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galacto-oligosaccharides

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https://www.readbyqxmd.com/read/28931149/can-a-galacto-oligosaccharide-reduce-the-risk-of-traveller-s-diarrhoea-a-placebo-controlled-randomized-double-blind-study
#1
Gunnar Hasle, Ragnhild Raastad, Gunnar Bjune, Pål A Jenum, Lise Heier
Background: Diarrhoea is a common medical problem affecting travellers to Asia, Africa and Latin America. The use of prophylactic antimicrobial agents may increase the risk of contracting resistant bacteria. Findings indicate that oligosaccharides, i.e. carbohydrate chains of 3-10 monosaccharides, reduce the risk of diarrhoea. Methods: We performed a placebo-controlled, double-blind study of a galacto-oligosaccharide, B-GOS (Bimuno®, Clasado Ltd, Milton Keynes UK), vs placebo for participants travelling to countries with a high/intermediate risk of diarrhoea for 7-15 days...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28929976/response-surface-methodology-as-a-tool-for-modelling-galacto-oligosaccharide-production
#2
Claudia I Vénica, Carina V Bergamini, María C Perotti
The experiments reported in this research paper describe the effects of β-galactosidase enzyme dose and cheese whey amount, on the maximum concentration and yield of galacto-oligosaccahride (GOS) and reaction time. The experimental plan was based on central composite rotational design (CCRD) and modelled by response surface methodology (RSM). The results indicate that the proposed mathematical models could adequately describe the concentration and yield of GOS and the reaction time within the limits of the factors that are being investigated...
September 20, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28911187/genome-analysis-of-food-processing-stressful-resistant-probiotic-bifidobacterium-animalis-subsp-lactis-bf052-and-its-potential-application-in-fermented-soymilk
#3
Pattra Charnchai, Sirima Suvarnakuta Jantama, Kaemwich Jantama
In this study, Bifidobacterium animalis subsp. lactis BF052 was demonstrated the growth capability in soymilk and could be thus supplemented as a probiotic starter that employed soymilk as one of its food vehicles. The complete genome sequence of BF052 was therefore determined to understand the genetic basis of BF052 as a technological and functional probiotic starter. The whole genome sequence of BF052 consists of a circular genome of 1938 624 bp with a G+C content of 60.50%. This research highlights relevant genes involving in its adaptive responses to industrial and/or environmental stresses and utilization of α-galacto-oligosaccharides in BF052 strain compared with other representative bifidobacterial genomes...
September 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28905280/enzymatic-synthesis-of-fucose-containing-galacto-oligosaccharides-using-%C3%AE-galactosidase-and-identification-of-novel-disaccharide-structures
#4
Anne Usvalampi, Hannu Maaheimo, Olli Tossavainen, Alexander D Frey
Fucosylated oligosaccharides have an important role in maintaining a healthy immune system and homeostatic gut microflora. This study employed a commercial β-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose. The production was optimized using experiment design and optimal conditions for a batch production in 3-liter scale. The reaction product was analyzed and the produced galactose-fucose disaccharides were purified. The structures of these disaccharides were determined using NMR and it was verified that one major product with the structure Galβ1-3Fuc and two minor products with the structures Galβ1-4Fuc and Galβ1-2Fuc were formed...
September 13, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28889122/galectin-9-produced-by-intestinal-epithelial-cells-enhances-aldehyde-dehydrogenase-activity-in-dendritic-cells-in-a-pi3k-and-p38-dependent-manner
#5
Sander de Kivit, Atanaska I Kostadinova, JoAnn Kerperien, Veronica Ayechu Muruzabal, Mary E Morgan, Leon M J Knippels, Aletta D Kraneveld, Johan Garssen, Linette E M Willemsen
Intestinal epithelial cells (IEC) drive regulatory T cell (Treg) responses by promoting the differentiation of aldehyde dehydrogenase (ALDH)-expressing CD103+ dendritic cells (DC). Apical stimulation of TLR9 by CpG DNA on IEC supports galectin-9 expression by IEC, which is promoted by short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (GF). While galectin-9 can induce the maturation of monocyte-derived DC (moDC), the contribution of galectin-9 on the induction of ALDH activity in DC is not known...
