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inducing mitochondrial biogenesis

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https://www.readbyqxmd.com/read/29667000/a-novel-mitochondrial-orf147-causes-cytoplasmic-male-sterility-in-pigeonpea-by-modulating-aberrant-anther-dehiscence
#1
Pooja Bhatnagar-Mathur, Ranadheer Gupta, Palakolanu Sudhakar Reddy, Bommineni Pradeep Reddy, Dumbala Srinivas Reddy, C V Sameerkumar, Rachit Kumar Saxena, Kiran K Sharma
A novel open reading frame (ORF) identified and cloned from the A4 cytoplasm of Cajanus cajanifolius induced partial to complete male sterility when introduced into Arabidopsis and tobacco. Pigeonpea (Cajanus cajan L. Millsp.) is the only legume known to have commercial hybrid seed technology based on cytoplasmic male sterility (CMS). We identified a novel ORF (orf147) from the A4 cytoplasm of C. cajanifolius that was created via rearrangements in the CMS line and co-transcribes with the known and unknown sequences...
April 17, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29662614/transcriptional-orchestration-of-mitochondrial-homeostasis-in-a-cellular-model-of-pgc-1-related-coactivator-dependent-thyroid-tumor
#2
Solenne Dumont, Soazig Le Pennec, Audrey Donnart, Raluca Teusan, Marja Steenman, Catherine Chevalier, Rémi Houlgatte, Frédérique Savagner
The PGC-1 (Peroxisome proliferator-activated receptor Gamma Coactivator-1) family of coactivators (PGC-1α, PGC-1β, and PRC) plays a central role in the transcriptional control of mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) processes. These coactivators integrate mitochondrial energy production into cell metabolism using complementary pathways. The XTC.UC1 cell line is a mitochondria-rich model of thyroid tumors whose biogenesis is almost exclusively dependent on PRC. Here we aim to propose an integrative view of the cellular pathways regulated by PRC through integration of cDNA and miRNA microarray data and chromatin immunoprecipitation results obtained from XTC...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29656453/chlorogenic-acid-protects-against-oxldl-induced-oxidative-damage-and-mitochondrial-dysfunction-by-modulating-sirt1-in-endothelial-cells
#3
Kun-Ling Tsai, Ching-Hsia Hung, Shih-Hung Chan, Pei-Ling Hsieh, Hsiu-Chung Ou, Yung-Hsin Cheng, Pei-Ming Chu
SCOPE: Endothelial dysfunction is an important mechanism in the development of atherosclerosis and is thought to be critical for predicting cardiovascular diseases. Previous reports suggested that Chlorogenic acid (CGA) is a potent antioxidant and anti-inflammatory compound. The molecular mechanisms underlying the inhibitory effects of CGA on oxLDL-induced oxidative injuries in human endothelial cells are still largely unknown. This study aimed to test the hypothesis that CGA protects against oxLDL-facilitated oxidative stress by upregulating SIRT1 and to explore the role of AMPK/PGC-1 pathway and mitochondrial biogenesis...
April 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29650039/carbon-black-suppresses-the-osteogenesis-of-mesenchymal-stem-cells-the-role-of-mitochondria
#4
Yulai Shen, Lu Wu, Dongdong Qin, Yankai Xia, Zhu Zhou, Xuemei Zhang, Xin Wu
BACKGROUND: The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an important role in the osteogenesis of MSCs and are potential targets of nanomaterials, so we studied the role of mitochondria in the CB Printex 90-induced effects on osteogenesis. RESULTS: Low doses of Printex 90 (3 ng/mL and 30 ng/mL) that did not cause deleterious effects on MSCs' viability significantly inhibited osteogenesis of MSCs...
