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Dipyridamole

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https://www.readbyqxmd.com/read/28521571/milk-caseins-as-useful-vehicle-for-delivery-of-dipyridamole-drug
#1
Hamid Dezhampanah, Masoomeh Esmaili, Leila Hasani
The interaction of bovine milk α- and β-caseins as an efficient drug carrier system with Dipyridamole (DIP) was investigated using spectroscopy and molecular docking studies at different temperatures (20-37(o)C). FTIR, CD and fluorescence spectroscopy methods demonstrated that α- and β-caseins interact with DIP molecule mainly via hydrophobic and hydrophilic interactions and change in secondary structure of α- and β-caseins. DIP showed a higher quenching efficiency and binding constant of α-casein than β-casein...
May 18, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28510131/generation-of-radical-form-of-dipyridamole-at-illumination-of-photosynthetic-reaction-centers-of-rb-sphaeroides
#2
P P Knox, K N Timofeev, V V Gorokhov, N Kh Seifullina, A B Rubin
The study of the effect of vasodilator, antiplatelet agent, and inhibitor P-glycoprotein dipyridamole (DIP) on the functioning of the transmembrane protein of the reaction center (RC) of Rb. sphaeroides showed that the activation of RC by constant light generates the DIP radical cation, which significantly affects the kinetics of recombination of charges divided between photoactive bacteriochlorophyll and quinone acceptors. Thus, the antioxidant properties of DIP may affect the functional activity of membrane proteins, and this apparently should be taken into account in the studies of the mechanisms of therapeutic action of this drug...
March 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28493475/change-of-left-ventricular-rigid-body-rotation-during-dipyridamole-induced-vasodilation-a-case-from-the-three-dimensional-speckle-tracking-echocardiographic-magyar-stress-study
#3
Attila Nemes, Gyula Szántó, Péter Domsik, Árpád Kormányos, Anita Kalapos, Nóra Ambrus, Tamás Forster
A patient with previous coronary stenting presented with stable angina and positive exercise treadmill test. Echocardiography with three-dimensional speckle-tracking demonstrated left ventricular rigid body rotation (near absence of left ventricular twist), whose characteristics changed dramatically during dipyridamole-induced vasodilatation. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound, 2017.
May 11, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28491036/pharmacological-activity-and-clinical-use-of-pdrn
#4
REVIEW
Francesco Squadrito, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Letteria Minutoli, Domenica Altavilla
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers. PDRN holds a mixture of deoxyribonucleotides with molecular weights ranging between 50 and 1,500 KDa, it is derived from a controlled purification and sterilization process of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon) sperm DNA. The procedure guarantees the absence of active protein and peptides that may cause immune reactions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28475928/development-and-characterization-of-mitochondrial-membrane-affinity-chromatography-columns-derived-from-skeletal-muscle-and-platelets-for-the-study-of-mitochondrial-transmembrane-proteins
#5
Nagendra Surendra Singh, Kaia-Liisa Habicht, Ruin Moaddel, Ruth Shimmo
Mitochondrial membrane fragments from human platelets and monkey skeletal muscles were successfully immobilized onto immobilized artificial membrane chromatographic support for the first time, resulting in mitochondrial membrane affinity chromatography (MMAC) columns. These columns were validated by characterization of translocator protein (TSPO), where multiple concentrations of dipyridamole were run and the binding affinities (Kd) determined. Further, the relative ranking data of TSPO ligands was consistent with previously reported rankings for both, the platelet (MMAC-Platelet) and the skeletal muscle (MMAC-Muscle) column (dipyridamole>PK11195>protoporphyrin IX>rotenone)...
