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mitochondrial complex II

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https://www.readbyqxmd.com/read/28204537/mitochondrial-complex-ii-regulates-a-distinct-oxygen-sensing-mechanism-in-monocytes
#1
Shraddha Sharma, Jianming Wang, Eduardo Cortes Gomez, Robert T Taggart, Bora E Baysal
No abstract text is available yet for this article.
February 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28195532/horizontal-transfer-of-whole-mitochondria-restores-tumorigenic-potential-in-mitochondrial-dna-deficient-cancer-cells
#2
Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Margaryta Sobol, Bing Yan, Bijay Pattnaik, Naveen Bhatraju, Jaroslav Truksa, Pavel Stopka, Pavel Hozak, Alfred Lam, Radislav Sedlacek, Paulo J Oliveira, Mikael Kubista, Anurag Agrawal, Katerina Dvorakova-Hortova, Jakub Rohlena, Michael V Berridge, Jiri Neuzil
Recently we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ(0) cells) is linked to acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To determine whether transfer of mtDNA involves whole mitochondria, we injected B16ρ(0) mouse melanoma cells into syngeneic C57BL/6N(su9-DsRed2) mice that express red fluorescent protein in their mitochondria. We document that mtDNA is acquired by transfer of whole mitochondria from the host animal, leading to normalisation of mitochondrial respiration...
February 14, 2017: ELife
https://www.readbyqxmd.com/read/28193782/mitochondrial-mass-and-activity-as-a-function-of-body-composition-in-individuals-with-spinal-cord-injury
#3
Laura C O'Brien, Rodney C Wade, Liron Segal, Qun Chen, Jeannie Savas, Edward J Lesnefsky, Ashraf S Gorgey
Spinal cord injury (SCI) is accompanied by deterioration in body composition and severe muscle atrophy. These changes put individuals at risk for insulin resistance, type II diabetes, and cardiovascular disease. To determine the relationships between skeletal muscle mitochondrial mass, activity, and body composition, 22 men with motor complete SCI were studied. Body composition assessment was performed using dual-energy X-ray absorptiometry and magnetic resonance imaging. Skeletal muscle biopsies were obtained from the vastus lateralis muscle to measure citrate synthase (CS) and complex III (CIII) activity...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28185716/mitochondrial-complex-ii-at-the-crossroads
#4
REVIEW
Ayenachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Karel Pacak, Jiri Neuzil
Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations...
February 6, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28176051/piracetam-attenuates-lps-induced-neuroinflammation-and-cognitive-impairment-in-rats
#5
Alok Tripathi, Pankaj Paliwal, Sairam Krishnamurthy
The present study was performed to investigate the effect of piracetam on neuroinflammation induced by lipopolysaccharide (LPS) and resulting changes in cognitive behavior. Neuroinflammation was induced by a single dose of LPS solution infused into each of the lateral cerebral ventricles in concentrations of 1 μg/μl, at a rate of 1 μl/min over a 5-min period, with a 5-min waiting period between the two infusions. Piracetam in doses of 50, 100, and 200 mg/kg i.p. was administered 30 min before LPS infusion and continued for 9 days...
February 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28176017/hypoxia-and-aerobic-metabolism-adaptations-of-human-endothelial-cells
#6
Agnieszka Koziel, Wieslawa Jarmuszkiewicz
The goal of our study was to assess the influence of chronic exposure to hypoxia on mitochondrial oxidative metabolism in human umbilical vein endothelial cells (EA.hy926 line) cultured for 6 days at 1% O2 tension. The hypoxia-induced effects were elucidated at the cellular and isolated mitochondria levels. Hypoxia elevated fermentation but did not change mitochondrial biogenesis or the aerobic respiratory capacity of endothelial cells. In endothelial cells, hypoxia caused a general decrease in mitochondrial respiration during carbohydrate, fatty acid, and amino acid oxidation but increased exclusively ketogenic amino acid oxidation...
