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https://www.readbyqxmd.com/read/28748204/data-on-effects-of-rotenone-on-calcium-retention-capacity-respiration-and-activities-of-respiratory-chain-complexes-i-and-ii-in-isolated-rat-brain-mitochondria
#1
Evelina Rekuviene, Laima Ivanoviene, Vilmante Borutaite, Ramune Morkuniene
The data presented in this article are related to the research article entitled "Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains" (Rekuviene et al., 2017) [1]. Data in this article present the direct effects of rotenone on calcium retention capacity (CRC) in isolated normal cortex and cerebellum mitochondria, effects of rotenone intravenous infusion on leak and phosphorylating respiration rates of isolated cortex and cerebellum mitochondria, on activities of respiratory chain complexes I and II in freezed-thawed/sonicated cortex and cerebellum mitochondria after brain ischemia...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28747868/protective-effect-of-momordica-charantia-water-extract-against-liver-injury-in-restraint-stressed-mice-and-the-underlying-mechanism
#2
Yuanyuan Deng, Qin Tang, Yan Zhang, Ruifen Zhang, Zhencheng Wei, Xiaojun Tang, Mingwei Zhang
Background: Momordica charantia is used in China for its jianghuo (heat-clearing and detoxifying) effects. The concept of shanghuo (the antonym of jianghuo, excessive internal heat) in traditional Chinese medicine is considered a type of stress response of the body. The stress process involves internal organs, especially the liver. Objective: We hypothesized that Momordica charantia water extract (MWE) has a hepatoprotective effect and can protect the body from stress. The aim of this study was to investigate the possible effects of MWE against liver injury in restraint-stressed mice...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28738277/new-ruthenium-compounds-bearing-semicarbazone-2-formylopyridine-moiety-playing-with-auxiliary-ligands-for-tuning-the-mechanism-of-biological-activity
#3
Michał Łomzik, Olga Mazuryk, Dorota Rutkowska-Zbik, Grażyna Stochel, Philippe C Gros, Małgorzata Brindell
Two ruthenium(II) complexes Ru1 and Ru2 bearing as a one ligand 2,2'-bipyridine substituted by a semicarbazone 2-formylopyridine moiety (bpySC: 5-(4-{4'-methyl-[2,2'-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone) and as the others 2,2'-bipyridine (bpy) and 4,7-diphenyl-1,10-phenanthroline (dip), respectively, as auxiliary ligands have been prepared. Their biological activity has been studied on murine colon carcinoma (CT26) and human lung adenocarcinoma (A549) cell lines. The anti-proliferative activity was dependent on the presence of bpy or dip in the complex, with one order of magnitude higher cytotoxicity for Ru2 (dip ligands)...
July 14, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28738167/methylene-blue-improves-mitochondrial-respiration-and-decreases-oxidative-stress-in-a-substrate-dependent-manner-in-diabetic-rat-hearts
#4
Oana M Duicu, Andreea Privistirescu, Adrian Wolf, Alexandra Petrus, Maria D Dănilă, Corina Ratiu, Danina M Muntean, Adrian Sturza
Diabetic cardiomyopathy has been systematically associated with compromised mitochondrial energetics and increased generation of reactive oxygen species (ROS) that underlie its progression to heart failure. Methylene blue is a redox-drug with reported protective effects mainly on brain mitochondria. The present study was purported to characterize the effects of acute administration of methylene blue on mitochondrial respiration, H2O2 production, and calcium sensitivity in rat heart mitochondria isolated from healthy and 2 months (streptozotocin-induced) diabetic rats...
July 24, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28732770/pharmacologic-modeling-of-primary-mitochondrial-respiratory-chain-dysfunction-in-zebrafish
#5
James Byrnes, Rebecca Ganetzky, Richard Lightfoot, Michael Tzeng, Eiko Nakamaru-Ogiso, Christoph Seiler, Marni J Falk
Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissue-specific manifestations, and major pathogenic factors contributing to each disorder, as well as their pre-clinical response to therapeutic candidates. We have developed a series of zebrafish (Danio rerio) models that inhibit, to variable degrees, distinct aspects of RC function, and enable quantification of animal development, survival, behaviors, and organ-level treatment effects on function as well as mitochondrial biochemistry and physiology...
