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Lactobacillus rhamnosus GG

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https://www.readbyqxmd.com/read/28700750/correction-genotypic-and-phenotypic-diversity-of-lactobacillus-rhamnosus-clinical-isolates-their-comparison-with-strain-gg-and-their-recognition-by-complement-system
#1
Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos
[This corrects the article DOI: 10.1371/journal.pone.0176739.].
2017: PloS One
https://www.readbyqxmd.com/read/28678821/a-casein-hydrolysate-based-formulation-attenuates-obesity-and-associated-non-alcoholic-fatty-liver-disease-and-atherosclerosis-in-ldlr-leiden-mice
#2
Marieke H Schoemaker, Robert Kleemann, Martine C Morrison, Joanne Verheij, Kanita Salic, Eric A F van Tol, Teake Kooistra, Peter Y Wielinga
BACKGROUND: Obesity frequently associates with the development of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Chronic inflammation in white adipose tissue (WAT) seems to be an important driver of these manifestations. OBJECTIVE: This study investigated a combination of an extensively hydrolyzed casein (eHC), docosahexaenoic acid (DHA), arachidonic acid (ARA), and Lactobacillus Rhamnosus GG (LGG) (together referred to as nutritional ingredients, NI) on the development of obesity, metabolic risk factors, WAT inflammation, NAFLD and atherosclerosis in high-fat diet-fed LDLr-/-...
2017: PloS One
https://www.readbyqxmd.com/read/28670908/effects-of-lactobacillus-rhamnosus-gg-on-the-maturation-and-differentiation-of-dendritic-cells-in-rotavirus-infected-mice
#3
Y Jiang, L Ye, Y Cui, G Yang, W Yang, J Wang, J Hu, W Gu, C Shi, H Huang, C Wang
Rotavirus-related diarrhoea is considered one of the most important diseases in field animal production. In addition to the classic vaccine strategy, a number of studies have utilised probiotics, such as Lactobacillus rhamnosus GG (LGG), to prevent rotavirus-induced diarrhoea. Although it has been partially revealed that Toll-like receptors (TLRs) are involved in the LGG-mediated protection against rotavirus infection, the details of the underlying immunologic mechanisms remain largely unknown. In this study, three-to-four-week-old female BALB/c mice were divided into three groups and orally administered phosphate buffered saline (PBS), PBS plus rotavirus or LGG plus rotavirus, respectively...
July 3, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28659890/pre-cultivation-with-selected-prebiotics-enhances-the-survival-and-the-stress-response-of-lactobacillus-rhamnosus-strains-in-simulated-gastrointestinal-transit
#4
Mariantonietta Succi, Patrizio Tremonte, Gianfranco Pannella, Luca Tipaldi, Autilia Cozzolino, Rossana Romaniello, Elena Sorrentino, Raffaele Coppola
In our study, we dwelled upon combinations of lactobacilli/prebiotics, considering four different strains belonging to the Lactobacillus rhamnosus species, including Lactobacillus rhamnosus GG (LGG), and different prebiotics often found in commercial synbiotic products, such as inulin, lactulose and polyols mannitol and sorbitol. In the first step of the research, the survival, the growth kinetic parameters and the protein expression of Lb. rhamnosus strains cultivated in presence of the different prebiotics as a unique carbon source were evaluated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28634130/the-inhibitory-impacts-of-lactobacillus-rhamnosus-gg-derived-extracellular-vesicles-on-the-growth-of-hepatic-cancer-cells
#5
Elham Behzadi, Hamideh Mahmoodzadeh Hosseini, Abbas Ali Imani Fooladi
Bacterial extracellular vesicles (EVs) have come forth into notice as possible important agent to mediate host-pathogen interactions. In this scientific research, the authors have tried to find out the effect of EVs derived from Lactobacillus rhamnosus GG (LDEVs) on the apoptosis induction in HepG2 cell line. The EVs were purified from the conditioned medium of Lactobacillus rhamnosus GG using ultrafiltration and confirmed by transmission electron microscopy (TEM). The HepG2 cells were treated with different concentrations of purified LDEVs and the cytotoxicity and their effects on the expression of bcl-2 and bax genes were assessed by the MTT assay and semi-quantitative RT-PCR, respectively...
