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Linglin Wu, Mark Mascal, Thomas Farmer, Sacha Pérocheau Arnaud, Maria Angelica Wong Chang
Electrolysis of biomass-derived carbonyl compounds is an alternative to condensation chemistry for supplying products with chain length >C6 for biofuel and renewable material production. Kolbe coupling of biomass-derived levulinic acid gives 2,7-octanedione, a new platform molecule only two low process-intensity steps removed from raw biomass. Hydrogenation to 2,7-octanediol provides a chiral secondary diol largely unknown to polymer chemistry, while intramolecular aldol condensation followed by hydrogenation yields branched cycloalkanes suitable for use as high-octane, cellulosic gasoline...
November 21, 2016: ChemSusChem
Antonio Irineudo Magalhães, Júlio Cesar de Carvalho, Jesus David Coral Medina, Carlos Ricardo Soccol
Itaconic acid is a promising chemical that has a wide range of applications and can be obtained in large scale using fermentation processes. One of the most important uses of this biomonomer is the environmentally sustainable production of biopolymers. Separation of itaconic acid from the fermented broth has a considerable impact in the total production cost. Therefore, optimization and high efficiency downstream processes are technological challenges to make biorefineries sustainable and economically viable...
November 15, 2016: Applied Microbiology and Biotechnology
Kaijia Xu, Yuzhi Wang, Yixue Li, Yunxuan Lin, Haibao Zhang, Yigang Zhou
Novel poly(deep eutectic solvent) grafted silica-coated magnetic microspheres (Fe3O4@SiO2-MPS@PDES) were prepared by polymerization of choline chloride-itaconic acid (ChCl-IA) and γ-MPS-modified magnetic silica composites, and were characterized by vibrating sample magnetometer (VSM), Fourier transform infrared spectrometry (FT-IR), X-ray photoelectron spectra (XPS), thermal gravimetric analysis (TGA) and transmission electron microscope (TEM). Then the synthetic Fe3O4@SiO2-MPS@PDES microspheres were applied for the magnetic solid-phase extraction (MSPE) of trypsin for the first time...
November 23, 2016: Analytica Chimica Acta
Huacai Ge, Tingting Hua, Jincui Wang
A novel nanoadsorbent (PIACS) with average size of 52.6nm was prepared by controlling grafted polymerization of itaconic acid on chitosan to emulsion stage and then crosslinking with glutaraldehyde. The preparation conditions were optimized and PIACS was characterized by FT-IR, XRD, SEM, TEM and TGA. The adsorption of PIACS for some metal ions was studied. The adsorption results showed that PIACS for adsorption of Hg(2+) and Pb(2+) had higher uptakes than some reported adsorbents. Various variables for adsorption of Hg(2+) and Pb(2+) were systematically researched...
October 25, 2016: International Journal of Biological Macromolecules
Dadong Liang, Yan Wang, Songyang Li, Yuqing Li, Miliang Zhang, Yang Li, Weishuai Tian, Junbo Liu, Shanshan Tang, Bo Li, Ruifa Jin
With the aid of theoretical calculations, a series of molecularly imprinted polymers (MIPs) were designed and prepared for the recognition of dicyandiamide (DCD) via precipitation polymerization using acetonitrile as the solvent at 333 K. On the basis of the long-range correction method of M062X/6-31G(d,p), we simulated the bonding sites, bonding situations, binding energies, imprinted molar ratios, and the mechanisms of interaction between DCD and the functional monomers. Among acrylamide (AM), N,N'-methylenebisacrylamide (MBA), itaconic acid (IA), and methacrylic acid (MAA), MAA was confirmed as the best functional monomer, because the strongest interaction (the maximum number of hydrogen bonds and the lowest binding energy) occurs between DCD and MAA, when the optimal molar ratios for DCD to the functional monomers were used, respectively...