April 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28475259/regadenoson-versus-dipyridamole-a-comparison-of-the-frequency-of-adverse-events-in-patients-undergoing-myocardial-perfusion-imaging
#6
Kallie A Amer, Jeff R Hurren, Stephanie B Edwin, Gerald Cohen
STUDY OBJECTIVE: To compare the frequency of adverse events in patients undergoing myocardial perfusion imaging (MPI) with either regadenoson or dipyridamole. DESIGN: Single-center, retrospective cohort study. SETTING: Large community teaching hospital. PATIENTS: A total of 568 adults who underwent single-photon emission tomography MPI with either regadenoson (284 patients) or dipyridamole (284 patients) as a vasodilator agent, following an institution conversion from regadenoson to dipyridamole in the MPI protocol on July 15, 2013, for cost-saving purposes...
May 5, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28465977/the-diagnostic-challenge-of-dipyridamole-atropine-stress-echocardiography-in-a-patient-with-myocardial-bridge
#7
Maurizio Cusmà Piccione, Concetta Zito, Olimpia Trio, Alessandra Oteri, Myriam D'Angelo, Giuseppe Andò
A 60-year-old male patient was submitted to dipyridamole-atropine stress echocardiography (DSE) for chest pain during exertion. At rest, no electrocardiographic (ECG) and transthoracic echocardiographic (TTE) abnormalities were observed. After dipyridamole infusion, the patient complained a mild chest discomfort, without ECG changes and TTE wall-motion abnormalities. Subsequently, worsening of the anginal symptoms combined with descending ST-depression and T-negative waves occurred after atropine and unexpectedly, aminophylline administration...
October 2016: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/28465976/addition-of-exercise-to-dipyridamole-stress-echocardiography-in-order-to-carry-on-the-ischemic-cascade-role-in-the-diagnosis-of-coronary-artery-disease-and-prognostic-value
#8
Piergiuseppe Piovesana, Pietro Offelli, Francesca D'Ambrosio, Fabio De Conti, Virginia Scarabeo, Marco Panfili, Francesco Antonini-Canterin
BACKGROUND: Sensitivity of dipyridamole stress echocardiography (SE) is often lower than required. The aim of the present work is the evaluation of the association of dipyridamole and exercise echocardiography. METHODS: From June 2007 to January 2011, 259 consecutive patients referred to Camposampiero Echocardiography Laboratory underwent SE. Stress protocol started with dipyridamole infusion of 0.84 mg/kg over 6 min. In patients without a new dyssynergy after dipyridamole, SE was carried on with supine exercise...
October 2016: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/28458364/improved-dissolution-of-dipyridamole-with-the-combination-of-ph-modifier-and-solid-dispersion-technology
#9
Yoshiki Kojo, Saori Matsunaga, Hiroki Suzuki, Chika Taniguchi, Yohei Kawabata, Koichi Wada, Yukinori Yamauchi, Yoshiki Seto, Hideyuki Sato, Satomi Onoue
The aim of this study was to develop a pH-independent release formulation of dipyridamole (DP) by the combined use of pH-modifier technology and solid dispersion (SD) technology employing enteric polymer, Eudragit(®) S100 (Eud). Tartaric acid (TA) was selected as an appropriate pH-modifier in terms of improving the dissolution behavior of DP under neutral conditions. Upon optimization of the ratio of TA to DP, SD of DP with Eud and TA (SD-Eud/DP/TA) was prepared by a freeze-drying method. Scanning electron microscopic images revealed that DP was dispersed in the polymer in SD-Eud/DP/TA, and DP in SD-Eud/DP/TA was in an amorphous state, supported by powder X-ray diffraction and differential scanning calorimetry analyses...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28446460/inhibition-of-cholinergic-neurotransmission-by-%C3%AE-3-adrenoceptors-depends-on-adenosine-release-and-a1-receptors-activation-in-human-and-rat-urinary-bladders
#10
Isabel Silva, Ana Filipa Costa, Sílvia Moreira, Fátima Ferreirinha, Maria Teresa Magalhães-Cardoso, Isabel Calejo, Miguel Silva-Ramos, Paulo Correia-de-Sá
The direct detrusor relaxant effect of β3-adrenoceptor agonists as a primary mechanism to improve overactive bladder symptoms has been questioned. Among other targets, activation of β3-adrenoceptors down-modulate nerve-evoked acetylcholine (ACh) release, but there is insufficient evidence for the presence of these receptors on bladder cholinergic nerve terminals. Our hypothesis is that adenosine formed from the catabolism of cyclic AMP in the detrusor may act as a retrograde messenger via prejunctional A1 receptors to explain inhibition of cholinergic activity by β3-adrenoceptors...