April 12, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29649104/coordination-of-gpr40-and-ketogenesis-signaling-by-medium-chain-fatty-acids-regulates-beta-cell-function
#5
Julien Benjamin Pujol, Nicolas Christinat, Yann Ratinaud, Claudia Savoia, Siobhan E Mitchell, El Hadji M Dioum
Diabetes prevalence increases with age, and β-cell dysfunction contributes to the incidence of the disease. Dietary lipids have been recognized as contributory factors in the development and progression of the disease. Unlike long chain triglycerides, medium chain triglycerides (MCT) increase fat burning in animal and human subjects as well as serum C-peptide in type 2 diabetes patients. We evaluated the beneficial effects of MCT on β-cells in vivo and in vitro. MCT improved glycemia in aged rats via β-cell function assessed by measuring insulin secretion and content...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29642957/characterization-of-mitochondrion-targeted-gtpases-in-plasmodium-falciparum
#6
Kirti Gupta, Ankit Gupta, Afreen Haider, Saman Habib
Ribosome assembly is critical for translation and regulating the response to cellular events and requires a complex interplay of ribosomal RNA and proteins with assembly factors. We investigated putative participants in the biogenesis of the reduced organellar ribosomes of Plasmodium falciparum and identified homologues of two assembly GTPases - EngA and Obg that were found in mitochondria. Both are indispensable in bacteria and P. berghei EngA is among the 'essential' parasite blood stage proteins identified recently...
April 12, 2018: Parasitology
https://www.readbyqxmd.com/read/29620216/doxycycline-targets-aldehyde-dehydrogenase%C3%A2-positive-breast-cancer-stem-cells
#7
Chang-Ching Lin, Miao-Chia Lo, Rebecca R Moody, Nicholas O Stevers, Samantha L Tinsley, Duxin Sun
Targeting cancer stem cells (CSCs) is a key strategy to prevent cancers from developing drug resistance and metastasis. Mitochondria have been reported to be a vulnerability of CSCs by multiple studies. Here, we report that doxycycline, functioning as an inhibitor of mitochondrial biogenesis, can effectively target breast cancer stem cells (BCSCs). Our results revealed that doxycycline significantly decreased the frequency of aldehyde dehydrogenase‑positive (ALDH+) BCSCs as well as mammosphere formation efficiency in HER2+ and triple‑negative breast cancer (TNBC) subtypes...
March 27, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29619069/-piper-retrofractum-vahl-extract-as-a-ppar-%C3%AE-and-ampk-activator-suppresses-uvb-induced-photoaging-through-mitochondrial-biogenesis-and-mmps-inhibition-in-human-dermal-fibroblasts-and-hairless-mice
#8
Jungon Yun, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Photoaging occurs by UVB-irradiation and involves production of reactive oxygen species (ROS) and overexpression of matrix metalloproteinases (MMPs), leading to extracellular matrix damage. Piper retrofractum Vahl. is used as a traditional medicine for antiflatulence, expectorant, sedative, and anti-irritant; however, its antiphotoaging effect has not yet been studied. The current study investigated the antiphotoaging effect of standardized Piper retrofractum extract (PRE) on UVB-damaged human dermal fibroblasts and hairless mouse skin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29611541/nanocurcumin-pyrroloquinoline-formulation-prevents-hypertrophy-induced-pathological-damage-by-relieving-mitochondrial-stress-in-cardiomyocytes-under-hypoxic-conditions
#9
Sarita Nehra, Varun Bhardwaj, Anju Bansal, Pronobesh Chattopadhyay, Deepika Saraswat
This study investigates the therapeutic effect of a nanocurcumin formulation (NCF) containing nanocurcumin (NC) and pyrroloquinoline quinone (PQQ) on ameliorating hypoxia-induced stress in hypertrophied primary human ventricular cardiomyocytes (HVCM) under hypoxic conditions, as validated in a Sprague-Dawley rat model of chronic hypobaric hypoxia (cHH)-induced right ventricular hypertrophy (RVH). Based on our previous findings, here, we analyzed the improvement in the protective efficacy of NCF against mitochondrial damage...
December 1, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29603067/secretome-of-differentiated-pc12-cells-restores-the-monocrotophos-induced-damages-in-human-mesenchymal-stem-cells-and-shsy-5y-cells-role-of-autophagy-and-mitochondrial-dynamics
#10
A Srivastava, S Singh, C S Rajpurohit, P Srivastava, A Pandey, D Kumar, V K Khanna, A B Pant
A perturbed cellular homeostasis is a key factor associated with xenobiotic exposure resulting in various ailments. The local cellular microenvironment enriched with secretory components aids in cell-cell communication that restores this homeostasis. Deciphering the underlying mechanism behind this restorative potential of secretome could serve as a possible solution to many health hazards. We, therefore, explored the protective efficacy of the secretome of differentiated PC12 cells with emphasis on induction of autophagy and mitochondrial biogenesis...