July 18, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28732077/mutations-in-the-caenorhabditis-elegans-orthologs-of-human-genes-required-for-mitochondrial-trna-modification-cause-similar-electron-transport-chain-defects-but-different-nuclear-responses
#6
Carmen Navarro-González, Ismaïl Moukadiri, Magda Villarroya, Ernesto López-Pascual, Simon Tuck, M-Eugenia Armengod
Several oxidative phosphorylation (OXPHOS) diseases are caused by defects in the post-transcriptional modification of mitochondrial tRNAs (mt-tRNAs). Mutations in MTO1 or GTPBP3 impair the modification of the wobble uridine at position 5 of the pyrimidine ring and cause heart failure. Mutations in TRMU affect modification at position 2 and cause liver disease. Presently, the molecular basis of the diseases and why mutations in the different genes lead to such different clinical symptoms is poorly understood...
July 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28730835/the-effect-of-very-low-calorie-diet-on-mitochondrial-dysfunction-in-subcutaneous-adipose-tissue-and-peripheral-monocytes-of-obese-subjects-with-type-2-diabetes-mellitus
#7
M Urbanová, M Mráz, V Ďurovcová, P Trachta, J Kloučková, P Kaválková, D Haluzíková, Z Lacinová, H Hansíková, L Wenchich, M Kršek, M Haluzík
Mitochondrial dysfunction is a potentially important player in the development of insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the changes of mRNA expression of genes encoding main enzymatic complexes of mitochondrial respiratory chain in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) of 11 subjects with simple obesity (OB), 16 obese patients with T2DM and 17 healthy lean subjects (C) before and after very low-calorie diet (VLCD) using quantitative real time PCR...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28730764/mtor-deregulation-in-oral-cavity-squamous-cell-carcinoma
#8
Nicholas S Mastronikolis, Evangelos Tsiambas, Theodoros A Papadas, Panagiotis P Fotiades, Athanasios T Papadas, Stylianos N Mastronikolis, Ioannis Kastanioudakis, Vasileios Ragos
Signal transduction pathways consist of a variety of inter- and intra-cellular molecules. They act as supporting mechanisms for cell survival and homeostasis. Among them, the phosphatidylinositol 3-kinase (PI3K)/tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a crucial role in regulating normal cell growth based on growth factor receptors (GFRs) interaction, including epidermal GFR (type II-HER2) and insulin GFR (IGF)...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28728896/platinum-iv-complexes-conjugated-with-phenstatin-analogue-as-inhibitors-of-microtubule-polymerization-and-reverser-of-multidrug-resistance
#9
Xiaochao Huang, Rizhen Huang, Shaohua Gou, Zhimei Wang, Zhixin Liao, Hengshan Wang
Pt(IV) complexes comprising a phenstatin analogue, as dual-targeting Pt(IV) prodrug, were designed and synthesized. They were found not only to carry the DNA binding platinum warhead into the tumor cells, but also to have a small molecular unit to inhibit tubulin polymerization. In vitro evaluation results revealed that Pt(IV) complexes showed better and more potent activity against the test human cancer cells including cisplatin resistant cell lines than their corresponding Pt(II) counterparts. In addition, the Pt(IV) derivative of cisplatin, complex 10, exhibited highly selective inhibition in human cancer cells and displayed no obvious toxicity to two human normal cell lines, respectively...
July 8, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28715403/improving-strength-power-muscle-aerobic-capacity-and-glucose-tolerance-through-short-term-progressive-strength-training-among-elderly-people
#10
Eva A Andersson, Per Frank, Marjan Pontén, Björn Ekblom, Maria Ekblom, Marcus Moberg, Kent Sahlin
This protocol describes the simultaneous use of a broad span of methods to examine muscle aerobic capacity, glucose tolerance, strength, and power in elderly people performing short-term resistance training (RET). Supervised progressive resistance training for 1 h three times a week over 8 weeks was performed by RET participants (71±1 years, range 65-80). Compared to a control group without training, the RET showed improvements on the measures used to indicate strength, power, glucose tolerance, and several parameters of muscle aerobic capacity...
