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https://www.readbyqxmd.com/read/26062019/humanin-derivatives-inhibit-necrotic-cell-death-in-neurons
#1
Aviv Cohen, Jenny Lerner-Yardeni, David Meridor, Roni Kasher, Ilana Nathan, Abraham H Parola
Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer's disease. Herein, we identify a novel function of the humanin-derivative AGA(C8R)-HNG17 (namely, protection against cellular necrosis). Necrosis is one of the main modes of cell death, which was until recently considered an unmoderated process. However, recent findings suggest the opposite. We have found that AGA(C8R)-HNG17 confers protection against necrosis in the neuronal cell lines PC-12 and NSC-34, where necrosis is induced in a glucose-free medium by either chemohypoxia or by a shift from apoptosis to necrosis...
June 4, 2015: Molecular Medicine
https://www.readbyqxmd.com/read/18537742/the-complex-structure-transition-of-humanin-peptides-by-sodium-dodecylsulfate-and-trifluoroethanol
#2
Yoshiko Kita, Takako Niikura, Fumio Arisaka, Tsutomu Arakawa
We have examined the structure of two Humanin (HN) analog peptides, HNG and AGA-(C8R)HNG17, in the presence of sodium dodecylsulfate (SDS) and trifluoroethanol (TFE) using CD and sedimentation velocity. Both HNG and AGA-(C8R)HNG17 underwent complex conformational changes with increasing concentrations of SDS and TFE, in contrast to general trend of increasing alpha-helix with their concentration. To our surprise, both peptides appear to converge into a similar structure in SDS and TFE at higher concentrations; e...
2008: Protein and Peptide Letters
https://www.readbyqxmd.com/read/18456318/the-structure-analysis-of-humanin-analog-aga-c8r-hng17-by-circular-dichroism-and-sedimentation-equilibrium-comparison-with-the-parent-molecule
#3
Fumio Arisaka, Takako Niikura, Tsutomu Arakawa, Yoshiko Kita
A 24-amino acid peptide, Humanin (HN), is a novel peptide that protects neuronal cells in vitro and in vivo from Alzheimer's disease-related toxicities. We have shown before that the structures of HN and a 1000-fold more active analog, HNG, with a Ser14Gly mutation are largely disordered. During additional mutational analysis, a shorter 17-amino acid form, AGA-(C8R)HNG17, was accidentally discovered to have a 100-fold higher activity than HNG. Here we have characterized the structural properties of the AGA-(C8R)HNG17 analog by circular dichroism (CD) and sedimentation equilibrium analysis...
August 15, 2008: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/17519506/neuroprotection-against-neurodegenerative-diseases-development-of-a-novel-hybrid-neuroprotective-peptide-colivelin
#4
REVIEW
Tomohiro Chiba, Ikuo Nishimoto, Sadakazu Aiso, Masaaki Matsuoka
Neuronal death is directly implicated in the pathogenesis of neurodegenerative diseases (NDDs). NDDs cannot be cured because the mechanisms underlying neuronal death are too complicated to be therapeutically suppressed. Neuroprotective factors, such as neurotrophins, certain growth factors, neurotrophic cytokines, and short neuroprotective peptides, support neuronal survival in both physiological and pathological conditions, suggesting that these factors may be good drug candidates for NDDs. We recently generated a novel neuroprotective peptide named Colivelin by attaching activity-dependent neurotrophic factor (ADNF) to the N-terminus of a potent Humanin derivative, AGA-(C8R)HNG17...
February 2007: Molecular Neurobiology
https://www.readbyqxmd.com/read/16958985/humanin-and-colivelin-neuronal-death-suppressing-peptides-for-alzheimer-s-disease-and-amyotrophic-lateral-sclerosis
#5
REVIEW
Masaaki Matsuoka, Yuichi Hashimoto, Sadakazu Aiso, Ikuo Nishimoto
Humanin (HN), a 24-amino-acid neuroprotective peptide, was originally found in the occipital lobe of an autopsied Alzheimer's disease (AD) patient. HN inhibits neuronal death by binding to its specific receptor on the cell membrane and triggering a Jak2/STAT3 prosurvival pathway. The activation of this pathway may represent a therapeutic approach to AD. HN also exhibits neuroprotective activity against toxicity by familial amyotrophic lateral sclerosis (ALS)-related mutant superoxide dismutase (SOD1). Recent investigations established that AGA-(C8R)-HNG17, a 17-amno-acid derivative of HN, is 10(5) times more potent as a neuroprotective than HN; at 10-picomolar and higher concentrations in vitro it completely suppresses neuronal death...
2006: CNS Drug Reviews
https://www.readbyqxmd.com/read/16564029/colivelin-prolongs-survival-of-an-als-model-mouse
#6
Tomohiro Chiba, Marina Yamada, Jumpei Sasabe, Kenzo Terashita, Sadakazu Aiso, Masaaki Matsuoka, Ikuo Nishimoto
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease for which there is no sufficiently effective therapy. We have reported in our earlier study that intracerebroventricular (i.c.v.) injection of activity-dependent neurotrophic factor (ADNF) improves motor performance of G93A-SOD1 transgenic mice without significant prolongation in survival. Here, we found that i.c.v. injection of a synthetic hybrid peptide named Colivelin composed of ADNF and AGA-(C8R)HNG17, a potent derivative of Humanin that is a bioactive peptide with anti-Alzheimer's disease activity, dose-dependently improved motor performance and prolonged survival of ALS mice...
May 12, 2006: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/16267233/development-of-a-femtomolar-acting-humanin-derivative-named-colivelin-by-attaching-activity-dependent-neurotrophic-factor-to-its-n-terminus-characterization-of-colivelin-mediated-neuroprotection-against-alzheimer-s-disease-relevant-insults-in-vitro-and-in-vivo
#7
COMPARATIVE STUDY
Tomohiro Chiba, Marina Yamada, Yuichi Hashimoto, Maiko Sato, Jumpei Sasabe, Yoshiko Kita, Kenzo Terashita, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka
Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a short bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-causative genes and amyloid-beta (Abeta) in vitro. It has been shown that HN suppresses memory impairment of mice induced by intracerebroventricular administration of Abeta. To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative...
November 2, 2005: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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