February 8, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28159809/cardiac-med1-deletion-promotes-early-lethality-cardiac-remodeling-and-transcriptional-reprogramming
#7
Kathryn M Spitler, Jessica M Ponce, Gavin Y Oudit, Duane D Hall, Chad E Grueter
The Mediator complex, a multisubunit nuclear complex, plays an integral role in regulating gene expression by acting as a bridge between transcription factors and RNA polymerase II. Genetic deletion of mediator subunit 1 (Med1) results in embryonic lethality, due in large part to impaired cardiac development. We first established that Med1 is dynamically expressed in cardiac development and disease, with marked upregulation of Med1 in both human and murine failing hearts. To determine if Med1 deficiency protects against cardiac stress, we generated two cardiac-specific Med1 knockout mouse models in which Med1 is conditionally deleted (Med1cKO mice) or inducibly deleted in adult mice (Med1cKO-MCM mice)...
February 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28142080/new-copper-i-and-heteronuclear-copper-i-ruthenium-ii-complexes-synthesis-structural-characterization-and-cytotoxicity
#8
João Lopes, David Alves, Tânia S Morais, Paulo J Costa, M Fátima M Piedade, Fernanda Marques, Maria J Villa de Brito, M Helena Garcia
A new family of copper(I) complexes of general formula [Cu(dppe)(NN)](+) have been synthesized and fully characterized, with dppe=1.2-bis(diphenylphosphino)ethane and NN representing several bidentate heteroaromatic ligands: 2,2'-bipy=2.2'-bipyridine (1), Me2bpy=4.4'-dimethyl-2,2'-bipyridine (2), dpytz=3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine (3), dpp=2.3-bis(2-pyridyl)pyrazine (4), and the metallaligand [Ru(η(5)-C5H5)(PPh3)(dpp)](+) (5), yielding the bimetallic copper(I)-ruthenium(II) complex [Cu(dppe)(μ-dpp)Ru(η(5)-C5H5)(PPh3)](2+) (6)...
January 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28132522/inhibition-of-nfe2l2-are-pathway-by-mitochondrial-ros-contributes-to-development-of-cardiomyopathy-and-left-ventricular-dysfunction-in-chagas-disease
#9
Jian-Jun Wen, Craig Porter, Nisha Jain Garg
AIMS: We investigated the effects of mitochondrial reactive oxygen species (mtROS) on NFE2L2 transcription factor activity during Trypanosoma cruzi (Tc) infection, and determined if enhancing the mtROS scavenging capacity preserved the heart function in Chagas disease. RESULTS: C57BL/6 wild type (WT, female) mice infected with Tc exhibited myocardial loss of mitochondrial membrane potential, complex-II driven coupled respiration, and 9-fold increase in mtROS production...
January 28, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28128056/review-treatment-of-leber-s-hereditary-optic-neuropathy
#10
Rustum Karanjia, Jasdeep Chahal, Michael Ammar, Alfredo A Sadun
Leber's hereditary optic neuropathy (LHON) is a rare mitochondrial disease of complex I of the respiratory chain. Patients typically present with subacute vision loss in one eye followed by the loss of vision in the second eye approximately 4-8 weeks later, ultimately leading to blindness. Therapeutic interventions have so far failed to prevent this vision loss; however, there has been recent interest in new managements for this prototypic mitochondrial disease. A review of the literature was performed and articles were identified using PubMed (the search terms LHON and treatment were used)...
January 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28122051/low-cytochrome-oxidase-1-links-mitochondrial-dysfunction-to-atherosclerosis-in-mice-and-pigs
#11
Paul Holvoet, Maarten Vanhaverbeke, Benjamine Geeraert, Dieuwke De Keyzer, Maarten Hulsmans, Stefan Janssens
BACKGROUND: Cytochrome oxidase IV complex regulates energy production in mitochondria. Therefore, we determined the relation of COX genes with atherosclerosis in mice and pigs. METHODS AND RESULTS: First, we compared atherosclerosis in the aortic arch of age-matched (24 weeks) C57BL/6J control (n = 10), LDL-receptor deficient (n = 8), leptin-deficient ob/ob (n = 10), and double knock-out (lacking LDL-receptor and leptin) mice (n = 12). Low aortic mitochondria-encoded cytochrome oxidase 1 in obese diabetic double knock-out mice was associated with a larger plaque area and higher propensity of M1 macrophages and oxidized LDL...
