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https://www.readbyqxmd.com/read/28428785/interferon-gamma-induces-changes-in-natural-killer-nk-cell-ligand-expression-and-alters-nk-cell-mediated-lysis-of-pediatric-cancer-cell-lines
#1
Arianexys Aquino-López, Vladimir V Senyukov, Zlatko Vlasic, Eugenie S Kleinerman, Dean A Lee
Natural killer (NK) cells have therapeutic potential for cancer due to their capacity for targeting tumor cells without prior sensitization. Our laboratory has developed an NK cell expansion protocol that generates large quantities of NK cells for therapeutic infusion that secret 20 times the amount of interferon gamma (IFNγ) than resting NK cells. IFNγ can upregulate major histocompatibility complex (MHC)-class I, an inhibitory ligand for NK cells, but can also upregulate intercellular adhesion molecule 1 (ICAM-1) which promotes NK:target cell interaction for an efficient lysis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28428556/treatment-of-donor-corneal-tissue-with-immunomodulatory-cytokines-a-novel-strategy-to-promote-graft-survival-in-high-risk-corneal-transplantation
#2
Maryam Tahvildari, Parisa Emami-Naeini, Masahiro Omoto, Alireza Mashaghi, Sunil K Chauhan, Reza Dana
Antigen-presenting cells (APCs) play an important role in transplant rejection and tolerance. In high-risk corneal transplantation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid tissues to sensitize host T cells. In this study, using a mouse model of corneal transplantation, we investigated whether enrichment of tolerogenic APCs (tolAPCs) in donor corneas can enhance graft survival in corneal allograft recipients with inflamed graft beds...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428135/the-immunotoxicological-pattern-of-subchronic-and-chronic-benzene-exposure-in-rats
#3
Alexander V Karaulov, Irina V Mikhaylova, Alexander I Smolyagin, Viktor M Boev, Alexandra Kalogeraki, Aristides M Tsatsakis, Ayse Basak Engin
Exposure to benzene and its inevitable metabolites can result in deleterious effects on human health, including lymphocytopenia, hematotoxicity and cancer. However, the duration of exposure might alter the effects including immune consequences. The aim of this study was to determine whether benzene could modulate lymphocyte proliferation induced by the T cell mitogen concanavalin A, in rats, at different exposure durations. 386 Wistar rats were assigned into control and treatment groups which was subdivided into groups for 45, 90 and 135days for 0,6mL/kg of drinking water mixed benzene treatment...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28425862/the-impact-of-il-17-in-atherosclerosis
#4
Xinjie Lu
Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel. Mouse model demonstrated that T and B cell deficiency reduces the atherosclerotic burden in the formation of an atherosclerotic lesion. CD4+ T helper cells (Th), such as Th1 cells known being the major CD4+ T cell subtype found in mouse models of atherogenesis, increase plaque formation caused by oxLDL...
April 19, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28425456/salt-suppresses-ifn%C3%AE-inducible-chemokines-through-the-ifn%C3%AE-jak1-stat1-signaling-pathway-in-proximal-tubular-cells
#5
Yohei Arai, Daiei Takahashi, Kenichi Asano, Masato Tanaka, Mayumi Oda, Shigeru B H Ko, Minoru S H Ko, Shintaro Mandai, Naohiro Nomura, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
The mechanisms of immunoactivation by salt are now becoming clearer. However, those of immunosuppression remain unknown. Since clinical evidence indicates that salt protects proximal tubules from injury, we investigated mechanisms responsible for salt causing immunosuppression in proximal tubules. We focused on cytokine-related gene expression profiles in kidneys of mice fed a high salt diet using microarray analysis and found that both an interferon gamma (IFNγ) inducible chemokine, chemokine (C-X-C motif) ligand 9 (CXCL9), and receptor, CXCR3, were suppressed...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425113/environmental-perfluorooctane-sulfonate-exposure-drives-t-cell-activation-in-bottlenose-dolphins
#6
Adam C Soloff, Bethany Jacobs Wolf, Natasha D White, Derek Muir, Sean Courtney, Gary Hardiman, Gregory D Bossart, Patricia A Fair
Perfluoroalkyl acids (PFAAs) are highly stable compounds that have been associated with immunotoxicity in epidemiologic studies and experimental rodent models. Lengthy half-lives and resistance to environmental degradation result in bioaccumulation of PFAAs in humans and wildlife. Perfluorooctane sulfonate (PFOS), the most prevalent PFAA detected within the environment, is found at high levels in occupationally exposed humans. We have monitored the environmental exposure of dolphins in the Charleston, SC region for over 10 years and levels of PFAAs, and PFOS in particular, were significantly elevated...
