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https://www.readbyqxmd.com/read/28913608/efficacy-of-%C3%AE-lipoic-acid-against-cadmium-toxicity-on-metal-ion-and-oxidative-imbalance-and-expression-of-metallothionein-and-antioxidant-genes-in-rabbit-brain
#1
Hamida M Saleh, Yasser S El-Sayed, Sherif M Naser, Abdelgawad S Eltahawy, Atsuto Onoda, Masakazu Umezawa
To explore the protective efficacy of α-lipoic acid (ALA) against Cd-prompted neurotoxicity, young male New Zealand rabbits (Oryctolagus cuniculus) were divided randomly into four groups. Group 1 (control) received demineralized water. Group 2 (Cd) administered cadmium chloride (CdCl2) 3 mg/kg bwt. Group 3 (ALA) administered ALA 100 mg/kg bwt. Group 4 (Cd + ALA) administered ALA 1 h after Cd. The treatments were administered orally for 30 consecutive days. Cd-induced marked disturbances in neurochemical parameters were indicated by the reduction in micro- and macro-elements (Zn, Fe, Cu, P, and Ca), with the highest reduction in Cd-exposed rabbits, followed by Cd + ALA group and then ALA group...
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28913364/the-nrf2-keap1-are-pathway-and-oxidative-stress-as-a-therapeutic-target-in-type-ii-diabetes-mellitus
#2
REVIEW
Joshua A David, William J Rifkin, Piul S Rabbani, Daniel J Ceradini
Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide, and prevalence continues to rise. Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. Only recently, however, has the role of the Nrf2/Keap1/ARE master antioxidant pathway in diabetic dysfunction begun to be elucidated. There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28912423/the-chinese-herbal-formula-free-and-easy-wanderer-ameliorates-oxidative-stress-through-keap1-nrf2-ho-1-pathway
#3
Chunlan Hong, Jingming Cao, Ching-Fen Wu, Onat Kadioglu, Anja Schüffler, Ulrich Kauhl, Sabine M Klauck, Till Opatz, Eckhard Thines, Norbert W Paul, Thomas Efferth
Posttraumatic stress disorder (PTSD) gains a lot of attention due to high prevalence and strong psychological upset, but the etiology remains undefined and effective treatment is quite limited. Growing studies demonstrated the involvement of oxidative stress in various psychiatry diseases, suggesting anti-oxidation therapy might be a strategy for PTSD treatment. Free and Easy Wanderer (FAEW) is a poly-herbal drug clinically used in China for hundreds of years in the treatment of psychiatric disorder. We hypothesized that FAEW exerts clinical effects through the activity against oxidative stress with fluoxetine as antidepressant control drug...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28906435/mitochondrial-biogenesis-in-response-to-chromium-vi-toxicity-in-human-liver-cells
#4
Xiali Zhong, Rita de Cássia da Silveira E Sá, Caigao Zhong
Hexavalent chromium (Cr(VI)) is a ubiquitous environmental pollutant, which poses a threat to human public health. Recent studies have shown that mitochondrial biogenesis can be activated by inflammatory and oxidative stress. However, whether mitochondrial biogenesis is involved in Cr(VI)-induced hepatotoxicity is unclear. Here, we demonstrated the induction of inflammatory response and oxidative stress, as indicated by upregulation of inflammatory factors and reactive oxygen species (ROS). Subsequently, we demonstrated that mitochondrial biogenesis, comprising the mitochondrial DNA copy number and mitochondrial mass, was significantly increased in HepG2 cells exposed to low concentrations of Cr(VI)...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28903401/7-deacetylgedunin-suppresses-inflammatory-responses-through-activation-of-keap1-nrf2-ho-1-signaling
#5
Jian-Yu Chen, Guo-Yuan Zhu, Xiao-Hui Su, Rui Wang, Juan Liu, Kangsheng Liao, Rutong Ren, Ting Li, Liang Liu
Macrophages play a critical role in a variety of inflammatory diseases. Activation of Keap1/Nrf2/HO-1 signaling results in inactivation of macrophages and amelioration of inflammatory and autoimmune conditions. Hence, discovery for the activators of Keap1/Nrf2/HO-1 signaling has become a promising strategy for treatment inflammatory diseases. In the current study, the anti-inflammatory potential of 7-deacetylgedunin (7-DGD), a limonin chemical isolated from the fruits of Toona sinensis (A. Juss.) Roem, was intensively examined in vivo and in vitro for the first time...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28899208/the-regulation-of-nrf2-by-nutrient-responsive-signaling-and-its-role-in-anabolic-cancer-metabolism
#6
Sae Bom Lee, Brianna Sellers, Gina DeNicola
SIGNIFICANCE: The stress-responsive transcription factor nuclear factor erythroid 2 p45-related factor 2, or NRF2, regulates the expression of many cytoprotective enzymes to mitigate oxidative stress under physiological conditions. NRF2 is activated in response to oxidative stress, growth factor signaling, and changes in nutrient status. In addition, somatic mutations that disrupt the interaction between NRF2 and its negative regulator Kelch-like erythroid cell-derived protein with CNC homology (ECH)- associated 1 (KEAP1) commonly occur in cancer and are thought to promote tumorigenesis...