September 9, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28884590/galacto-oligosaccharides-ameliorate-dysbiotic-bifidobacteriaceae-decline-in-japanese-patients-with-type-2-diabetes
#6
M Gonai, A Shigehisa, I Kigawa, K Kurasaki, O Chonan, T Matsuki, Y Yoshida, M Aida, K Hamano, Y Terauchi
Gut microbiota affects the host's metabolism, and it is suggested that there are differences in gut microbiota composition between patients with type 2 diabetes and healthy individuals. Additionally, dysbiosis may increase the concentration of lipopolysaccharides (LPS), causing metabolic endotoxemia, which induces impaired glucose tolerance. Several studies have reported relationships between metabolic diseases and the gut microbiota; and prebiotics, such as oligosaccharides, are commonly consumed to regulate gut microbiotas in healthy individuals...
September 8, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28877890/tackling-iron-deficiency-in-infants-galacto-oligosaccharides-may-be-up-to-the-task
#7
Fudi Wang
No abstract text is available yet for this article.
September 6, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28858205/impact-of-novel-prebiotic-galacto-oligosaccharides-on-various-biomarkers-of-colorectal-cancer-in-wister-rats
#8
Tahir Rasool Qamar, Sanaullah Iqbal, Fatima Syed, Muhammad Nasir, Habib Rehman, Muhammad Aamir Iqbal, Rui Hai Liu
Colorectal cancer (CRC) is one of the leading causes of cancer deaths around the globe. Bioactive food ingredients such as prebiotics have protective potential in colon cancer. Data on galacto-oligosaccharides (GalOS) against CRC are very limited and GalOS used in this study have β-1,6 and β-1,3 as major glycosidic linkages and, to our best knowledge, were never used before against any cancer treatment. This study aims to investigate the protective role of novel GalOS against various biomarkers of CRC including aberrant crypt foci (ACF), bacterial enzymes and short chain fatty acids (SCFA) in a rodent model induced with 1,2-dimethylhydrazine dihydrochloride (DMH)...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28839490/effects-of-prenatal-consumption-of-caprine-milk-oligosaccharides-on-mice-mono-associated-with-bifidobacterium-bifidum-agr2166
#9
Caroline Thum, Kikuji Itoh, Wayne Young, Adrian Cookson, Warren McNabb, Nicole Roy
BACKGROUND: Prenatal consumption of oligosaccharides are associated with changes in the maternal gastrointestinal tract (GIT) microbiota with health consequences for the offspring. It has previously been demonstrated that caprine milk oligosaccharides (CMO) stimulate the growth and fermentation rate of Bifidobacterium bifidum AGR2166. OBJECTIVE: The objective of this study was to examine the effects of B. bifidum AGR2166 and prenatal consumption of CMO, alone or in combination, on the dam's large intestine, foetal development and ability of B...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28814396/consumption-of-galacto-oligosaccharides-increases-iron-absorption-from-a-micronutrient-powder-containing-ferrous-fumarate-and-sodium-iron-edta-a-stable-isotope-study-in-kenyan-infants
#10
Daniela Paganini, Mary A Uyoga, Colin I Cercamondi, Diego Moretti, Edith Mwasi, Clarissa Schwab, Salome Bechtler, Francis M Mutuku, Valeria Galetti, Christophe Lacroix, Simon Karanja, Michael B Zimmermann
Background: Whether consumption of prebiotics increases iron absorption in infants is unclear.Objective: We set out to determine whether prebiotic consumption affects iron absorption from a micronutrient powder (MNP) containing a mixture of ferrous fumarate and sodium iron EDTA (FeFum+NaFeEDTA) in Kenyan infants.Design: Infants (n = 50; aged 6-14 mo) consumed maize porridge that was fortified with an MNP containing FeFum+NaFeEDTA and 7.5 g galacto-oligosaccharides (GOSs) (Fe+GOS group, n = 22) or the same MNP without GOSs (Fe group, n = 28) each day for 3 wk...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28809383/increasing-symptoms-in-irritable-bowel-symptoms-with-ingestion-of-galacto-oligosaccharides-are-mitigated-by-%C3%AE-galactosidase-treatment
#11
