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Lactobacillus rhamnosus GG

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https://www.readbyqxmd.com/read/27884128/a-randomised-controlled-demonstration-trial-of-multifaceted-nutritional-intervention-and-or-probiotics-the-healthy-mums-and-babies-humba-trial
#1
Karaponi Okesene-Gafa, Minglan Li, Rennae S Taylor, John M D Thompson, Caroline A Crowther, Christopher J D McKinlay, Lesley M E McCowan
BACKGROUND: Maternal obesity is associated with adverse pregnancy outcomes and has lifelong negative implications for offspring health. The Institute of Medicine recommends limited gestational weight gain (GWG) in obese women for optimal maternal and infant outcomes. However, there is a gap regarding an effective and sustainable intervention strategy to achieve this goal. The aim of the healthy mums and babies (HUMBA) demonstration trial is to assess whether a multifaceted nutritional intervention and/or an oral probiotic treatment in obese pregnant women can reduce excessive GWG and optimise pregnancy outcomes...
November 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#2
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
November 17, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27853451/high-protective-efficacy-of-probiotics-and-rice-bran-against-human-norovirus-infection-and-diarrhea-in-gnotobiotic-pigs
#3
Shaohua Lei, Ashwin Ramesh, Erica Twitchell, Ke Wen, Tammy Bui, Mariah Weiss, Xingdong Yang, Jacob Kocher, Guohua Li, Ernawati Giri-Rachman, Nguyen Van Trang, Xi Jiang, Elizabeth P Ryan, Lijuan Yuan
Probiotics have been recognized as vaccine adjuvants and therapeutic agents to treat acute gastroenteritis in children. We previously showed that rice bran (RB) reduced human rotavirus diarrhea in gnotobiotic pigs. Human noroviruses (HuNoVs) are the major pathogens causing non-bacterial acute gastroenteritis worldwide. In this study, Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN) were first screened for their ability to bind HuNoV P particles and virions derived from clinical samples containing HuNoV genotype GII...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27821063/high-fat-diet-induced-atherosclerosis-is-accompanied-with-low-colonic-bacterial-diversity-and-altered-abundances-that-correlates-with-plaque-size-plasma-a-fabp-and-cholesterol-a-pilot-study-of-high-fat-diet-and-its-intervention-with-lactobacillus-rhamnosus
#4
Yee Kwan Chan, Manreetpal Singh Brar, Pirkka V Kirjavainen, Yan Chen, Jiao Peng, Daxu Li, Frederick Chi-Ching Leung, Hani El-Nezami
BACKGROUND: Atherosclerosis appears to have multifactorial causes - microbial component like lipopolysaccharides (LPS) and other pathogen associated molecular patterns may be plausible factors. The gut microbiota is an ample source of such stimulants, and its dependent metabolites and altered gut metagenome has been an established link to atherosclerosis. In this exploratory pilot study, we aimed to elucidate whether microbial intervention with probiotics L. rhamnosus GG (LGG) or pharmaceuticals telmisartan (TLM) could improve atherosclerosis in a gut microbiota associated manner...
November 8, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27786292/isolated-exopolysaccharides-from-lactobacillus-rhamnosus-gg-alleviated-adipogenesis-mediated-by-tlr2-in-mice
#5
Zhen Zhang, Zhigang Zhou, Yu Li, Linkang Zhou, Qianwen Ding, Li Xu
The fibroblast cell line of 3T3-L1 was used as a cell model for screening and evaluating the feasibility of probiotic components in improving animal lipid metabolisms. The extracts from 12 Lactobacillus strains caused significantly reduced triacylglycerol (TAG) accumulation but with severe inflammation induction in 3T3-L1 adipocytes. Interestingly, exopolysaccharides (EPS) from LGG (Lactobacillus rhamnosus GG) significantly decreased the TAG accumulation without any inflammation. The anti-obesity effect of EPS was confirmed in high-fat-diets feeding mice...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27779809/long-term-safety-and-efficacy-of-perinatal-probiotic-intervention-evidence-from-a-follow-up-study-of-four-randomized-double-blind-placebo-controlled-trials
#6
Krista Lundelin, Tuija Poussa, Seppo Salminen, Erika Isolauri
BACKGROUND: Societies worldwide are faced with a progressive increase in immune-mediated health problems such as allergic, autoimmune and inflammatory diseases, as well as obesity. Perinatal administration of specific probiotic bacteria is an attractive approach in reducing the risk of these conditions, but long-term efficacy and safety data are lacking. The aim here was to evaluate the clinical benefit and long-term safety of specific probiotics administered during the perinatal period...