April 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28424066/short-term-exposure-to-pm2-5-and-vanadium-and-changes-in-asthma-gene-dna-methylation-and-lung-function-decrements-among-urban-children
#7
Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R Jezioro, Lori Hoepner, Jamie Ross, Frederica P Perera, Steven N Chillrud, Rachel L Miller
BACKGROUND: Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested subcohort of African American and Dominican children. METHODS: Six day integrated levels of air pollutants were measured from children's homes (age 9-14; n = 163), repeated 6 months later (n = 98)...
April 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28419376/latent-tb-infection-and-pulmonary-tb-disease-among-patients-with-diabetes-mellitus-in-bandung-indonesia
#8
Raspati C Koesoemadinata, Susan M McAllister, Nanny N M Soetedjo, Dwi Febni Ratnaningsih, Rovina Ruslami, Sarah Kerry, Ayesha J Verrall, Lika Apriani, Reinout van Crevel, Bachti Alisjahbana, Philip C Hill
Background: Screening and treatment of latent TB infection (LTBI) and TB disease could reduce diabetes mellitus (DM)-associated TB. We aimed to describe the prevalence of LTBI and pulmonary TB among patients with DM in a TB-endemic setting. Methods: Patients with DM attending a hospital and community centres in Bandung, Indonesia, underwent LTBI screening using interferon gamma release assay (IGRA). TB was investigated by sputum smear, culture and x-ray. TB contacts from a parallel study were age- and sex-matched to patients with DM to compare LTBI and TB disease prevalence...
April 13, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28419140/niche-matters-the-comparison-between-bone-marrow-stem-cells-and-endometrial-stem-cells-and-stromal-fibroblasts-reveal-distinct-migration-and-cytokine-profiles-in-response-to-inflammatory-stimulus
#9
Masuma Khatun, Anna Sorjamaa, Marika Kangasniemi, Meeri Sutinen, Tuula Salo, Annikki Liakka, Petri Lehenkari, Juha S Tapanainen, Olli Vuolteenaho, Joseph C Chen, Siri Lehtonen, Terhi T Piltonen
OBJECTIVE: Intrinsic inflammatory characteristics play a pivotal role in stem cell recruitment and homing through migration where the subsequent change in niche has been shown to alter these characteristics. The bone marrow mesenchymal stem cells (bmMSCs) have been demonstrated to migrate to the endometrium contributing to the stem cell reservoir and regeneration of endometrial tissue. Thus, the aim of the present study was to compare the inflammation-driven migration and cytokine secretion profile of human bmMSCs to endometrial mesenchymal stem cells (eMSCs) and endometrial fibroblasts (eSFs)...
2017: PloS One
https://www.readbyqxmd.com/read/28419006/plasma-interferon-gamma-inducible-protein-10-ip10-level-associates-with-abnormal-memory-b-cells-phenotypes-in-perinatal-hiv-infection
#10
German A Contreras, James R Murphy, Gloria P Heresi
We demonstrate for perinatally HIV infected children and adolescents receiving cART and in good clinical status with respect to HIV disease that high concentrations of IP10 associate with increased exhausted memory B cells.
