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Hyperpolarized Xe

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https://www.readbyqxmd.com/read/29114616/detection-of-regional-radiation-induced-lung-injury-using-hyperpolarized-129-xe-chemical-shift-imaging-in-a-rat-model-involving-partial-lung-irradiation-proof-of-concept-demonstration
#1
Brandon Zanette, Elaine Stirrat, Salomeh Jelveh, Andrew Hope, Giles Santyr
Purpose: The purpose of this work was to use magnetic resonance imaging (MRI) of hyperpolarized (HP) (129)Xe dissolved in pulmonary tissue (PT) and red blood cells (RBCs) to detect regional changes to PT structure and perfusion in a partial-lung rat model of radiation-induced lung injury and compare with histology. Methods and materials: The right medial region of the lungs of 6 Sprague-Dawley rats was irradiated (20 Gy, single-fraction). A second nonirradiated cohort served as the control group...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29058007/a-cryptophane-based-turn-on-129-xe-nmr-biosensor-for-monitoring-calmodulin
#2
Brittany A Riggle, Mara L Greenberg, Yanfei Wang, Rebecca F Wissner, Serge D Zemerov, E James Petersson, Ivan J Dmochowski
We present the first cryptophane-based "turn-on" (129)Xe NMR biosensor, employing a peptide-functionalized cryptophane to monitor the activation of calmodulin (CaM) protein in solution. In the absence of CaM binding, interaction between the peptide and cryptophane completely suppresses the hyperpolarized (129)Xe-cryptophane NMR signal. Biosensor binding to Ca(2+)-activated CaM produces the expected (129)Xe-cryptophane NMR signal.
October 31, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29034509/3d-diffusion-weighted-129-xe-mri-for-whole-lung-morphometry
#3
Ho-Fung Chan, Neil J Stewart, Graham Norquay, Guilhem J Collier, Jim M Wild
PURPOSE: To obtain whole lung morphometry measurements from (129) Xe in a single breath-hold with 3D multiple b-value (129) Xe diffusion-weighted MRI (DW-MRI) with an empirically optimized diffusion time and compressed sensing for scan acceleration. METHODS: Prospective three-fold undersampled 3D multiple b-value hyperpolarized (129) Xe DW-MRI datasets were acquired, and the diffusion time (Δ) was iterated so as to provide diffusive length scale (LmD ) estimates from the stretched exponential model (SEM) that are comparable to those from (3) He...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28940774/functional-airway-obstruction-observed-with-hyperpolarized-129-xenon-mri
#4
Erin J Song, Chris R Kelsey, Bastiaan Driehuys, Leith Rankine
Hyperpolarized (129) Xenon-MRI (HP (129) Xe MRI) is an emerging imaging modality that allows assessment of both ventilation and gas transfer. Most research to date has focused on non-malignant pulmonary diseases. However, the capability of evaluating the two primary physiological processes of the lung (ventilation and gas transfer) makes HP (129) Xe MRI a promising imaging modality in the management of patients with lung cancer.
September 22, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28940334/uncovering-a-third-dissolved-phase-129-xe-resonance-in-the-human-lung-quantifying-spectroscopic-features-in-healthy-subjects-and-patients-with-idiopathic-pulmonary-fibrosis
#5
Scott H Robertson, Rohan S Virgincar, Elianna A Bier, Mu He, Geoffrey M Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized (129) Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized (129) Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °)...
