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inducing mitochondrial biogenesis

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https://www.readbyqxmd.com/read/29472946/heavy-chronic-intermittent-ethanol-exposure-alters-small-noncoding-rnas-in-mouse-sperm-and-epididymosomes
#1
Gregory R Rompala, Anais Mounier, Cody M Wolfe, Qishan Lin, Iliya Lefterov, Gregg E Homanics
While the risks of maternal alcohol abuse during pregnancy are well-established, several preclinical studies suggest that chronic preconception alcohol consumption by either parent may also have significance consequences for offspring health and development. Notably, since isogenic male mice used in these studies are not involved in gestation or rearing of offspring, the cross-generational effects of paternal alcohol exposure suggest a germline-based epigenetic mechanism. Many recent studies have demonstrated that the effects of paternal environmental exposures such as stress or malnutrition can be transmitted to the next generation via alterations to small noncoding RNAs in sperm...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29464885/effect-of-roux-en-y-gastric-bypass-on-liver-mitochondrial-dynamics-in-a-rat-model-of-obesity
#2
Jessica Sacks, Anny Mulya, Ciaran E Fealy, Hazel Huang, John D Mosinski, Mangesh R Pagadala, Hideharu Shimizu, Esam Batayyah, Philip R Schauer, Stacy A Brethauer, John P Kirwan
Bariatric surgery provides significant and durable improvements in glycemic control and hepatic steatosis, but the underlying mechanisms that drive improvements in these metabolic parameters remain to be fully elucidated. Recently, alterations in mitochondrial morphology have shown a direct link to nutrient adaptations in obesity. Here, we evaluate the effects of Roux-en-Y gastric bypass (RYGB) surgery on markers of liver mitochondrial dynamics in a diet-induced obesity Sprague-Dawley (SD) rat model. Livers were harvested from adult male SD rats 90-days after either Sham or RYGB surgery and continuous high-fat feeding...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29462458/m-aaa-complexes-are-not-crucial-for-the-survival-of-arabidopsis-under-optimal-growth-conditions-despite-their-importance-for-mitochondrial-translation
#3
Marta Kolodziejczak, Renata Skibior-Blaszczyk, Hanna Janska
For optimal mitochondrial activity, the mitochondrial proteome must be properly maintained or altered in response to developmental and environmental stimuli. Based on studies of yeast and humans, one of the key players in this control is m-AAA proteases, mitochondrial inner membrane-bound ATP-dependent metalloenzymes. This study focuses on the importance of m-AAA proteases in plant mitochondria providing their first experimentally proven physiological substrate. We found that the Arabidopsis m-AAA complexes composed of AtFTSH3 and/or AtFTSH10 are involved in the proteolytic maturation of ribosomal subunit L32...
February 15, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29458418/amyloid-%C3%AE-induced-impairments-on-mitochondrial-dynamics-hippocampal-neurogenesis-and-memory-are-restored-by-phosphodiesterase-7-inhibition
#4
Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez, Eva Carro
BACKGROUND: The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood-brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an Alzheimer's disease (AD) model (in APP/PS1 mice). The objective of this study was to investigate the neurogenic and cellular effects of oral administration of S14 on amyloid β (Aβ) overload. METHODS: We orally administered the PDE7 inhibitor S14 (15 mg/kg/day) or vehicle in 6-month-old APP/PS1 mice...
