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Jayabrata Maity, Samit Kumar Ray
With an objective to improve the adsorption properties of a synthetic hydrogel, potato starch (PS) was incorporated in the ter-copolymer (TP) of acrylic acid (AA), acrylamide (AM) and bi-carboxylic itaconic acid (IA) during polymerization of the monomers. The resulting TP-PS composite hydrogels were characterized by FTIR, XRD, TGA, NMR, SEM/EDX and rheological properties. These hydrogels were used for removal of Cu(II) and Cd(II) as single and binary competitive mixtures from water. The effect of PS as well as various physico-chemical parameters such as solution pH, adsorbent dosage, contact time of gel with metal ion in water and concentration of metal ion in water was studied in batch experiments...
November 7, 2017: Journal of Physical Chemistry. B
Badal C Saha, Gregory J Kennedy
Itaconic acid (IA) is a building block platform chemical that is currently produced industrially from glucose by fermentation with Aspergillus terreus. However, lignocellulosic biomass has the potential to serve as low cost source of sugars for production of IA. Previously, 100 A. terreus strains were evaluated for production of IA from pentose sugars in shake-flasks. Six selected strains were then investigated for IA production in shake-flasks. But none of the strains grew and produced IA using biomass hydrolyzates...
November 3, 2017: Journal of Microbiological Methods
Vinod Kumar Gupta, Swadeep Sood, Shilpi Agarwal, Adesh K Saini, Deepak Pathania
Tragacanth gum-cl-poly (lactic acid-co-itaconic acid) (TG-cl-p(LA-co-IA)) hydrogel is synthesized through graft copolymerization reaction using microwave assisted technique. The synthesized hydrogel was characterised using various analytical and characterization techniques such as FTIR, FESEM, XRD, TGA, TEM and SEM. It was observed that, the maximum percentage swelling (Ps) of the hydrogel was 311.61% after 6h at room temperature and 298.06% after 3h at 60°C and TG-cl-p(LA-co-IA) exhibited highest Amoxicillin loading (73%) in double distilled waterafter 24h...
October 28, 2017: International Journal of Biological Macromolecules
Michael A Reid, Jihye Paik, Jason W Locasale
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B12 levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B12 metabolism and the immunomodulatory metabolite, itaconate.
November 2, 2017: Cell
F Shokrolahi, M Zandi, P Shokrollahi, M Atai, E Ghafarzadeh, M Hanifeh
The physical, mechanical and biological properties of multicomponent acrylate-based hard lenses are directly influenced by degree of conversion achieved during copolymerization. In this research, polyhedral oligomeric silsesquioxane (POSS) acrylate is introduced into the polymer backbone in combination with hydroxyethyl methacrylate, dimethyl itaconate, methyl methacrylate, 3-(trimethoxysilyl) propyl methacrylate and triethylene glycol dimethacrylate in free-radical bulk polymerization. Kinetics of curing process was investigated by two techniques: differential scanning calorimetry and FTIR spectroscopy...
October 25, 2017: Progress in biomaterials
Vesna V Panic, Sanja I Seslija, Ivanka G Popovic, Vuk D Spasojevic, Aleksandar R Popovic, Vladimir B Nikolic, Pavle M Spasojevic
For the preparation of fully biobased unsaturated polyester resins (UPRs), the replacement of styrene with alternate nonpetroleum-based monomers turned out to be one of the most challenging tasks. Its complexity lies in the fact that reactive diluents (RD) have to have low viscosity and volatility, good compatibility with prepolymer, and capability to homopolymerize and copolymerize with its unsaturations. In this context, we directed our efforts to develop fully biobased UPRs using the dialkyl itaconates as an alternative to styrene...
November 8, 2017: Biomacromolecules
Hongying Shen, Gregory C Campanello, Daniel Flicker, Zenon Grabarek, Junchi Hu, Cheng Luo, Ruma Banerjee, Vamsi K Mootha
CLYBL encodes a ubiquitously expressed mitochondrial enzyme, conserved across all vertebrates, whose cellular activity and pathway assignment are unknown. Its homozygous loss is tolerated in seemingly healthy individuals, with reduced circulating B12 levels being the only and consistent phenotype reported to date. Here, by combining enzymology, structural biology, and activity-based metabolomics, we report that CLYBL operates as a citramalyl-CoA lyase in mammalian cells. Cells lacking CLYBL accumulate citramalyl-CoA, an intermediate in the C5-dicarboxylate metabolic pathway that includes itaconate, a recently identified human anti-microbial metabolite and immunomodulator...
