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Malignant pleural effusion

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https://www.readbyqxmd.com/read/29214072/asymptomatic-malignant-pleural-effusion-to-observe-or-to-manage
#1
Sevak Keshishyan, Kassem Harris
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29214068/diagnosis-and-management-of-malignant-pleural-effusions-state-of-the-art-in-2017
#2
REVIEW
Neeraj R Desai, Hans J Lee
Malignant pleural effusion (MPE) is a known complication of both thoracic and extra thoracic malignancies. The presence of MPE regardless of the primary site translates into advanced stage disease. Diagnosis and management of MPE with the goals of palliation and improving quality of life poses a challenge for chest physicians. Recently, multiple studies have made attempts to answer questions regarding optimal management in various clinical scenarios. We will review the current evidence and available options for the management of MPE...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29214061/medical-thoracoscopy-and-its-evolving-role-in-the-diagnosis-and-treatment-of-pleural-disease
#3
REVIEW
Vivek Murthy, Jamie L Bessich
Establishing the etiology of exudative pleural effusions in the setting of an unrevealing pleural fluid analysis often requires biopsies from the parietal pleura. While closed pleural biopsy (CPB) has been a popular minimally-invasive approach, it has a poor diagnostic yield, barring a diagnosis of tuberculous pleurisy. Medical thoracoscopy (MT) is a minimally-invasive ambulatory procedure performed under local anesthesia or moderate sedation which allows for direct visualization of biopsy targets as well as simultaneous therapeutic interventions, including chemical pleurodesis and indwelling tunneled pleural catheter (ITPC) placement...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29208852/extremely-high-serum-ferritin-an-instrumental-marker-of-masquerading-adult-onset-still-s-disease-with-hemophagocytic-syndrome
#4
Shun Yamashita, Naoko E Furukawa, Tomoyo Matsunaga, Yuka Hirakawa, Masaki Tago, Shu-Ichi Yamashita
BACKGROUND Adult-onset Still's disease (AOSD) is a rare multi-systemic inflammatory disorder of unknown etiology characterized by spiking fever, characteristic rash, and arthritis. It often associates with high serum ferritin levels. CASE REPORT An 88-year-old woman had fever of over 39°C without response to extended-spectrum antibiotics for 6 days. She had non-specific erythema with infiltration on her trunk. She had leukocytosis with neutrophilia of 80%, mild hepatic dysfunction, normal level of rheumatoid factor and antinuclear antibody, thrombocytopenia, elevated d-dimer and soluble interleukin2 receptor, extremely high serum ferritin (78 662 ng/mL), and splenomegaly...
December 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29208371/integrated-semi-targeted-metabolomics-analysis-reveals-distinct-metabolic-dysregulation-in-pleural-effusion-caused-by-tuberculosis-and-malignancy
#5
Nanying Che, Yan Ma, Huabin Ruan, Lina Xu, Xueying Wang, Xinting Yang, Xiaohui Liu
BACKGROUND: Tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) are the 2 most frequent causes of exudative pleural effusions (PEs). However, the clinical differentiation is challenging. METHODS: Metabolic signatures in pleural effusion from 156 patients were profiled. An integrated semi-targeted metabolomics platform was incorporated for high throughput metabolite identification and quantitation. In this platform, orbitrap based mass spectrometry with data dependent MS/MS acquisition was applied in the analysis...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29204290/meningeal-carcinomatosis-and-spinal-cord-infiltration-caused-by-a-locally-invasive-pulmonary-adenocarcinoma-in-a-cat
#6
Christoforos Posporis, Llorenç Grau-Roma, Olga Travetti, Maria Oliveira, Laura Polledo, Annette Wessmann
Case summary: A 12-year-old domestic shorthair cat was presented with acute non-painful hindlimb proprioceptive ataxia localising to T3-L3 spinal cord segments. MRI revealed paravertebral muscular hyperintensity on T2-weighted images at the level of T7-T8 vertebrae. The cat improved on conservative management but deteriorated 3 months later. Repeated MRI showed meningeal enhancement at the same level and hyperintensity of the paravertebral musculature extending to the right thoracic wall and pleural space on short tau inversion recovery images...