June 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28627210/lactobacillus-rhamnosusgg-reduces-hepatic-fibrosis-in-a-model-of-chronic-liver-disease-in-rats
#6
Thais Ortiz Hammes, Renata Leke, Thayssa Dalla Costa Escobar, Laisa Beduschi Fracasso, Fabiola Schons Meyer, Michael Éverton Andrades, Themis Reverbel da Silveira
BACKGROUND: The intestinal dysbiosis is common in chronic liver disease and can induce to inflammatory responses and mediate the collagen deposition in the liver. AIM: To evaluate the probiotic Lactobacillus rhamnosus GG (LGG) for the treatment of liver fibrosis in a model of chronic cholestatic liver disease in rats. METHODS: Male adult Wistar rats (n = 29) were submitted to common bile duct ligation (BDL groups) or manipulation of common bile duct without ligation (Ctrl groups)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28611498/in-vitro-characterization-of-lactobacillus-plantarum-strains-with-inhibitory-activity-on-enteropathogens-for-use-as-potential-animal-probiotics
#7
Sasikumar Arunachalam Palaniyandi, Karthiyaini Damodharan, Joo-Won Suh, Seung Hwan Yang
The present study evaluates the probiotic properties of three Lactobacillus plantarum strains MJM60319, MJM60298, and MJM60399 possessing antimicrobial activity against animal enteric pathogens. The three strains did not show bioamine production, mucinolytic and hemolytic activity and were susceptible to common antibiotics. The L. plantarum strains survived well in the simulated orogastrointestinal transit condition and showed adherence to Caco-2 cells in vitro. The L. plantarum strains showed strong antimicrobial activity against enterotoxigenic Escherichia coli, Shiga toxin-producing E...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28580919/crystallization-and-x-ray-diffraction-analysis-of-spae-a-basal-pilus-protein-from-the-gut-adapted-lactobacillus-rhamnosus-gg
#8
Arjun K Mishra, Abhin Kumar Megta, Airi Palva, Ingemar von Ossowski, Vengadesan Krishnan
SpaE is the predicted basal pilin subunit in the sortase-dependent SpaFED pilus from the gut-adapted and commensal Lactobacillus rhamnosus GG. Thus far, structural characterization of the cell-wall-anchoring basal pilins has remained difficult and has been limited to only a few examples from pathogenic genera and species. To gain a further structural understanding of the molecular mechanisms that are involved in the anchoring and assembly of sortase-dependent pili in less harmful bacteria, L. rhamnosus GG SpaE for crystallization was produced by recombinant expression in Escherichia coli...
June 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28579977/in-silico-prediction-in-vitro-antibacterial-spectrum-and-physicochemical-properties-of-a-putative-bacteriocin-produced-by-lactobacillus-rhamnosus-strain-l156-4
#9
Letícia de C Oliveira, Aline M M Silveira, Andréa de S Monteiro, Vera L Dos Santos, Jacques R Nicoli, Vasco A de C Azevedo, Siomar de C Soares, Marcus V Dias-Souza, Regina M D Nardi
A bacteriocinogenic Lactobacillus rhamnosus L156.4 strain isolated from the feces of NIH mice was identified by 16S rRNA gene sequencing and MALDI-TOF mass spectrometry. The entire genome was sequenced using Illumina, annotated in the PGAAP, and RAST servers, and deposited. Conserved genes associated with bacteriocin synthesis were predicted using BAGEL3, leading to the identification of an open reading frame (ORF) that shows homology with the L. rhamnosus GG (ATCC 53103) prebacteriocin gene. The encoded protein contains a conserved protein motif associated a structural gene of the Enterocin A superfamily...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28574970/probiotics-for-the-prevention-of-nosocomial-diarrhea-in-children
#10
Iva Hojsak, Hania Szajewska, Roberto Berni Canani, Alfredo Guarino, Flavia Indrio, Sanja Kolacek, Rok Orel, Raanan Shamir, Yvan Vandenplas, Johannes B van Goudoever, Zvi Weizman
This document provides recommendations developed by the ESPGHAN Working Group (WG) on Probiotics and Prebiotics on the role of probiotics in the prevention of nosocomial diarrhea in children based on a systematic review of previously completed systematic reviews and of subsequently published randomized controlled trials (RCTs). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines. Recommendations were given only if at least 2 RCTs examined the same probiotic strain...
