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galacto-oligosaccharides

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https://www.readbyqxmd.com/read/28075353/biochemical-and-structural-insights-into-a-novel-thermostable-%C3%AE-1-3-galactosidase-from-marinomonas-sp-bsi20414
#1
Haitao Ding, Qian Zeng, Lili Zhou, Yong Yu, Bo Chen
A novel β-1,3-galactosidase, designated as MaBGA (β-galactosidase from Marinomonas sp. BSi20414), was successfully purified to homogeneity from Marinomonas sp. BSi20414 isolated from Arctic sea ice by ammonium sulfate precipitation and anion exchange chromatography, resulting in an 8.12-fold increase in specific activity and 9.9% recovery in total activity. MaBGA displayed its maximum activity at pH 6.0 and 60 °C, and maintained at least 90% of its initial activity over the pH range of 5.0-8.0 after incubating for 1 h...
January 8, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28001151/evaluation-of-clinical-safety-and-beneficial-effects-of-stachyose-enriched-%C3%AE-galacto-oligosaccharides-on-gut-microbiota-and-bowel-function-in-humans
#2
Ting Li, Xinshan Lu, Xingbin Yang
Deshipu stachyose granules (DSG) is a mixture of α-galacto-oligosaccharides derived from the dietary roots of Lycopus lucidus Turcz. Our previous study showed that DSG could improve the faecal microbial composition, and facilitate intestinal peristalsis and fecal excretion in mice. This study was designed to investigate the effect of DSG on gut microbiota and bowel function in humans. Two human intervention studies were conducted. In the first study, 100 healthy adults were treated without or with 5 g per day of DSG for 14 days...
December 21, 2016: Food & Function
https://www.readbyqxmd.com/read/27974055/host-microbiome-interactions-in-human-type-2-diabetes-following-prebiotic-fibre-galacto-oligosaccharide-intake
#3
Camilla Pedersen, Edith Gallagher, Felicity Horton, Richard J Ellis, Umer Z Ijaz, Huihai Wu, Etana Jaiyeola, Onyinye Diribe, Thibaut Duparc, Patrice D Cani, Glenn R Gibson, Paul Hinton, John Wright, Roberto La Ragione, M Denise Robertson
Aberrant microbiota composition and function have been linked to several pathologies, including type 2 diabetes. In animal models, prebiotics induce favourable changes in the intestinal microbiota, intestinal permeability (IP) and endotoxaemia, which are linked to concurrent improvement in glucose tolerance. This is the first study to investigate the link between IP, glucose tolerance and intestinal bacteria in human type 2 diabetes. In all, twenty-nine men with well-controlled type 2 diabetes were randomised to a prebiotic (galacto-oligosaccharide mixture) or placebo (maltodextrin) supplement (5·5 g/d for 12 weeks)...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27942845/in-vitro-assessment-of-iron-availability-from-commercial-young-child-formulae-supplemented-with-prebiotics
#4
Tatiana Christides, Julia Clark Ganis, Paul Anthony Sharp
PURPOSE: Iron is essential for development and growth in young children; unfortunately, iron deficiency (ID) is a significant public health problem in this population. Young Child Formulae (YCF), milk-derived products fortified with iron and ascorbic acid (AA, an enhancer of iron absorption) may be good sources of iron to help prevent ID. Furthermore, some YCF are supplemented with prebiotics, non-digestible carbohydrates suggested to enhance iron bioavailability. The aim of our study was to evaluate iron bioavailability of YCF relative to prebiotic and AA concentrations...
December 9, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27931127/prebiotics-and-synbiotics-in-ulcerative-colitis
#5
Axel Laurell, Klas Sjöberg
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with unclear pathogenesis. A dysbiotic intestinal microbiota is regarded as a key component in the disease process and there has been significant interest in developing new treatments which target the microbiota. AIM: To give an overview of the studies to date investigating prebiotics and synbiotics for the treatment of UC. METHODS: A literature search of PubMed and related search engines was carried out using the terms "ulcerative colitis" in combination with "prebiotic", "synbiotic" or "dietary fibre"...
