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Lactobacillus rhamnosus GG

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https://www.readbyqxmd.com/read/28919861/lactobacillus-rhamnosus-gg-an-overview-to-explore-the-rationale-of-its-use-in-cancer
#1
REVIEW
Giuseppe L Banna, Francesco Torino, Francesco Marletta, Maria Santagati, Rossella Salemi, Elisa Cannarozzo, Luca Falzone, Francesco Ferraù, Massimo Libra
Cancer is the second leading cause of death in the western world. In the era of precision medicine, a significant number of cancer patients can be cured with several anti-cancer therapeutic regimens. However, therapy failure may be caused by treatment side effects, such as diarrhea, especially occurring in patients with gastrointestinal or pelvic malignancies. In particular, diarrhea is one of the most frequent gastrointestinal toxicity during cancer treatment and it can result from nearly bot chemo- and radio-therapeutic strategies currently used...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28917929/development-of-carboxymethyl-cellulose-chitosan-hybrid-micro-and-macroparticles-for-encapsulation-of-probiotic-bacteria
#2
P Singh, B Medronho, L Alves, G J da Silva, M G Miguel, B Lindman
Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5μm) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28912815/feasibility-of-metatranscriptome-analysis-from-infant-gut-microbiota-adaptation-to-solid-foods-results-in-increased-activity-of-firmicutes-at-six-months
#3
Floor Hugenholtz, Jarmo Ritari, Lotta Nylund, Mark Davids, Reetta Satokari, Willem M de Vos
Newborns are rapidly colonized by microbes and their intestinal tracts contain highly dynamic and rapidly developing microbial communities in the first months of life. In this study, we describe the feasibility of isolating mRNA from rapidly processed faecal samples and applying deep RNA-Seq analysis to provide insight into the active contributors of the microbial community in early life. Specific attention is given to the impact of removing rRNA from the mRNA on the phylogenetic and transcriptional profiling and its analysis depth...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28910860/isolation-of-probiotic-piliated-lactobacillus-rhamnosus-strains-from-human-faecal-microbiota-using-spaaantiserum-based-colony-immunoblotting
#4
Zhen-Quan Yang, Yu Xue, Mi Zhang, Sheng-Qi Rao, Lu Gao, Yong-Qi Yin, Da-Wei Chen, Xiao-Hui Zhou, Xin-An Jiao
Piliated Lactobacillus rhamnosus (pLR) strains possess higher adherent capacity than non-piliated strains. The objective of this study was to isolate and characterise probiotic pLR strains in human faecal samples. To this end, mouse polyclonal antiserum (anti-SpaA) against the recombinant pilus protein (SpaA) of L. rhamnosus strain GG (LGG) was prepared and tested for its reactivity and specificity. With the anti-SpaA, a method combining the de Man Rogosa and Sharpe (MRS) agar plating separation and colony immunoblotting (CIB) was developed to isolate pLR from 124 human faecal samples...
September 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28874323/the-effect-of-probiotics-and-zinc-supplementation-on-the-immune-response-to-oral-rotavirus-vaccine-a-randomized-factorial-design-placebo-controlled-study-among-indian-infants
#5
Robin P Lazarus, Jacob John, E Shanmugasundaram, Anand K Rajan, S Thiagarajan, Sidhartha Giri, Sudhir Babji, Rajiv Sarkar, P Saravankumar Kaliappan, Srinivasan Venugopal, Ira Praharaj, Uma Raman, Meghana Paranjpe, Nicholas C Grassly, Edward P K Parker, Umesh D Parashar, Jacqueline E Tate, Jessica A Fleming, A Duncan Steele, Jayaprakash Muliyil, Asha M Abraham, Gagandeep Kang
BACKGROUND: Strategies are needed to improve oral rotavirus vaccine (RV), which provides suboptimal protection in developing countries. Probiotics and zinc supplementation could improve RV immunogenicity by altering the intestinal microbiota and immune function. METHODS: Infants 5weeks old living in urban Vellore, India were enrolled in a randomized, double-blind, placebo-controlled trial with a 4-arm factorial design to assess the effects of daily zinc (5mg), probiotic (10(10)Lactobacillus rhamnosus GG) or placebo on the immunogenicity of two doses of RV (Rotarix®, GlaxoSmithKline Biologicals) given at 6 and 10weeks of age...