July 2017: JFMS Open Reports
https://www.readbyqxmd.com/read/29199894/local-and-systemic-effects-of-a-silver-nitrate-coated-indwelling-pleural-catheter-in-an-animal-model-of-pleurodesis
#7
Alain Tremblay, Christine T Kearney, Chris Hanks, Jennifer Hughes Hanks, David S White, Marcia E Pereira, Craig E Zook, Karen Sargis, Luke Zhang
Purpose/Aim of the study: This study assessed the safety and potential toxicity of a silver nitrate coated indwelling pleural catheter (SNCIPC) designed to create pleurodesis in a large animal model. MATERIALS AND METHODS: Sixteen animals underwent insertion of either a SNCIPC or an uncoated silicone catheter. Half of the animals were sacrificed at day 7 and the others at day 30. Animal weight and assessment of well-being, pleural fluid and blood collection were performed at regular intervals...
December 4, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29199701/demographic-clinical-biochemical-radiological-and-etiological-characteristics-of-malignant-pleural-effusions-from-eastern-india
#8
K Saha, M K Maikap, A Maji, M Moitra, D Jash
CONTEXT: There are very limited data regarding clinical, radiological and etiological aspects of malignant pleural effusion (MPE) from Eastern India. AIMS: To review natural history, clinical features, radiological features and etiology of MPEs. SETTING AND DESIGN: Hospital based cross-sectional descriptive study. MATERIALS AND METHODS: We had reviewed166 diagnosed cases of MPEsregarding demography; clinical, radiological and biochemical characteristics, diagnostic modalities and etiologies...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29194291/the-great-mimicker-pseudo-meig-syndrome-in-a-pregnant-patient-a-review
#9
Thelina Amaratunga, Noam Millo, Vallerie Gordon, Cyrille Blcamumpaka, Yi Yan, Stephanie Sparkes, Ashraf Goubran
Meig syndrome is the triad of benign ovarian tumor, ascites, and pleural effusion. Pseudo-Meig syndrome mimics the Meig syndrome triad; however, in pseudo-Meig syndrome, the ovarian tumor usually represents a primary malignancy or metastases. Differentiating Meig from pseudo-Meig syndrome is challenging both clinically and with diagnostic imaging but is important because prognoses for these distinct entities are drastically different. Evidence-based sonographic prediction models are valuable because they can aid in this distinction...
November 29, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29190798/human-pleural-fluid-is-a-potent-growth-medium-for-streptococcus-pneumoniae
#10
Natalia D Popowicz, Sally M Lansley, Hui M Cheah, Ian D Kay, Christine F Carson, Grant W Waterer, James C Paton, Jeremy S Brown, Y C Gary Lee
Empyema is defined by the presence of bacteria and/or pus in pleural effusions. However, the biology of bacteria within human pleural fluid has not been studied. Streptococcus pneumoniae is the most common cause of pediatric and frequent cause of adult empyema. We investigated whether S. pneumoniae can proliferate within human pleural fluid and if growth is affected by the cellular content of the fluid and/or characteristics of pneumococcal surface proteins. Invasive S. pneumoniae isolates (n = 24) and reference strain recovered from human blood or empyema were inoculated (1...
2017: PloS One
https://www.readbyqxmd.com/read/29189866/-role-of-surgery-in-saprochaete-capitata-s-capitata-sepsis-in-a-patient-with-acute-myeloid-leukemia
#11
Jasna Radich R, Carlos Álvarez Z, Ana Valenzuela R, Felipe Castillo H, Francisco Moraga V, Jorge Castillo A
Saprochaete capitata (S. capitata) fungal sepsis is a severe condition with a clinical presentation that is similar to other yeast originated fungal sepsis. It is observed in patients with hematological malignancies such as acute myeloid leukemia and neutropenia. We report a 23 year old male presenting with cough, fever and malaise. A bone marrow biopsy led to the diagnosis of acute myeloid leukemia. During the first cycle of chemotherapy the patient presented fever: blood cultures were positive for Klebsiella pneumoniae...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29188375/tunneled-pleural-catheter-use-for-pleural-palliation-does-not-increase-infection-rate-in-patients-with-treatment-related-immunosuppression
#12
Candice L Wilshire, Christopher R Gilbert, Brian E Louie, Ralph W Aye, Alexander S Farivar, Eric Vallières, Jed A Gorden
PURPOSE: Concerns for infections resulting from antineoplastic therapy-associated immunosuppression may deter referral for symptom palliation with a tunneled pleural catheter (TPC) in patients with malignant/para-malignant pleural effusions (MPE/PMPE). While rates of TPC-related infections range from 1 to 21%, those in patients receiving antineoplastic therapy with correlation to immune status has not been established. We aimed to assess TPC-related infection rates in patients on antineoplastic therapy, determine relation to immune system competency, and assess impact on the patient...