October 26, 2016: International Journal of Molecular Sciences
Man Zhang, Rui Wang, Zhenqiang Shi, Xuelian Huang, Weifeng Zhao, Changsheng Zhao
A novel family of multi-responsive, tough, and reversible hydrogels were prepared by the combination of dipole-dipole interaction, hydrogen bonding interaction and slightly chemical cross-linking, using monomers of acrylonitrile, sodium allylsulfonate and itaconic acid. Reversible gel-sol transition was achieved by the flexible conversion of the dipole-dipole interactions between acrylonitrile-acrylonitrile and acrylonitrile-sodium thiocyanate, and the hydrogels could freely form desired shapes. The dipole-dipole and hydrogen bonding interactions improved the mechanical strength of the hydrogels with a compressive stress of 2...
October 11, 2016: Journal of Hazardous Materials
Elena Geiser, Sandra K Przybilla, Meike Engel, Wiebke Kleineberg, Linda Büttner, Eda Sarikaya, Tim den Hartog, Jürgen Klankermayer, Walter Leitner, Michael Bölker, Lars M Blank, Nick Wierckx
The Ustilaginaceae family of smut fungi, especially Ustilago maydis, gained biotechnological interest over the last years, amongst others due to its ability to naturally produce the versatile bio-based building block itaconate. Along with itaconate, U. maydis also produces 2-hydroxyparaconate. The latter was proposed to be derived from itaconate, but the underlying biochemistry and associated genes were thus far unknown. Here, we confirm that 2-hydroxyparaconate is a secondary metabolite of U. maydis and propose an extension of U...
October 14, 2016: Metabolic Engineering
Martin Holm Rau, Patricia Calero, Rebecca M Lennen, Katherine S Long, Alex T Nielsen
BACKGROUND: Economically viable biobased production of bulk chemicals and biofuels typically requires high product titers. During microbial bioconversion this often leads to product toxicity, and tolerance is therefore a critical element in the engineering of production strains. RESULTS: Here, a systems biology approach was employed to understand the chemical stress response of Escherichia coli, including a genome-wide screen for mutants with increased fitness during chemical stress...
October 13, 2016: Microbial Cell Factories
Loredana Elena Nita, Aurica P Chiriac, Alina Diaconu, Nita Tudorachi, Liliana Mititelu-Tartau
Over the last 10 years, the development of intelligent biomaterials for medical and pharmaceutical applications has attracted growing interest by combining interdisciplinary efforts. Between them nanogels represent one of the most attractive carriers for innovative drug delivery systems. In the present investigation new variants of multi-responsive nanogels have been synthesized by crosslinking poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5] undecane) copolymer (having different molar ratios between comonomers) with 1,12-dodecandiol...
October 8, 2016: International Journal of Pharmaceutics
Filippos Michopoulos, Niki Karagianni, Nichola M Whalley, Mike A Firth, Christoforos Nikolaou, Ian David Wilson, Susan E Critchlow, George Kollias, Georgios A Theodoridis
Rheumatoid arthritis is a progressive, highly debilitating disease where early diagnosis, enabling rapid clinical intervention, would provide obvious benefits to patients, healthcare systems and society. Novel biomarkers that enable non-invasive early diagnosis of the onset and progression of the disease provide one route to achieving this goal. Here a metabolic profiling method has been applied to investigate disease development in the Tg197 arthritis mouse model. Hind limb extract profiling demonstrated clear differences in metabolic phenotypes between control (wild type), and Tg197 transgenic mice and highlighted raised concentrations of itaconic acid as a potential marker of the disease...
October 5, 2016: Journal of Proteome Research
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N-bis(acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content...
January 2, 2017: Carbohydrate Polymers
Elina K Palonen, Milla-Riina Neffling, Sheetal Raina, Annika Brandt, Tajalli Keshavarz, Jussi Meriluoto, Juhani Soini
Aspergillus terreus is an industrially important filamentous fungus producing a wide spectrum of secondary metabolites, including lovastatin and itaconic acid. It also produces butyrolactone I which has shown potential as an antitumour agent. Additionally, butyrolactone I has been implicated to have a regulating role in the secondary metabolism and morphology of A. terreus. In this study, a quantitative time-course liquid chromatography-electrospray ionisation-tandem mass spectrometry (LC-ESI-MS-MS) analysis of butyrolactone I is reported for the first time in nine-day long submerged cultures of A...
