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https://www.readbyqxmd.com/read/27587466/developing-ezh2-targeted-therapy-for-lung-cancer
#1
Arthur E Frankel, Xin Liu, John D Minna
Epigenetic targets are exciting new avenues for cancer drug discovery. Zhang and colleagues have designed the open-source EZH2 inhibitor JQEZ5 and shown antitumor efficacy in vitro and in vivo in preclinical studies in murine and human lung adenocarcinoma models expressing high levels of EZH2. Cancer Discov; 6(9); 949-52. ©2016 AACRSee related article by Zhang and colleagues, p. 1006.
September 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27312177/oncogenic-deregulation-of-ezh2-as-an-opportunity-for-targeted-therapy-in-lung-cancer
#2
Haikuo Zhang, Jun Qi, Jaime M Reyes, Lewyn Li, Prakash K Rao, Fugen Li, Charles Y Lin, Jennifer A Perry, Matthew A Lawlor, Alexander Federation, Thomas De Raedt, Yvonne Y Li, Yan Liu, Melissa A Duarte, Yanxi Zhang, Grit S Herter-Sprie, Eiki Kikuchi, Julian Carretero, Charles M Perou, Jacob B Reibel, Joshiawa Paulk, Roderick T Bronson, Hideo Watanabe, Christine Fillmore Brainson, Carla F Kim, Peter S Hammerman, Myles Brown, Karen Cichowski, Henry Long, James E Bradner, Kwok-Kin Wong
UNLABELLED: As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates transcriptional silencing of developmental gene networks. Overexpression of EZH2 is commonly observed in human epithelial cancers, such as non-small cell lung carcinoma (NSCLC), yet definitive demonstration of malignant transformation by deregulated EZH2 remains elusive. Here, we demonstrate the causal role of EZH2 overexpression in NSCLC with new genetically engineered mouse models of lung adenocarcinoma...
September 2016: Cancer Discovery
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