November 2, 2017: Cell
B C Saha, G J Kennedy
Itaconic acid (IA), an unsaturated 5-carbon dicarboxylic acid, is a building block platform chemical that is currently produced industrially from glucose by fermentation with Aspergillus terreus. Softwood has the potential to serve as low cost source of sugars for its production. Effective utilization of all softwood derived sugars such as glucose, mannose and galactose by the fungus for production of IA will lower the cost of its production. In this work, 20 A. terreus strains were evaluated for the first time for IA production from mannose and galactose in shake-flasks at initial pH of 3·1, 33°C and 200 rev min(-1) for 7 days...
October 4, 2017: Letters in Applied Microbiology
Ahmad Shaabani, Seyyed Emad Hooshmand
A planning strategy for diversity-oriented catalyst-free synthesis of pseudopeptides containing rhodanine scaffolds has been developed via a novel one-pot sequential six-component reaction in water. This approach is an efficient, environmentally friendly and expeditious procedure for direct access to wide ranges of pharmacologically significant and structurally interesting compounds based on the union of multicomponent reactions approach via tandem Michael/domino cycloaddition/Ugi reactions sequence from readily available starting materials...
January 2018: Ultrasonics Sonochemistry
Richa Bafana, Sarvanadevi Sivanesan, R A Pandey
Several fungi and starch-rich industrial residues were screened for itaconic acid (IA) production. Out of 15 strains, only three fungal strains were found to produce IA, which was confirmed by HPLC and GC-MS analysis. These strains were identified as Aspergillus terreus strains C1 and C2, and Ustilago maydis strain C3 by sequencing of 18S rRNA gene and internal transcribed spacer regions. Cis-aconitate decarboxylase (cad) gene, which encodes a key enzyme in IA production in A. terreus, was characterized from strains C1 and C2...
September 2017: Indian Journal of Microbiology
Long Huang, Meiying Liu, Liucheng Mao, Qiang Huang, Hongye Huang, Qing Wan, Jianwen Tian, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
As a new type of mesoporous silica materials with large pore diameter (pore size between 2 and 50nm) and high specific surface areas, SBA-15 has been widely explored for different applications especially in the biomedical fields. The surface modification of SBA-15 with functional polymers has demonstrated to be an effective way for improving its properties and performance. In this work, we reported the preparation of PEGylated SBA-15 polymer composites through surface-initiated chain transfer free radical polymerization for the first time...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Marjan Ghorbani, Hamed Hamishehkar
The aim of this study was to design and develop a new pH-responsive nano-platform for controlled and targeted delivery of anticancer drugs. Engineering of pH-responsive nanocarriers was prepared via decoration of gold nanoparticles (NPs) by thiolated (methoxy-poly(ethylene glycol)-b-poly((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (mPEG-b-p(DMAEMA-co-IA) copolymer and fully characterized by various techniques and subsequently used for loading and targeted delivery of anticancer agent, methotrexate (MTX)...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Björn-Johannes Harder, Katja Bettenbrock, Steffen Klamt
Based on the recently constructed Escherichia coli itaconic acid production strain ita23, we aimed to improve the productivity by applying a two-stage process strategy with decoupled production of biomass and itaconic acid. We constructed a strain ita32 (MG1655 ΔaceA Δpta ΔpykF ΔpykA pCadCs), which, in contrast to ita23, has an active tricarboxylic acid (TCA) cycle and a fast growth rate of 0.52 hr(-1) at 37°C, thus representing an ideal phenotype for the first stage, the growth phase. Subsequently we implemented a synthetic genetic control allowing the downregulation of the TCA cycle and thus the switch from growth to itaconic acid production in the second stage...