October 25, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27745813/lactobacillus-rhamnosus-gg-treatment-improves-intestinal-permeability-and-modulates-inflammatory-response-and-homeostasis-of-spleen-and-colon-in-experimental-model-of-pseudomonas-aeruginosa-pneumonia
#7
Ludmila Khailova, Christine H Baird, Aubri A Rush, Christopher Barnes, Paul E Wischmeyer
BACKGROUND & AIMS: Recent clinical trials and in vivo models demonstrate probiotic administration can reduce occurrence and improve outcome of pneumonia and sepsis, both major clinical challenges worldwide. Potential probiotic benefits include maintenance of gut epithelial barrier homeostasis and prevention of downstream organ dysfunction due to systemic inflammation. However, mechanism(s) of probiotic-mediated protection against pneumonia remain poorly understood. This study evaluated potential mechanistic targets in the maintenance of gut barrier homeostasis following Lactobacillus rhamnosus GG (LGG) treatment in a mouse model of pneumonia...
October 1, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27741159/protective-role-of-postbiotic-mediators-secreted-by-lactobacillus-rhamnosus-gg-versus-lipopolysaccharide-induced-damage-in-human-colonic-smooth-muscle-cells
#8
Alessia Cicenia, Floriana Santangelo, Lucrezia Gambardella, Lucia Pallotta, Valerio Iebba, Annunziata Scirocco, Massimo Marignani, Guglielmo Tellan, Marilia Carabotti, Enrico Stefano Corazziari, Serena Schippa, Carola Severi
BACKGROUND: Some beneficial effects of probiotics may be due to secreted probiotic-derived factors, identified as "postbiotic" mediators. The aim of this study was to evaluate whether supernatants harvested from Lactobacillus rhamnosus GG (LGG) cultures (ATCC53103 strain) protect colonic human smooth muscle cells (HSMCs) from lipopolysaccharide (LPS)-induced myogenic damage. MATERIALS AND METHODS: LGG was grown in de Man, Rogosa, Share medium at 37°C and samples were collected in middle and late exponential, stationary, and overnight phases...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27696418/impact-of-a-novel-synbiotic-supplementation-during-gestation-and-lactation-on-immune-responses-in-the-swiss-albino-mice-offspring
#9
Himaja Nallagatla, Rajkumar Hemalatha, Narendra Babu Kondapalli, Shujauddin Mohammed
BACKGROUND: Prebiotics from various regularly consumed cereals and novel substrates are currently being utilised as functional foods. The aim of this study was to determine the effect of synbiotic, formulated with prebiotic extracted from natural resources like green gram (Vigna radiata) along with probiotic Lactobacillus rhamnosus GG (LGG) in modulating immune responses in the offspring when supplemented during gestation and lactation. RESULTS: Synbiotic supplementation was effective in improving cell mediated immunity and humoral immunity among F0 dams...
October 3, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27680208/the-different-effects-of-probiotics-treatment-on-salmonella-induced-interleukin-8-response-in-intestinal-epithelia-cells-via-pi3k-akt-and-nod2-expression
#10
F-C Huang, S-C Huang
Salmonella spp. remains a major public health problem for the whole world. Intestinal epithelial cells serve as an essential component of the innate mucosal immune system to defend against Salmonella infection. A substantial amount of evidence has accumulated that probiotics can regulate interleukin 8 (IL-8) involved in innate immunity. However, the exact effect of probiotics on epithelial IL-8 response to Salmonella infection is not well understood. Therefore, we investigated the action of probiotics on Salmonella-infected Caco-2 cells and its novel mechanisms...