April 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28401352/randomized-comparison-between-provisional-and-routine-kissing-balloon-technique-after-main-vessel-crossover-stenting-for-coronary-bifurcation-lesions
#11
Masahiro Yamawaki, Masaki Fujita, Shinya Sasaki, Masanori Tsurugida, Mamoru Nanasato, Motoharu Araki, Keisuke Hirano, Yoshiaki Ito, Reiko Tsukahara, Toshiya Muramatsu
We compared the myocardial ischemic burden of provisional and routine final kissing-balloon inflation (FKI) with the 1-stent strategy using a second-generation drug-eluting stent for coronary bifurcation lesions (CBL). There are no established guidelines for side branch (SB) intervention after main vessel stenting. In total, 113 CBL patients were randomized to receive different SB intervention strategies: provisional-FKI group (n = 57; FKI only when SB flow was TIMI <3) and routine-FKI group (n = 56; mandatory FKI with aggressive treatment until SB-residual stenosis <50%)...
April 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28376099/the-adenosine-generating-enzymes-cd39-cd73-control-microglial-processes-ramification-in-the-mouse-brain
#12
Marina Matyash, Oleksandr Zabiegalov, Stefan Wendt, Vitali Matyash, Helmut Kettenmann
Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified morphology in the postnatal brain. Microglia express all essential purinergic elements such as receptors, nucleoside transporters and ecto-enzymes, including CD39 (NTPDase1) and CD73 (5'-nucleotidase), which sequentially degrade extracellular ATP to adenosine. Here, we show that constitutive deletion of CD39 and CD73 or both caused an inhibition of the microglia ramified phenotype in the brain with a reduction in the length of processes, branching frequency and number of intersections with Sholl spheres...
2017: PloS One
https://www.readbyqxmd.com/read/28350995/the-difference-in-association-between-aspirin-use-and-other-thrombocyte-aggregation-inhibitors-and-survival-in-patients-with-colorectal-cancer
#13
M A Frouws, E Rademaker, E Bastiaannet, M P P van Herk-Sukel, V E Lemmens, C J H Van de Velde, J E A Portielje, G J Liefers
BACKGROUND: Several studies have suggested that the association between aspirin and improved cancer survival is mediated through the mechanism of aspirin as thrombocyte aggregation inhibitors (TAI). The aim of this study was to provide epidemiological evidence for this mechanism assessing the association between overall survival and the use of aspirin and non-aspirin TAI in patients with colorectal cancer. METHODS: In this observational study, data from the Netherlands Comprehensive Cancer Organisation were linked to PHARMO Database Network...
March 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28294860/-coronary-flow-reserve-in-the-left-anterior-and-posterior-descending-arteries-as-an-additional-option-to-dipyridamole-stress-echocardiography-for-detection-of-stenosis
#14
A A Boshchenko, A V Vrublevsky, R S Karpov
AIM: to assess additive diagnostic value of simultaneous evaluation of coronary flow reserve (CFR) in the left anterior descending (LAD) artery and posterior descending artery (PDA) during dipyridamole stress echocardiography (stress-Echo) for detection of LAD and PDA stenoses >50%. METHODS: 108 in-patients (mean age 50+/-11 years) with cardiac chest pain underwent dipyridamole stress-Echo with ECG-analysis, wall motion analysis by 2-dimentional imaging (2D) and coronary flow reserve (CFR) evaluation in both LAD and PDA by pulse-wave Doppler...
