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https://www.readbyqxmd.com/read/29182023/pdgfr%C3%AE-specific-affibody-directed-delivery-of-a-photosensitizer-ir700-is-efficient-for-vascular-targeted-photodynamic-therapy-of-colorectal-cancer
#1
Qiuxiao Shi, Ze Tao, Hao Yang, Qing Fan, Danfeng Wei, Lin Wan, Xiaofeng Lu
Vascular-targeted photodynamic therapy (PDT) is an important strategy for cancer therapy. Conventional vascular-targeted PDT has been achieved by passive photosensitizer (PS) delivery, which involves a high risk of adverse effects. Active PS delivery is urgently required for vascular-targeted PDT. Although endothelial cells and pericytes are major cellular components of tumor blood vessels, little attention has been paid to pericyte-targeted PDT for cancer therapy. PDGFRβ is abundantly expressed in the pericytes of various tumors...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29180757/discovery-of-high-affinity-pdgf-vegfr-interactions-redefining-rtk-dynamics
#2
Spencer B Mamer, Si Chen, Jared C Weddell, Alexandra Palasz, Ashley Wittenkeller, Manu Kumar, P I Imoukhuede
Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, e.g., VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF-PDGFRs binding challenges this paradigm and calls for investigation of other ligand-receptor binding possibilities. We utilized surface plasmon resonance to identify and measure PDGF-to-VEGFR binding rates, establishing cut-offs for binding and non-binding interactions. We quantified the kinetics of the recent VEGF-A:PDGFRβ interaction for the first time with KD = 340 pM...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166712/-effects-of-endostatin-pretreatment-on-fibrosis-of-human-skin-fibroblasts-and-the-mechanisms
#3
H T Ren, Y Li, S D Wang, C M Han
Objective: To explore the effects of endostatin pretreatment on fibrosis of human skin fibroblasts and the mechanisms. Methods: Human skin fibroblasts were routinely cultured in vitro, and then the cells of passage 3 to 5 were used in the following experiments. The cells were divided into blank control, endostatin, platelet-derived growth factor-BB (PDGF-BB), endostatin+ PDGF-BB, transforming growth factor-β(1) (TGF-β(1)), and endostatin+ TGF-β(1) groups according to the random number table, with 3 wells in each group...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29158445/pdgfr%C3%AE-pdgfr%C3%AE-signaling-balance-modulates-progenitor-cell-differentiation-into-white-and-beige-adipocytes
#4
Zhanguo Gao, Alexes C Daquinag, Fei Su, Brad Snyder, Mikhail G Kolonin
Relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose tissue function have remained unclear. Here, by defining the developmental timing of PDGFRα and PDGFRβ expression in mouse subcutaneous and visceral adipose depots, we uncover depot-specificity of preadipocyte delineation. We demonstrate that PDGFRα expression precedes PDGFRβ expression in all subcutaneous but only in a fraction of visceral adipose stromal cells...
November 20, 2017: Development
https://www.readbyqxmd.com/read/29152075/a-novel-multikinase-inhibitor-r8-exhibits-potent-inhibition-on-cancer-cells-through-both-apoptosis-and-autophagic-cell-death
#5
Yuqiong Xie, Chunchun Li, Yali Huang, Zhenyu Jia, Jiang Cao
Chemotherapy is an important treatment for cancer patients, especially for those with unresectable lesions. Targeted therapy of cancer by specific inhibition of aberrant tyrosine kinase activities in cancer cells with chemically synthesized tyrosine kinase inhibitors (TKIs), shows better responses while less side effects than traditional chemotherapeutic drugs. It is common that cancer cells often exhibit deregulation of several tyrosine kinases simultaneously, multikinase TKIs (MKIs) therefore have greater advantages over single-target TKIs...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29144234/lrp1-integrates-murine-macrophage-cholesterol-homeostasis-and-inflammatory-responses-in-atherosclerosis
#6
Xunde Xian, Yinyuan Ding, Marco Dieckmann, Li Zhou, Florian Plattner, Mingxia Liu, John S Parks, Robert E Hammer, Philippe Boucher, Shirling Tsai, Joachim Herz
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor with diverse physiological roles, ranging from cellular uptake of lipoproteins and other cargo by endocytosis to sensor of the extracellular environment and integrator of a wide range of signaling mechanisms. As a chylomicron remnant receptor, LRP1 controls systemic lipid metabolism in concert with the LDL receptor in the liver, whereas in smooth muscle cells (SMC) LRP1 functions as a co-receptor for TGFβ and PDGFRβ in reverse cholesterol transport and the maintenance of vascular wall integrity...