December 8, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27885320/from-by-product-to-valuable-components-efficient-enzymatic-conversion-of-lactose-in-whey-using-%C3%AE-galactosidase-from-streptococcus-thermophilus
#6
Barbara Geiger, Hoang-Minh Nguyen, Stefanie Wenig, Hoang Anh Nguyen, Cindy Lorenz, Roman Kittl, Geir Mathiesen, Vincent G H Eijsink, Dietmar Haltrich, Thu-Ha Nguyen
β-Galactosidase from Streptococcus thermophilus was overexpressed in a food-grade organism, Lactobacillus plantarum WCFS1. Laboratory cultivations yielded 11,000 U of β-galactosidase activity per liter of culture corresponding to approximately 170 mg of enzyme. Crude cell-free enzyme extracts obtained by cell disruption and subsequent removal of cell debris showed high stability and were used for conversion of lactose in whey permeate. The enzyme showed high transgalactosylation activity. When using an initial concentration of whey permeate corresponding to 205 g L(-1) lactose, the maximum yield of galacto-oligosaccharides (GOS) obtained at 50°C reached approximately 50% of total sugar at 90% lactose conversion, meaning that efficient valorization of the whey lactose was obtained...
December 15, 2016: Biochemical Engineering Journal
https://www.readbyqxmd.com/read/27854268/deoxynivalenol-and-its-modified-forms-are-there-major-differences
#7
Arash Alizadeh, Saskia Braber, Peyman Akbari, Aletta Kraneveld, Johan Garssen, Johanna Fink-Gremmels
Considering the diverse toxic effects of the Fusarium toxin deoxynivalenol (DON), its common occurrence in wheat-based products, and its stability during processing, DON constitutes an increasing health concern for humans and animals. In addition to the parent compound DON, human and animal exposure encompasses the acetylated fungal metabolites 3-acetyl-deoxynivalenol (3ADON) and 15-acetyl-deoxynivalenol (15ADON) as well as the plant-derived DON-glucoside (DON3G) and the bacterial product de-epoxy-DON (DOM-1)...
November 16, 2016: Toxins
https://www.readbyqxmd.com/read/27811108/draft-genome-sequences-of-lactobacillus-animalis-strain-p38-and-lactobacillus-reuteri-strain-p43-isolated-from-chicken-cecum
#8
Morvarid Rezvani, Mary Mendoza, Matthew D Koci, Caitlyn Daron, Josh Levy, Hosni M Hassan
Here, we present the genome sequence of Lactobacillus animalis strain P38 and Lactobacillus reuteri strain P43, both isolated from the cecum content of a 4-week old chicken fed a diet supplemented with the prebiotic β(1-4)galacto-oligosaccharide (GOS). These indigenous Lactobacillus isolates are potential probiotic organisms for poultry.
November 3, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27798337/similar-to-those-who-are-breastfed-infants-fed-a-formula-containing-2-fucosyllactose-have-lower-inflammatory-cytokines-in-a-randomized-controlled-trial
#9
Karen C Goehring, Barbara J Marriage, Jeffery S Oliver, Julie A Wilder, Edward G Barrett, Rachael H Buck
BACKGROUND: Evidence suggests that human milk oligosaccharides (HMOs) provide multiple benefits to infants, including prebiotic effects, gut maturation, antimicrobial activities, and immune modulation. Clinical intervention studies with HMOs are required to confirm these benefits in infants. OBJECTIVE: Our objective was to investigate the effects of feeding formulas supplemented with the HMO 2'-fucosyllactose (2'-FL) on biomarkers of immune function in healthy term infants...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27771020/effects-of-inulin-type-fructans-galacto-oligosaccharides-and-related-synbiotics-on-inflammatory-markers-in-adult-patients-with-overweight-or-obesity-a-systematic-review
#10
REVIEW
Ricardo Fernandes, Vinicius A do Rosario, Michel C Mocellin, Marilyn G F Kuntz, Erasmo B S M Trindade
BACKGROUND & AIMS: Studies in humans with overweight or obesity have reported that some prebiotics and synbiotics have beneficial effects on metabolic endotoxaemia and immune function. However, to date, no systematic review of controlled clinical trials assessed this topic. The aim of this study was to evaluate the effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adults with overweight or obesity. METHODS: A systematic review of the literature was performed until November 6, 2015 in four electronic databases and reference lists of all included articles and relevant reviews in the field, without using any filter...