September 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28871492/frequency-of-antibiotic-associated-diarrhea-and-related-complications-in-pediatric-patients-who-underwent-hypospadias-repair-a-comparative-study-using-probiotics-vs-placebo
#6
Ciro Esposito, Agnese Roberti, Francesco Turrà, Mariapina Cerulo, Giovanni Severino, Alessandro Settimi, Maria Escolino
This study aimed to evaluate the effectiveness of probiotics (Lactobacillus rhamnosus GG), as a preventive measure of antibiotic-associated diarrhea (AAD) in children who underwent hypospadias repair and its clinical consequences on postoperative outcome, comparing the group treated with probiotics + antibiotics with two control groups (only antibiotics and antibiotics + placebo). We performed a prospective, randomized, placebo-controlled study with three groups of patients (30 boys for each group) who underwent hypospadias repair in our unit from March 2016 to December 2016...
September 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28867864/stability-of-lactobacillus-rhamnosus-gg-incorporated-in-edible-films-impact-of-anionic-biopolymers-and-whey-protein-concentrate
#7
Christos Soukoulis, Solmaz Behboudi-Jobbehdar, William Macnaughtan, Christopher Parmenter, Ian D Fisk
The incorporation of probiotics and bioactive compounds, via plasticised thin-layered hydrocolloids, within food products has recently shown potential to functionalise and improve the health credentials of processed food. In this study, choice of polymer and the inclusion of whey protein isolate was evaluated for their ability to stabalise live probiotic organisms. Edible films based on low (LSA) and high (HSA) viscosity sodium alginate, low esterified amidated pectin (PEC), kappa-carrageenan/locust bean gum (κ-CAR/LBG) and gelatine (GEL) in the presence or absence of whey protein concentrate (WPC) were shown to be feasible carriers for the delivery of L...
September 2017: Food Hydrocolloids
https://www.readbyqxmd.com/read/28856907/to-add-or-not-to-add-probiotics-to-infant-formulae-an-updated-systematic-review
#8
A Skórka, M Pieścik-Lech, M Kołodziej, H Szajewska
We updated evidence on the effects of the administration of probiotic-supplemented infant formulae (IF) compared with unsupplemented IF. Five databases were searched up to September 2016 for randomised controlled trials. Twenty publications were identified, including five new RCTs. Supplementation of IF with Bifidobacterium lactis Bb12, either alone or with Streptococcus thermophilus, had no effect on growth, respiratory illness, antibiotic use, stool frequency or consistency. However, there was a significant reduction in the number of episodes of gastrointestinal infections (Bb12) and a lower frequency of colic or irritability (when both strains were used)...
August 31, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28843807/a-comparative-study-of-procedures-for-binding-of-aflatoxin-m1-to-lactobacillus-rhamnosus-gg
#9
Jean Claude Assaf, Ali Atoui, André El Khoury, Ali Chokr, Nicolas Louka
Several strains of lactic acid bacteria (LAB), frequently used in food fermentation and preservation, have been reported to bind different types of toxins in liquid media. This study was carried out to investigate the effect of different concentrations of Lactobacillus rhamnosus GG (ATCC 53103) to bind aflatoxin M1 (AFM1) in liquid media. AFM1 binding was tested following repetitive washes or filtration procedures in combination with additional treatments such as heating, pipetting, and centrifugation. The mixture of L...
August 6, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28837002/early-gut-mycobiota-and-mother-offspring-transfer
#10
Kasper Schei, Ekaterina Avershina, Torbjørn Øien, Knut Rudi, Turid Follestad, Saideh Salamati, Rønnaug Astri Ødegård
BACKGROUND: The fungi in the gastrointestinal tract, the gut mycobiota, are now recognised as a significant part of the gut microbiota, and they may be important to human health. In contrast to the adult gut mycobiota, the establishment of the early gut mycobiota has never been described, and there is little knowledge about the fungal transfer from mother to offspring. METHODS: In a prospective cohort, we followed 298 pairs of healthy mothers and offspring from 36 weeks of gestation until 2 years of age (1516 samples) and explored the gut mycobiota in maternal and offspring samples...