2017: PloS One
https://www.readbyqxmd.com/read/28120943/melatonin-ameliorates-myocardial-ischemia-reperfusion-injury-in-type-1-diabetic-rats-by-preserving-mitochondrial-function-role-of-ampk-pgc-1%C3%AE-sirt3-signaling
#12
Liming Yu, Bing Gong, Weixun Duan, Chongxi Fan, Jian Zhang, Zhi Li, Xiaodong Xue, Yinli Xu, Dandan Meng, Buying Li, Meng Zhang, Bin Zhang, Zhenxiao Jin, Shiqiang Yu, Yang Yang, Huishan Wang
Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial ischemia/reperfusion (MI/R) injury. Melatonin has been reported to be a safe and potent cardioprotective agent. However, its role on mitochondrial biogenesis or reactive oxygen species (ROS) production in type 1 diabetic myocardium and the underlying mechanisms remain unknown. We hypothesize that melatonin ameliorates MI/R injury in type 1 diabetic rats by preserving mitochondrial function via AMPK-PGC-1α-SIRT3 signaling pathway...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115150/mitochondrial-dysfunction-oxidative-stress-and-apoptotic-induction-in-microglial-bv-2-cells-treated-with-sodium-arsenate
#13
Wafa Kharroubi, Samia Haj Ahmed, Thomas Nury, Pierre Andreoletti, Rachid Sakly, Mohamed Hammami, Gérard Lizard
The treatment of microglial BV-2 cells with sodium arsenate (As(V): 0.1-400μmol/L - 48hr) induces a dose-dependent response. The neurotoxic effects of high concentrations of As(V) (100, 200 and 400μmol/L) are characterized by increased levels of mitochondrial complexes I, II, and IV followed by increased superoxide anion generation. Moreover, As(V) triggers an apoptotic mode of cell death, demonstrated by an apoptotic SubG1 peak, associated with an alteration of plasma membrane integrity. There is also a decrease in transmembrane mitochondrial potential and mitochondrial adenosine triphosphate ATP...
January 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28115024/east-and-west-separation-of-rhipicephalus-sanguineus-mitochondrial-lineages-in-the-mediterranean-basin
#14
Sándor Hornok, Attila D Sándor, Snežana Tomanović, Relja Beck, Gianluca D'Amico, Jenő Kontschán, Nóra Takács, Tamás Görföl, Mohammed Lamine Bendjeddou, Gábor Földvári, Róbert Farkas
BACKGROUND: Rhipicephalus sanguineus belongs to a complex of hard tick species with high veterinary-medical significance. Recently, new phylogenetic units have been discovered within R. sanguineus, which therefore needs taxonomic revision. The present study was initiated to provide new information on the phylogeography of relevant haplotypes from less studied regions of Europe and Africa. With this aim, molecular-phylogenetic analyses of two mitochondrial markers were performed on 50 ticks collected in Hungary, the Balkans, countries along the Mediterranean Sea, Kenya and Ivory Coast...
January 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28111084/prepregnancy-maternal-diabetes-combined-with-obesity-impairs-placental-mitochondrial-function-involving-nrf2-are-pathway-and-detrimentally-alters-metabolism-of-offspring
#15
Yang Duan, Fuqiang Sun, Shengshun Que, Yueqin Li, Suyan Yang, Geli Liu
Metabolic disorders usually increase the level of reactive oxygen species (ROS) and damage mitochondrial function. The placenta supplies nutrients and hormonal signals to the fetus for regulating fetal metabolism, and is also prone to injury by oxidants. The aim of this study was to determine the effect of pre-existing maternal type 2 diabetes mellitus (DM) combined with obesity on placental mitochondrial function and metabolism disorders of offspring. The study included 96 pregnant women. The women were put into the following groups: healthy women (control, n=24), women with DM (DM, n=24), women with obesity (OB, n=24) and women with both DM and obesity (DM+OB, n=24)...