April 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28414969/cytokines-in-the-management-of-rotavirus-infection-a-systematic-review-of-in-vivo-studies
#11
REVIEW
Gopalsamy Rajiv Gandhi, Victor Santana Santos, Marina Denadai, Valdete Kaliane da Silva Calisto, Jullyana de Souza Siqueira Quintans, Ana Mara de Oliveira E Silva, Adriano Antunes de Souza Araújo, Narendra Narain, Luis Eduardo Cuevas, Lucindo José Quintans Júnior, Ricardo Queiroz Gurgel
OBJECTIVE: Rotavirus is a leading cause of childhood diarrhoea. Rotavirus vaccines are effective against severe rotavirus gastroenteritis, but have lower efficacy in low income countries in Africa. Anti-rotavirus treatment is not available. This study reviews the literature of animal studies evaluating whether cytokine mediated pathways of immune activation could improve rotavirus therapy. METHODS: We performed a systematic review of articles in English published from 2010 to 2016 reporting agents with in vivo antirotavirus activity for the management of rotavirus infection...
April 14, 2017: Cytokine
https://www.readbyqxmd.com/read/28413722/performance-of-interferon-%C3%AE-release-assay-in-the-diagnosis-of-tuberculous-lymphadenitis-a-meta-analysis
#12
Qianqian Liu, Wenzhang Li, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Binmiao Liang, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
BACKGROUND: The diagnostic values of interferon-gamma release assays (IGRA) in tuberculosis (TB) vary a lot with different site of infections, with especially higher sensitivities in chronic forms of TB such as tuberculosis of the lymph node. We conducted a meta-analysis to comprehensively evaluate the overall accuracy of diagnostic IGRA for tuberculous lymphadenitis. METHODS: Pubmed, Web of Science, EMBASE, Wanfang and CNKI databases up to February 17, 2017 were searched to identify published studies...
2017: PeerJ
https://www.readbyqxmd.com/read/28411140/batf3-dependent-cd8%C3%AE-dendritic-cells-aggravates-atherosclerosis-via-th1-cell-induction-and-enhanced-ccl5-expression-in-plaque-macrophages
#13
Yalin Li, Xueyan Liu, Wei Duan, Hua Tian, Guangming Zhu, Hao He, Shutong Yao, Shuying Yi, Wengang Song, Hua Tang
Dendritic cells (DCs) play an important role in controlling T cell-mediated adaptive immunity in atherogenesis. However, the role of the basic leucine zipper transcription factor, ATF-like 3 (Batf3)-dependent CD8α(+) DC subset in atherogenesis remains unclear. Here we show that Batf3(-/-)Apoe(-/-) mice, lacking CD8α(+) DCs, exhibited a significant reduction in atherogenesis and T help 1 (Th1) cells compared with Apoe(-/-) controls. Then, we found that CD8α(+) DCs preferentially induce Th1 cells via secreting interleukin-12 (IL-12), and that the expression of interferon-gamma (IFN-γ)or chemokine (C-C motif) ligand 5 (CCL5) in aorta were significantly decreased in Batf3(-/-)Apoe(-/-) mice...
April 6, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28406012/immunomodulatory-magnetic-microspheres-for-augmenting-tumor-specific-infiltration-of-natural-killer-nk-cells
#14
Wooram Park, Andrew C Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R Harris, Andrew C Larson, Dong-Hyun Kim
The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images...
April 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28401852/t-helper-type-1-t-helper-type-2-shift-and-nasal-remodeling-after-fine-particulate-matter-exposure-in-a-rat-model-of-allergic-rhinitis
#15
Zhi-Qiang Guo, Wei-Yang Dong, Jian Xu, Zhi-Cong Hong, Ren-Wu Zhao, Cong-Rui Deng, Guo-Shun Zhuang, Ru-Xin Zhang
BACKGROUND: Exposure to fine particulate matter (particulate matter less than or equal to 2.5 mg [PM2.5]) increases therisk of allergic rhinitis (AR), but the underlying mechanisms remains unclear. Thus, we investigated the roles of T-helper (Th)1-Th2 cytokines and nasal remodeling after ambient PM2.5 exposure in a rat model of AR. METHODS: Female Sprague-Dawley rats were randomized into six groups: a negative control group, a group of healthy rats exposed to 3000 mg/m3 PM2...