November 16, 2017: ELife
https://www.readbyqxmd.com/read/29131001/atorvastatin-calcium-inhibits-pdgf-%C3%AE-%C3%AE-induced-proliferation-and-migration-of-vsmcs-through-the-g0-g1-cell-cycle-arrest-and-suppression-of-activated-pdgfr%C3%AE-pi3k-akt-signaling-cascade
#7
Shuang Chen, Siyuan Dong, Zhao Li, Xiaofan Guo, Naijin Zhang, Bo Yu, Yingxian Sun
BACKGROUND/AIMS: Abnormal proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of vascular lesions, such as atherosclerosis and restenosis. PDGF-ββ, an isoform of PDGF (platelet-derived growth factor), has been demonstrated to induce proliferation and migration of VSMCs. Atorvastatin calcium, a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has favorable protective effects on VSMCs. This study examined the effects of atorvastatin calcium on the proliferation and migration of PDGF-ββ-treated VSMCs, as well as its underlying mechanisms...
November 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29119737/endostatin-inhibits-fibrosis-by-modulating-the-pdgfr-erk-signal-pathway-an-in-vitro-study
#8
Yuan Li, Hai-Tao Ren
Accumulating evidence indicates that endostatin inhibits fibrosis. However, the mechanism is yet to be clarified. The aim of this study is to evaluate the effect of endostatin on platelet-derived growth factor-BB (PDGF-BB)- or transforming growth factor β1 (TGF-β1)-induced fibrosis in cultured human skin fibroblasts, and to further examine the molecular mechanisms involved. Human dermal fibroblasts were cultured in Dulbecco's modified Eagle's medium (DMEM) and serum-starved for 48 h before treatment. Cells were grouped as follows: "PDGF-BB", "PDGF-BB+ endostatin", "TGF-β1", "TGF-β1+endostatin", "endostatin", and "blank control"...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29093274/notch3-regulates-stem-to-mural-cell-differentiation-in-infantile-hemangioma
#9
Andrew K Edwards, Kyle Glithero, Peter Grzesik, Alison A Kitajewski, Naikhoba Co Munabi, Krista Hardy, Qian Kun Tan, Michael Schonning, Thaned Kangsamaksin, Jan K Kitajewski, Carrie J Shawber, June K Wu
Infantile hemangioma (IH) is a vascular tumor that begins with rapid vascular proliferation shortly after birth, followed by vascular involution in early childhood. We have found that NOTCH3, a critical regulator of mural cell differentiation and maturation, is expressed in hemangioma stem cells (HemSCs), suggesting that NOTCH3 may function in HemSC-to-mural cell differentiation and pathological vessel stabilization. Here, we demonstrate that NOTCH3 is expressed in NG2+PDGFRβ+ perivascular HemSCs and CD31+GLUT1+ hemangioma endothelial cells (HemECs) in proliferating IHs and becomes mostly restricted to the αSMA+NG2loPDGFRβlo mural cells in involuting IHs...
November 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/29089036/uric-acid-causes-kidney-injury-through-inducing-fibroblast-expansion-endothelin-1-expression-and-inflammation
#10
Muhammad Mansyur Romi, Nur Arfian, Untung Tranggono, Wiwit Ananda Wahyu Setyaningsih, Dwi Cahyani Ratna Sari
BACKGROUND: Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage. Endothelin-1 (ET-1) is a well-known profibrotic factor in the kidney and is associated with fibroblast expansion. We examined the role of hyperuricemia conditions in causing elevation of ET-1 expression and kidney injury. METHODS: Hyperuricemia was induced in mice using daily intraperitoneal injection of uric acid 125 mg/Kg body weight...
