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Hyperpolarized Xe

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https://www.readbyqxmd.com/read/28508450/simultaneous-assessment-of-both-lung-morphometry-and-gas-exchange-function-within-a-single-breath-hold-by-hyperpolarized-129-xe-mri
#1
Jianping Zhong, Huiting Zhang, Weiwei Ruan, Junshuai Xie, Haidong Li, He Deng, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou
During the measurement of hyperpolarized (129) Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application...
May 16, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28475947/depolarization-of-nuclear-spin-polarized-129-xe-gas-by-dark-rubidium-during-spin-exchange-optical-pumping
#2
M A Antonacci, Alex Burant, Wolfgang Wagner, Rosa T Branca
Continuous-flow spin-exchange optical pumping (SEOP) continues to serve as the most widespread method of polarizing (129)Xe for magnetic resonance experiments. Unfortunately, continuous-flow SEOP still suffers from as-yet unidentified inefficiencies that prevent the production of large volumes of xenon with a nuclear spin polarization close to theoretically calculated values. In this work we use a combination of ultra-low field nuclear magnetic resonance spectroscopy and atomic absorption spectroscopy (AAS) measurements to study the effects of dark Rb vapor on hyperpolarized (129)Xe in situ during continuous-flow SEOP...
June 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28384123/magnetic-resonance-imaging-with-hyperpolarized-agents-methods-and-applications
#3
Erin Adamson, Kai Ludwig, David Mummy, Sean B Fain
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (<sup>3</sup>He) and xenon (<sup>129</sup>Xe) gases have reached the stage where they are under study in clinical research. HP <sup>129</sup>Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28382694/quantitative-analysis-of-hyperpolarized-129-xe-gas-transfer-mri
#4
Ziyi Wang, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Elianna A Bier, Sudarshan Rajagopal, Yuh Chin Huang, Thomas G O'Riordan, Craig R Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: Hyperpolarized (129) Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of (129) Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize information from these images of pulmonary gas transfer are lacking. Here, we introduce a novel method to transform these data into quantitative maps of pulmonary ventilation, and (129) Xe gas transfer to barrier and RBC compartments...
April 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28371091/novel-magnetic-resonance-imaging-for-assessment-of-bronchial-stenosis-in-lung-transplant-recipients
#5
Kamran Mahmood, Lukas Ebner, Mu He, Scott Haile Robertson, Ziyi Wang, H Page McAdams, Momen M Wahidi, Scott L Shofer, Yuh-Chin T Huang, Bastiaan Driehuys
Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scan and bronchoscopy with significant limitations. We hypothesize that magnetic resonance imaging (MRI) employing both ultrashort echo time (UTE) scans and hyperpolarized (HP) (129) Xe gas can offer structural and functional assessment of bronchial stenosis seen after lung transplantation. Six patients with lung transplantation-related bronchial stenosis underwent HP (129) Xe MRI and UTE MRI...
March 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28266629/an-optimized-microfabricated-platform-for-the-optical-generation-and-detection-of-hyperpolarized-129-xe
#6
Daniel J Kennedy, Scott J Seltzer, Ricardo Jiménez-Martínez, Hattie L Ring, Nicolas S Malecek, Svenja Knappe, Elizabeth A Donley, John Kitching, Vikram S Bajaj, Alexander Pines
Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized (129)Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of (129)Xe gas. This device was limited by (129)Xe polarizations less than 1%, (129)Xe NMR signals smaller than 20 nT, and transport of hyperpolarized (129)Xe over millimeter lengths...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28245140/correlation-of-lci-with-hyperpolarized-129-xe-magnetic-resonance-imaging-in-pediatric-cf-subjects
#7
Nikhil Kanhere, Marcus J Couch, Krzysztof Kowalik, Brandon Zanette, Jonathan H Rayment, David Manson, Padmaja Subbarao, Felix Ratjen, Giles Santyr
No abstract text is available yet for this article.