January 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28110440/molecular-characterization-of-echinococcus-granulosus-isolates-from-bulgarian-human-cystic-echinococcosis-patients
#16
Irina Marinova, Markus Spiliotis, Junhua Wang, Marin Muhtarov, Ilias Chaligiannis, Smaro Sotiraki, Iskra Rainova, Bruno Gottstein, Ghalia Boubaker
Although cystic echinococcosis (CE) is highly endemic in Bulgaria, there is still scarce information about species and/or genotypes of the Echinococcus granulosus complex that infect humans. Our study tackled the genetic diversity of E. granulosus complex in a cohort of 30 Bulgarian CE patients. Ten animal E. granulosus isolates from neighboring Greece were additionally included. Specimens were comparatively analyzed for partial sequences of five mitochondrial (mt) (cox I, nad I, rrnS, rrnL, and atp6) and three nuclear (nc) genes (act II, hbx 2, and ef-1α) using a PCR-sequencing approach...
January 21, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28108329/exercise-increases-mitochondrial-complex-i-activity-and-drp1-expression-in-the-brains-of-aged-mice
#17
Aaron M Gusdon, Jason Callio, Giovanna Distefano, Robert M O'Doherty, Bret H Goodpaster, Paul M Coen, Charleen T Chu
Exercise is known to have numerous beneficial effects. Recent studies indicate that exercise improves mitochondrial energetics not only in skeletal muscle but also in other tissues. While exercise elicits positive effects on memory, neurogenesis, and synaptic plasticity, the effects of exercise on brain mitochondrial energetics remain relatively unknown. Herein, we studied the effects of exercise training in old and young mice on brain mitochondrial energetics, in comparison to known effects on peripheral tissues that utilize fatty acid oxidation...
January 18, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28107432/ongoing-speciation-and-gene-flow-between-taxonomically-challenging-trochulus-species-complex-gastropoda-hygromiidae
#18
Małgorzata Proćków, Tomasz Strzała, Elżbieta Kuźnik-Kowalska, Jarosław Proćków, Paweł Mackiewicz
Geographical isolation, selection and genetic drift can cause the geographical diversification of populations and lead to speciation. Land snail species in the genus Trochulus show overlaps in geographical ranges as well as in morphology, but genetic data do not always support the species-level taxonomy based on morphological characters. Such a group offers an excellent opportunity to explore the processes involved. We have addressed the problem by determining the status of the restricted endemic T. graminicola within the larger context of Trochulus taxonomy...
2017: PloS One
https://www.readbyqxmd.com/read/28101459/venlafaxine-induced-cytotoxicity-towards-isolated-rat-hepatocytes-involves-oxidative-stress-and-mitochondrial-lysosomal-dysfunction
#19
Elham Ahmadian, Hossein Babaei, Alireza Mohajjel Nayebi, Aziz Eftekhari, Mohammad Ali Eghbal
Purpose: Depression is a public disorder worldwide. Despite the widespread use of venlafaxine in the treatment of depression, it has been associated with the incidence of toxicities. Hence, the goal of the current investigation was to evaluate the mechanisms of venlafaxine-induced cell death in the model of the freshly isolated rat hepatocytes. Methods: Collagenase-perfused rat hepatocytes were treated with venlafaxine and other agents. Cell damage, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial membrane potential decline, lysosomal damage, glutathione (GSH) level were analyzed...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28099141/antitumor-activity-of-a-trans-thiosemicarbazone-schiff-base-palladium-ii-complex-on-human-gastric-adenocarcinoma-cells
#20
Bingchang Zhang, Haiqing Luo, Qinjuan Xu, Lirong Lin, Bing Zhang
The development of transition-metal-based antitumor drug candidates increases the metallopharmaceuticals study dramatically. Two trans-thiosemicarbazone-based, Schiff base palladium (Pd) (II) complexes, DMABTSPd (TSPd) and DMABPTSPd (PTSPd), were prepared and characterized as described in our previous study. Here, we investigated whether the two complexes have antitumor effect on human gastric adenocarcinoma cell lines, BGC-823 and SGC-7901, compared with normal human gastric mucosal epithelial cell line, Ges-1...
January 13, 2017: Oncotarget
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