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Malignant pleural effusion

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https://www.readbyqxmd.com/read/29472801/diagnostic-value-of-tumour-markers-in-pleural-effusions
#1
Darian Volarić, Veljko Flego, Gordana Žauhar, Ljiljana Bulat-Kardum
Introduction: We investigated whether tumour markers carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cancer antigen 125 (CA-125), and cytokeratin 19 fragment (CYFRA 21-1) in pleural effusions and serum can be used to distinguish pleural effusion aetiology. Materials and methods: During the first thoracentesis, we measured pleural fluid and serum tumour marker concentrations and calculated the pleural fluid/serum ratio for patients diagnosed with pleural effusion, using electrochemiluminescence immunoassays...
February 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29470536/metastatic-site-as-a-predictor-of-nivolumab-efficacy-in-patients-with-advanced-non-small-cell-lung-cancer-a-retrospective-multicenter-trial
#2
Motohiro Tamiya, Akihiro Tamiya, Takako Inoue, Madoka Kimura, Kei Kunimasa, Kenji Nakahama, Yoshihiko Taniguchi, Takayuki Shiroyama, Shun-Ichi Isa, Kazumi Nishino, Toru Kumagai, Hidekazu Suzuki, Tomonori Hirashima, Shinji Atagi, Fumio Imamura
PURPOSE: To conduct a retrospective multicenter trial to determine the significance of metastatic site as a predictor of nivolumab efficacy in patients with advanced non-small cell lung cancer. METHODS: This study was conducted across three medical centers in Japan. We retrospectively reviewed all patients who commenced nivolumab treatment at these centers between December 17, 2015 and July 31, 2016. Clinical data were collected, including age, sex, smoking status, Eastern Cooperative Oncology Group performance status, and metastatic site (lymph nodes, liver, brain, bone, lungs [intrapulmonary metastasis], and malignant pleural effusion) at the time of commencing nivolumab treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29466906/melanin-bleaching-with-warm-hydrogen-peroxide-and-integrated-immunohistochemical-analysis-an-automated-platform
#3
Chia-Hsing Liu, Chih-Hung Lin, Min-Jan Tsai, Yu-Hsuan Chen, Sheau-Fang Yang, Kun-Bow Tsai
OBJECTIVE: Diagnosing melanocytic lesions is among the most challenging problems in the practice of pathology. The difficulty of physically masking melanin pigment and the similarity of its color to commonly used chromogens often complicate examination of the cytomorphology and immunohistochemical staining results for tumor cells. Melanin bleach can be very helpful for histopathological diagnosis of heavily pigmented melanocytic lesions. Although various depigmentation methods have been reported, no standardized methods have been developed...
February 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29465823/differential-expression-of-various-clones-of-estrogen-receptor-in-cell-block-preparation-of-lung-adenocarcinoma
#4
Laleh Hakima, Kathie Schlesinger, Jaya Sunkara, Rouzan G Karabakhtsian
BACKGROUND: Women treated for breast cancer are at increased risk of developing pulmonary nodules which could represent new primary lung carcinomas or metastatic breast carcinoma. The FNA biopsy is frequently the first diagnostic choice in determining the primary site of the tumor. Estrogen receptor (ER) positivity in diagnostic tissue is generally used to favor breast over lung primary. However, the recent studies have shown a wide range of ER antibody cross reactivity with lung adenocarcinoma...