November 29, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29187476/a-case-of-the-resected-lymphohistiocytoid-mesothelioma-bap1-is-a-key-of-accurate-diagnosis
#13
Taichi Matsubara, Gouji Toyokawa, Yuichi Yamada, Kazuki Nabeshima, Naoki Haratake, Yuka Kozuma, Takaki Akamine, Shinkichi Takamori, Fumihiro Shoji, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: Malignant mesothelioma (MM) is a well-known malignant tumor that occurs in the pleura and is histopathologically classified into three subtypes. Lymphohistiocytoid mesothelioma (LHM) is considered a variant of epithelioid MM, and few cases have been reported. First case of LHM was reported by Henderson et al. in 1988. It is difficult to precisely diagnose LHM, and it is often misdiagnosed as reactive mesothelial cell proliferation. CASE REPORT: An 82-year-old man, with the smoking history of nine pack-years, was referred to our Department due to an abnormal shadow and pleural effusion in the left lung field on the chest X-ray imaging...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29180928/the-importance-of-serum-and-pleural-fluid-level-of-vascular-endothelial-growth-factor-vegf-and-vegf-fluid-serum-ratio-in-the-differential-diagnosis-of-malignant-mesothelioma-related-pleural-effusion
#14
Yakup Düzköprü, Zeynep Oruç, Muhammet A Kaplan, Refik Ülkü, Çetin Tanrıkulu, Derya Esmer, Ali Bırak, Mehmet Küçüköner, Zuhat Urakçı, Abdurrahman Işıkdoğan
Aim of the study: Vascular endothelial growth factor (VEGF) is one of the parameters that has been studied in differential diagnosis of malignant fluids. This study is aimed at evaluate applicability of serum, fluid VEGF level and fluid to serum VEGF ratio in the diagnosis of malignant pleural mesothelioma (MPM). Material and methods: The patients with pleural effusion over age of 18, between 2011 and 2015 were included in the study. They were divided into three groups: group 1 - mesothelioma patients; group 2 - other malignancies; and group 3 - benign aetiologies...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29171372/-two-pulmonary-lesions-on-an-x-ray-of-the-chest
#15
L Draaijers, I H van Schelven, Y Hendrix
We present an X-ray of a 89-year-old man, showing two solitary pulmonary lesions. Although malignancy was suspected, these lesions appeared to be intrafissural pleural effusions, caused by congestive heart failure. One week after treatment with furosemide, the pulmonary lesions had disappeared completely.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29166899/medical-thoracoscopy-for-exudative-pleural-effusion-an-eight-year-experience-from-a-country-with-a-young-population
#16
Merlin Thomas, Wanis H Ibrahim, Tasleem Raza, Kamran Mushtaq, Adeel Arshad, Mushtaq Ahmed, Salma Taha, Saber Al Sarafandi, Hanfa Karim, Hisham A Abdul-Sattar
BACKGROUND: With the exception of areas with high prevalence of tuberculosis, medical thoracoscopy is becoming the diagnostic modality of choice for exudative pleural effusions. The aims of this study were to determine the diagnostic yield and safety of medical thoracoscopy for exudative pleural effusions and ascertain the etiology of such effusions in Qatar. METHODS: This is a retrospective-descriptive study of 407 patients who underwent diagnostic medical thoracoscopy for exudative pleural effusions from January, 2008 till December, 2015 at the only tertiary referral center performing this procedure in Qatar...