October 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28932564/assessment-of-pulmonary-microstructural-changes-by-hyperpolarized-129-xe-diffusion-weighted-imaging-in-an-elastase-instilled-rat-model-of-emphysema
#6
Ke Wang, Ting Pan, Hao Yang, Weiwei Ruan, Jianping Zhong, Guangyao Wu, Xin Zhou
BACKGROUND: The purpose of this study was to explore the feasibility of hyperpolarized (129)Xe diffusion-weighted imaging (DWI) for the evaluation of pulmonary microstructural changes in the presence of pancreatic porcine elastase (PPE)-induced pulmonary emphysema rat model. METHODS: Sixteen male Sprague-Dawley (SD) rats were randomly divided into two groups, the emphysema model group and control group. Experimental emphysematous models were made by instilling elastase into rat lungs of model group, the control group were instilled with isodose saline...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28921655/fast-dynamic-ventilation-mri-of-hyperpolarized-129-xe-using-spiral-imaging
#7
Ozkan Doganay, Tahreema N Matin, Anthony Mcintyre, Brian Burns, Rolf F Schulte, Fergus V Gleeson, Daniel Bulte
PURPOSE: To develop and optimize a rapid dynamic hyperpolarized (129) Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS: Spiral k-space trajectories were designed with the number of interleaves Nint  = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of view = 15 cm. DXeV images were acquired from a gas-flow phantom to investigate the ability of Nint  = 1, 2, 4, and 8 to capture signal-time curves...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28860333/using-hyperpolarized-129-xe-mri-to-quantify-regional-gas-transfer-in-idiopathic-pulmonary-fibrosis
#8
Jennifer M Wang, Scott H Robertson, Ziyi Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Rose Marie Smigla, Thomas G O'Riordan, John Sundy, Lukas Ebner, Craig R Rackley, Page McAdams, Bastiaan Driehuys
BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized (129)Xe MRI can address this gap through its unique capability to image gas transfer three-dimensionally from airspaces to interstitial barrier tissues to red blood cells (RBCs). This must be validated by testing the degree to which it correlates with pulmonary function tests (PFTs) and CT scores, and its spatial distribution reflects known physiology and patterns of disease...
August 31, 2017: Thorax
https://www.readbyqxmd.com/read/28858563/imaging-human-brain-perfusion-with-inhaled-hyperpolarized-129-xe-mr-imaging
#9
Madhwesha R Rao, Neil J Stewart, Paul D Griffiths, Graham Norquay, Jim M Wild
Purpose To evaluate the feasibility of directly imaging perfusion of human brain tissue by using magnetic resonance (MR) imaging with inhaled hyperpolarized xenon 129 ((129)Xe). Materials and Methods In vivo imaging with (129)Xe was performed in three healthy participants. The combination of a high-yield spin-exchange optical pumping (129)Xe polarizer, custom-built radiofrequency coils, and an optimized gradient-echo MR imaging protocol was used to achieve signal sensitivity sufficient to directly image hyperpolarized (129)Xe dissolved in the human brain...
August 31, 2017: Radiology
https://www.readbyqxmd.com/read/28804157/electron-microscopic-observations-of-rb-particles-and-pitting-in-129-xe-spin-exchange-optical-pumping-cells
#10
C Flower, M S Freeman, M Plue, B Driehuys
High-volume production of hyperpolarized (129)Xe by spin-exchange optical pumping (SEOP) has historically fallen short of theoretical predictions. Recently, this shortfall was proposed to be caused by the formation of alkali metal clusters during optical pumping. However, this hypothesis has yet to be verified experimentally. Here, we seek to detect the presence of alkali particles using a combination of both transmission (TEM) and scanning (SEM) electron microscopy. From TEM studies, we observe the presence of particles exhibiting sizes ranging from approximately 0...
July 14, 2017: Journal of Applied Physics
https://www.readbyqxmd.com/read/28800249/reply-from-authors-of-correlation-of-lci-with-hyperpolarized-129-xe-magnetic-resonance-imaging-in-pediatric-cf-subjects
#11
Nikhil Kanhere, Marcus J Couch, Jonathan H Rayment, Felix Ratjen, Giles Santyr
No abstract text is available yet for this article.
August 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28681470/spatial-fuzzy-c-means-thresholding-for-semiautomated-calculation-of-percentage-lung-ventilated-volume-from-hyperpolarized-gas-and-1-h-mri
#12
Paul J C Hughes, Felix C Horn, Guilhem J Collier, Alberto Biancardi, Helen Marshall, Jim M Wild
PURPOSE: To develop an image-processing pipeline for semiautomated (SA) and reproducible analysis of hyperpolarized gas lung ventilation and proton anatomical magnetic resonance imaging (MRI) scan pairs. To compare results from the software for total lung volume (TLV), ventilated volume (VV), and percentage lung ventilated volume (%VV) calculation to the current manual "basic" method and a K-means segmentation method. MATERIALS AND METHODS: Six patients were imaged with hyperpolarized (3) He and same-breath lung (1) H MRI at 1...
July 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28508450/simultaneous-assessment-of-both-lung-morphometry-and-gas-exchange-function-within-a-single-breath-hold-by-hyperpolarized-129-xe-mri
#13
Jianping Zhong, Huiting Zhang, Weiwei Ruan, Junshuai Xie, Haidong Li, He Deng, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou
During the measurement of hyperpolarized (129) Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application...