February 21, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29465202/-lung-ultrasound-in-patients-with-hematological-malignancies-and-acute-respiratory-failure-due-to-pneumonia
#5
V A Novikov, G M Galstyan, I An E G Gemdzh, I E Kostina, M K Gitis
PURPOSE: To compare the accuracy of bedside lung ultrasound (LUS) and chest computed tomography (CT) for the de- tection of lung lesions in patients with hematological malignancies and acute respiratory failure (ARF). MATERIALS AND METHODS: 39 patients with hematological malignancies and ARF were enrolled in prospective study. The investigation of the patients included LUS, chest C, extravascular lung water index (EVLW) by transpulmonary ther- modilution, and bronchoalveolar lavage (BAL)...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29452999/chylothorax-as-a-risk-factor-for-thrombosis-in-adults-a-proof-of-concept-study
#6
Sumedh S Hoskote, Hemang Yadav, Prashant Jagtap, Dennis A Wigle, Craig E Daniels
BACKGROUND: Postoperative chylothorax in children is associated with an increased risk of vascular thrombosis, hypothesized to be from loss of antithrombin into chylous fluid resulting in a hypercoagulable state. In adults, an increased thrombotic risk with chylothorax has not been described. Adults undergoing Ivor-Lewis esophagogastrectomy have two strong thrombotic risk factors-active malignancy and postoperative state-allowing for relative homogeneity in baseline thrombotic risk; therefore, we studied the association of chylothorax with thrombosis in this population...
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29445180/myeloid-derived-interleukin-1%C3%AE-drives-oncogenic-kras-nf-%C3%AE%C2%BA%C3%AE-addiction-in-malignant-pleural-effusion
#7
Antonia Marazioti, Ioannis Lilis, Malamati Vreka, Hara Apostolopoulou, Argyro Kalogeropoulou, Ioanna Giopanou, Georgia A Giotopoulou, Anthi C Krontira, Marianthi Iliopoulou, Nikolaos I Kanellakis, Theodora Agalioti, Anastasios D Giannou, Celestial Jones-Paris, Yoichiro Iwakura, Dimitrios Kardamakis, Timothy S Blackwell, Stavros Taraviras, Magda Spella, Georgios T Stathopoulos
Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediates MPE development and this is fueled by host-provided interleukin IL-1β. Indeed, IKKα is required for the MPE-competence of KRAS-mutant tumor cells by activating non-canonical NF-κB signaling...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29444649/patterns-of-pleural-pressure-amplitude-and-respiratory-rate-changes-during-therapeutic-thoracentesis
#8
Monika Zielinska-Krawczyk, Elzbieta M Grabczak, Marcin Michnikowski, Krzysztof Zielinski, Piotr Korczynski, Anna Stecka, Tomasz Golczewski, Rafal Krenke
BACKGROUND: Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the study was to assess the changes in pleural pressure amplitude (Pplampl ) during the respiratory cycle and respiratory rate (RR) in patients undergoing pleural fluid withdrawal. METHODS: The study included 23 patients with symptomatic pleural effusion...
February 14, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29433714/malignant-pleural-effusion-from-diagnostics-to-therapeutics
#9
REVIEW
Rachelle Asciak, Najib M Rahman
Malignant pleural effusion is a common complication of cancer and denotes a poor prognosis. It usually presents with dyspnea and a unilateral large pleural effusion. Thoracic computed tomography scans and ultrasound are helpful in distinguishing malignant from benign effusions. Pleural fluid cytology is diagnostic in about 60% of cases. In cytology-negative disease, pleural biopsies are helpful. Current management is palliative. Previously, first-line treatment for recurrent symptomatic malignant pleural effusion was chest drain insertion and talc pleurodesis, with indwelling pleural catheter insertion reserved for patients with trapped lung or failed talc pleurodesis...