February 20, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29456586/dietary-canolol-protects-the-heart-against-the-deleterious-effects-induced-by-the-association-of-rapeseed-oil-vitamin-e-and-coenzyme-q10-in-the-context-of-a-high-fat-diet
#5
Thibault Leger, Isabelle Hininger-Favier, Frédéric Capel, Alain Geloen, Jean-Paul Rigaudière, Chrystèle Jouve, Elodie Pitois, Gaelle Pineau, Carole Vaysse, Jean-Michel Chardigny, Marie-Caroline Michalski, Corinne Malpuech-Brugère, Luc Demaison
Background: Obesity progressively leads to cardiac failure. Omega-3 polyunsaturated fatty acids (PUFA) have been shown to have cardio-protective effects in numerous pathological situations. It is not known whether rapeseed oil, which contains α-linolenic acid (ALA), has a similar protective effect. Omega-3 PUFAs are sensitive to attack by reactive oxygen species (ROS), and lipid peroxidation products could damage cardiac cells. We thus tested whether dietary refined rapeseed oil (RSO) associated with or without different antioxidants (vitamin E, coenzyme Q10 and canolol) is cardio-protective in a situation of abdominal obesity...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29451200/modulation-of-mitochondrial-bioenergetics-as-a-therapeutic-strategy-in-alzheimer-s-disease
#6
REVIEW
Isaac G Onyango
Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have not translated into any effective disease-modifying therapies. This could be because interventions are being tested too late in the disease process. While existing therapies provide symptomatic and clinical benefit, they do not fully address the molecular abnormalities that occur in AD neurons...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29440697/ectopic-expression-of-s28a-mutated-histone-h3-modulates-longevity-stress-resistance-and-cardiac-function-in-drosophila
#7
J P Joos, A R Saadatmand, C Schnabel, I Viktorinová, T Brand, M Kramer, S Nattel, D Dobrev, P Tomancak, J Backs, P Kleinbongard, G Heusch, K Lorenz, E Koch, S Weber, A El-Armouche
Histone H3 serine 28 (H3S28) phosphorylation and de-repression of polycomb repressive complex (PRC)-mediated gene regulation is linked to stress conditions in mitotic and post-mitotic cells. To better understand the role of H3S28 phosphorylation in vivo, we studied a Drosophila strain with ectopic expression of constitutively-activated H3S28A, which prevents PRC2 binding at H3S28, thus mimicking H3S28 phosphorylation. H3S28A mutants showed prolonged life span and improved resistance against starvation and paraquat-induced oxidative stress...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439250/hoxa5-promotes-adipose-differentiation-via-increasing-dna-methylation-level-and-inhibiting-pka-hsl-signal-pathway-in-mice
#8
Weina Cao, Yatao Xu, Dan Luo, Muhammad Saeed, Chao Sun
BACKGROUND/AIMS: Impaired adipogenesis may be the underlying cause in the development of obesity and type II diabetes. Mechanistically, the family of Homeobox transcription factors is implicated in the regulation of adipocyte fate. Hoxa5 is highly expressed in adipocytes, and its mRNA expression is decreased during differentiation. However, the function of Hoxa5 in adipose tissue has been poorly understood. The aim of this study is to unveil the role of Hoxa5 on adipocyte differentiation and its underlying mechanisms...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29438981/pgam5-released-from-damaged-mitochondria-induces-mitochondrial-biogenesis-via-wnt-signaling
#9
Dominic B Bernkopf, Kowcee Jalal, Martina Brückner, Karl X Knaup, Marc Gentzel, Alexandra Schambony, Jürgen Behrens
Mitochondrial abundance is dynamically regulated and was previously shown to be increased by Wnt/β-catenin signaling. Pgam5 is a mitochondrial phosphatase which is cleaved by the rhomboid protease presenilin-associated rhomboid-like protein (PARL) and released from membranes after mitochondrial stress. In this study, we show that Pgam5 interacts with the Wnt pathway component axin in the cytosol, blocks axin-mediated β-catenin degradation, and increases β-catenin levels and β-catenin-dependent transcription...
February 8, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29436167/sestrin2-facilitates-glutamine-dependent-transcription-of-pgc-1%C3%AE-and-survival-of-liver-cancer-cells-under-glucose-limitation
#10
Ashish Kumar, Sagnik Giri, Chandrima Shaha
Differential utilization of metabolites and metabolic plasticity can confer adaptation to cancer cells under metabolic stress. Glutamine is one of the vital and versatile nutrients which cancer cells consume avidly for their proliferation, therefore, mechanisms related to glutamine metabolism has been identified as targets. Recently, SESN2 (sestrin2), a stress inducible protein has been reported to regulate survival in glutamine depleted cancer cells, based on this, we explored if SESN2 could regulate glutamine metabolism during glucose starvation...
