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Malignant pleural effusion

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https://www.readbyqxmd.com/read/28927859/pleural-fluid-analysis-and-pleural-elastance-as-predictors-of-response-to-pleurodesis-in-patients-with-malignant-pleural-effusion
#1
Lucía Ferreiro, Esther San José, Francisco Gude, Luis Valdés
No abstract text is available yet for this article.
September 15, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28927127/vascular-endothelial-growth-factor-and-protein-level-in-pleural-effusion-for-differentiating-malignant-from-benign-pleural-effusion
#2
Da-Wei Wu, Wei-An Chang, Kuan-Ting Liu, Meng-Chi Yen, Po-Lin Kuo
Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926296/randomised-controlled-trial-of-urokinase-versus-placebo-for-non-draining-malignant-pleural-effusion
#3
Eleanor K Mishra, Amelia O Clive, Genevieve H Wills, Helen E Davies, Andrew E Stanton, Mohamed Al-Aloul, Alan Hart-Thomas, Justin Pepperell, Matthew Evison, Tarek Saba, Richard Neil Harrison, Anur Guhan, Matthew E Callister, Ramamurthy Sathyamurthy, Sunita Rehal, John P Corcoran, Robert Hallifax, Ioannis Psallidas, Nicky Russell, Rachel Shaw, Melissa Dobson, John M Wrightson, Alex West, Y C Gary Lee, Andrew J Nunn, Robert F Miller, Nick A Maskell, Najib M Rahman
RATIONALE: Patients with malignant pleural effusion (MPE) experience breathlessness, which is treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and pleurodesis failure. Intrapleural fibrinolytics lyse septations within pleural fluid, improving drainage. OBJECTIVES: To assess the effects of intrapleural urokinase on dyspnea and pleurodesis success in patients with non-draining malignant effusion. METHODS: Prospective double blind randomised trial; patients with non-draining effusion were randomly allocated 1:1 to intrapleural urokinase (100,000 IU three doses 12 hourly) or matched placebo...
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28923053/analysis-of-b7-h4-expression-in-metastatic-pleural-adenocarcinoma-and-therapeutic-potential-of-its-antagonists
#4
Cheng Chen, Qiu-Xia Qu, Fang Xie, Wei-Dong Zhu, Ye-Han Zhu, Jian-An Huang
BACKGROUND: The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancers but its role in malignant pleural tissue has yet to be established. METHODS: Here, patients with metastatic pleural adenocarcinoma (MPA) or with early-stage lung adenocarcinoma were clinically and statistically analyzed. Immunohistochemistry and confocal microscopy were used to determinate the expression of B7-H4 in the cancer cells...
September 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28918827/indwelling-pleural-catheters-for-nonmalignant-effusions-evidence-based-answers-to-clinical-concerns
#5
REVIEW
David Maurice Chambers, Bilal Abaid, Umair Gauhar
Pleural effusions occur in 1.5 million patients yearly and are a common cause of dyspnea. For nonmalignant effusions, initial treatment is directed at the underlying cause, but when effusions become refractory to medical therapy, palliative options are limited. Tunneled pleural catheters (TPCs) are commonly used for palliation of malignant effusions, but many clinicians are reluctant to recommend these devices for palliation of nonmalignant effusions, citing concerns of infection, renal failure, electrolyte disturbances and protein-loss malnutrition...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28904792/desmoplastic-small-round-cell-tumors-of-the-pleura-a-review-of-the-clinical-literature
#6
REVIEW
Alessandro Giuseppe Fois, Pietro Pirina, Antonella Arcadu, Francesca Becciu, Sandra Manca, Viviana Marras, Sara Canu, Gaetano Castagna, Giorgio Carlo Ginesu, Angelo Zinellu, Panagiotis Paliogiannis
Desmoplastic small round cell tumor of the pleura is a rare malignancy, with only a few cases reported in the scientific literature. The aim of the present review is to discuss the demographic, pathological, clinical, and therapeutic features of this rare tumor. English-language articles published since 1989, when the first case of desmoplastic small round cell tumor of the pleura was described, were retrieved, and fifteen cases included in fourteen articles were revised. The mean age of the patients was 25...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28903441/loss-of-steroid-hormone-receptors-is-common-in-malignant-pleural-and-peritoneal-effusions-of-breast-cancer-patients-treated-with-endocrine-therapy
#7
Willemijne A M E Schrijver, Karianne Schuurman, Annelot van Rossum, Ton Peeters, Natalie Ter Hoeve, Wilbert Zwart, Paul J van Diest, Cathy B Moelans
Discordance in estrogen receptor alpha (ERα), progesterone receptor (PR), androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) status between primary breast cancers and solid distant metastases ("conversion") has been reported previously. Even though metastatic spread to the peritoneal and pleural cavities occurs frequently and is associated with high mortality, the rate of receptor conversion and the prognostic implications thereof remain elusive. We therefore determined receptor conversion in 91 effusion metastases (78 pleural, 13 peritoneal effusions) of 69 patients by immunohistochemistry (IHC) and in situ hybridization...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900718/prognosis-of-cancer-with-synchronous-or-metachronous-malignant-pleural-effusion
#8
José M Porcel, Cristina Solé, Antonieta Salud, Silvia Bielsa
PURPOSE: Malignant pleural effusions (MPE) may either coincide with or follow the diagnosis of a primary tumor. Whether this circumstance influences prognosis has not been well substantiated. METHODS: Retrospective review of all consecutive patients who were cared for at a Spanish university hospital during an 11-year period and received a diagnosis of MPE. RESULTS: Of 401 patients, the MPE was the first evidence of cancer in 265 (66%), and it followed a previously diagnosed neoplasm in 136 (34%)...