August 24, 2017: Microbiome
https://www.readbyqxmd.com/read/28835355/efficacy-of-lactobacillus-reuteri-dsm-17938-for-the-treatment-of-acute-gastroenteritis-in-children-protocol-of-a-randomized-controlled-trial
#11
Henryk Szymański, Hania Szajewska
BACKGROUND: Acute gastroenteritis (AGE) is one of the most common diseases among children. Oral rehydration therapy is the key treatment. However, despite proven efficacy, it remains underused. This is because oral rehydration solution neither reduces the frequency of bowel movements and fluid loss nor shortens the duration of illness. Hence, there is interest in adjunctive treatments. According to the 2014 guidelines developed by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, the use of the following probiotics may be considered in the management of children with AGE in addition to rehydration therapy: Lactobacillus rhamnosus GG (low quality of evidence; strong recommendation) and Saccharomyces boulardii (low quality of evidence; strong recommendation)...
August 23, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28827186/probiotics-and-antibiotic-associated-diarrhea-in-children-a-review-and-new-evidence-on-lactobacillus-rhamnosus-gg-during-and-after-antibiotic-treatment
#12
REVIEW
Cecilia Mantegazza, Paola Molinari, Enza D'Auria, Micol Sonnino, Lorenzo Morelli
Antibiotic associated diarrhea (AAD) is a common complication in childhood in the outpatient and inpatient settings. This review provides up to date information on the use of probiotics in the prevention and treatment of AAD, including that from Clostridium Difficile, in children. The most recently systematic reviews and subsequently published randomized controlleds trials are considered. Different single and multistrain probiotics are described; a specific recommendation for the use of Lactobacillus Rhamnosus GG (LGG) and Saccharomyces boulardii (Sb) emerges...
August 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28772020/interplay-between-lactobacillus-rhamnosus-gg-and-candida-and-the-involvement-of-exopolysaccharides
#13
Camille N Allonsius, Marianne F L van den Broek, Ilke De Boeck, Shari Kiekens, Eline F M Oerlemans, Filip Kiekens, Kenn Foubert, Dieter Vandenheuvel, Paul Cos, Peter Delputte, Sarah Lebeer
A number of clinical studies have shown protective effects of lactobacilli against Candida species in the gastrointestinal tract, the urogenital tract and the oral cavity, while others did not show clear effects. Evidence on the mode of action of lactobacilli against Candida is also still lacking. In this study, the anti-Candida activity of the model probiotic strain Lactobacillus rhamnosus GG was explored in different assays to determine molecular interactions. We found that L. rhamnosus GG was able to interfere with Candida growth, morphogenesis and adhesion...
August 3, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28771188/apigenin-impacts-the-growth-of-the-gut-microbiota-and-alters-the-gene-expression-of-enterococcus
#14
Minqian Wang, Jenni Firrman, Liqing Zhang, Gustavo Arango-Argoty, Peggy Tomasula, LinShu Liu, Weidong Xiao, Kit Yam
Apigenin is a major dietary flavonoid with many bioactivities, widely distributed in plants. Apigenin reaches the colon region intact and interacts there with the human gut microbiota, however there is little research on how apigenin affects the gut bacteria. This study investigated the effect of pure apigenin on human gut bacteria, at both the single strain and community levels. The effect of apigenin on the single gut bacteria strains Bacteroides galacturonicus, Bifidobacterium catenulatum, Lactobacillus rhamnosus GG, and Enterococcus caccae, was examined by measuring their anaerobic growth profiles...
August 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28771130/indigenous-lactobacilli-strains-of-food-and-human-sources-reverse-enteropathogenic-e-coli-o26-h11-induced-damage-in-intestinal-epithelial-cell-lines-effect-on-redistribution-of-tight-junction-proteins
#15
Ruchi Jariwala, Hemanti Mandal, Tamishraha Bagchi
The aim of the study was to investigate the neutralizing effect of lactobacilli isolated from indigenous food and human sources on enteropathogenic Escherichia coli (EPEC) O26 : H11-induced epithelial barrier dysfunction in vitro. This was assessed by transepithelial electrical resistance (TEER) and permeability assays using intestinal cell lines, HT-29 and Caco-2. Furthermore, the expression and distribution of tight junction (TJ) proteins were analysed by qRT-PCR and immunofluorescence assay, respectively...