C J Tuck, K M Taylor, P R Gibson, J S Barrett, J G Muir
OBJECTIVES: Galacto-oligosaccharides (GOS) are dietary FODMAPs (fermentable carbohydrates) associated with triggering gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). This randomized, double-blind, placebo-controlled, cross-over trial aimed to assess whether oral α-galactosidase co-ingestion with foods high in GOS and low in other FODMAPs would reduce symptoms. METHODS: Patients meeting the Rome III criteria for IBS who were hydrogen-producers on breath testing were recruited...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28774885/prebiotic-galacto-oligosaccharides-mitigate-the-adverse-effects-of-iron-fortification-on-the-gut-microbiome-a-randomised-controlled-study-in-kenyan-infants
#12
Daniela Paganini, Mary A Uyoga, Guus A M Kortman, Colin I Cercamondi, Diego Moretti, Tanja Barth-Jaeggi, Clarissa Schwab, Jos Boekhorst, Harro M Timmerman, Christophe Lacroix, Simon Karanja, Michael B Zimmermann
OBJECTIVE: Iron-containing micronutrient powders (MNPs) reduce anaemia in African infants, but the current high iron dose (12.5 mg/day) may decrease gut Bifidobacteriaceae and Lactobacillaceae, and increase enteropathogens, diarrhoea and respiratory tract infections (RTIs). We evaluated the efficacy and safety of a new MNP formula with prebiotic galacto-oligosaccharides (GOS) combined with a low dose (5 mg/day) of highly bioavailable iron. DESIGN: In a 4-month, controlled, double-blind trial, we randomised Kenyan infants aged 6...
August 3, 2017: Gut
https://www.readbyqxmd.com/read/28730134/innovative-dietary-intervention-answers-to-baby-colic
#13
Ioannis Xinias, A Analitis, Antigoni Mavroudi, Ioannis Roilides, Maria Lykogeorgou, Varvara Delivoria, Vasilis Milingos, Mayra Mylonopoulou, Yvan Vandenplas
PURPOSE: The purpose of this paper is to evaluate the efficacy of a lactose- reduced synbiotic partial whey hydrolysate in formula fed infants presenting with colic and the impact of this dietary intervention in mean crying time and quality of life. METHODS: Forty infants with infantile colic were treated during one month with parental reassurance and the intervention formula (partial whey hydrolysate, reduced lactose, Bifidobacterium lactis BB12 and galacto-oligosaccharides) and were compared to a control group of 20 infants with infantile colic treated with parental reassurance and a standard infant formula...
June 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28705786/investigation-of-the-efficacy-of-synbiotics-in-the-treatment-of-functional-constipation-in-children-a-randomized-double-blind-placebo-controlled-study
#14
Ahmet Baştürk, Reha Artan, Atike Atalay, Aygen Yılmaz
BACKGROUND/AIMS: The aim of this study was to demonstrate the efficacy of synbiotic (Lactobacillus casei, L. rhamnosus, L. plantarum, and Bifidobacterium lactis and prebiotics [fiber, polydextrose, fructo-oligosaccharides, and galacto-oligosaccharides]) treatment in children with functional constipation. MATERIALS AND METHODS: This study was performed in patients aged 4-18 years, and the patients were diagnosed to have functional constipation according to the Roma III diagnostic criteria...
July 13, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28646668/%C3%AE-galactosidase-from-aspergillus-lacticoffeatus-a-promising-biocatalyst-for-the-synthesis-of-novel-prebiotics
#15
Beatriz B Cardoso, Sara C Silvério, Luís Abrunhosa, José A Teixeira, Lígia R Rodrigues
β-galactosidase (EC 3.2.1.23) are interesting enzymes able to catalyze lactose hydrolysis and transfer reactions to produce lactose-based prebiotics with potential application in the pharmaceutical and food industry. In this work, Aspergillus lacticoffeatus is described, for the first time, as an effective β-galactosidase producer. The extracellular enzyme production was evaluated in synthetic and alternative media containing cheese whey and corn steep liquor. Although β-galactosidase production occurred in all media (expect for the one composed solely by cheese whey), the highest enzymatic activity values (460U/mL) were obtained for the synthetic medium...