August 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28475947/depolarization-of-nuclear-spin-polarized-129-xe-gas-by-dark-rubidium-during-spin-exchange-optical-pumping
#14
M A Antonacci, Alex Burant, Wolfgang Wagner, Rosa T Branca
Continuous-flow spin-exchange optical pumping (SEOP) continues to serve as the most widespread method of polarizing (129)Xe for magnetic resonance experiments. Unfortunately, continuous-flow SEOP still suffers from as-yet unidentified inefficiencies that prevent the production of large volumes of xenon with a nuclear spin polarization close to theoretically calculated values. In this work we use a combination of ultra-low field nuclear magnetic resonance spectroscopy and atomic absorption spectroscopy (AAS) measurements to study the effects of dark Rb vapor on hyperpolarized (129)Xe in situ during continuous-flow SEOP...
June 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28384123/magnetic-resonance-imaging-with-hyperpolarized-agents-methods-and-applications
#15
Erin B Adamson, Kai D Ludwig, David G Mummy, Sean B Fain
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium ((3)He) and xenon ((129)Xe) gases have reached the stage where they are under study in clinical research. HP (129)Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases. With advances in polarizer technology and unique capabilities for imaging of (129)Xe gas exchange into lung tissue and blood, HP (129)Xe MRI is attracting new attention...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28382694/quantitative-analysis-of-hyperpolarized-129-xe-gas-transfer-mri
#16
Ziyi Wang, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Elianna A Bier, Sudarshan Rajagopal, Yuh Chin Huang, Thomas G O'Riordan, Craig R Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: Hyperpolarized (129) Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of (129) Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize information from these images of pulmonary gas transfer are lacking. Here, we introduce a novel method to transform these data into quantitative maps of pulmonary ventilation, and (129) Xe gas transfer to barrier and RBC compartments...
April 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28371091/novel-magnetic-resonance-imaging-for-assessment-of-bronchial-stenosis-in-lung-transplant-recipients
#17
K Mahmood, L Ebner, M He, S H Robertson, Z Wang, H P McAdams, M M Wahidi, S L Shofer, Y T Huang, B Driehuys
Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo time (UTE) scans and hyperpolarized (HP) (129) Xe gas can offer structural and functional assessment of bronchial stenosis seen after lung transplantation. Six patients with lung transplantation-related bronchial stenosis underwent HP (129) Xe MRI and UTE MRI in the same session...
July 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28266629/an-optimized-microfabricated-platform-for-the-optical-generation-and-detection-of-hyperpolarized-129-xe
#18
Daniel J Kennedy, Scott J Seltzer, Ricardo Jiménez-Martínez, Hattie L Ring, Nicolas S Malecek, Svenja Knappe, Elizabeth A Donley, John Kitching, Vikram S Bajaj, Alexander Pines
Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized (129)Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of (129)Xe gas. This device was limited by (129)Xe polarizations less than 1%, (129)Xe NMR signals smaller than 20 nT, and transport of hyperpolarized (129)Xe over millimeter lengths...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28245140/correlation-of-lung-clearance-index-with-hyperpolarized-129-xe-magnetic-resonance-imaging-in-pediatric-subjects-with-cystic-fibrosis
#19
Nikhil Kanhere, Marcus J Couch, Krzysztof Kowalik, Brandon Zanette, Jonathan H Rayment, David Manson, Padma Subbarao, Felix Ratjen, Giles Santyr
No abstract text is available yet for this article.
October 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28192930/mitochondria-targeted-and-intracellular-biothiol-triggered-hyperpolarized-129-xe-magnetofluorescent-biosensor
#20
Qingbin Zeng, Qianni Guo, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S Bouchard, Xin Zhou
Biothiols such as gluthathione (GSH), cysteine (Cys), homocysteine (Hcy), and thioredoxin (Trx) play vital roles in cellular metabolism. Various diseases are associated with abnormal cellular biothiol levels. Thus, the intracellular detection of biothiol levels could be a useful diagnostic tool. A number of methods have been developed to detect intracellular thiols, but sensitivity and specificity problems have limited their applications. To address these limitations, we have designed a new biosensor based on hyperpolarized xenon magnetic resonance detection, which can be used to detect biothiol levels noninvasively...
February 9, 2017: Analytical Chemistry
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