March 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29429254/-evaluation-of-the-diagnosis-value-of-carcinoembryonic-antigen-in-malignant-pleural-effusion
#10
Y X Yu, Z H Tong, X X Zhou, L R Liang, Z Wang, L L Xu, X J Wang, Y B Wu, H J Li, Z Lu
Objective: To investigate the diagnostic value of serum and pleural fluid carcinoembryonic antigen (CEA) for malignant pleural effusion (MPE). Methods: The concentration of CEA in serum and pleural fluid of 286 patients with the diagnosis confirmed by pleural biopsy through medical thoracoscopy were retrospectively analyzed. MPE was confirmed in 171 cases which were divided into two groups (adenocarcinoma group with 121cases and non-adenocarcinoma group with 50 cases) and benign pleural effusion in 115 cases...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29417036/rhabdomyosarcoma-mimicking-as-pleural-effusion
#11
Tiwari K Vijayesh, Abhishek Kumar, Nitesh Mohan, Pooja Bansal, Prashant Choudhary
Rhabdomyosarcoma (RMS), a malignant neoplasm of skeletal muscle origin, is the most common soft tissue sarcoma caused by infectious disease etiology, especially in nondeveloped countries. Despite being a relatively rare cancer, it accounts for approximately 40% of all recorded soft tissue sarcomas. Alveolar RMSs are seen to occur in children, while around 80% cases occur in the first three decades of life. We present here, a case of a 12-year-old child having alveolar RMS, presenting clinically and radiologically with pleural effusion...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29414821/procedures-performed-during-hospitalizations-for-malignant-pleural-effusions-data-from-the-2012-national-inpatient-sample
#12
Marc Fortin, Niloofar Taghizadeh, Alain Tremblay
BACKGROUND: Malignant pleural effusions (MPE) are a common clinical problem. Little is known about the burden of MPE and of the treatments used to alleviate its symptoms on the United States Health Care System. OBJECTIVES: We aimed to obtain a better portrait of inpatient pleural procedures performed in the United States. METHODS: We conducted a retrospective analysis of MPE-associated hospitalizations using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, Agency for Healthcare Research and Quality (HCUP-NIS 2012)...
February 7, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29413055/computed-tomography-in-the-evaluation-of-malignant-pleural-mesothelioma-association-of-tumor-size-to-a-sarcomatoid-histology-a-more-advanced-tnm-stage-and-poor-survival
#13
Juuso Paajanen, Sanna Laaksonen, Ilkka Ilonen, Henrik Wolff, Kirsti Husgafvel-Pursiainen, Eeva Kuosma, Hely Ollila, Marjukka Myllärniemi, Tapio Vehmas
OBJECTIVES: Appropriate clinical staging of malignant pleural mesothelioma (MPM) is critical for correct treatment decisions. Newly revised TNM staging protocol has been released for MPM. We investigated baseline computed tomography (CT) characteristics of MPM patients, the new staging system and a simple tumor size (TS) assessment in terms of survival. MATERIALS AND METHODS: As part of our study that included all MPM patients diagnosed in Finland 2000-2012, we retrospectively reviewed 161 CT scans of MPM patients diagnosed between 2007 and 2012 in the Hospital District of Helsinki and Uusimaa...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29411725/vascular-endothelial-growth-factor-in-pleural-effusions-and-correlation-with-radiologic-and-biochemical-parameters
#14
N Bayram, Y Karakan, M Uyar, B Ozyurt, A Filiz
INTRODUCTION: Pleural effusion is a common clinical problem with management difficulties. The aim of this study is to evaluate vascular endothelial growth factor (VEGF) in differential diagnosis of pleural effusions and the presence of correlation between radiological features and biochemical properties. MATERIALS AND METHODS: The study included patients with pleural effusion. VEGF levels in the pleural fluid were measured by enzyme-linked immunosorbent assay. RESULTS: A total of 97 patients who had exudative pleural effusion related to lung cancer (n = 17), nonpulmonary malignancies (n = 25), mesothelioma (n = 9), pneumonia (n = 14), tuberculosis (n = 8), miscellaneous causes (n = 6), and transudative effusion (n = 18) were included...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29402263/effect-of-the-2015-earthquake-on-pediatric-inpatient-pattern-at-a-tertiary-care-hospital-in-nepal
#15
Bishnu Rath Giri, Ram Hari Chapagain, Samana Sharma, Sandeep Shrestha, Sunita Ghimire, P Ravi Shankar
BACKGROUND: Earthquakes impact child health in many ways. Diseases occurring immediately following an earthquake have been studied in field based hospitals but studies on the inpatient disease pattern among children without trauma in a permanent hospital setup is lacking. METHODS: We examined the diagnoses of all children without trauma, admitted to Kanti Children's Hospital, Kathmandu for fifteen-week duration (from 4th week to end of the 18th week) following the 7...