June 2, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28559134/exosomes-isolated-from-sera-of-mice-fed-lactobacillus-strains-affect-inflammatory-cytokine-production-in-macrophages-in%C3%A2-vitro
#11
Ayako Aoki-Yoshida, Shinichi Saito, Takeshi Tsuruta, Arisa Ohsumi, Hinako Tsunoda, Kei Sonoyama
Orally administered Lactobacillus strains, including L. plantarum No.14 and L. rhamnosus GG, reportedly reduce inflammatory cytokine production in mice. The present study tested our idea that circulating exosomes mediate the action of Lactobacillus strains. The lipopolysaccharide-induced production of TNF-α and IL-6 in vitro was attenuated in peritoneal exudate cells (PECs) isolated from C57BL/6N mice that had been fed L. plantarum No.14. When PECs were cultured for 24 h with exosomes isolated from the serum of mice fed L...
May 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28502295/-lactobacillus-rhamnosus-gg-improves-symptoms-and-its-mechnism-in-mice-with-ovalbumin-induced-food-allergy
#12
Shuanfeng Fang, Yu Zhang, Yun Zhang, Xiaohua Zhu, Bei Yie
Objective To investigate the effect of Lactobacillus rhamnosus GG (LGG) on peripheral blood IL-4/IFN-γ in mice with ovalbumin-induced food allergy. Methods The mice with food allergy were divided into 3 groups (n=10 in each group): food allergy model group, low-dose LGG group (1×10(8) CFU/mL, 200 μL/d) and high-dose LGG group (1×10(9) CFU/mL, 200 μL/d). The healthy mice (n=10) served as a control group. Mice in the LGG groups were given LGG for consecutive 22 days after modeling. The control mice and the food allergy model mice were given normal saline instead of LGG...
May 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28493885/genotypic-and-phenotypic-diversity-of-lactobacillus-rhamnosus-clinical-isolates-their-comparison-with-strain-gg-and-their-recognition-by-complement-system
#13
Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos
Lactobacillus rhamnosus strains are ubiquitous in fermented foods, and in the human body where they are commensals naturally present in the normal microbiota composition of gut, vagina and skin. However, in some cases, Lactobacillus spp. have been implicated in bacteremia. The aim of the study was to examine the genomic and immunological properties of 16 clinical blood isolates of L. rhamnosus and to compare them to the well-studied L. rhamnosus probiotic strain GG. Blood cultures from bacteremic patients were collected at the Helsinki University Hospital laboratory in 2005-2011 and L...
2017: PloS One
https://www.readbyqxmd.com/read/28443531/probiotics-to-prevent-necrotising-enterocolitis-and-nosocomial-infection-in-very-low-birth-weight-preterm-infants
#14
J Uberos, E Aguilera-Rodríguez, A Jerez-Calero, M Molina-Oya, A Molina-Carballo, E Narbona-López
The aim of the study was to determine whether routine probiotic supplementation (RPS) with Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus +Lactobacillus bifidum is associated with reduced risk of necrotising enterocolitis (NEC)≥Stage II in preterm neonates born at ≤32 weeks' gestation. We conducted a retrospective cohort study on the effect of probiotic supplementation in very low birth weight infants in our neonatal unit by comparing two periods: before and after supplementation. The incidence of NEC≥Stage II, late-onset sepsis and all-cause mortality was compared for an equal period 'before' (Period I) and 'after' (Period II) RPS with LGG or L...
April 26, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28403649/a-survey-of-probiotic-use-practices-among-patients-at-a-tertiary-medical-centre
#15
K Draper, C Ley, J Parsonnet
Probiotic use has skyrocketed in recent years. Little is known, however, about patient knowledge and practices regarding probiotic use, especially in the context of antibiotic use. An invitation to complete a short, anonymous, electronic survey was sent by email to 965 patients at a tertiary medical centre in California who had agreed to be contacted for participation in research studies. Questions were asked about both probiotic and antibiotic use in the prior three months. Of 333 survey respondents, 55% had recently used probiotics, including food products and/or supplements (90 and 60% of probiotic users, respectively)...