July 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28707237/selenium-protects-against-cadmium-induced-kidney-apoptosis-in-chickens-by-activating-the-pi3k-akt-bcl-2-signaling-pathway
#11
Rong-Kun Bao, Shu-Fang Zheng, Xin-Yue Wang
Cadmium (Cd) is a toxic heavy metal that can induce apoptosis. Selenium (Se) is a necessary trace element and can antagonize the toxicity of many heavy metals, including Cd. PI3K/AKT/Bcl-2 is a key survival signaling pathway that regulates cellular defense system against oxidative injury as well as cell proliferation, survival, and apoptosis. The antagonistic effects of Se on Cd-induced toxicity have been reported. However, little is known about the effect of Se on Cd-induced apoptosis in chicken kidneys via the PI3K/AKT/Bcl-2 signaling pathway...
July 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28705993/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-skeletal-muscle-mitochondrial-content-and-dynamics-and-lipids-after-10-days-of-bed-rest-in-older-adults
#12
Robert A Standley, Giovanna Distefano, Suzette L Pereira, Min Tian, Owen J Kelly, Paul M Coen, Nicolaas E P Deutz, Robert R Wolfe, Bret H Goodpaster
Loss of muscle mass during periods of disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation during 10 days of strict bed rest (BR) attenuates the loss of lean mass in older adults. To elucidate potential molecular mechanisms of HMB effects on muscle during bed rest and resistance training rehabilitation (RT), we examined mediators of skeletal muscle mitochondrial dynamics, autophagy and atrophy, and intramyocellular lipids...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28695374/impact-of-aromaticity-on-anticancer-activity-of-polypyridyl-ruthenium-ii-complexes-synthesis-structure-dna-protein-binding-lipophilicity-and-anticancer-activity
#13
Petar Čanović, Ana Rilak Simović, Snežana Radisavljević, Ioannis Bratsos, Nicola Demitri, Marina Mitrović, Ivanka Zelen, Živadin D Bugarčić
With the aim of assessing how the aromaticity of the inert chelating ligand can influence the activity of ruthenium(II) polypyridyl complexes, two new monofunctional ruthenium(II) complexes, [Ru(Cl-Ph-tpy)(phen)Cl]Cl (1) and [Ru(Cl-Ph-tpy)(o-bqdi)Cl]Cl (2) (where Cl-Ph-tpy = 4'-(4-chlorophenyl)-2,2':6',2″-terpyridine, phen = 1,10-phenanthroline, o-bqdi = o-benzoquinonediimine), were synthesized. All complexes were fully characterized by elemental analysis and spectroscopic techniques (IR, UV-Vis, 1D and 2D NMR, XRD)...
July 10, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28694208/single-nucleotide-polymorphisms-minisequencing-in-hypervariable-regions-for-screening-of-thais
#14
Punlop Thongngam, Worraanong Leewattanapasuk, Tanin Bhoopat, Padchanee Sangthong
Mitochondrial DNA (mtDNA) analysis has displayed an important role and been considered as a powerful tool in various fields of forensic science applications. Nowadays, single nucleotide polymorphisms (SNPs) on mtDNA have become additional DNA markers when conventional STR typing practically fails. mtDNA sequencing of polymerase chain reaction (PCR) products from the hypervariable region I (HVRI) and II (HVRII) is the standard method of mtDNA analysis. However, mtDNA sequencing is rather expensive, time consuming and technically complex...
July 7, 2017: Gene
https://www.readbyqxmd.com/read/28690197/high-fat-diet-induces-skeletal-muscle-oxidative-stress-in-a-fiber-type-dependent-manner-in-rats
#15
Ricardo A Pinho, Diane M Sepa-Kishi, George Bikopoulos, Michelle V Wu, Abinas Uthayakumar, Arta Mohasses, Meghan C Hughes, Christopher G R Perry, Rolando B Ceddia
This study investigated the effects of high-fat (HF) diet on parameters of oxidative stress among muscles with distinct fiber type composition and oxidative capacities. To accomplish that, male Wistar rats were fed either a low-fat standard chow (SC) or a HF diet for 8 weeks. Soleus, extensor digitorum longus (EDL), and epitrochlearis muscles were collected and mitochondrial H2O2 (mtH2O2) emission, palmitate oxidation, and gene expression and antioxidant system were measured. Chronic HF feeding enhanced fat oxidation in oxidative and glycolytic muscles...