November 22, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29164255/effect-of-an-indwelling-pleural-catheter-vs-talc-pleurodesis-on-hospitalization-days-in-patients-with-malignant-pleural-effusion-the-ample-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Rajesh Thomas, Edward T H Fysh, Nicola A Smith, Pyng Lee, Benjamin C H Kwan, Elaine Yap, Fiona C Horwood, Francesco Piccolo, David C L Lam, Luke A Garske, Ranjan Shrestha, Christopher Kosky, Catherine A Read, Kevin Murray, Y C Gary Lee
Importance: Indwelling pleural catheter and talc pleurodesis are established treatments for malignant pleural effusions among patients with poor prognosis. Objective: To determine whether indwelling pleural catheters are more effective than talc pleurodesis in reducing total hospitalization days in the remaining lifespan of patients with malignant pleural effusion. Design, Setting, and Participants: This open-label, randomized clinical trial included participants recruited from 9 centers in Australia, New Zealand, Singapore, and Hong Kong between July 2012 and October 2014; they were followed up for 12 months (study end date: October 16, 2015)...
November 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29163783/abundant-expression-of-tim-3-lag-3-pd-1-and-pd-l1-as-immunotherapy-checkpoint-targets-in-effusions-of-mesothelioma-patients
#18
Elly Marcq, Jorrit De Waele, Jonas Van Audenaerde, Eva Lion, Eva Santermans, Niel Hens, Patrick Pauwels, Jan P van Meerbeeck, Evelien L J Smits
Malignant pleural mesothelioma (MPM) is an aggressive cancer with an increasing incidence, poor prognosis and limited effective treatment options. Hence, new treatment strategies are warranted which include immune checkpoint blockade approaches with encouraging preliminary data. Research on the immunological aspects of the easily accessible mesothelioma microenvironment could identify prognostic and/or predictive biomarkers and provide useful insights for developing effective immunotherapy. In this context, we investigated the immune cell composition of effusions (pleural and ascites fluids) from 11 different chemotherapy-treated MPM patients...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29141727/point-of-care-ultrasound-for-extrapulmonary-tuberculosis-in-india-a-prospective-cohort-study-in-hiv-positive-and-hiv-negative-presumptive-tuberculosis-patients
#19
Stefan F Weber, Kavitha Saravu, Tom Heller, Rajagopal Kadavigere, Shashidhar Vishwanath, Stephan Gehring, Sabine Bélard, And Pocus Eti Study Group
Diagnosing extrapulmonary tuberculosis (EPTB) is challenging. Point-of-care ultrasound (POCUS) for human immunodeficiency virus (HIV)-associated EPTB is applied in sub-Saharan Africa. This study aimed at evaluating the applicability of POCUS for diagnosing EPTB in HIV-positive and HIV-negative presumptive tuberculosis (TB) patients in India, a country of moderate relative TB and HIV burden. Presumptive TB patients at Kasturba Hospital, Manipal, India, prospectively underwent POCUS evaluating for pericardial, pleural and ascitic effusion, abdominal lymphadenopathy, and hepatic and splenic microabscesses...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29137310/ex-vivo-evaluation-of-tumor-cell-specific-drug-responses-in-malignant-pleural-effusions
#20
Carl-Olof Hillerdal, Rita Ötvös, Tünde Szatmári, Sulaf Abd Own, Gunnar Hillerdal, Åsa-Lena Dackland, Katalin Dobra, Anders Hjerpe
The effect of chemotherapy may be improved by combining the most effective drugs based on testing the sensitivity of the individual tumor ex vivo. Such estimations of tumor cells from effusions have so far not been implemented in the clinical routine as a basis for individualized choice of therapy. One obstacle for such analyses is the admixture of benign cells that might obscure the results. In this paper we test and compare two ways of performing the analysis specifically on tumor cells. First we enrich the tumor cells, using antibody labeled magnetic separation, and measure the effects of subsequent drug exposure with the metabolic activity assays WST-1 and alamar blue...
October 10, 2017: Oncotarget
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