February 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28192930/mitochondria-targeted-and-intracellular-biothiol-triggered-hyperpolarized-129-xe-magnetofluorescent-biosensor
#8
Qingbin Zeng, Qianni Guo, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S Bouchard, Xin Zhou
Biothiols such as gluthathione (GSH), cysteine (Cys), homocysteine (Hcy), and thioredoxin (Trx) play vital roles in cellular metabolism. Various diseases are associated with abnormal cellular biothiol levels. Thus, the intracellular detection of biothiol levels could be a useful diagnostic tool. A number of methods have been developed to detect intracellular thiols, but sensitivity and specificity problems have limited their applications. To address these limitations, we have designed a new biosensor based on hyperpolarized xenon magnetic resonance detection, which can be used to detect biothiol levels noninvasively...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28065276/using-imaging-as-a-biomarker-for-asthma
#9
REVIEW
Abhaya Trivedi, Chase Hall, Eric A Hoffman, Jason C Woods, David S Gierada, Mario Castro
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28046370/th-cd-202-09-free-breathing-proton-mri-functional-lung-avoidance-maps-to-guide-radiation-therapy
#10
D Capaldi, K Sheikh, D Hoover, B Yaremko, D Palma, G Parraga
PURPOSE: Pulmonary functional MRI using inhaled gas contrast agents was previously investigated as a way to identify well-functioning lung in patients with NSCLC who are clinical candidates for radiotherapy. Hyperpolarized noble-gas ((3) He and (129) Xe) MRI has also been optimized to measure functional lung information, but for a number of reasons, the clinical translation of this approach to guide radiotherapy planning has been limited. As an alternative, free-breathing pulmonary 1H MRI using clinically available MRI systems and pulse sequences provides a non-contrast-enhanced method to generate both ventilation and perfusion maps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041987/retigabine-diminishes-the-effects-of-acetylcholine-adrenaline-and-adrenergic-agonists-on-the-spontaneous-activity-of-guinea-pig-smooth-muscle-strips-in-vitro
#11
Elisaveta Apostolova, Plamen Zagorchev, Vesela Kokova, Lyudmil Peychev
PURPOSE: The aim of this study is to evaluate the effect of retigabine on the smooth muscle response to acetylcholine, adrenaline, α-and β-adrenoceptor agonists. METHODS: We studied the change in the spontaneous smooth muscle contraction of guinea pig gastric corpus strips before and after 20-min treatment with 2μM retigabine. We also evaluated the effect of retigabine on the smooth muscle response to 10μM acetylcholine, 1 and 10μM adrenaline, 1μM methoxamine, 0...
December 23, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28026061/detection-of-smoke-induced-pulmonary-lesions-by-hyperpolarized-129-xe-diffusion-kurtosis-imaging-in-rat-models
#12
Weiwei Ruan, Jianping Zhong, Yu Guan, Yi Xia, Xiuchao Zhao, Yeqing Han, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou
PURPOSE: To demonstrate that hyperpolarized (HP) xenon diffusion kurtosis imaging (DKI) is able to detect smoke-induced pulmonary lesions in rat models. METHODS: Multi-b DKI with hyperpolarized xenon was used for the first time in five smoke-exposed rats and five healthy rats. Additionally, DKI with b values of up to 80 s/cm(2) were used in two healthy rats to probe the critical b value (a limit beyond which the DKI cannot describe the non-Gaussian diffusion). RESULTS: The mean apparent diffusion coefficient (Dapp ) and diffusion kurtosis (Kapp ) extracted by the DKI model revealed significant changes in the smoke-exposed rats compared with those in the control group (P = 0...
December 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27875871/remote-detection-of-hyperpolarized-129-xe-resonances-via-multiple-distant-dipolar-field-interactions-with-1-h
#13
Le Zhang, Michael Antonacci, Alex Burant, Karl M Koshlap, Rosa Tamara Branca
A remote detection scheme utilizing the distant dipolar field interaction between two different spin species was proposed by Granwehr et al. [J. Magn. Reson. 176(2), 125 (2005)]. In that sequence (1)H spins were detected indirectly via their dipolar field interaction with (129)Xe spins, which served as the sensing spins. Here we propose a modification of the proposed detection scheme that takes advantage of the longer T1 relaxation time of xenon to create a long lasting dipolar field with which the fast relaxing (1)H spins are allowed to interact many times during a single acquisition...
November 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27851882/uncovering-a-third-dissolved-phase-129-xe-resonance-in-the-human-lung-quantifying-spectroscopic-features-in-healthy-subjects-and-patients-with-idiopathic-pulmonary-fibrosis
#14
Scott H Robertson, Rohan S Virgincar, Elianna A Bier, Mu He, Geoffrey M Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized (129)Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized (129)Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °)...