September 29, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27618619/investigating-the-effect-of-different-treatments-with-lactic-acid-bacteria-on-the-fate-of-listeria-monocytogenes-and-staphylococcus-aureus-infection-in-galleria-mellonella-larvae
#11
Athena Grounta, Paschalis Harizanis, Eleftherios Mylonakis, George-John E Nychas, Efstathios Z Panagou
The use of Galleria mellonella as a model host to elucidate microbial pathogenesis and search for novel drugs and therapies has been well appreciated over the past years. However, the effect of microorganisms with functional appeal in the specific host remains scarce. The present study investigates the effect of treatment with selected lactic acid bacteria (LAB) with probiotic potential, as potential protective agents by using live or heat-killed cells at 6 and 24 h prior to infection with Listeria monocytogenes and Staphylococcus aureus or as potential therapeutic agents by using cell-free supernatants (CFS) after infection with the same pathogens...
2016: PloS One
https://www.readbyqxmd.com/read/27594560/the-role-of-probiotics-in-prevention-of-oral-diseases
#12
Magdalena Janczarek, Teresa Bachanek, Elżbieta Mazur, Renata Chałas
The dynamic development of knowledge in the field of probiotics was commenced at the beginning of the 20th century. Since then, many ways of their possible usage in medicine have been established. In accordance with the WHO, probiotics are live microorganisms, which if applied in adequate amounts may benefit the host. Among probiotics, fungi and bacteria are distinguished, and mechanisms of action of these organisms in the oral cavity and gut are parallel. Application in dentistry, in prophylaxis and treatment of oral diseases is still not well known...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27588102/probiotic-pre-administration-reduces-mortality-in-a-mouse-model-of-cecal-ligation-and-puncture-induced-sepsis
#13
Lufang Chen, Keying Xu, Qifeng Gui, Yue Chen, Deying Chen, Yunmei Yang
A number of clinical trials have demonstrated that the use of probiotics has the potential to prevent nosocomial infections. However, the mechanism underlying probiotic-induced anti-infection and sepsis remains to be investigated. In the present study, 200 µl/day of Lactobacillus rhamnosus GG (LGG) or normal saline (control) was orally administrated to 4-week-old C57BL6 mice 4 weeks prior to cecal ligation and puncture (CLP). A number of mice were sacrificed 24 h after CLP, and the remaining mice were used for survival studies...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27568925/presumed-allergic-proctocolitis-resolves-with-probiotic-monotherapy-a-report-of-4-cases
#14
Victoria J Martin, Wayne G Shreffler, Qian Yuan
BACKGROUND The prevalence of allergic diseases has been dramatically rising in the United States and other developed nations over recent decades. Growing evidence suggests a partial role for the microbiome in the development of these allergic diseases. Food protein-induced allergic proctocolitis (AP) (also referred to as cow's milk protein intolerance or allergy) is among the earliest and most common food allergic diseases of infancy, yet its pathophysiology is not well understood. The currently accepted clinical practice is to restrict the diet until 12 months of age...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27537843/lectin-like-molecules-of-lactobacillus-rhamnosus-gg-inhibit-pathogenic-escherichia-coli-and-salmonella-biofilm-formation
#15
Mariya I Petrova, Nicole C E Imholz, Tine L A Verhoeven, Jan Balzarini, Els J M Van Damme, Dominique Schols, Jos Vanderleyden, Sarah Lebeer
OBJECTIVES: Increased antibiotic resistance has catalyzed the research on new antibacterial molecules and alternative strategies, such as the application of beneficial bacteria. Since lectin molecules have unique sugar-recognizing capacities, and pathogens are often decorated with sugars that affect their survival and infectivity, we explored whether lectins from the probiotic strain Lactobacillus rhamnosus GG have antipathogenic properties. METHODS: The genome sequence of L...