March 30, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29602395/the-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-coactivator-1%C3%AE-pgc-1%C3%AE-in-kidney-disease
#11
REVIEW
Szu-Yuan Li, Katalin Susztak
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key transcriptional regulator of mitochondrial biogenesis and function. Several recent studies have evaluated the role of PGC-1α in various renal cell types in healthy and disease conditions. Renal tubule cells mostly depend on mitochondrial fatty acid oxidation for energy generation. A decrease in PGC-1α expression and fatty acid oxidation is commonly observed in patient samples and mouse models with acute and chronic kidney disease...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29596470/dysfunction-in-the-mitochondrial-fe-s-assembly-machinery-leads-to-formation-of-the-chemoresistant-truncated-vdac1-isoform-without-hif-1%C3%AE-activation
#12
Ioana Ferecatu, Frédéric Canal, Lucilla Fabbri, Nathalie M Mazure, Cécile Bouton, Marie-Pierre Golinelli-Cohen
Biogenesis of iron-sulfur clusters (ISC) is essential to almost all forms of life and involves complex protein machineries. This process is initiated within the mitochondrial matrix by the ISC assembly machinery. Cohort and case report studies have linked mutations in ISC assembly machinery to severe mitochondrial diseases. The voltage-dependent anion channel (VDAC) located within the mitochondrial outer membrane regulates both cell metabolism and apoptosis. Recently, the C-terminal truncation of the VDAC1 isoform, termed VDAC1-ΔC, has been observed in chemoresistant late-stage tumor cells grown under hypoxic conditions with activation of the hypoxia-response nuclear factor HIF-1α...
2018: PloS One
https://www.readbyqxmd.com/read/29594326/dysregulation-of-autophagy-in-rat-liver-with-mitochondrial-dna-depletion-induced-by-the-nucleoside-analogue-zidovudine
#13
Ana Santos-Llamas, Maria J Monte, Jose J G Marin, Maria J Perez
The nucleoside reverse transcriptase inhibitor zidovudine (AZT), used in HIV infection treatment, induces mitochondrial DNA (mtDNA) depletion. A cause-effect relationship between mtDNA status alterations and autophagy has been reported. Both events are common in several liver diseases, including hepatocellular carcinoma. Here, we have studied autophagy activation in rat liver with mtDNA depletion induced by AZT administration in drinking water for 35 days. AZT at a concentration of 1 mg/ml, but not 0.5 mg/ml in the drinking water, decreased mtDNA levels in rat liver and extrahepatic tissues...
March 28, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29590220/a-fatty-acid-analogue-targeting-mitochondria-exerts-a-plasma-triacylglycerol-lowering-effect-in-rats-with-impaired-carnitine-biosynthesis
#14
Carine Lindquist, Bodil Bjørndal, Christine Renate Rossmann, Asbjørn Svardal, Seth Hallström, Rolf Kristian Berge
L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria. We investigated how the triacylglycerol (TAG)-lowering drug 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) influenced lipid metabolism in carnitine-depleted, 3-(2,2,2-trimethylhydrazinium)propionate dehydrate (Mildronate; meldonium)-treated male Wistar rats. As indicated, carnitine biosynthesis was impaired by Mildronate. However, TAG levels of both plasma and liver were decreased by 1-triple TTA in Mildronate-treated animals...
2018: PloS One
https://www.readbyqxmd.com/read/29588219/exercise-induced-reductions-in-mitochondrial-adp-sensitivity-contribute-to-the-induction-of-gene-expression-and-mitochondrial-biogenesis-through-enhanced-mitochondrial-h-2-o-2-emission
#15
Paula M Miotto, Graham P Holloway
Acute exercise rapidly induces mitochondrial gene expression, however, the intracellular events regulating this process remain incompletely understood. The purpose of this study was to determine whether reductions in mitochondrial ADP sensitivity during exercise have a biological role in regulating mitochondrial-derived reactive oxygen species (ROS) production and the induction of mitochondrial biogenesis. Mitochondrial creatine kinase wildtype (WT) and knockout (KO) mice have divergent responses in ADP sensitivity during exercise, and we therefore used these mice to determine the relationship between mitochondrial ADP sensitivity, ROS production, and mitochondrial adaptations to exercise...