November 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27825066/diffusion-mediated-129-xe-gas-depolarization-in-magnetic-field-gradients-during-continuous-flow-optical-pumping
#15
Alex Burant, Rosa Tamara Branca
The production of large volumes of highly polarized noble gases like helium and xenon is vital to applications of magnetic resonance imaging and spectroscopy with hyperpolarized (HP) gas in humans. In the past ten years, (129)Xe has become the gas of choice due to its lower cost, higher availability, relatively high tissue solubility, and wide range of chemical shift values. Though near unity levels of xenon polarization have been achieved in-cell using stopped-flow Spin Exchange Optical Pumping (SEOP), these levels are currently unmatched by continuous-flow SEOP methods...
December 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27759913/accurate-mr-thermometry-by-hyperpolarized-129-xe
#16
Le Zhang, Alex Burant, Andrew McCallister, Victor Zhao, Karl M Koshlap, Simone Degan, Michael Antonacci, Rosa Tamara Branca
PURPOSE: To investigate the temperature dependence of the resonance frequency of lipid-dissolved xenon (LDX) and to assess the accuracy of LDX-based MR thermometry. METHODS: The chemical shift temperature dependence of water protons, methylene protons, and LDX was measured from samples containing tissues with varying fat contents using a high-resolution NMR spectrometer. LDX results were then used to acquire relative and absolute temperature maps in vivo and the results were compared with PRF-based MR thermometry...
October 19, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27732160/chronic-obstructive-pulmonary-disease-lobar-analysis-with-hyperpolarized-129-xe-mr-imaging
#17
Tahreema N Matin, Najib Rahman, Annabel H Nickol, Mitchell Chen, Xiaojun Xu, Neil J Stewart, Tom Doel, Vicente Grau, James M Wild, Fergus V Gleeson
Purpose To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ((129)Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized (129)Xe MR imaging at 1...
March 2017: Radiology
https://www.readbyqxmd.com/read/27707585/the-role-of-hyperpolarized-129-xenon-in-mr-imaging-of-pulmonary-function
#18
REVIEW
Lukas Ebner, Jeff Kammerman, Bastiaan Driehuys, Mark L Schiebler, Robert V Cadman, Sean B Fain
In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium ((3)He) and xenon ((129)Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available (129)Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27689918/treatment-response-of-ethyl-pyruvate-in-a-mouse-model-of-chronic-obstructive-pulmonary-disease-studied-by-hyperpolarized-129-xe-mri
#19
Atsuomi Kimura, Yukiko Yamauchi, Shota Hodono, Neil James Stewart, Osamu Hosokawa, Yu Hagiwara, Hirohiko Imai, Hideaki Fujiwara
PURPOSE: The purpose of this work was to investigate disease progression and treatment response in a murine model of chronic obstructive pulmonary disease (COPD) using a preclinical hyperpolarized (129) Xe (HPXe) magnetic resonance imaging (MRI) strategy. METHODS: COPD phenotypes were induced in 32 mice by 10 weeks of exposure to cigarette smoke (CS) and lipopolysaccharide (LPS). Efficacy of ethyl pyruvate (EP), an anti-inflammatory drug, was investigated by administering EP to 16 of the 32 mice after 6 weeks of CS and LPS exposure...
September 30, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27662575/hyperpolarized-129xenon-magnetic-resonance-imaging-to-quantify-regional-ventilation-differences-in-mild-to-moderate-asthma-a-prospective-comparison-between-semiautomated-ventilation-defect-percentage-calculation-and-pulmonary-function-tests
#20
Lukas Ebner, Mu He, Rohan S Virgincar, Timothy Heacock, Suryanarayanan S Kaushik, Matthew S Freemann, H Page McAdams, Monica Kraft, Bastiaan Driehuys
OBJECTIVES: The aim of this study was to investigate ventilation in mild to moderate asthmatic patients and age-matched controls using hyperpolarized (HP) Xenon magnetic resonance imaging (MRI) and correlate findings with pulmonary function tests (PFTs). MATERIALS AND METHODS: This single-center, Health Insurance Portability and Accountability Act-compliant prospective study was approved by our institutional review board. Thirty subjects (10 young asthmatic patients, 26 ± 6 years; 3 males, 7 females; 10 older asthmatic patients, 64 ± 6 years; 3 males, 7 females; 10 healthy controls) were enrolled...
February 2017: Investigative Radiology
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