September 12, 2017: Lung
https://www.readbyqxmd.com/read/28889390/dna-methylation-analysis-from-body-fluids
#9
Dimo Dietrich
Circulating cell-free DNA (ccfDNA) can be found in various body fluids, i.e., blood (serum and plasma), urine, pleural effusions, and ascites. While ccfDNA predominantly originates from physiological processes, a fraction might be related to pathological events, e.g., cancer. Aberrant DNA methylation, which is considered a hallmark of cancer, can be assessed accurately in ccfDNA. Consequently, DNA methylation testing in body fluids represents a powerful diagnostic tool in the clinical management of malignant diseases...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28885675/up-regulated-hmgb1-in-the-pleural-effusion-of-non-small-cell-lung-cancer-nsclc-patients-reduces-the-chemosensitivity-of-nsclc-cells
#10
Ying Ma, Shirong Kang, Xu Wu, Bateer Han, Zhiyong Jin, Zhanlin Guo
BACKGROUND: Pleural effusion is one of the complications of human non-small cell lung cancer (NSCLC). High mobility group box-1 protein (HMGB1) correlates highly with invasion and metastasis in multiple tumors. The aim of this study was to explore the clinical value of HMGB1 in NSCLC patients, and to investigate the role of HMGB1 in the development of pleural effusion. In addition, we also investigated the regulatory role of HMGB1 in the sensitivity of NSCLC cells to cisplatin. METHODS: 46 NSCLC malignant pleural effusion (MPE) and 31 benign pleural effusion samples were quantitatively analyzed with Enzyme-Linked Immunosorbent Assay (ELISA) for cytokines, such as IL-1beta, IL-6, IL-8 and HMGB1...
September 2, 2017: Tumori
https://www.readbyqxmd.com/read/28885340/a-case-report-of-lung-adenocarcinoma-with-polyserous-effusions-as-the-onset-symptom
#11
Ping Han, Ruipin Yao, Dongxia Zhai, Chao Cheng, Fangyong Yang, Shuai Sun, Danying Zhang, Chaoqin Yu
RATIONALE: Coexistence of lung adenocarcinoma and polyserous effusions is quite rare. This complexity of etiology adds difficulty to the diagnosis and is likely to cause misdiagnosis and maldiagnosis. PATIENT CONCERNS: A 43-year-old woman was admitted with symptoms of dry cough, chest suffocation, polyserous effusions, and generalized edema. Only a small number of heterocysts were detected in the ascites, and malignant cells were detected in the pleural and pericardial effusions...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28881848/biomarkers-for-early-diagnosis-of-malignant-mesothelioma-do-we-need-another-moonshot
#12
REVIEW
Sabrina Lagniau, Kevin Lamote, Jan P van Meerbeeck, Karim Y Vermaelen
Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection will result in better patient management and outcome. Many efforts have already been made to find suitable biomarkers in blood and pleural effusions, but have not yet resulted in a valid and reproducible diagnostic one. In this review, we will highlight the strengths and shortcomings of blood and fluid based biomarkers and highlight the potential of breath analysis as a non-invasive screening tool for MPM...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879702/diagnostic-values-of-svegfr-1-and-endostatin-in-malignant-pleural-effusions-in-patients-with-lung-cancer
#13
Ying-Ying Zhu, Hui-Mei Wu, Rong-Yu Liu
BACKGROUND: The diagnosis of malignant pleural effusion (MPE) remains a common clinical challenge because of the sensitivity of conventional cytology for the detection is insufficient. Thus, a sensitive clinical marker for diagnosis is required. The aim of this study was to assess the role of two anti-angiogenic cytokines, soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and endostatin, in diagnosing MPE. METHODS: Effusion samples from 44 patients with MPE caused by lung cancer and from 36 patients with benign pleural effusion (BPE) were collected...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28878661/the-successful-treatment-of-pulmonary-pleomorphic-carcinoma-with-pembrolizumab-a-case-report
#14
Yoko Matsumoto, Tamaki Miura, Hajime Horiuchi, Kazuhiro Usui
Pulmonary pleomorphic carcinomas are rare malignant tumors, and no standard treatments have been established. We herein report the successful treatment of a patient with pulmonary pleomorphic carcinoma with pembrolizumab. A 51-year-old man who was a current smoker presented to our hospital due to dyspnea and hemosputum. Chest X-ray showed right-sided pneumothorax with pleural effusion; chest tube drainage was therefore performed. Computed tomography after chest tube drainage showed a cavitary nodule in the right upper lobe and right hilar and bilateral mediastinal lymphadenopathy...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28876642/outcome-of-liver-resection-for-carcinoid-neuroendocrine-metastases