March 24, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29580918/pgc-1%C3%AE-sparks-the-fire-of-neuroprotection-against-neurodegenerative-disorders
#16
REVIEW
Jianjun Lv, Shuai Jiang, Zhi Yang, Wei Hu, Zheng Wang, Tian Li, Yang Yang
Recently, growing evidence has demonstrated that peroxisome proliferator activated receptor γ (PPARγ) coactivator-1α (PGC-1α) is a superior transcriptional regulator that acts via controlling the expression of anti-oxidant enzymes and uncoupling proteins and inducing mitochondrial biogenesis, which plays a beneficial part in the central nervous system (CNS). Given the significance of PGC-1α, we summarize the current literature on the molecular mechanisms and roles of PGC-1α in the CNS. Thus, in this review, we first briefly introduce the basic characteristics regarding PGC-1α...
March 23, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29578301/resveratrol-improves-muscle-atrophy-by-modulating-mitochondrial-quality-control-in-stz-induced-diabetic-mice
#17
Dongtao Wang, Huili Sun, Gaofeng Song, Yajun Yang, Xiaohu Zou, Pengxun Han, Shunmin Li
SCOPE: In this study, we aimed to determine the effects of resveratrol (RSV) on muscle atrophy in streptozocin (STZ)-induced diabetic mice and to explore mitochondrial quality control as a possible mechanism. METHODS AND RESULTS: The experimental mice were fed either a control diet or an identical diet containing 0.04% RSV for 8 weeks. Examinations were subsequently carried out, including the effects of RSV on muscle atrophy and muscle function, as well as on the signalling pathways related to protein degradation and mitochondrial quality control processes...
March 26, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29576218/mutations-in-pmpcb-encoding-the-catalytic-subunit-of-the-mitochondrial-presequence-protease-cause-neurodegeneration-in-early-childhood
#18
F-Nora Vögtle, Björn Brändl, Austin Larson, Manuela Pendziwiat, Marisa W Friederich, Susan M White, Alice Basinger, Cansu Kücükköse, Hiltrud Muhle, Johanna A Jähn, Oliver Keminer, Katherine L Helbig, Carolyn F Delto, Lisa Myketin, Dirk Mossmann, Nils Burger, Noriko Miyake, Audrey Burnett, Andreas van Baalen, Mark A Lovell, Naomichi Matsumoto, Maie Walsh, Hung-Chun Yu, Deepali N Shinde, Ulrich Stephani, Johan L K Van Hove, Franz-Josef Müller, Ingo Helbig
Mitochondrial disorders causing neurodegeneration in childhood are genetically heterogeneous, and the underlying genetic etiology remains unknown in many affected individuals. We identified biallelic variants in PMPCB in individuals of four families including one family with two affected siblings with neurodegeneration and cerebellar atrophy. PMPCB encodes the catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins...
March 21, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29572227/human-elongation-factor-4-regulates-cancer-bioenergetics-by-acting-as-a-mitochondrial-translation-switch
#19
Ping Zhu, Yong Zhang Liu, Fenglin Zhang, Xiu Feng Bai, Zilei Chen, Fugen Shangguan, Bo Zhang, Lingyun Zhang, Qian Qian Chen, Deyao Xie, Linhua Lan, Xiangdong Xue, Xing-Jie Liang, Bin Lu, Taotao Wei, Yan Qin
Mitochondria regulate cellular bioenergetics and redox states and influence multiple signaling pathways required for tumorigenesis. In this study, we determined that the mitochondrial translation elongation factor 4 (EF4) is a critical component of tumor progression. EF4 was ubiquitous in human tissues with localization to the mitochondria (mtEF4) and performed quality control on respiratory chain biogenesis. Knockout of mtEF4 induced respiratory chain complex defects and apoptosis, while its overexpression stimulated cancer development...
March 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29569721/resolvin-d1-attenuates-liver-ischemia-reperfusion-injury-through-modulating-thioredoxin-2-mediated-mitochondrial-quality-control
#20
Jung-Woo Kang, Hyo-Sun Choi, Sun-Mee Lee
BACKGROUND AND PURPOSE: Liver ischemia and reperfusion (IR) injury is a sterile inflammatory response involving production of reactive oxygen species. Mitochondrial homeostasis is maintained by mitochondrial quality control (QC). Thioredoxin (TRX) 2 is a key mitochondrial redox-sensitive protein. Resolvin D1 (RvD1), a specialized pro-resolving lipid mediator, exerts anti-inflammatory and antioxidant activities. We investigated mechanisms of RvD1 protection against IR-induced oxidative damage, focusing on TRX2-mediated mitochondrial QC...
March 23, 2018: British Journal of Pharmacology
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