September 13, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28899203/an-overview-of-the-advantages-of-keap1-nrf2-system-activation-during-inflammatory-disease-treatment
#7
Nadine Keleku-Lukwete, Mikiko Suzuki, Masayuki Yamamoto
Inflammation can be defined as a protective immune response against harmful exogenous and endogenous stimuli. Nevertheless, prolonged or autoimmune inflammatory response are likely to cause pathological states associated with a production of inflammation-associated molecules along with ROS (reactive oxygen species). KEAP1-NRF2 (Kelch-like ECH-associated protein 1-Nuclear factor erythroid 2-related factor 2) signaling provides a cell protection mechanism against oxidative insults when endogenous stress defense mechanisms are imbalanced...
September 13, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28887507/carnosic-acid-prevents-dextran-sulfate-sodium-induced-acute-colitis-associated-with-the-regulation-of-the-keap1-nrf2-pathway
#8
Neng Yang, Zongling Xia, Naiyuan Shao, Bowen Li, Lian Xue, Ya Peng, Feng Zhi, Yilin Yang
Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBDs) with high prevalence in humans. Carnosic acid (CA) has been reported to possess antioxidative properties; however, its role in IBDs has not been determined. In the present study, we found that CA significantly prevented the loss of body weight and shortening of colon length in acute colitis induced by dextran sodium sulfate (DSS). Pronounced infiltration of immune cells and a loss of crypt architecture and goblet cells were ameliorated by CA...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887111/impairment-of-gill-structural-integrity-by-manganese-deficiency-or-excess-related-to-induction-of-oxidative-damage-apoptosis-and-dysfunction-of-the-physical-barrier-as-regulated-by-nf-%C3%AE%C2%BAb-caspase-and-nrf2-signaling-in-fish
#9
Wei-Dan Jiang, Ren-Jun Tang, Yang Liu, Pei Wu, Sheng-Yao Kuang, Jun Jiang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Lin Feng
This study is for the first time to explore the possible effects of dietary manganese (Mn) on structural integrity and the related signaling in the gills of fish. Grass carp (Ctenopharyngodon idella) were fed with six diets containing graded levels of Mn [3.65-27.86 mg Mn/kg diet] for 8 weeks. The results firstly demonstrated that Mn deficiency aggravated inflammation indicated by up-regulation of pro-inflammatory cytokines (tumour necrosis factor α, interleukin 8, and interleukin 1β mRNA levels) and down-regulation of anti-inflammatory cytokines (interleukin 10, transforming growth factor-β1) mRNA levels, which might be partially related to the up-regulation of nuclear factor kappa B (NF-κB p65) and down-regulation of nuclear inhibitor factor κBα (iκBα) mRNA levels in the gills of fish...