October 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27757792/synthesis-and-purification-of-galacto-oligosaccharides-state-of-the-art
#11
REVIEW
Carlos Vera, Andrés Córdova, Carla Aburto, Cecilia Guerrero, Sebastián Suárez, Andrés Illanes
Lactose-derived non-digestible oligosaccharides are prominent components of functional foods. Among them, galacto-oligosaccharides (GOS) outstand for being prebiotics whose health-promoting effects are supported on strong scientific evidences, having unique properties as substitutes of human milk oligosaccharides in formulas for newborns and infants. GOS are currently produced enzymatically in a kinetically-controlled reaction of lactose transgalactosylation catalyzed by β-galactosidases from different microbial strains...
December 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27738596/middle-east-consensus-statement-on-the-diagnosis-and-management-of-functional-gastrointestinal-disorders-in-12-months-old-infants
#12
REVIEW
Yvan Vandenplas, Muath Abdurrahman Alturaiki, Wafaa Al-Qabandi, Fawaz AlRefaee, Ziad Bassil, Bassam Eid, Ahmed El Beleidy, Ali Ibrahim Almehaidib, Pierre Mouawad, Maroun Sokhn
This paper covers algorithms for the management of regurgitation, constipation and infantile colic in infants. Anti-regurgitation formula may be considered in infants with troublesome regurgitation, while diagnostic investigations or drug therapy are not indicated in the absence of warning signs. Although probiotics have shown some positive evidence for the management of functional gastrointestinal disorders (FGIDs), the evidence is not strong enough to make a recommendation. A partially hydrolyzed infant formula with prebiotics and β-palmitate may be considered as a dietary intervention for functional constipation in formula fed infants...
September 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/27688855/dietary-prebiotics-and-probiotics-influence-the-growth-performance-feed-utilisation-and-body-indices-of-snakehead-channa-striata-fingerlings
#13
Mohammad Bodrul Munir, Roshada Hashim, Mohammad Suhaimee Abdul Manaf, Siti Azizah Mohd Nor
This study used a two-phase feeding trial to determine the influence of selected dietary prebiotics and probiotics on growth performance, feed utilisation, and morphological changes in snakehead (Channa striata) fingerlings as well as the duration of these effects over a post-experimental period without supplementation. Triplicate groups of fish (22.46 ±0.17 g) were raised on six different treatment diets: three prebiotics (0.2% β-glucan, 1% galacto-oligosaccharides [GOS], 0.5% mannan-oligosaccharides [MOS]), two probiotics (1% live yeast [Saccharomyces cerevisiae] and 0...
August 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27501980/role-of-the-ganspqab-operon-in-degradation-of-galactan-by-bacillus-subtilis
#14
Hildegard Watzlawick, Kambiz Morabbi Heravi, Josef Altenbuchner
Bacillus subtilis possesses different enzymes for the utilization of plant cell wall polysaccharides. This includes a gene cluster containing galactan degradation genes (ganA and ganB), two transporter component genes (ganQ and ganP), and the sugar-binding lipoprotein-encoding gene ganS (previously known as cycB). These genes form an operon that is regulated by GanR. The degradation of galactan by B. subtilis begins with the activity of extracellular GanB. GanB is an endo-β-1,4-galactanase and is a member of glycoside hydrolase (GH) family 53...
October 15, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27490566/novel-combination-of-prebiotics-galacto-oligosaccharides-and-inulin-inhibited-aberrant-crypt-foci-formation-and-biomarkers-of-colon-cancer-in-wistar-rats
#15
Tahir Rasool Qamar, Fatima Syed, Muhammad Nasir, Habib Rehman, Muhammad Nauman Zahid, Rui Hai Liu, Sanaullah Iqbal
The selectivity and beneficial effects of prebiotics are mainly dependent on composition and glycosidic linkage among monosaccharide units. This is the first study to use prebiotic galacto-oligosaccharides (GOS) that contains β-1,6 and β-1,3 glycosidic linkages and the novel combination of GOS and inulin in cancer prevention. The objective of the present study is to explore the role of novel GOS and inulin against various biomarkers of colorectal cancer (CRC) and the incidence of aberrant crypt foci (ACF) in a 1,2-dimethyl hydrazine dihydrochloride (DMH)-induced rodent model...