June 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28644357/effect-of-synbiotic-on-the-gut-microbiota-of-cesarean-delivered-infants-a-randomized-double-blind-multicenter-study
#16
Mei Chin Chua, Kaouther Ben-Amor, Christophe Lay, Anne G E Neo, Wei Chin Chiang, Rajeshwar Rao, Charmaine Chew, Surasith Chaithongwongwatthana, Nipon Khemapech, Jan Knol, Voranush Chongsrisawat
We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P < 0...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28637685/milk-oligosaccharides-inhibit-human-rotavirus-infectivity-in-ma104-cells
#17
Daniel R Laucirica, Vassilis Triantis, Ruud Schoemaker, Mary K Estes, Sasirekha Ramani
Background: Oligosaccharides in milk act as soluble decoy receptors and prevent pathogen adhesion to the infant gut. Milk oligosaccharides reduce infectivity of a porcine rotavirus strain; however, the effects on human rotaviruses are less well understood.Objective: In this study, we determined the effect of specific and abundant milk oligosaccharides on the infectivity of 2 globally dominant human rotavirus strains.Methods: Four milk oligosaccharides-2'-fucosyllactose (2'FL), 3'-sialyllactose (3'SL), 6'-sialyllactose (6'SL), and galacto-oligosaccharides-were tested for their effects on the infectivity of human rotaviruses G1P[8] and G2P[4] through fluorescent focus assays on African green monkey kidney epithelial cells (MA104 cells)...
September 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28589996/implications-of-the-maillard-reaction-on-bovine-alpha-lactalbumin-and-its-proteolysis-during-in-vitro-infant-digestion
#18
Yousef Joubran, Alice Moscovici, Reto Portmann, Uri Lesmes
This study investigated the functionality and digestibility of Maillard reaction products (MRPs) of alpha-lactalbumin (α-la), a major whey protein and component of infant formulas. The impact of different carbohydrates (glucose, galactose or galacto-oligosaccharides (GOS)) and heating duration was studied. SDS-PAGE, UV and color measurements monitored reaction extent, which varied between carbohydrates whereby galactose reacted more readily than glucose. Surface hydrophobicity and antioxidant capacity were found to be significantly (p < 0...
June 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28582809/dietary-galacto-oligosaccharides-improve-skin-health-a-randomized-double-blind-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Yang Hee Hong, Un Jae Chang, Young Suk Kim, Eun Young Jung, Hyung Joo Suh
BACKGROUND AND OBJECTIVES: To study the effects of galacto-oligosaccharides (GOS) on the skin, we investigated skin-related parameters in healthy adults who received GOS for 12 weeks. METHODS AND STUDY DESIGN: This double-blind, randomized, placebo-controlled study included subjects divided into two groups (control and GOS) by stratified block randomization. The GOS group received 1.0 g of GOS twice a day, whereas the control group received only vehicle. RESULTS: The results showed that the increase in corneometer values from baseline to week 12 was significantly greater in the GOS group than in the control group (6...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28525543/fermentable-carbohydrates-fodmaps-exacerbate-functional-gastrointestinal-symptoms-in-patients-with-inflammatory-bowel-disease-a-randomised-double-blind-placebo-controlled-cross-over-re-challenge-trial
#20
Selina R Cox, Alexis C Prince, Clio E Myers, Peter M Irving, James O Lindsay, Miranda C Lomer, Kevin Whelan
Background and Aims: Preliminary evidence suggests fermentable carbohydrate restriction might ameliorate functional gastrointestinal symptoms (FGS) in quiescent inflammatory bowel disease (IBD). Our aim was to determine whether fermentable carbohydrates exacerbate FGS in quiescent IBD using a randomised, double-blinded, placebo-controlled, cross-over, re-challenge trial. Methods: Patients with quiescent IBD and FGS responsive to a low FODMAP diet were allocated to a series of 3-day fermentable carbohydrate challenges in random order (fructan, 12 g/d; galacto-oligosaccharides, GOS, 6 g/d; sorbitol, 6 g/d; and glucose placebo, 12 g/d), each separated by a standardised washout period...
May 19, 2017: Journal of Crohn's & Colitis
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