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Boric acid

Haseeb Khaliq, Wang Jing, Xiao Ke, Yang Ke-Li, Sun Peng-Peng, Lei Cui, Qiu Wei-Wei, Lei Zhixin, Liu Hua-Zhen, Song Hui, Zhong Ju-Ming, Peng Ke-Mei
The nuclear-related factor 2 (Nrf2) pathway is the most important mechanism in antioxidant capacity, which regulates the cell's redox homeostasis. In addition, Nrf2 pathway also can inhibit cell apoptosis. The mechanism of boron actions on various organs is well documented. But, it is not known whether boron can also regulate the Nrf2 pathway in the kidneys. Therefore, in this research, the actions of boron on the kidneys of ostrich chicks, especially the antioxidant effects, have been studied. The ostrich chicks were divided into six groups and supplemented with boric acid (BA) (source of boron) in the drinking water (0, 40, 80, 160, 320, 640 mg respectively) to examine apoptotic, antioxidant, biochemical, and histochemical alterations induced by boron administration in the ostrich chick's kidney...
March 13, 2018: Biological Trace Element Research
Ayse Betul Ergul, Mehmet Kara, Cigdem Karakukcu, Arzu Tasdemir, Humeyra Aslaner, Mehmet Ali Ergul, Sebahattin Muhtaroglu, Gozde Erturk Zararsiz, Yasemin Altuner Torun
Boron plays roles in the metabolism of calcium, vitamin D, steroid hormones, healthy bone development, and maintenance of cell membranes. The biological effects of boron are dose-dependent but follow a U-shaped pattern, rendering it important to define the active range. The studies of Bahadoran et al. on rats and Naghii et al. on humans showed that low doses of boron (3 and 10 mg/day) prevented kidney stone formation. The aim of this study was to determine whether high doses of boron have an anti-urolithiatic or antioxidant effect on nephrolithiasis in an experimental rat model...
March 8, 2018: Biological Trace Element Research
Xiangyu Ge, Jinjin Li, Chenhui Zhang, Jianbin Luo
Boric acid is a weak acid and has been used as a lubrication additive due to its special structure. In this study, we report that boric acid could achieve robust superlubricity (μ< 0.01) as an additive in polyethylene glycol (PEG) aqueous solution at Si3N4/SiO2 interfaces. The superlow and steady friction coefficient of approximately 0.004-0.006 could be achieved with boric acid in neutral conditions (pH of approximately 6.4), which is different from the acidic conditions leading to superlubricity. The influence of various factors, including boric acid concentration, sliding speed, applied load, PEG molecular weight, and the volume of lubricant on the superlubricity were investigated...
March 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Norma Beatriz Moraga, Verónica Irazusta, María Julia Amoroso, Verónica Beatriz Rajal
Boron is widespread in the environment. Although contaminated soils are hard to recover different strategies have been investigated in the recent years. Bioremediation is one of the most studied because it is eco-friendly and less costly than other techniques. The aim of this research was to evaluate whether two Streptomyces strains isolated from boron contaminated soils in Salta, Argentina, may help remove boron from such soils. For this, they were grown in different liquid media with two boric acid concentrations and their specific growth rate and specific boric acid consumption rate were determined...
August 2017: Journal of Environmental Chemical Engineering
Christopher O Miles, Jane Kilcoyne, Pearse McCarron, Sabrina D Giddings, Thor Waaler, Thomas Rundberget, Ingunn A Samdal, Kjersti E Løvberg
Azaspiracids (AZAs) belong to a family of more than 50 polyether toxins originating from marine dinoflagellates such as Azadinium spinosum. All of the AZAs reported thus far contain a 21,22-dihydroxy group. Boric acid gel (BAG) can bind selectively to compounds containing vic-diols or α-hydroxycarboxylic acids via formation of reversible boronate complexes. Here we report use of BAG to selectively capture and release AZAs from extracts of blue mussels. Analysis of the extracts and BAG fractions by LC-MS showed that this procedure resulted in an excellent clean-up of the AZAs in the extract...
March 4, 2018: Journal of Agricultural and Food Chemistry
Han Yao, Jana Vandenbossche, Cari E Sänger-van de Griend, Yorick Janssens, Cristina Soto Fernández, Xiaolong Xu, Evelien Wynendaele, Govert Willem Somsen, Rob Haselberg, Bart De Spiegeleer
A capillary zone electrophoresis (CZE) method with UV detection was developed for the quantification of the E.colil-asparaginase (l-ASNase) and its acidic variants. During the initial method development, a variety of experimental conditions were screened. Subsequently, a Design of Experiments (DoE) was used to optimize the pH and concentration of the selected background electrolyte (BGE) containing both TRIS and boric acid. Optimization was performed taking into account both the separation efficiency of l-ASNase and its acidic variants as well as overall method robustness...