August 1, 2016: Nutrients
https://www.readbyqxmd.com/read/27472478/partly-fermented-infant-formulae-with-specific-oligosaccharides-support-adequate-infant-growth-and-are-well-tolerated
#16
Frédéric Huet, Marieke Abrahamse-Berkeveld, Sebastian Tims, Umberto Simeoni, Gérard Beley, Christoph Savagner, Yvan Vandenplas, Jonathan O'B Hourihane
OBJECTIVE: Fermented formulae (FERM) and a specific mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS compared with either 1 feature, in healthy term infants. METHODS: Four hundred thirty-two infants were enrolled before 28 days of age and followed up to 17 weeks of age and assigned to 1 of the 4 groups: (i) formula with scGOS/lcFOS, (ii) scGOS/lcFOS + 15% FERM, (iii) scGOS/lcFOS + 50% FERM, or (iv) 50% fermented formula (50% FERM)...
October 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27466606/intake-of-high-fat-yogurt-but-not-of-low-fat-yogurt-or-prebiotics-is-related-to-lower-risk-of-depression-in-women-of-the-sun-cohort-study
#17
Aurora Perez-Cornago, Almudena Sanchez-Villegas, Maira Bes-Rastrollo, Alfredo Gea, Patricio Molero, Francisca Lahortiga-Ramos, Miguel Angel Martínez-González
BACKGROUND: Yogurt and prebiotic consumption has been linked to better health. However, to our knowledge, no longitudinal study has assessed the association of yogurt and prebiotic consumption with depression risk. OBJECTIVE: We longitudinally evaluated the association of yogurt and prebiotic consumption with depression risk in a Mediterranean cohort. METHODS: The SUN (Seguimiento Universidad de Navarra) Project is a dynamic, prospective cohort of Spanish university graduates...
September 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27366924/recyclable-strategy-for-the-production-of-high-purity-galacto-oligosaccharides-by-kluyveromyces-lactis
#18
Huaisheng Sun, Shengping You, Mengfan Wang, Wei Qi, Rongxin Su, Zhimin He
A recyclable strategy for the production of high-purity (>95%) galacto-oligosaccharides (GOS) was developed using Kluyveromyces lactis in both the synthesis and purification steps. For the synthesis of GOS, ethanol-permeabilized cells (p-cells) of K. lactis were used because the enhanced permeability facilitated the mass transfer of the substrate and the release of oligosaccharide products. For the purification of GOS, non-permeabilized K. lactis cells (np-cells) were preferred as a result of their intrinsic cell membrane barrier toward GOS, which led to the selective consumption of carbohydrate...
July 20, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27342764/influence-of-lactose-hydrolysis-on-galacto-oligosaccharides-lactose-volatile-profile-and-physicochemical-parameters-of-different-yogurt-varieties
#19
Claudia I Vénica, Irma V Wolf, Carina V Bergamini, María C Perotti
BACKGROUND: Different types of reduced-lactose yogurt, obtained by lactose hydrolysis using β-galactosidase enzyme, are commercially available. The breakdown of lactose modifies the carbohydrate profile, including the production of prebiotic galacto-oligosaccharides (GOS), which could affect the survival and activity of starter and probiotic cultures and the parameters of yogurt quality. The extension of these changes is dependent on the yogurt matrix composition. This study aimed to evaluate the influence of lactose hydrolysis on GOS, lactose, volatile profile and physicochemical parameters of different yogurt varieties during storage...
December 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27295033/characterizing-microbiota-independent-effects-of-oligosaccharides-on-intestinal-epithelial-cells-insight-into-the-role-of-structure-and-size-structure-activity-relationships-of-non-digestible-oligosaccharides
#20
Peyman Akbari, Johanna Fink-Gremmels, Rianne H A M Willems, Elisabetta Difilippo, Henk A Schols, Margriet H C Schoterman, Johan Garssen, Saskia Braber
PURPOSE: The direct effects of galacto-oligosaccharides (GOS), including Vivinal(®) GOS syrup (VGOS) and purified Vivinal(®) GOS (PGOS), on the epithelial integrity and corresponding interleukin-8 (IL-8/CXCL8) release were examined in a Caco-2 cell model for intestinal barrier dysfunction. To investigate structure-activity relationships, the effects of individual DP fractions of VGOS were evaluated. Moreover, the obtained results with GOS were compared with Caco-2 monolayers incubated with fructo-oligosaccharides (FOS) and inulin...
June 13, 2016: European Journal of Nutrition
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