2016: PloS One
https://www.readbyqxmd.com/read/27525288/lactobacillus-rhamnosus-gg-activation-of-dendritic-cells-and-neutrophils-depends-on-the-dose-and-time-of-exposure
#16
Shirong Cai, Matheswaran Kandasamy, Juwita N Rahmat, Sin Mun Tham, Boon Huat Bay, Yuan Kun Lee, Ratha Mahendran
This study evaluates the ability of Lactobacillus rhamnosus GG (LGG) to activate DC and neutrophils and modulate T cell activation and the impact of bacterial dose on these responses. Murine bone marrow derived DC or neutrophils were stimulated with LGG at ratios of 5 : 1, 10 : 1, and 100 : 1 (LGG : cells) and DC maturation (CD40, CD80, CD86, CD83, and MHC class II) and cytokine production (IL-10, TNF-α, and IL-12p70) were examined after 2 h and 18 h coculture and compared to the ability of BCG (the present immunotherapeutic agent for bladder cancer) to stimulate these cells...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27525046/epigenetic-features-of-foxp3-in-children-with-cow-s-milk-allergy
#17
Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D'Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore, Roberto Berni Canani
BACKGROUND: DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. RESULTS: Forty children (aged 3-18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4)...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27520820/probiotic-lactobacillus-rhamnosus-reduces-organophosphate-pesticide-absorption-and-toxicity-to-drosophila-melanogaster
#18
Mark Trinder, Tim W McDowell, Brendan A Daisley, Sohrab N Ali, Hon S Leong, Mark W Sumarah, Gregor Reid
: Organophosphate pesticides used in agriculture can pose health risks to humans and wildlife. We hypothesized that dietary supplementation with Lactobacillus, a genus of commensal bacteria, would reduce absorption and toxicity of consumed organophosphate pesticides (parathion and chlorpyrifos [CP]). Several Lactobacillus species were screened for toleration of 100 ppm of CP or parathion in MRS broth based on 24-h growth curves. Certain Lactobacillus strains were unable to reach stationary-phase culture maxima and displayed an abnormal culture morphology in response to pesticide...
October 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27480757/probiotics-prevention-of-severe-pneumonia-and-endotracheal-colonization-trial-prospect-a-pilot-trial
#19
Deborah J Cook, Jennie Johnstone, John C Marshall, Francois Lauzier, Lehana Thabane, Sangeeta Mehta, Peter M Dodek, Lauralyn McIntyre, Joe Pagliarello, William Henderson, Robert W Taylor, Rodrigo Cartin-Ceba, Eyal Golan, Margaret Herridge, Gordon Wood, Daniel Ovakim, Tim Karachi, Michael G Surette, Dawn M E Bowdish, Daphnee Lamarche, Chris P Verschoor, Erick H Duan, Diane Heels-Ansdell, Yaseen Arabi, Maureen Meade
BACKGROUND: Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest that probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and the overall incidence of infection in critically ill patients. However, these studies are small, largely single-center, and at risk of bias. The aim of the PROSPECT pilot trial was to determine the feasibility of conducting a larger trial of probiotics to prevent VAP in mechanically ventilated patients in the intensive care unit (ICU)...
2016: Trials
https://www.readbyqxmd.com/read/27463506/systematic-exploration-of-the-glycoproteome-of-the-beneficial-gut-isolate-lactobacillus-rhamnosus-gg
#20
Hanne L P Tytgat, Geert Schoofs, Jos Vanderleyden, Els J M Van Damme, Ruddy Wattiez, Sarah Lebeer, Baptiste Leroy
Glycoproteins form an interesting class of macromolecules involved in bacterial-host interactions, but they are not yet widely explored in Gram-positive and beneficial species. Here, an integrated and widely applicable approach was followed to identify putative bacterial glycoproteins, combining proteome fractionation with 2D protein and glycostained gels and lectin blots. This approach was validated for the microbiota isolate Lactobacillus rhamnosus GG. The approach resulted in a list of putative glycosylated proteins receiving a 'glycosylation score'...
2016: Journal of Molecular Microbiology and Biotechnology
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