September 2, 2017: Biotechnology and Bioengineering
Young-Chul Joo, Seung Kyou You, Sang Kyu Shin, Young Jin Ko, Ki Ho Jung, Sang A Sim, Sung Ok Han
Dimethyl itaconate is an important raw material for copolymerization, but it is not synthesized from itaconic acid by organisms. Moreover, Corynebacterium glutamicum is used as an important industrial host for the production of organic acids, but it does not metabolize itaconic acid. Therefore, the biosynthetic route toward dimethyl itaconate from itaconic acid is highly needed. In this study, a biological procedure for dimethyl itaconate production is developed from rice wine waste-derived itaconic acid using the engineered C...
August 28, 2017: Biotechnology Journal
Long Huang, Jing Wu, Meiying Liu, Liucheng Mao, Hongye Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Mesoporous silica nanoparticles have attracted considerable research attention due to their various applications. Surface modification of these mesoporous silica nanoparticles with polymers not only can improve their water dispersity but can also endow several new functions, such as drug loading and delivery or targeting capability. In this work, we report a novel strategy for the direct surface grafting of phospholipid choline-containing copolymers onto Santa Barbara Amorphous-15 (SBA-15) through surface-initiated chain transfer free radical polymerization...
August 24, 2017: Journal of Colloid and Interface Science
Anna Janaszewska, Maciej Studzian, Johannes F Petersen, Mario Ficker, Valentina Paolucci, Jørn B Christensen, Donald A Tomalia, Barbara Klajnert-Maculewicz
Traditional amine terminated PAMAM dendrimers may be readily surface engineered by a facile one-pot conversion with dialkyl itaconate esters into 4-carbomethoxypyrrolidone terminated PAMAM (G=0-4) dendrimers. These terminated dendrimers are uniquely characterized by exhibiting blue fluorescence emissions (λexc=370nm, λmaxem=440nm). Thanks to this property they can be directly analyzed by confocal microscopy and flow cytometry without additional fluorescence labeling, treatment of dendrimers with chemicals or adjusting pH...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
Penphitcha Amonpattaratkit, Sureerat Khunmanee, Dong Hyun Kim, Hansoo Park
In this work, crosslinkers were prepared by conjugating high- and low-molecular-weight gelatin with different mole ratios of itaconic acid (IA) with double bonds. Then, the gelatin-itaconic acid (gelatin-IA) crosslinkers were compared with the gelatin-methacrylate (gelatin-MA) crosslinkers. The molecular weights and structures of gelatin-MA and gelatin-IA were confirmed using gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). Additionally, the swelling ratio and biodegradation properties of the hydrogels using IA as starting monomers and gelatin-IA and gelatin-MA as crosslinkers were investigated...
July 19, 2017: Materials
Wei Zhang, Xuhui She, Liping Wang, Huajun Fan, Qing Zhou, Xiaowen Huang, James Z Tang
A novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis...
April 28, 2017: Materials
Adonia E Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K Srivastava, Hong A Vu, Danilo Cucchi, Stephen P McAdoo, Elitsa A Ananieva, Claudio Mauro, Jacques Behmoaras
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show that BCAT1 is the predominant BCAT isoform in human primary macrophages. We identify ERG240 as a leucine analogue that blocks BCAT1 activity. Selective inhibition of BCAT1 activity results in decreased oxygen consumption and glycolysis. This decrease is associated with reduced IRG1 levels and itaconate synthesis, suggesting involvement of BCAA catabolism through the IRG1/itaconate axis within the tricarboxylic acid cycle in activated macrophages...
July 12, 2017: Nature Communications
Liucheng Mao, Meiying Liu, Long Huang, Dazhuang Xu, Qing Wan, Guangjian Zeng, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Surface modification of mesoporous silica nanoparticles (MSNs) with functional polymers has become one of the most interest topics over the last decade. Among various surface modification strategies, surface-initiated atom transfer radical polymerization (ATRP) has been regarded as one of the most effective methods. However, the typical ATRP strategy is relied on the transition metal ions and their organic ligands as the polymerization catalyst systems. In this work, a novel surface-initiated ATRP method was established for surface functionalization of MSNs using 10-Phenylphenothiazine (PTH) as the catalyst, 2-methacryloyloxyethyl phosphorylcholine (MPC) and itaconic acid (IA) as the monomers...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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