April 2016: Kardiologiia
https://www.readbyqxmd.com/read/28293274/optimally-repeatable-kinetic-model-variant-for-myocardial-blood-flow-measurements-with-82-rb-pet
#15
Adrian F Ocneanu, Robert A deKemp, Jennifer M Renaud, Andy Adler, Rob S B Beanlands, Ran Klein
Purpose. Myocardial blood flow (MBF) quantification with (82)Rb positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic (82)Rb PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: (1) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), (2) dual spillover correction (SOC-On/Off), (3) right blood correction (RBC-On/Off), (4) arterial blood transit delay (Delay-On/Off), and (5) distribution volume (DV) constraint (Global/Regional-DV)...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28290842/-serial-assessment-of-transthoracic-coronary-flow-reserve-as-method-of-assessing-efficacy-of-intracoronary-intervention-in-the-left-anterior-and-posterior-descending-arteries
#16
A A Boshchenko, A V Vrublevsky, R S Karpov
Transthoracic echocardiography (TTE) has been described as an accurate technique for noninvasive evaluation of coronary flow reserve (CFR) of the left anterior descending artery (LAD) and posterior descending artery (PDA). Aim of this study was to find out whether serial measurement of CFR in LAD and PDA using TTE allows detection of stenosis elimination after intracoronary intervention and is a marker of successful procedure. METHODS: The study group comprised 14 patients with single-vessel coronary disease (stenosis 82+/-14%) of the LAD (9 patients) or right coronary artery (RCA, 5 patients) scheduled for stent implantation...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28265728/impact-of-comorbidity-and-prescription-drugs-on-haemorrhage-in-cholecystectomy
#17
J Strömberg, G Sandblom
BACKGROUND: The purpose of the present study was to analyse the impact of patient-related risk factors and medication drugs on haemorrhagic complications following cholecystectomy. METHODS: All cholecystectomies registered in the Swedish population-based Register for Gallstone Surgery and ERCP (GallRiks) were identified. Risk factors for bleeding were assessed by linking data in the GallRiks to the National Patient Register and the Prescribed Drug Register, respectively...
March 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28263914/the-impact-of-supersaturation-level-for-oral-absorption-of-bcs-class-iib-drugs-dipyridamole-and-ketoconazole-using-in-vivo-predictive-dissolution-system-gastrointestinal-simulator-gis
#18
Yasuhiro Tsume, Kazuki Matsui, Amanda L Searls, Susumu Takeuchi, Gregory E Amidon, Duxin Sun, Gordon L Amidon
The development of formulations and the assessment of oral drug absorption for Biopharmaceutical Classification System (BCS) class IIb drugs is often a difficult issue due to the potential for supersaturation and precipitation in the gastrointestinal (GI) tract. The physiological environment in the GI tract largely influences in vivo drug dissolution rates of those drugs. Thus, those physiological factors should be incorporated into the in vitro system to better assess in vivo performance of BCS class IIb drugs...
March 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28231003/utilization-of-gastrointestinal-simulator-an-in-vivo-predictive-dissolution-methodology-coupled-with-computational-approach-to-forecast-oral-absorption-of-dipyridamole
#19
Kazuki Matsui, Yasuhiro Tsume, Susumu Takeuchi, Amanda Searls, Gordon L Amidon
Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI) tract, which makes it difficult to predict their oral absorption profile. The aim of this study was to investigate the utility of the gastrointestinal simulator (GIS), a novel in vivo predictive dissolution (iPD) methodology, in predicting the in vivo behavior of the weakly basic drug dipyridamole when coupled with in silico analysis. The GIS is a multicompartmental dissolution apparatus, which represents physiological gastric emptying in the fasted state...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28217026/atrial-arrhythmias-and-scintigraphic-d-shape-sign-in-pulmonary-artery-hypertension
#20
Federico Ferrando-Castagnetto, Roberto Ricca-Mallada, Valentina Selios, Rodolfo Ferrando
Pulmonary hypertension significantly changes biventricular anatomy and physiology, frequently evolving to clinical deterioration and right ventricular failure. The case of a woman developing atrial arrhythmias complicating dipyridamole stress in concomitance with scintigraphic "D-shaped" left ventricle is briefly reported. Although rare, our finding may suggest that nonselective vasodilators should be used with caution in this clinical setting.
January 2017: World Journal of Nuclear Medicine
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