September 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28881148/protective-effect-of-%C3%AE-bisabolol-on-rotenone-induced-toxicity-in-i-drosophila-melanogaster-i
#10
Gerlânia de Oliveira Leite, Assis Ecker, Rodrigo Lopes Seeger, Bárbara Nunes Krum, Thiago Henrique Lugokenski, Roselei Fachinetto, Jéssie Haigert Sudati, Nilda Vargas Barbosa, Caroline Wagner
(-)-α-Bisabolol (BISA) is a sesquiterpene alcohol, which has with several recognized biological activities, including anti-inflammatory, anti-irritant, and antibacterial properties. In the present study, we investigated the influence of BISA (5, 25, and 250 μM) on rotenone (500 μM)-induced toxicity in <i>Drosophila melanogaster</i> for 7 days. BISA supplementation significantly decreased rotenone-induced mortality and locomotor deficits. The loss of motor function induced by rotenone correlated with a significant change in stress response factors; it decreased thiol levels, inhibited mitochondria complex I, and increased the mRNA expression of antioxidant marker proteins such as superoxide dismutase (SOD), catalase (CAT), and the keap1 gene product...
September 7, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28871145/reversible-keap1-inhibitors-are-preferential-pharmacological-tools-to-modulate-cellular-mitophagy
#11
Nikolaos D Georgakopoulos, Michele Frison, Maria Soledad Alvarez, Hélène Bertrand, Geoff Wells, Michelangelo Campanella
Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without collapsing their membrane potential (ΔΨm). PMI is an inhibitor of the protein-protein interaction (PPI) between the transcription factor Nrf2 and its negative regulator, Keap1 and is able to up-regulate the expression of autophagy-associated proteins, including p62/SQSTM1...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865787/sex-dependent-effects-of-subacute-mercuric-chloride-exposure-on-histology-antioxidant-status-and-immune-related-gene-expression-in-the-liver-of-adult-zebrafish-danio-rerio
#12
Qi-Liang Chen, Ya-Ling Sun, Zhi-Hao Liu, Ying-Wen Li
Mercury (Hg) is a global pollutant that causes negative health effects. In order to assess Hg-induced hepatotoxicity in fish and examine whether gender differences existed in response to Hg exposure, adult zebrafish were exposed to 0, 15 and 30 μg L(-1) Hg(2+) for 30 days, and histology, antioxidant status and the transcription levels of several immune-related genes were examined in the liver. Hg(2+) exposure caused a dose-dependent increase in histopathological lesions of the liver, including vacuolization, parenchyma disorganization and pyknotic nucleus, and these lesions were more severe in males than in females...
August 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28865326/hydrogen-sulfide-attenuates-calcification-of-vascular-smooth-muscle-cells-via-keap1-nrf2-nqo1-activation
#13
Parisa Aghagolzadeh, Ramin Radpour, Matthias Bachtler, Harry van Goor, Edward R Smith, Adam Lister, Alex Odermatt, Martin Feelisch, Andreas Pasch
BACKGROUND AND AIMS: Vascular calcification is a common health problem related to oxidative stress, inflammation, and circulating calciprotein particles (CPP). Hydrogen sulfide is an endogenous signaling molecule with antioxidant properties and potential for drug development targeting redox signaling. Yet, its molecular mechanisms of action in vascular smooth muscle cell (VSMC) calcification have not been delineated. We therefore sought to identify key pathways involved in the calcification-inhibitory properties of sulfide employing our recently developed CPP-induced VSMC calcification model...
August 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28864287/age-related-cataracts-role-of-unfolded-protein-response-ca-2-mobilization-epigenetic-dna-modifications-and-loss-of-nrf2-keap1-dependent-cytoprotection
#14
REVIEW
Palsamy Periyasamy, Toshimichi Shinohara
Age-related cataracts are closely associated with lens chronological aging, oxidation, calcium imbalance, hydration and crystallin modifications. Accumulating evidence indicates that misfolded proteins are generated in the endoplasmic reticulum (ER) by most cataractogenic stresses. To eliminate misfolded proteins from cells before they can induce senescence, the cells activate a clean-up machinery called the ER stress/unfolded protein response (UPR). The UPR also activates the nuclear factor-erythroid-2-related factor 2 (Nrf2), a central transcriptional factor for cytoprotection against stress...
September 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28854119/new-tricks-for-an-old-dog-brf2-dependent-rna-polymerase-iii-transcription-in-oxidative-stress-and-cancer
#15
Jerome Gouge, Alessandro Vannini
Here, we discuss the role of Brf2, an RNA Polymerase III core transcription factor, as a master switch of the oxidative stress response. We highlight the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations.