June 4, 2014: Microorganisms
Amparo Jiménez-Quero, Eric Pollet, Minjie Zhao, Eric Marchioni, Luc Averous, Vincent Phalip
The production of high-value chemicals from natural resources as alternative of petroleum-based products is currently expanding in parallel with biorefinery. The use of lignocellulosic biomass as raw material is promising to achieve economic and environmental sustainability. Filamentous fungi, particularly Aspergillus species, are already used industrially to produce organic acid as well as many enzymes. The production of lignocellulose degrading enzymes opens the possibility for direct fungal fermentation towards organic acids as itaconic and fumaric acids...
September 23, 2016: Journal of Microbiology and Biotechnology
Kangqi Sun, Juhua Guo, Yufeng He, Pengfei Song, Yubing Xiong, Rong-Min Wang
Using feather keratin (FK) as a biocompatible and inexpensive biopolymer, a kind of dual-sensitive keratin-based polymer hydrogel (FK/PNiPA/PIAc-Gel) with interpenetrating network structure was prepared by two-step polymerization of N-isopropyl acrylamide (NiPA) and itaconic acid (IAc) in presence of crosslinker. After being characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy, its swelling behaviors and environmental sensitivity were investigated...
October 3, 2016: Journal of Biomaterials Science. Polymer Edition
Harding H Luan, Ruslan Medzhitov
Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.
September 13, 2016: Cell Metabolism
S K Bajpai, Pooja Jyotishi, M Bajpai
In the present work, AgNPs loaded chitosan/poly(acrylamide-co-itaconic acid) inter-polyelectrolyte complex (IPC) films have been prepared for antimicrobial applications. The AgNPs-loaded IPC films have been characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA) and Surface plasmon resonance (SPR). Particle size of synthesized AgNPs was found to be in the range 10-30nm...
December 10, 2016: Carbohydrate Polymers
Zeynep Altintas, Mohammed J Abdin, Alexander M Tothill, Kal Karim, Ibtisam E Tothill
Novel molecularly imprinted polymer nanoparticles (nanoMIPs) were designed for endotoxin from Escherichia coli 0111:B4, using computational modeling. The screening process based on binding energy between endotoxin and each monomer was performed with 21 commonly used monomers, resulting in the selection of itaconic acid, methacrylic acid and acrylamide as functional monomers due to their strong binding interaction with the endotoxin template. The nanoMIPs were successfully synthesized with functional groups on the outer surface to aid in the immobilization onto sensor surface...
September 7, 2016: Analytica Chimica Acta
Abeer H Hossain, An Li, Anja Brickwedde, Lars Wilms, Martien Caspers, Karin Overkamp, Peter J Punt
BACKGROUND: The industrially relevant filamentous fungus Aspergillus niger is widely used in industry for its secretion capabilities of enzymes and organic acids. Biotechnologically produced organic acids promise to be an attractive alternative for the chemical industry to replace petrochemicals. Itaconic acid (IA) has been identified as one of the top twelve building block chemicals which have high potential to be produced by biotechnological means. The IA biosynthesis cluster (cadA, mttA and mfsA) has been elucidated in its natural producer Aspergillus terreus and transferred to A...
2016: Microbial Cell Factories
(no author information available yet)
Every month the editors of Cell Chemical Biology bring you highlights of the most recent chemical biology literature. Our July 2016 selection includes reports on itaconate as a key metabolite that regulates inflammation, visualization of microRNA in living zebrafish embryos, and the development of a promising SHP2 inhibitor.
July 21, 2016: Cell Chemical Biology
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss, Carla J Weinheimer, Shabaana Khader, Gwendalyn J Randolph, Edward J Pearce, Russell G Jones, Abhinav Diwan, Michael S Diamond, Maxim N Artyomov
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which regulates the pro-inflammatory IL-1β-HIF-1α axis. Itaconate is one of the most highly induced metabolites in activated macrophages, yet its functional significance remains unknown. Here, we show that itaconate modulates macrophage metabolism and effector functions by inhibiting succinate dehydrogenase-mediated oxidation of succinate...
July 12, 2016: Cell Metabolism
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