keyword
MENU ▼
Read by QxMD icon Read
search

CYP17A1

keyword
https://www.readbyqxmd.com/read/29149676/high-salt-diet-decreases-reproductive-performance-in-rams-and-down-regulates-gene-expression-of-some-components-of-the-renin-angiotensin-system-in-the-testis
#1
Yi Fang, Rongzhen Zhong, Xuezhao Sun, Daowei Zhou
Although salt-tolerant plants can be used to combat dryland salinity, these plants contain high concentrations of salt (NaCl), which may have deleterious effects if fed to livestock. Twenty-four Merino rams (9 mo of age) with similar body weight were equally allocated to two groups and fed a normal- or high-salt diet (0.5 and 12% NaCl, respectively) for 3 mo. Rams fed the high-salt diet had lower live weight gains, higher water intake, smaller testes (466 ± 48.4 vs 604 ± 51.1 g) and reductions (P <0...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29144824/17%C3%AE-hydroxylase-deficiency-is-an-underdiagnosed-disease-high-frequency-of-misdiagnoses-in-a-large-cohort-of-brazilian-patients
#2
Rafaela Fontenele, Marivânia Costa-Santos, Claudio E Kater
OBJECTIVE: 17α-Hydroxylase deficiency (P450c17D) is characterized by hypogonadism and mineralocorticoid hypertension. We aimed to estimate the relative incidence and spectrum of preliminary misdiagnoses in Brazilian P450c17D patients. DESIGN: Cross-sectional study. METHODS: We reviewed, updated, and analyzed data of 40 P450c17D patients (21 XY, 19 XX). RESULTS: Complete data were unavailable for two patients. Seven patients were relatives of an index case...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29126147/adrenocorticotropin-acutely-regulates-pregnenolone-sulfate-production-by-the-human-adrenal-in-vivo-and-in-vitro
#3
Juilee Rege, Aya T Nanba, Richard J Auchus, Jianwei Ren, Hwei-Ming Peng, William E Rainey, Adina F Turcu
Background: Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulation, and ACTH is considered the major regulator of its synthesis. Pregnenolone sulfate (PregS) and 5-Androstenediol-3-sulfate (AdiolS) have recently emerged as biomarkers of adrenal disorders. Objective: To define the relative human adrenal production of ∆5-steroid sulfates under basal and cosyntropin-stimulated conditions. Methods: Liquid chromatography-tandem mass spectrometry was used to quantify three unconjugated and four sulfated ∆5-steroids in: 1) paired adrenal vein (AV) and mixed venous serum samples (21 patients), and 2) cultured human adrenal cells, both before and after cosyntropin stimulation; 3) microdissected zona fasciculata (ZF) and zona reticularis (ZR) from 5 human adrenal glands; 4) reconstituted in vitro human 17α-hydroxylase/17,20-lyase (CYP17A1/ P450 17A1) system...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29107177/efficiency-of-the-sulfate-pathway-in-comparison-to-the-%C3%AE-4-and-%C3%AE-5-pathway-of-steroidogenesis-in-the-porcine-testis
#4
M C Klymiuk, J Neunzig, R Bernhardt, A Sánchez-Guijo, M F Hartmann, S A Wudy, G Schuler
Sulfonated steroids are increasingly recognized as a circulating reservoir of precursors for the local production of active steroids in certain target tissues. As an alternative to sulfonation of unconjugated steroids by cytosolic sulfotransferases, their direct formation from sulfonated precursors has been described. However, productivity and physiological relevance of this sulfate pathway of steroidogenesis are still widely unclear. Applying the porcine testis as a model, conversion of pregnenolone sulfate (P5S, sulfate pathway) by CYP17A1 was assessed in comparison to the parallel conversions of pregnenolone (P5, Δ5-pathway) and progesterone (P4, Δ4-pathway)...