August 30, 2017: Transcription
https://www.readbyqxmd.com/read/28846113/vps34-stimulation-of-p62-phosphorylation-for-cancer-progression
#16
X Jiang, Y Bao, H Liu, X Kou, Z Zhang, F Sun, Z Qian, Z Lin, X Li, X Liu, L Jiang, Y Yang
Vps34, a class III PtdIns3 lipid kinase involved in the control of both autophagic and endocytic systems, has been studied extensively in numerous fundamental cellular processes. Accumulating evidence indicates that Vps34 may also contribute to the development and progression of human cancers. However, the mechanism of Vps34 in tumorigenesis remains elusive. Here, we report an unanticipated role of Vps34 in the activation of p62 for cancer development. We identified that Vps34 is a transcriptional activator of p62 through competition of Nrf2 (nuclear factor erythroid 2-related factor 2) for Keap1 binding...
August 28, 2017: Oncogene
https://www.readbyqxmd.com/read/28842592/neglected-role-of-hydrogen-sulfide-in-sulfur-mustard-poisoning-keap1-s-sulfhydration-and-subsequent-nrf2-pathway-activation
#17
Wenqi Meng, Zhipeng Pei, Yongwei Feng, Jie Zhao, Yongchun Chen, Wenwen Shi, Qingqiang Xu, Fengwu Lin, Mingxue Sun, Kai Xiao
Sulfur mustard (SM) is a chemical warfare agent and a terrorism choice that targets various organs and tissues, especially lung tissues. Its toxic effects are tightly associated with oxidative stress. The signaling molecule hydrogen sulfide (H2S) protects the lungs against oxidative stress and activates the NF-E2 p45-related factor 2 (Nrf2) pathway. Here, we sought to establish whether endogenous H2S plays a role in SM induced lesion in mouse lungs and lung cells and whether endogenous H2S plays the role through Nrf2 pathway to protect against SM-induced oxidative damage...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842501/stress-sensing-mechanisms-and-the-physiological-roles-of-the-keap1-nrf2-system-during-cellular-stress
#18
Takafumi Suzuki, Masayuki Yamamoto
Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. Nrf2 induces the expression of detoxification and antioxidant enzymes and suppresses the induction of pro-inflammatory cytokine genes. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3-based E3 ubiquitin ligase. Keap1 regulates the activity of Nrf2 and acts as a sensor for oxidative and electrophilic stresses. In this review, we discuss the molecular mechanisms by which the Keap1-Nrf2 system senses and regulates the cellular response to environmental stresses...
August 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28841174/purification-preliminary-characterization-and-hepatoprotective-effects-of-polysaccharides-from-dandelion-root
#19
Liangliang Cai, Dongwei Wan, Fanglian Yi, Libiao Luan
In this study, purification, preliminary characterization and hepatoprotective effects of water-soluble polysaccharides from dandelion root (DRP) were investigated. Two polysaccharides, DRP1 and DRP2, were isolated from DRP. The two polysaccharides were α-type polysaccharides and didn't contain protein. DRP1, with a molecular weight of 5695 Da, was composed of glucose, galactose and arabinose, whereas DRP2, with molecular weight of 8882 Da, was composed of rhamnose, galacturonic acid, glucose, galactose and arabinose...
August 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28839075/a-pgam5-keap1-nrf2-complex-is-required-for-stress-induced-mitochondrial-retrograde-trafficking
#20
Gary B O'Mealey, Kendra S Plafker, William L Berry, Ralf Janknecht, Jefferson Y Chan, Scott M Plafker
The Nrf2 transcription factor is a master regulator of the cellular anti-stress response. A population of the transcription factor associates with the mitochondria through a complex with KEAP1 and the mitochondrial outer membrane histidine phosphatase, PGAM5. To determine the function of this mitochondrial complex, we knocked down each component and assessed mitochondrial morphology and distribution. We discovered that depletion of Nrf2 or PGAM5, but not KEAP1, inhibits mitochondrial retrograde trafficking induced by proteasome inhibition...
August 24, 2017: Journal of Cell Science
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