April 13, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28369512/galleria-mellonella-as-an-in-vivo-model-for-assessing-the-protective-activity-of-probiotics-against-gastrointestinal-bacterial-pathogens
#16
Concetta Scalfaro, Angelo Iacobino, Chiara Nardis, Giovanna Franciosa
The antagonistic activity against gastrointestinal bacterial pathogens is an important property of probiotic bacteria and a desirable feature for pre-selection of novel strains with probiotic potential. Pre-screening of candidate probiotics for antibacterial activity should be based on in vitro and in vivo tests. This study investigated whether the protective activity of probiotic bacteria against gastrointestinal bacterial pathogens can be evaluated using Galleria mellonella larvae as an in vivo model. Larvae were pre-inoculated with either of two widely used probiotic bacteria, Lactobacillus rhamnosus GG or Clostridium butyricum Miyairi 588, and then challenged with Salmonella enterica Typhimurium, enteropathogenic Escherichia coli or Listeria monocytogenes...
April 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28346719/reduced-th22-cell-proportion-and-prevention-of-atopic-dermatitis-in-infants-following-maternal-probiotic-supplementation
#17
Anne Dorthea Bjerkenes Rø, Melanie Rae Simpson, Torstein Baade Rø, Ola Storrø, Roar Johnsen, Vibeke Videm, Torbjørn Øien
In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children. OBJECTIVE: To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD...
March 27, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28293233/the-soil-bacterium-methylococcus-capsulatus-bath-interacts-with-human-dendritic-cells-to-modulate-immune-function
#18
Stine Indrelid, Charlotte Kleiveland, René Holst, Morten Jacobsen, Tor Lea
The prevalence of inflammatory bowel disease (IBD) has increased in Western countries during the course of the twentieth century, and is evolving to be a global disease. Recently we showed that a bacterial meal of a non-commensal, non-pathogenic methanotrophic soil bacterium, Methylococcus capsulatus Bath prevents experimentally induced colitis in a murine model of IBD. The mechanism behind the effect has this far not been identified. Here, for the first time we show that M. capsulatus, a soil bacterium adheres specifically to human dendritic cells, influencing DC maturation, cytokine production, and subsequent T cell activation, proliferation and differentiation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28287654/use-of-imaging-techniques-to-identify-efficient-controlled-release-systems-of-lactobacillus-rhamnosus-gg-during-in-vitro-digestion
#19
Justine Guerin, Jennifer Burgain, Frédéric Borges, Bhesh Bhandari, Stéphane Desobry, Joël Scher, Claire Gaiani
Matrix composition plays a crucial role in the controlled release of viable and functional bacteria in the intestine. Imaging tools such as electronic and confocal microscopies were used in this work to investigate the influence of matrix composition on matrix integrity and porosity, bacterial spatial distribution and viability during simulated in vitro digestion. L. rhamnosus GG was encapsulated in matrices having different casein/whey protein ratios. The formulation with a casein/whey ratio of 60/40 presented a porous weak gel structure that resulted in its fast disintegration in gastric media showing the presence of dead bacteria in the intestine...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28262688/lactobacillus-rhamnosus-gg-supernatant-enhance-neonatal-resistance-to-systemic-escherichia-coli-k1-infection-by-accelerating-development-of-intestinal-defense
#20
Xiaolong He, Qing Zeng, Santhosh Puthiyakunnon, Zhijie Zeng, Weijun Yang, Jiawen Qiu, Lei Du, Swapna Boddu, Tongwei Wu, Danxian Cai, Sheng-He Huang, Hong Cao
The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. coli) K1 infection. The preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neonatal rat models. Our in vitro results showed that LCS could block adhesion, invasion and translocation of E. coli K1 to Caco-2 monolayer via up-regulating mucin production and maintaining intestinal integrity. In vivo experiments revealed that pre-treatment with LCS significantly decrease susceptibility of neonatal rats to oral E...
March 6, 2017: Scientific Reports
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