April 11, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28400196/association-of-rnaset2-gene-polymorphisms-with-decreased-expression-and-clinical-characteristics-of-severity-in-crohn-s-disease
#16
Rivkah Gonsky, Phillip Fleshner, Richard L Deem, Eva Biener-Ramanujan, Dalin Li, Alka A Potdar, Janine Bilsborough, Shaohong Yang, Dermot P B McGovern, Stephan R Targan
BACKGROUND & AIMS: Variants in the tumor necrosis factor superfamily member 15 gene (TNFSF15, also called TL1A) have been associated with risk for inflammatory bowel diseases (IBD). TL1A affects expression of multiple cytokines to promote mucosal inflammation. Little is known about the TL1A-response pathways that regulate cytokine expression. We investigated T-cell gene expression patterns to determine the mechanisms by which TL1A regulates cytokine production, and whether these associate with outcomes of patients with Crohn's disease (CD)...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28399920/patterns-of-inflammatory-responses-and-parasite-tolerance-vary-with-malaria-transmission-intensity
#17
Temitope W Ademolue, Yaw Aniweh, Kwadwo A Kusi, Gordon A Awandare
BACKGROUND: In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of malaria, this study investigated inflammatory cytokine responses in children with malaria from areas of different transmission intensities (ranging from low to high). METHODS: Blood samples were obtained from children confirmed with malaria at community hospitals in three areas with differing transmission intensities...
April 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28397473/factors-contributing-to-false-negative-enzyme-linked-immunospot-assay-for-interferon-gamma-results-in-active-tuberculosis
#18
Guoli Lian, Fangxiong Du, Hongyan Wu, Min He, Zhigang Liu
BACKGROUND: The enzyme-linked immunospot assay test (T-SPOT.TB) is effective for detecting TB, but there are still some persons with tuberculosis (TB) who have negative results. The aim of this study was to analyze the factors that contribute to false negative results in active TB patients. METHODS: We investigated the clinical trial and laboratory data of the active TB patients hospitalized in the First Affiliated Hospital of Xi'an Jiaotong University from May 2013 to November 2014...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28397044/interferon-%C3%AE-alters-the-immune-related-mirna-expression-of-microvesicles-derived-from-mesenchymal-stem-cells
#19
Ai-Qi Zhao, Hui Xie, Sheng-Yan Lin, Qian Lei, Wen-Xiang Ren, Fei Gao, Hao Guo, An-Yuan Guo, Zhi-Chao Chen, Hong-Xiang Wang
Increasing studies have demonstrated that interferon gamma (IFN-γ), which serves as a critical inflammatory cytokine, is essential to induce the immunosuppressive effects of mesenchymal stem cells (MSCs). However, the mechanisms underlying the enhanced immunosuppressive effects of IFN-γ-stimulated MSCs (γMSCs) are not fully understood. MSC-derived microvesicles (MSC-MVs) have been viewed as potential pivotal mediators of the immunosuppressive effects of MSCs. Moreover, microRNAs (miRNAs) are important regulators of immunological processes and can be shuttled from cell to cell by MVs...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28393295/elevated-galectin-9-suppresses-th1-effector-function-and-induces-apoptosis-of-activated-cd4-t-cells-in-osteoarthritis
#20
Shufeng Yang, Jin Wang, Fengrong Chen, Guoyin Liu, Zhiqiang Weng, Jianmin Chen
T cell immunoglobulin and mucin domain 3 (Tim-3) is a critical regulatory molecule found on activated Th1 cells, exhausted CD8(+) T cells, and resting monocytes/macrophages. Galectin-9 (Gal-9) is an identified ligand for Tim-3. Interaction between Tim-3 and Gal-9 is thought to inhibit Th1 responses. The regulation and function of Tim-3 and Gal-9 in osteoarthritis (OA) have not been intensively investigated. We found that in peripheral blood, CD4(+) T cells, but not CD8(+) T cells or CD14(+) monocytes, from OA patients presented significantly elevated Tim-3 and Gal-9 expression compared to those from healthy controls (HC)...
April 10, 2017: Inflammation
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