October 26, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29075189/a-short-term-exposure-to-tributyltin-blocks-leydig-cell-regeneration-in-the-adult-rat-testis
#5
Xiaolong Wu, Jianpeng Liu, Yue Duan, Shiyu Gao, Yao Lü, Xiaoheng Li, Qiqi Zhu, Xianwu Chen, Jing Lin, Leping Ye, Ren-Shan Ge
Background: Tributyltin (TBT) is widely used as an antifouling agent that may cause reproductive toxicity. The mechanism of TBT on Leydig cell development is still unknown. The objective of the present study was to investigate whether a brief exposure to low doses of TBT permanently affects Leydig cell development and to clarify the underlying mechanism. Methods: Adult male Sprague Dawley rats were randomly assigned into four groups and gavaged normal saline (control), 0.1, 1.0, or 10.0 mg/kg/day TBT for a consecutive 10 days, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29069700/evaluation-of-cortisol-production-in-aldosterone-producing-adenoma
#6
Kosuke Inoue, Yuto Yamazaki, Yuya Tsurutani, Sachiko Suematsu, Chiho Sugisawa, Jun Saito, Masao Omura, Hironobu Sasano, Tetsuo Nishikawa
Aldosterone-producing adenoma (APA) is sometimes accompanied with subclinical hypercortisolism. We investigated the ability of cortisol production in APA, both clinically and pathologically. A retrospective cohort study was conducted at Yokohama Rosai Hospital from 2009 to 2016. Thirty patients with APA and serum cortisol levels during the 1 mg dexamethasone suppression test (F-DST)<3.0 μg/dl were included. We evaluated the 1) difference between pre-adrenalectomy F-DST (pre-F-DST) and post-adrenalectomy F-DST (ΔF-DST), 2) correlation between ∆F-DST and pre-F-DST, tumour size determined by CT, and type of adrenalectomy (total or partial), and 3) relationship between the ratio of F-DST divided by tumour size (ΔF-DST/pre-F-DST/mm) and immunoreactivity of CYP17A1, CYP11B1, and CYP11B2...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29069423/testosterone-and-corticosterone-in-the-mesocorticolimbic-system-of-male-rats-effects-of-gonadectomy-and-caloric-restriction
#7
Daniel J Tobiansky, Anastasia M Korol, Chunqi Ma, Jordan E Hamden, Cecilia Jalabert, Ryan J Tomm, Kiran K Soma
Steroid hormones can modulate motivated behaviors through the mesocorticolimbic system. Gonadectomy (GDX) is a common method to determine how steroids influence the mesocorticolimbic system and caloric restriction (CR) is often used to invigorate motivated behaviors. The assumption is that the effect of these manipulations on brain steroid levels reflects circulating steroid levels. We now know that the brain regulates local steroid levels in a region-specific manner; however, previous studies have low spatial resolution...
October 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/29065432/preimplantation-factor-pif-regulates-stress-induced-adrenal-steroidogenesis-and-anti-inflammatory-cytokines-potential-application-for-bioartificial-adrenal-transplant
#8
Mariya Balyura, Evgeny Gelfgat, Enrico Ullmann, Barbara Ludwig, Eytan R Barnea, Stefan R Bornstein
The main treatment algorithm for adrenal insufficiency is hormonal replacement, however, inadequate hormone substitution often leads to severe side effects. Adrenal cell transplantation could be a more effective alternative but would require life-long immune suppressive therapy. PreImplantation Factor (PIF) is an endogenous peptide secreted by viable human embryos that leads to maternal tolerance without immunosuppression. PIF could be effective for xenogeneic cell transplantation such as of bovine adrenocortical cells (BAC), which are used for bioartificial adrenal gland development that may more effectively restore complex adrenal functions...
October 24, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29059671/polymorphisms-in-sex-hormone-metabolism-genes-and-risk-of-preeclampsia-in-taiyuan-china
#9
Ping Zhang, Hailan Yang, Yongliang Feng, Weiwei Wu, Shuzhen Li, Brian Thompson, Bingjie Xie, Pengge Guo, Mei Li, Ying Wang, Nan Zhao, Suping Wang, Yawei Zhang
OBJECTIVE: Aberrant synthesis and metabolism of sex hormone are likely to be associated with alterations in vascular function in preeclampsia (PE). The study aims to investigate whether single nucleotide polymorphisms (SNPs) in sex hormone-related genes are associated with PE. METHOD: We performed a nested case-control study including 436 pregnant women (203 PE and 233 healthy or normal pregnant women) to investigate associations between 96 SNPs in 28 sex hormone-related genes and risk of PE...
October 24, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29049452/hsd3b1-and-response-to-a-nonsteroidal-cyp17a1-inhibitor-in-castration-resistant-prostate-cancer
#10
Nima Almassi, Chad Reichard, Jianbo Li, Carly Russell, Jaselle Perry, Charles J Ryan, Terence Friedlander, Nima Sharifi
Importance: The HSD3B1 (1245C) germline variant encodes for a gain-of-function missense in 3β-hydroxysteroid dehydrogenase isoenzyme 1 (3βHSD1) that results in increased dihydrotestosterone synthesis from extragonadal precursors and is predictive of more rapid progression to castration-resistant prostate cancer (CRPC). Objective: To determine whether the HSD3B1 (1245C) genotype is predictive of clinical response to extragonadal androgen ablation with nonsteroidal 17α-hydroxylase/17,20-lyase (CYP17A1) inhibition in men with metastatic CRPC...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29045471/parental-and-offspring-contribution-of-genetic-markers-of-adult-blood-pressure-in-early-life-the-family-study
#11
Sébastien Robiou-du-Pont, Sonia S Anand, Katherine M Morrison, Sarah D McDonald, Stephanie A Atkinson, Koon K Teo, David Meyre
Previous genome wide association studies (GWAS) identified associations of multiple common variants with diastolic and systolic blood pressure traits in adults. However, the contribution of these loci to variations of blood pressure in early life is unclear. We assessed the child and parental contributions of 33 GWAS single-nucleotide polymorphisms (SNPs) for blood pressure in 1,525 participants (515 children, 406 mothers and 237 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) study followed-up for 5 years...