February 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29391043/precise-preoperative-diagnosis-of-struma-ovarii-with-pseudo-meigs-syndrome-mimicking-ovarian-cancer-with-the-combination-of-131i-scintigraphy-and-18f-fdg-pet-case-report-and-review-of-the-literature
#16
Sayaka Fujiwara, Hideaki Tsuyoshi, Toshiya Nishimura, Nozomu Takahashi, Yoshio Yoshida
BACKGROUND: Struma ovarii is a rare ovarian neoplasm that often appears malignant on conventional imaging. Pseudo-Meigs' syndrome with ascites, pleural effusion, and elevated serum CA 125 levels is much rarer and leads to misdiagnosis of ovarian cancer and unnecessary extended surgery. CASE PRESENTATION: A 50-year-old woman with abdominal distention and dyspnoea was referred to our hospital. Ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) showed a polycystic ovarian tumor with a solid component, pleural effusion, and massive ascites with negative cytology...
February 2, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29390436/endostar-combined-with-chemotherapy-in-a-pediatric-osteosarcoma-with-pulmonary-metastasis-and-malignant-pleural-effusion-a-case-report
#17
Sujing Jiang, Guannan Wang, Ying Dong
RATIONALE: Angiogenesis is a key factor for tumor growth and metastasis both in cancer and sarcoma. Endostar, a novel safe and well-tolerated recombinant human endostatin, can suppress the expression of VEGF and the activation of ERK, MAPK, and AKT, and then inhibit tumor progression. PATIENT CONCERNS: A pediatric osteosarcoma with pulmonary metastasis and malignant pleural effusion. DIAGNOSES: Osteosarcoma with pulmonary metastasis and malignant pleural effusion...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390367/targeted-therapy-with-apatinib-in-a-patient-with-relapsed-small-cell-lung-cancer-a-case-report-and-literature-review
#18
Jun Zhao, Xiaoling Zhang, Chaojie Gong, Jialei Zhang
RATIONALE: Small cell lung cancer (SCLC) is a lethal malignancy. Once relapsed, the disease is irreversible and most of the patients will die of cancer aggravation in 1 to 2 months. In the past several decades, little progress has been made in the systemic treatment of SCLC. Apatinib, as a novel small-molecule tyrosine kinase inhibitor specifically targeting the vascular endothelial growth factor receptor 2 (VEGFR2), has achieved progress in treatment of a variety of cancers. However, there has been no report of the targeted therapy with apatinib in SCLC yet...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390299/black-pleural-effusion-due-to-pancreatic-pseudocyst-a-case-report
#19
Feng Guo, Junli Wu, Yunpeng Peng, Min Tu, Bin Xiao, Cuncai Dai, Kuirong Jiang, Wentao Gao, Qiang Li, Jishu Wei, Jianmin Chen, Chunhua Xi, Zipeng Lu, Yi Miao
RATIONALE: Black pleural effusion (BPE) is an extremely uncommon type of pleural fluid, which can be due to infection, primary or metastatic malignancy, and hemorrhage. As reported in previous studies, BPE is also observed in some patients with pancreatic pseudocyst. PATIENT CONCERNS: We herein reported a case of a 14-year-old female patient who was admitted to our center with a history of cough for 1 and a half months and right chest pain for 1 month. Before this, she was consecutively hospitalized in 3 different hospitals due to the same symptoms...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29372629/chest-tube-drainage-of-the-pleural-space-a-concise-review-for-pulmonologists
#20
REVIEW
José M Porcel
Chest tube insertion is a common procedure usually done for the purpose of draining accumulated air or fluid in the pleural cavity. Small-bore chest tubes (≤14F) are generally recommended as the first-line therapy for spontaneous pneumothorax in non-ventilated patients and pleural effusions in general, with the possible exception of hemothoraces and malignant effusions (for which an immediate pleurodesis is planned). Large-bore chest drains may be useful for very large air leaks, as well as post-ineffective trial with small-bore drains...
January 24, 2018: Tuberculosis and Respiratory Diseases
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