populations found in paraspinal muscle biopsies from humans with acute vs chronic lumbar spine pathology...
June 2020: JOR Spine
https://read.qxmd.com/read/32606981/anlotinib-suppresses-colorectal-cancer-proliferation-and-angiogenesis-via-inhibition-of-akt-erk-signaling-cascade
#40
JOURNAL ARTICLE
Qian Yang, Laichao Ni, Saber Imani, Zhangqiang Xiang, Rui Hai, Ruilin Ding, Shaozhi Fu, Jing Bo Wu, Qinglian Wen
Background: Anlotinib is a highly potent multi-target tyrosine kinase inhibitor, with very good anti-tumor activity against a variety of solid tumors. However, its effect on colorectal cancer (CRC) is not yet clearly understood. The objective of this study was to investigate the anti-tumor effect and underlying mechanism of anlotinib in the pathogenesis of CRC. Materials and Methods: Effects of anlotinib on CT26 cells proliferation and microvessel formation in endothelial cells were determined by MTT assay and tube formation assay...
2020: Cancer Management and Research
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