2017: PloS One
https://www.readbyqxmd.com/read/29029336/differential-effects-of-exposure-to-single-versus-a-mixture-of-endocrine-disrupting-chemicals-on-steroidogenesis-pathway-in-mouse-testes
#12
Julio Buñay, Eduardo Larriba, Daniel Patiño-Garcia, Leonor Cruz-Fernandes, Sergio Castañeda-Zegarra, María Rodriguez-Fernandez, Jesús Del Mazo, Ricardo D Moreno
Endocrine-disrupting chemicals (EDCs) generate reproductive dysfunctions affecting the biosynthesis of steroid hormones and genes of the steroidogenic pathway. EDCs effects are mainly reported as a result of exposure to single compounds. However, humans are environmentally exposed to a mixture of EDCs. Herein, we assess chronic exposure to single alkylphenols and phthalates versus a mixture in mouse testes histology and steroidogenesis. Pregnant mice were exposed through drinking water to: 0.3 mg/Kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP), 0...
September 22, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29027195/tspyl-family-regulates-cyp17a1-and-cyp3a4-expression-potential-mechanism-contributing-to-abiraterone-response-in-metastatic-castration-resistant-prostate-cancer
#13
Sisi Qin, Duan Liu, Manish Kohli, Liguo Wang, Peter T Vedell, David W Hillman, Nifang Niu, Jia Yu, Richard M Weinshilboum, Liewei Wang
The testis-specific Y-encoded-like protein (TSPYL) gene family includes TSPYL1 to TSPYL6. We previously reported that TSPYL5 regulates cytochrome P450 (CYP) 19A1 expression. Here, we show that TSPYLs, especially, TSPYL 1, 2 and 4, can regulate the expression of many CYP genes, including CYP17A1, a key enzyme in androgen biosynthesis, and CYP3A4, an enzyme that catalyzes the metabolism of abiraterone, a CYP17 inhibitor. Furthermore, a common TSPYL1 SNP, rs3828743 (G/A) (Pro62Ser), abolishes TSPYL1's ability to suppress CYP3A4 expression, resulting in reduced abiraterone concentrations and increased cell proliferation...
October 13, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28985536/perfluorooctane-sulfonate-impairs-rat-leydig-cell-development-during-puberty
#14
Lili Li, Xiaoheng Li, Xianwu Chen, Yong Chen, Jianpeng Liu, Fenfen Chen, Fei Ge, Leping Ye, Qingquan Lian, Ren-Shan Ge
Perfluorooctane sulfonate (PFOS) possibly delays male sexual development. However, its effects on pubertal Leydig cell development are unclear. The objective of the present study was to investigate the effects of in vivo PFOS exposure on rat Leydig cell development during puberty. Immature male Sprague Dawley rats were gavaged 5 or 10 mg/kg PFOS on postnatal day 35 for 21 days. Compared to the control (0 mg/kg), PFOS lowered serum testosterone levels without altering luteinizing hormone and follicle-stimulating hormone levels on postnatal day 56...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28982933/steroidogenesis-during-postnatal-testicular-development-of-galea-spixii
#15
P R S Santos, F D Oliveira, M A M Arroyo, M F Oliveira, P Castelucci, A J Conley, A C Assis Neto
The androgen/estrogen balance is essential for normal sexual development and reproduction in mammals. Studies performed herein investigated the potential for estrogen synthesis in cells of the testes of a hystricomorph rodent, Galea spixii The study characterized the expression of the key enzymes responsible for estrogen and androgen synthesis, cytochromes P450 aromatase (P450arom), 17α-hydroxylase/17,20-lyase (P450c17) respectively, as well as the redox partner NADPH cytochrome P450 oxido-reductase (CPR) required to support electron transfer and catalysis of these P450s, by immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) analysis, throughout postnatal sexual development...