August 4, 2017: Microbiology
https://www.readbyqxmd.com/read/28770173/oral-administration-of-lactobacillus-rhamnosus-gg-ameliorates-salmonella-infantis-induced-inflammation-in-a-pig-model-via-activation-of-the-il-22bp-il-22-stat3-pathway
#16
Gui-Yan Yang, Jiao Yu, Jin-Hui Su, Lian-Guo Jiao, Xiao Liu, Yao-Hong Zhu
The high rate of Salmonella enterica serovar Infantis (S. Infantis) infection poses significant risk for the development of non-typhoidal Salmonella gastroenteritis. However, efficient strategies to prevent or treat the infection remain elusive. Here, we explored the effect of the probiotic Lactobacillus rhamnosus GG (LGG) administration in preventing S. Infantis infection in a pig model. Probiotic LGG (1.0 × 10(10) CFU/day) was orally administered to newly weaned piglets for 1 week before S. Infantis challenge...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28761060/administration-of-lactobacillus-salivarius-li01-or-pediococcus-pentosaceus-li05-prevents-ccl4-induced-liver-cirrhosis-by-protecting-the-intestinal-barrier-in-rats
#17
Ding Shi, Longxian Lv, Daiqiong Fang, Wenrui Wu, Chenxia Hu, Lichen Xu, Yanfei Chen, Jing Guo, Xinjun Hu, Ang Li, Feifei Guo, Jianzhong Ye, Yating Li, Dewi Andayani, Lanjuan Li
Alterations in the gut microbiome have been reported in liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate the effects and mechanisms of Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, Lactobacillus rhamnosus GG, Clostridium butyricum MIYAIRI and Bacillus licheniformis Zhengchangsheng on CCl4-induced cirrhotic rats. Only administration of LI01 or LI05 prevented liver fibrosis and down-regulated the hepatic expression of profibrogenic genes...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28758133/probiotic-lactobacillus-strains-stimulate-the-inflammatory-response-and-activate-human-macrophages
#18
L M Rocha-Ramírez, R A Pérez-Solano, S L Castañón-Alonso, S S Moreno Guerrero, A Ramírez Pacheco, M García Garibay, C Eslava
Lactobacilli have been shown to promote health functions. In this study, we analyzed the mechanism by which four different strains of probiotics affected innate immunity, such as regulation of ROS, cytokines, phagocytosis, bactericidal activity, signaling by NF-κB pp65, and TLR2 activation. The production of ROS was dependent on the concentration and species of Lactobacillus. The results obtained from the tested strains (Lactobacillus rhamnosus GG, L. rhamnosus KLSD, L. helveticus IMAU70129, and L. casei IMAU60214) showed that strains induced early proinflammatory cytokines such as IL-8,TNF-α, IL-12p70, and IL-6...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28753043/the-impact-of-storage-conditions-on-the-stability-of-lactobacillus-rhamnosus-gg-and-bifidobacterium-animalis-subsp-lactis-bb12-in-human-milk
#19
Anastasia Mantziari, Juhani Aakko, Himanshu Kumar, Satu Tölkkö, Elloise du Toit, Seppo Salminen, Erika Isolauri, Samuli Rautava
Human milk is the optimal source of complete nutrition for neonates and it also guides the development of infant gut microbiota. Importantly, human milk can be supplemented with probiotics to complement the health benefits of breastfeeding. Storage of human milk for limited periods of time is often unavoidable, but little is known about the effect of different storage conditions (temperature) on the viability of the added probiotics. Therefore, in this study, we evaluated how different storage conditions affect the viability of two specific widely used probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp...
July 28, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28700750/correction-genotypic-and-phenotypic-diversity-of-lactobacillus-rhamnosus-clinical-isolates-their-comparison-with-strain-gg-and-their-recognition-by-complement-system
#20
Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos
[This corrects the article DOI: 10.1371/journal.pone.0176739.].
2017: PloS One
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