Keunhong Jeong, Chawita Netirojjanakul, Henrik K Munch, Jinny Sun, Joel A Finbloom, David E Wemmer, Alexander Pines, Matthew B Francis
We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
August 17, 2016: Bioconjugate Chemistry