October 31, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29065778/upregulation-of-vegfr1-in-a-rat-model-of-esophagogastric-anastomotic-healing
#11
Laura Christina Landes, Daniel Drescher, Evangelos Tagkalos, Peter P Grimminger, René Thieme, Boris Jansen-Winkeln, Hauke Lang, Ines Gockel
INTRODUCTION: Anastomotic leakage after gastrointestinal surgery is a significant cause of morbidity and mortality. Esophagogastric and colorectal anastomoses are vulnerable to leakage. Extended knowledge of growth factors and their receptors is needed to understand anatomic healing. METHODS: The expression pattern of vascular growth factor receptor (VEGFR1-3), epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFRα/β) and keratinocyte growth factor receptor (KGFR) were analyzed by semiquantitative-PCR in the rat intestinal tract and in esophagogastric anastomosis 5d after surgery...
October 25, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29061963/%C3%AE-v-integrins-on-mesenchymal-cells-regulate-skeletal-and-cardiac-muscle-fibrosis
#12
I R Murray, Z N Gonzalez, J Baily, R Dobie, R J Wallace, A C Mackinnon, J R Smith, S N Greenhalgh, A I Thompson, K P Conroy, D W Griggs, P G Ruminski, G A Gray, M Singh, M A Campbell, T J Kendall, J Dai, Y Li, J P Iredale, H Simpson, J Huard, B Péault, N C Henderson
Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ(+) cells contribute to skeletal muscle and cardiac fibrosis via a mechanism that depends on αv integrins. Mice in which αv integrin is depleted in PDGFRβ(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis. In addition, a small-molecule inhibitor of αv integrins attenuates fibrosis, even when pre-established, in both skeletal and cardiac muscle, and improves skeletal muscle function...
October 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29039563/inhibition-of-human-lung-cancer-proliferation-through-targeting-stromal-fibroblasts-by-dihydromyricetin
#13
Kai-Jie Fan, Bo Yang, Yang Liu, Xiao-Dong Tian, Bo Wang
In the present study, the effects of dihydromyricetin on the proliferative potential of fibroblasts and lung carcinoma cells were investigated. Markedly higher expression levels of smooth muscle actin and platelet derived growth factors (PDGFs) were observed in the fibroblasts using reverse transcription-polymerase chain reaction analysis. The expression levels of PDGF-A and PDGF-B were also higher in the lung cancer cells. Western blot analysis revealed higher expression levels of the receptor for platelet-derived growth factor (PDGFRβ) in the lysates from fibroblasts obtained from normal tissues and carcinoma tissues...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29016864/loss-of-host-derived-osteopontin-creates-a-glioblastoma-promoting-microenvironment
#14
Frank Szulzewsky, Nina Schwendinger, Dilansu Güneykaya, Patrick J Cimino, Dolores Hambardzumyan, Michael Synowitz, Eric C Holland, Helmut Kettenmann
Background: Microglia and periphery-derived monocytes infiltrate human and mouse glioblastoma and their density is positively correlated with malignancy. Using microarray and RNA sequencing we have previously shown that glioblastoma-associated microglia/monocytes (GAMs) express osteopontin/SPP1. Methods: We used qRT-PCR, immunofluorescence stainings, western-blot, and flow-cytometry to identify the various sources of osteopontin (OPN) expression in human and mouse glioblastoma...
August 26, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28970051/pdgf-receptors-in-tumor-stroma-biological-effects-and-associations-with-prognosis-and-response-to-treatment
#15
Arne Östman
Platelet-derived growth factor (PDGF) ligands and their receptors (PDGFRα and PDGFRβ) regulate mesenchymal cells, such as fibroblasts and pericytes. These cells are important constituents of tumor stroma where they impact on tumor growth, metastasis and drug response. Studies in model systems have demonstrated ability of the PDGF system to regulate the tumor-stimulatory effects of fibroblasts, as well as their ability to promote cancer cell migration and invasion. Animal studies imply PDGFR-signaling as a regulator of tumor drug uptake...