May 15, 2018: Talanta
Ömer Hazman, Mehmet Fatih Bozkurt, Abdurrahman Fatih Fidan, Fadime Erkan Uysal, Sefa Çelik
The development of treatment protocols that can reduce side effects in chemotherapy applications is extremely important in terms of cancer treatment. In this context, it was aimed to investigate the effects of boric acid and borax on cisplatin toxicity (nephrotoxicity) in rats. In the experimental phase, eight groups were formed from rats. Boric acid and borax were given to the treatment groups with three different doses using gavage. On the fifth day of the study, cisplatin (10 mg/kg) was administered to all rats except the control group...
March 2, 2018: Inflammation
Chunhui Ruan, Lisha Liu, Qingbing Wang, Xinli Chen, Qinjun Chen, Yifei Lu, Yu Zhang, Xi He, Yujie Zhang, Qin Guo, Tao Sun, Chen Jiang
An ideal gene-carrying vector is supposed to exhibit outstanding gene condensing capability with positively charged macromolecules to protect the carried gene during in vivo circulation, and a rapid dissociation upon microenvironmental stimuli at the aimed sites to release the escorted gene. Currently, it still remains a challenge to develop an ideal gene carrier with efficient transfection ability and meanwhile low toxicity for clinical applications. Herein, we innovatively introduced a ROS-biodegradable boric acid ester linkage in elaborating the design of gene carrier...
March 2, 2018: ACS Applied Materials & Interfaces
Júlia Carina Niemeyer, Letícia Scopel Camargo Carniel, Fernanda Benedet de Santo, Mayrine Silva, Osmar Klauberg-Filho
Reference substances are recommended to evaluate the quality of laboratory test species and the reliability of ecotoxicity data. Boric acid (BA) has been recommended as reference substance in some standardized tests in OECD soil, but no data are available for Tropical Artificial Soil (TAS). For this purpose, avoidance tests with Eisenia andrei, lethality tests with E. andrei and Folsomia candida, and reproduction tests with E. andrei, Enchytraeus crypticus and F. candida were carried out in TAS (5% organic matter), following ISO guidelines, and compared between two laboratories...
February 28, 2018: Ecotoxicology
Jong Kyu Kim, Hosang Ahn, Jong-Ho Kim, Yang-Jin Ban, Keugtae Kim, Jin Chul Joo
Innovative nanoscale ZnO-laponite-polyvinyl alcohol composites (NZLPc) were developed as a valid alternative to nanoscale photocatalysts for mineralization of chlorinated hydrocarbons without difficulties in recovery of nanoscale photocatalyst particles. NZLPc were synthesized by mixing nanoscale ZnO particles with laponite in PVA solution, and by crosslinking PVA solution in the presence of boric acid (≥1.6 M). Different mixing ratios of the raw materials were investigated to develop the stable NZLPc, and X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy characterizations were performed...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Şükrü Serter Çatav, Tuncer Okan Genç, Müjgan Kesik Oktay, Köksal Küçükakyüz
Boron (B) toxicity, which occurs in semi-arid and arid environments, can adversely affect the growth and yield of many plants. The aim of this study was to determine the effects of different concentrations of boric acid (3, 6, 9 and 12 mM) on growth, oxidative stress and genotoxicity parameters in root and shoot tissues of wheat seedlings. Our results indicate that B stress inhibits root and shoot growth of wheat in a concentration-dependent manner, and leads to increases in TBARS and H2O2 contents in shoot tissue...
February 12, 2018: Bulletin of Environmental Contamination and Toxicology
Saira Butt, Amir Tirmizi
This study presents a case report of a female patient with symptomatic refractory Trichomonas vaginalis infection who was not able to clear her infection with high-dose oral metronidazole, oral tinidazole, intra-vaginal zinc sulfate, intra-vaginal metronidazole, intra-vaginal tinidazole, and intra-vaginal boric acid. She was unable to tolerate intra-vaginal paromomycin. A combination of intravenous metronidazole, oral tinidazole liquid suspension, and intra-vaginal boric acid for 14 days subsequently achieved a complete symptomatic and laboratory cure...
January 1, 2018: International Journal of STD & AIDS
Indri Adriztina, Linda Irwani Adenin, Yuliani Mardiati Lubis
Chronic suppurative otitis media (CSOM) is one of the most common chronic infectious diseases worldwide, especially affecting children. The patients or the parents of the affected children are often worried about the cost of medical visits, prescription medicines, or inconsistently effective medication. The complications of CSOM have been greatly reduced because of the development of antibiotics; however, the irrational use of antibiotics has led to the emergence of organisms resistant to the commonly used drugs...
January 2018: Korean Journal of Family Medicine
M M Jarabo, M A Asencio, R Carranza, O Herráez, M Huertas, A Arias-Arias, O Redondo, M A Galán, M S Illescas, P Zamarrón, S Solís, S Jiménez-Alvarez
OBJECTIVE: Urine culture, the gold standard to confirm the presence of urinary tract infection (UTI), is the most requested assay in the microbiology department. Our objective was to determine the diagnostic yield of the UF-Series cytometer as a screening method for UTI. METHODS: All the urine samples sent to the six Microbiology Laboratories participating in a period of 5 working days were analyzed. We collected demographic variables, apart from those variables related to urine samples: source and sample type (midstream, catheterized or nephrostomy urines), collection with/without boric acid, cytometer parameters (leukocyturia, bacteriuria, bacteria morphology and epithelial cells) and urine culture results...