July 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28687361/combined-effects-of-diets-and-temperature-on-mitochondrial-function-growth-and-nutrient-efficiency-in-rainbow-trout-oncorhynchus-mykiss
#16
Jonathan C Eya, Rodrigue Yossa, Dayan Perera, Olasupo Okubajo, Ann Gannam
A 4×3 factorial experiment was conducted to evaluate the effects of two dietary protein sources (mixed fishmeal/plant protein-, and plant protein- based diet), two dietary lipid levels (10% and 20%) and three water temperatures (10°C, 14°C, and 18°C) on the growth performance, nutrient utilization efficiencies and mitochondrial enzyme complex activities in rainbow trout Oncorhynchus mykiss (average weight±SD, 39.5±5g) over a 180day rearing period. At the end of the experiment, weight gain (WG), condition factor (CF), and feed efficiency (FE) were significantly affected by diet×temperature interaction (P<0...
July 4, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28681937/maternal-nicotine-exposure-leads-to-decreased-cardiac-protein-disulfide-isomerase-and-impaired-mitochondrial-function-in-male-rat-offspring
#17
Nicole G Barra, Maria Lisyansky, Taylor A Vanduzer, Sandeep Raha, Alison C Holloway, Daniel B Hardy
Smoking throughout pregnancy can lead to complications during gestation, parturition and neonatal development. Thus, nicotine replacement therapies are a popular alternative thought to be safer than cigarettes. However, recent studies in rodents suggest that fetal and neonatal nicotine exposure alone results in cardiac dysfunction and high blood pressure. While it is well known that perinatal nicotine exposure causes increased congenital abnormalities, the mechanisms underlying longer-term deficits in cardiac function are not completely understood...
July 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28679683/cold-water-immersion-following-sprint-interval-training-does-not-alter-endurance-signaling-pathways-or-training-adaptations-in-human-skeletal-muscle
#18
James R Broatch, Aaron C Petersen, David John Bishop
We investigated the underlying molecular mechanisms by which post-exercise cold-water immersion (CWI) may alter key markers of mitochondrial biogenesis following both a single session and six weeks of sprint interval training (SIT). Nineteen males performed a single SIT session, followed by one of two 15-min recovery conditions: cold-water immersion (COLD; 10°C) or a passive room-temperature control (CON; 23°C). Sixteen of these participants also completed six weeks SIT, each session followed immediately by their designated recovery condition...
July 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28678860/multi-scale-ancient-dna-analyses-confirm-the-western-origin-of-michelsberg-farmers-and-document-probable-practices-of-human-sacrifice
#19
Alice Beau, Maïté Rivollat, Hélène Réveillas, Marie-Hélène Pemonge, Fanny Mendisco, Yohann Thomas, Philippe Lefranc, Marie-France Deguilloux
In Europe, the Middle Neolithic is characterized by an important diversification of cultures. In northeastern France, the appearance of the Michelsberg culture has been correlated with major cultural changes and interpreted as the result of the settlement of new groups originating from the Paris Basin. This cultural transition has been accompanied by the expansion of particular funerary practices involving inhumations within circular pits and individuals in "non-conventional" positions (deposited in the pits without any particular treatment)...
2017: PloS One
https://www.readbyqxmd.com/read/28677803/grape-seed-procyanidin-b2-ameliorates-hepatic-lipid-metabolism-disorders-in-db-db-mice
#20
Mei Yin, Pei Zhang, Fei Yu, Zhen Zhang, Qian Cai, Weida Lu, Baoying Li, Weidong Qin, Mei Cheng, Hao Wang, Haiqing Gao
Diabetes is commonly associated with liver lipid metabolism disorders. AMP-activated protein kinase (AMPK) has a key role in regulating lipid metabolism. Grape seed procyanidin B2 (GSPB2), a natural polyphenol polymer, ameliorates mitochondrial dysfunction and inhibits oxidative stress or apoptosis via AMPK pathways. In the present study, the hypothesis that GSPB2 treatment may ameliorate liver lipid metabolic disorders by activating AMPK and downstream pathways was tested in diabetic mice. Db/m mice were used as controls, and diabetic db/db mice were randomly divided into 2 groups for treatment: Vehicle and GSPB2 (30 mg/kg/day for 10 weeks)...
September 2017: Molecular Medicine Reports
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