September 29, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28963969/intercellular-resistance-to-braf-inhibition-can-be-mediated-by-extracellular-vesicle-associated-pdgfr%C3%AE
#16
Laura J Vella, Andreas Behren, Bradley Coleman, David W Greening, Andrew F Hill, Jonathan Cebon
Treatment of BRAF mutant melanoma with kinase inhibitors has been associated with rapid tumor regression; however, this clinical benefit is short-lived, and most patients relapse. A number of studies suggest that the extracellular environment promotes BRAF inhibitor resistance and tumor progression. Extracellular vesicles, such as exosomes, are functional mediators in the extracellular environment. They are small vesicles known to carry a concentrated group of functional cargo and serve as intercellular communicators not only locally but also systemically...
November 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28963640/development-of-response-classifier-for-vascular-endothelial-growth-factor-receptor-vegfr-tyrosine-kinase-inhibitor-tki-in-metastatic-renal-cell-carcinoma
#17
Heounjeong Go, Mun Jung Kang, Pil-Jong Kim, Jae-Lyun Lee, Ji Y Park, Ja-Min Park, Jae Y Ro, Yong Mee Cho
Vascular endothelial growth factor receptor (VEGFR)-targeted therapy improved the outcome of metastatic renal cell carcinoma (mRCC) patients. However, a prediction of the response to VEGFR-tyrosine kinase inhibitor (TKI) remains to be elucidated. We aimed to develop a classifier for VEGFR-TKI responsiveness in mRCC patients. Among 101 mRCC patients, ones with complete response, partial response, or ≥24 weeks stable disease in response to VEGFR-TKI treatment were defined as clinical benefit group, whereas patients with <24 weeks stable disease or progressive disease were classified as clinical non-benefit group...
September 29, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28952224/increased-expression-of-platelet-derived-growth-factor-receptor-%C3%AE-on-trephine-biopsies-correlates-with-advanced-myeloma
#18
Antonios Bilalis, Evi Pouliou, Maria Roussou, Asimina Papanikolaou, Anna Tassidou, Theophanis Economopoulos, Evangelos Terpos
PURPOSE: Multiple myeloma (MM), a major cause of cancer mortality, is considered the second most frequent haematological malignancy in Europe. Angiogenesis is a multifactorial process that drives the tumorigenesis in solid tumors and in MM. The platelet derived growth factor (PDGF) receptors are cell surface tyrosine kinase receptors and play an important role in angiogenesis, cancer cell proliferation and dissemination. Few studies have been conducted regarding the expression of PDGF receptors and the correlation with clinical-pathological parameters and prognosis in MM...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28952221/research-of-the-effect-of-mir-663-on-the-proliferation-of-prostate-cancer-cells-and-the-correlations-of-mir-663-with-pathological-grade-and-clinical-stage
#19
Shifeng Wang, Jingsong Liu, Changming Li, Xue Yang
PURPOSE: To investigate the effect of miR-663 on the proliferation of prostate cancer (PCa) cells, and the correlations of miR-663 with pathological grade and clinical stage. METHODS: PC-3 and DU-145 PCa cell lines were transfected by artificially synthesized miR-663 and its antisense plasmid, and cell proliferation was assessed using 5-ethynyl-2'-deoxyuridine and methyl thiazolyl tetrazolium assays. Real-time polymerase chain reaction (RT-PCR) was applied to assess the expression of miR-663 in tissue samples collected from 46 patients who were diagnosed with PCa but did not receive any treatment...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28951244/tyrosines-740-751-of-pdgfr%C3%AE-contribute-to-the-activation-of-akt-hif1%C3%AE-tgf%C3%AE-nexus-to-drive-high-glucose-induced-glomerular-mesangial-cell-hypertrophy
#20
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Glomerular mesangial cell hypertrophy contributes to the complications of diabetic nephropathy. The mechanism by which high glucose induces mesangial cell hypertrophy is poorly understood. Here we explored the role of the platelet-derived growth factor receptor-β (PDGFRβ) tyrosine kinase in driving the high glucose-induced mesangial cell hypertrophy. We show that high glucose stimulates the association of the PDGFRβ with PI 3 kinase leading to tyrosine phosphorylation of the latter. High glucose-induced Akt kinase activation was also dependent upon PDGFRβ and its tyrosine phosphorylation at 740/751 residues...
September 23, 2017: Cellular Signalling
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