January 29, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Ashraf M Metwally, Abeer A Radi, Rasha M El-Shazoly, Afaf M Hamada
Boron (B) toxicity often limits crop yield and the quality of production in agricultural areas. Here, we investigated the effects of calcium (Ca), silicon (Si) and salicylic acid (SA) on development of B toxicity, B allocation in canola (Brassica napus cultivar Sarw 4) and its role in non-enzymatic antioxidants in relation to yield of this cultivar under B toxicity. Canola seedlings were subjected to four B levels induced by boric acid in the absence or presence of Ca, Si and SA. The results showed that Ca, Si and SA addition ameliorated the inhibition in canola growth, water content (WC), and improved siliqua number, siliqua weight and seed index...
January 22, 2018: Journal of Plant Research
Mauricelio Bezerra da Silva, Regina C R Santos, Paulo T C Freire, Ewerton W S Caetano, Valder N Freire
Boric acid (H3BO3) is being used effectively nowadays in traps/baits for the management of Aedes aegypti L. and Aedes albopictus Skuse species of mosquitoes, which are the main spreading vectors worldwide for diseases like malaria, dengue and zika. Previously, we have published results on the structural, electronic and optical properties of its molecular triclinic H3BO3-2A and trigonal H3BO3-3T polymorphs within the framework of density functional theory (DFT). Due to the renewed importance of these materials, the focus of this work is on the vibrational properties of the bulk boric acid 2A and 3T polymorphs...
January 12, 2018: Journal of Physical Chemistry. A
Eisuke Sato, Alexander Zaboronok, Tetsuya Yamamoto, Kei Nakai, Sergey Taskaev, Olga Volkova, Ludmila Mechetina, Alexander Taranin, Vladimir Kanygin, Tomonori Isobe, Bryan J Mathis, Akira Matsumura
In the current article, we provide in vitro efficacy evaluation of a unique accelerator-based neutron source, constructed at the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation), for boron neutron capture therapy (BNCT), which is particularly effective in the case of invasive cancers. U251MG, CHO-K1 and V79 cells were incubated and irradiated in various concentrations of boric acid with epithermal neutrons for 2-3 h in a plexiglass phantom, using 2.0 MeV proton energy and 1.5-3.0 mA proton current, resulting in a neutron fluence of 2...
December 21, 2017: Journal of Radiation Research
Sui Ouchi, Kazuaki Matsumoto, Maki Okubo, Yuta Yokoyama, Junko Kizu
Colistin sulfate, composed of a mixture of colistin A sulfate (CLA) and colistin B sulfate (CLB), is available for treating life-threatening infections caused by multidrug-resistant Gram-negative bacteria. In this study, the CLA and CLB were quantified separately. Colistin sulfate was extracted from rat plasma with a solid-phase extraction C18 cartridge and reacted with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), and the fluorescent derivatives were subjected to reversed phase high-performance liquid chromatography analysis and used to investigate the pharmacokinetics of CLA and CLB in rat plasma...
December 12, 2017: Biomedical Chromatography: BMC
Torstein Grønseth, Lene K Vestby, Live L Nesse, Even Thoen, Olivier Habimana, Magnus von Unge, Juha T Silvola
OBJECTIVES: The aim of the study was to evaluate the antibacterial efficacy of Lugol's solution, acetic acid, and boric acid against Staphylococcus aureus biofilm. METHODS: The efficacy of Lugol's solution 1%, 0.1%, and 0.05%, acetic acid 5% or boric acid 4.7% for treatment of Staphylococcus aureus biofilm in vitro was tested using 30 clinical strains. Susceptibility in the planktonic state was assessed by disk diffusion test. Antiseptic effect on bacteria in biofilm was evaluated by using a Biofilm-oriented antiseptic test (BOAT) based on metabolic activity, a biofilm bactericidal test based on culturing of surviving bacteria and confocal laser scanning microscopy combined with LIVE/DEAD staining...
December 2017: International Journal of Pediatric Otorhinolaryngology
Nicola Thorley, Jonathan Ross
OBJECTIVES: Trichomoniasis, caused by Trichomonas vaginalis (TV), is the most common curable sexually transmitted infection worldwide. Current guidance in the UK is to treat TV with a nitroimidazole antibiotic. The high prevalence of TV, high rate of antibiotic resistance and limited tolerability to nitroimidazoles suggest that alternative treatment regimens are needed. Intravaginal boric acid (BA) has been used safely for the treatment of candida vulvovaginitis and bacterial vaginosis, and in vitro studies suggest BA is active against TV...
December 9, 2017: Sexually Transmitted Infections
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