February 12, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29427714/peroxiredoxin-3-attenuates-traumatic-neuronal-injury-through-preservation-of-mitochondrial-function
#11
Wei Hu, Xing-Bo Dang, Gang Wang, Shuai Li, Yue-Lin Zhang
Peroxiredoxins (PRDXs) are a highly conserved family of thiol peroxidases that scavenge peroxides in cells. PRDX3 is one member of PRDXs localized in the mitochondria, and has been shown to be involved in antioxidant defense and redox signaling. In this study, we investigated the role of PRDX3 in neuronal trauma using a traumatic neuronal injury (TNI) model in primary cultured cortical neurons. We found that TNI significantly decreased the expression of PRDX3 at both mRNA and protein levels. Overexpression of PRDX3 by lentivirus (LV-PRDX3) transfection attenuated lactate dehydrogenase (LDH) release and neuronal apoptosis after TNI...
February 7, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29420554/medium-chain-triglycerides-enhances-exercise-endurance-through-the-increased-mitochondrial-biogenesis-and-metabolism
#12
Ying Wang, Zhenzhen Liu, Yi Han, Jiping Xu, Wen Huang, Zhaoshen Li
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature induced exercise performance impairment. We found that MCT up-regulates the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism...
2018: PloS One
https://www.readbyqxmd.com/read/29420235/loss-of-mitochondrial-protease-clpp-protects-mice-from-diet-induced-obesity-and-insulin-resistance
#13
Shylesh Bhaskaran, Gavin Pharaoh, Rojina Ranjit, Ashley Murphy, Satoshi Matsuzaki, Binoj C Nair, Brittany Forbes, Suzana Gispert, Georg Auburger, Kenneth M Humphries, Michael Kinter, Timothy M Griffin, Sathyaseelan S Deepa
Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPRmt), a retrograde signaling response that helps to maintain mitochondrial protein homeostasis. Mitochondrial dysfunction is associated with the development of metabolic disorders, and to understand the effect of a defective UPRmt on metabolism, ClpP knockout (ClpP-/-) mice were analyzed. ClpP-/- mice fed ad libitum have reduced adiposity and paradoxically improved insulin sensitivity...
February 2, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29413962/homocysteine-causes-dysfunction-of-chondrocytes-and-oxidative-stress-through-repression-of-sirt1-ampk-pathway-a-possible-link-between-hyperhomocysteinemia-and-osteoarthritis
#14
Ching-Hou Ma, Yen Chun Chiua, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Pei-Ling Hsieh, Kun-Ling Tsai
Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism. Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are two critical sensors that regulate mitochondrial biogenesis and have been recognized as therapeutic targets in osteoarthritis (OA). This study was designed to test whether Hcy caused pro-osteoarthritic changes through modulation of SIRT1 and AMPK. Our results showed that administration of Hcy reduced the SIRT1/AMPK/PGC-1α signaling in chondrocytes, leading to mitochondrial dysfunction as a result of increased oxidative stress and apoptosis...
January 31, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413492/attenuation-of-obesity-and-insulin-resistance-by-fish-oil-supplementation-is-associated-with-improved-skeletal-muscle-mitochondrial-function-in-mice-fed-a-high-fat-diet
#15
Amanda R Martins, Amanda R Crisma, Laureane N Masi, Catia L Amaral, Gabriel N Marzuca-Nassr, Lucas H M Bomfim, Bruno G Teodoro, André L Queiroz, Tamires D A Serdan, Rosangela P Torres, Jorge Mancini-Filho, Alice C Rodrigues, Tatiana C Alba-Loureiro, Tania C Pithon-Curi, Renata Gorjao, Leonardo R Silveira, Rui Curi, Philip Newsholme, Sandro M Hirabara
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved mechanisms still remain unresolved. In this study, we evaluated the effects of fish oil (FO), a source of n-3 PUFAs, on obesity, insulin resistance and muscle mitochondrial function in mice fed a high-fat diet (HFD). C57Bl/6 male mice, 8 weeks old, were divided into four groups: control diet (C), high-fat diet (H), C+FO (CFO) and H+FO (HFO)...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29408999/hippocampal-mutant-app-and-amyloid-beta-induced-cognitive-decline-dendritic-spine-loss-defective-autophagy-mitophagy-and-mitochondrial-abnormalities-in-a-mouse-model-of-alzheimer-s-disease
#16
Maria Manczak, Ramesh Kandimalla, Xiangling Yin, P Hemachandra Reddy
The purpose of our study was to determine the toxic effects of hippocampal mutant APP and amyloid beta (Aβ) in 12-month-old APP transgenic mice. Using rotarod and Morris Water Maze tests, immunoblotting & immunofluorescence, Golgi-cox staining and transmission electron microscopy, we assessed cognitive behavior, protein levels of synaptic, autophagy, mitophagy, mitochondrial dynamics, biogenesis, dendritic protein MAP2, and quantified dendritic spines and mitochondrial number and length in 12-month-old APP mice that express swedish mutation...