November 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28981526/association-between-polymorphisms-in-sex-hormones-synthesis-and-metabolism-and-prostate-cancer-aggressiveness
#16
Inmaculada Robles-Fernandez, Luis Javier Martinez-Gonzalez, Manrique Pascual-Geler, Jose Manuel Cozar, Ignacio Puche-Sanz, Maria Jose Serrano, Jose Antonio Lorente, Maria Jesus Alvarez-Cubero
Novel biomarkers for prostate cancer (PCa) diagnosis and prognosis are necessary to improve the accuracy of current ones employed in clinic. We performed a retrospective study between the association of several polymorphisms in the main genes involved in the synthesis and metabolism of sex hormones and PCa risk and aggressiveness. A total of 311 Caucasian men (155 controls and 156 patients) were genotyped for 9 SNPs in AR, CYP17A1, LHCGR, ESR1 and ESR2 genes. Diagnostic PSA serum levels, Gleason score, tumor stage, D´Amico risk and data of clinical progression were obtained for patients at the moment of the diagnosis and after 54 months of follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28977599/inhibition-of-androgen-receptor-function-and-level-in-castration-resistant-prostate-cancer-cells-by-2-isoxazol-4-ylmethyl-thio-1-4-phenylpiperazin-1-yl-ethanone
#17
Khalid Z Masoodi, Kurtis Eisermann, Zhenyu Yang, Javid A Dar, Laura E Pascal, Minh Nguyen, Katherine O'Malley, Erica Parrinello, Firuz G Feturi, Alex N Kenefake, Joel B Nelson, Paul A Johnston, Peter Wipf, Zhou Wang
The androgen receptor (AR) plays a critical role in the development of castration-resistant prostate cancer (CRPC) as well as in the resistance to the second-generation AR antagonist enzalutamide and the selective inhibitor of cytochrome P450 17A1 (CYP17A1) abiraterone. Novel agents targeting AR may inhibit the growth of prostate cancer cells resistant to enzalutamide and/or abiraterone. Through a high-throughput/high-content screening of a 220,000-member small molecule library, we have previously identified 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone (IMTPPE) (SID 3712502) as a novel small molecule capable of inhibiting AR transcriptional activity and protein level in C4-2 prostate cancer cells...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28974703/sex-steroid-production-associated-with-puberty-is-absent-in-germ-cell-free-salmon
#18
Lene Kleppe, Eva Andersson, Kai Ove Skaftnesmo, Rolf B Edvardsen, Per Gunnar Fjelldal, Birgitta Norberg, Jan Bogerd, Rüdiger W Schulz, Anna Wargelius
In all vertebrates studied so far, germ cells are not required for pubertal maturation of the gonadal steroidogenic system, subsequent development of secondary sex characteristics and reproductive behavior. To explore if the absence of germ cells affects puberty or growth in Atlantic salmon, germ cell-free (GCF), dnd knockout and wild type (WT) postsmolts were stimulated to enter puberty. No GCF fish entered puberty, whereas 66.7% (males) and 30% (females) WT fish completed or entered puberty, respectively...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28973382/ziram-delays-pubertal-development-of-rat-leydig-cells
#19
Xiaoling Guo, Songyi Zhou, Yong Chen, Xianwu Chen, Jianpeng Liu, Fei Ge, Qingquan Lian, Xiaomin Chen, Ren-Shan Ge
Ziram [zinc, bis (dimethyldithiocarbamate)] is an agricultural dithiocarbamate fungicide. By virtual screening, we have identified that ziram is a potential endocrine disruptor. To investigate its effects on pubertal development of Leydig cells, 35-day-old male Sprague Dawley rats orally received ziram (2 or 4 mg/kg/day) for 4 weeks and immature Leydig cells isolated from 35-day-old rat testes were treated with ziram (0.5-50 μM in vitro). Serum hormones, Leydig cell number and specific gene or protein expression levels after in vivo treatment were determined and medium androgen levels were measured as well as apoptosis of Leydig cells after in vitro treatment were determined...
September 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972875/effect-of-melatonin-on-bovine-theca-cells-in-vitro
#20
T Feng, L F Schutz, B C Morrell, M C Perego, L J Spicer
Melatonin affects granulosa cell function in several species but its function in theca cells is less clear, particularly in monotocous animals. Thus, the objectives of this study were to determine the effects of melatonin on theca cell steroidogenesis, gene expression and cell proliferation in a monotocous species, namely cattle. Ovaries were collected from a local bovine abattoir, from which theca cells were isolated from large (8-22mm) follicles and treated with various hormones in serum-free medium for 24h or 48h...
October 4, 2017: Reproduction, Fertility, and Development
keyword
keyword
119416
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"