#15
M D Polkinghorne, J E J Krige, E Jonas, U K Kotze, M M Bernon
BACKGROUND: Gastrointestinal carcinoid tumours, despite their low malignant potential, frequently metastasize to the liver. While liver resection improves survival and provides symptomatic relief, multifocal bilobar disease complicates surgical management. METHOD: All patients with carcinoid liver secondaries managed by resection from 1990-2015 were identified from a prospective departmental database. Demographic data, operative management, morbidity using the Accordion classification and mortality were analysed...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28864369/predictive-factors-and-treatment-outcomes-of-tuberculous-pleural-effusion-in-patients-with-cancer-and-pleural-effusion
#16
Jaehee Lee, Yong Dae Lee, Jae Kwang Lim, Deok Heon Lee, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Chang Ho Kim
BACKGROUND: Patients with cancer are at an increased risk of tuberculosis. As pleural effusion has great clinical significance in patients with cancer, the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) is important. However, the predictive factors and treatment outcomes of TPE in patients with cancer have rarely been studied. MATERIALS AND METHODS: Confirmed TPE cases identified at cancer diagnosis and during anticancer management from 2008-2015 were retrospectively investigated...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28864054/quality-gaps-and-comparative-effectiveness-of-management-strategies-for-recurrent-malignant-pleural-effusions
#17
David E Ost, Jiangong Niu, Hui Zhao, Horiana B Grosu, Sharon H Giordano
BACKGROUND: Guidelines for recurrent malignant pleural effusions (MPE) recommend definitive procedures, such as indwelling pleural catheters (IPC) or pleurodesis, over repeat thoracentesis. We hypothesized that many patients have multiple thoracenteses rather than definitive procedures and that this results in more procedures and complications. METHODS: Retrospective cohort study using SEER-Medicare data from 2007-2011. Patients age 66-90 with a MPE were included...
August 29, 2017: Chest
https://www.readbyqxmd.com/read/28862207/effectiveness-of-intraperitoneal-or-intrapleural-administration-of-triamcinolone-acetonide-for-the-control-of-malignant-ascites-and-pleural-effusion-kansai-clinical-oncology-group-g1102-study
#18
Kimihiko Ito, Hiroshi Tsubamoto, Kayo Inoue, Yukari Miyoshi, Yoshihiro Ito, Kensuke Hori
OBJECTIVES: We conducted a retrospective multi-institutional study to evaluate the efficacy and toxicity of intraperitoneal or intrapleural triamcinolone acetonide (TA), a slowly metabolized corticosteroid administration for the management of malignant ascites or pleural effusion. MATERIALS AND METHODS: The medical records of patients with gynecologic cancer who were treated with paracentesis or thoracocentesis followed by administration of 400 mg of TA between 2005 and 2014 were reviewed...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28862203/utility-of-cell-block-to-detect-malignancy-in-fluid-cytology-adjunct-or-necessity
#19
Sumedha Dey, Dipanwita Nag, Ayandip Nandi, Ranjana Bandyopadhyay
AIM OF THE STUDY: Cell block (CB) technique when supplemented with conventional smear, provides increased cellularity, preservation of architectural pattern with excellent morphology, and a clear background. We compare the utility of CB technique compared to conventional smear in detection of malignancy in serous effusions. MATERIALS AND METHODS: An institution-based observational and analytical study was carried out over 1 year on 50 patients with effusions. The residual amount of centrifuged deposit after preparation of conventional smear was mixed with 10% alcohol-formalin solution, and CBs were prepared...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28861332/eml4-alk-positive-lung-adenocarcinoma-presenting-an-unusual-metastatic-pattern-in-a-29-year-old-woman-who-is-alive-and-well%C3%A2-in%C3%A2-her-third-year-follow-up-a-case-report
#20
Fatma Tokat, Handan Zeren, Pinar Barut, Sualp Tansan, Umit Ince
Non-small cell lung cancer (NSCLC) is a frequent tumor entity with high mortality. Although several newly discovered chromosomal translocations and mutations opened new horizons for targeted therapy, literature still lacks large series of NSCLC with chromosomal abberations and their correlations with histological and clinical features. We present a case of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) translocation positive adenocarcinoma of the lung with an unusual metastatic pattern in a 29-year-old young woman...
2017: Respiratory Medicine Case Reports
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