Pin Ha, Jin Hee Kwak, Yulong Zhang, Jiayu Shi, Luan Tran, Timothy Pan Liu, Hsin-Chuan Pan, Samantha Lee, Jong Kil Kim, Eric Chen, Yasaman Shirazi-Fard, Louis S Stodieck, Andy Lin, Zhong Zheng, Stella Nuo Dong, Xinli Zhang, Benjamin M Wu, Kang Ting, Chia Soo
Microgravity-induced bone loss results in a 1% bone mineral density loss monthly and can be a mission critical factor in long-duration spaceflight. Biomolecular therapies with dual osteogenic and anti-resorptive functions are promising for treating extreme osteoporosis. We previously confirmed that NELL-like molecule-1 (NELL-1) is crucial for bone density maintenance. We further PEGylated NELL-1 (NELL-polyethylene glycol, or NELL-PEG) to increase systemic delivery half-life from 5.5 to 15.5 h. In this study, we used a bio-inert bisphosphonate (BP) moiety to chemically engineer NELL-PEG into BP-NELL-PEG and specifically target bone tissues...
September 18, 2023: NPJ Microgravity