February 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29408195/hydrogen-sulfide-regulates-cardiac-mitochondrial-biogenesis-via-the-activation-of-ampk
#17
Yuuki Shimizu, Rohini Polavarapu, Kattri-Liis Eskla, Chad K Nicholson, Christopher A Koczor, Rui Wang, William Lewis, Sruti Shiva, David J Lefer, John W Calvert
BACKGROUND: Hydrogen sulfide (H2S) is an important regulator of mitochondrial bioenergetics, but its role in regulating mitochondrial biogenesis is not well understood. Using both genetic and pharmacological approaches, we sought to determine if H2S levels directly influenced cardiac mitochondrial content. RESULTS: Mice deficient in the H2S-producing enzyme, cystathionine γ-lyase (CSE KO) displayed diminished cardiac mitochondrial content when compared to wild-type hearts...
January 29, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29407220/carbon-monoxide-co-modulates-hydrogen-peroxide-h2o2-mediated-cellular-dysfunction-by-targeting-mitochondria-in-rabbit-lens-epithelial-cells
#18
Yang Huang, Zi Ye, Tianju Ma, Hang Li, Yang Zhao, Wenqian Chen, Yibing Wang, Xinlin Yan, Yi Gao, Zhaohui Li
Mitochondrial components are of great importance for the maintenance of lens transparency. In our previous work, we confirmed that carbon monoxide (CO) can protect human and rabbit lens epithelial cells (LECs) from hydrogen peroxide (H2O2)-mediated apoptosis, while the mechanism remains undefined. Because CO can bind to mitochondrial cytochrome c oxidase (COX), we evaluated the effect of CO on the regulation of mitochondrial biogenesis and function in H2O2-treated rabbit LECs. To evaluate mitochondrial biogenesis, several mitochondrial transcription factors (PGC-1α, NRF-1, and mtTFA) were detected by western blot analysis...
January 30, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29398615/insulin-like-growth-factor-receptor-signaling-regulates-working-memory-mitochondrial-metabolism-and-amyloid-%C3%AE-uptake-in-astrocytes
#19
Sreemathi Logan, Gavin A Pharaoh, M Caleb Marlin, Dustin R Masser, Satoshi Matsuzaki, Benjamin Wronowski, Alexander Yeganeh, Eileen E Parks, Pavithra Premkumar, Julie A Farley, Daniel B Owen, Kenneth M Humphries, Michael Kinter, Willard M Freeman, Luke I Szweda, Holly Van Remmen, William E Sonntag
OBJECTIVE: A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction in circulating levels of insulin-like growth factor-1 (IGF-1) that is closely associated with neuronal aging and neurodegeneration. In this study, we investigated the effect of the decline in IGF-1 signaling with age on astrocyte mitochondrial metabolism and astrocyte function and its association with learning and memory...
February 1, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29396369/cardiac-natriuretic-peptides-promote-adipose-browning-through-mtor-complex-1
#20
Dianxin Liu, Ryan P Ceddia, Sheila Collins
OBJECTIVE: Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed 'browning'), has great therapeutic potential to treat obesity and its comorbidities because of the net increase in energy expenditure. β-adrenergic-cAMP-PKA signaling has long been known to regulate these processes. Recently PKA-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) was shown to be necessary for adipose 'browning' as well as proper development of the interscapular BAT...
January 17, 2018: Molecular Metabolism
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