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Hyperpolarized Xe

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https://www.readbyqxmd.com/read/28932564/assessment-of-pulmonary-microstructural-changes-by-hyperpolarized-129-xe-diffusion-weighted-imaging-in-an-elastase-instilled-rat-model-of-emphysema
#1
Ke Wang, Ting Pan, Hao Yang, Weiwei Ruan, Jianping Zhong, Guangyao Wu, Xin Zhou
BACKGROUND: The purpose of this study was to explore the feasibility of hyperpolarized (129)Xe diffusion-weighted imaging (DWI) for the evaluation of pulmonary microstructural changes in the presence of pancreatic porcine elastase (PPE)-induced pulmonary emphysema rat model. METHODS: Sixteen male Sprague-Dawley (SD) rats were randomly divided into two groups, the emphysema model group and control group. Experimental emphysematous models were made by instilling elastase into rat lungs of model group, the control group were instilled with isodose saline...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28921655/fast-dynamic-ventilation-mri-of-hyperpolarized-129-xe-using-spiral-imaging
#2
Ozkan Doganay, Tahreema N Matin, Anthony Mcintyre, Brian Burns, Rolf F Schulte, Fergus V Gleeson, Daniel Bulte
PURPOSE: To develop and optimize a rapid dynamic hyperpolarized (129) Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS: Spiral k-space trajectories were designed with the number of interleaves Nint  = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of view = 15 cm. DXeV images were acquired from a gas-flow phantom to investigate the ability of Nint  = 1, 2, 4, and 8 to capture signal-time curves...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28860333/using-hyperpolarized-129-xe-mri-to-quantify-regional-gas-transfer-in-idiopathic-pulmonary-fibrosis
#3
Jennifer M Wang, Scott H Robertson, Ziyi Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Rose Marie Smigla, Thomas G O'Riordan, John Sundy, Lukas Ebner, Craig R Rackley, Page McAdams, Bastiaan Driehuys
BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized (129)Xe MRI can address this gap through its unique capability to image gas transfer three-dimensionally from airspaces to interstitial barrier tissues to red blood cells (RBCs). This must be validated by testing the degree to which it correlates with pulmonary function tests (PFTs) and CT scores, and its spatial distribution reflects known physiology and patterns of disease...
August 31, 2017: Thorax
https://www.readbyqxmd.com/read/28858563/imaging-human-brain-perfusion-with-inhaled-hyperpolarized-129-xe-mr-imaging
#4
Madhwesha R Rao, Neil J Stewart, Paul D Griffiths, Graham Norquay, Jim M Wild
Purpose To evaluate the feasibility of directly imaging perfusion of human brain tissue by using magnetic resonance (MR) imaging with inhaled hyperpolarized xenon 129 ((129)Xe). Materials and Methods In vivo imaging with (129)Xe was performed in three healthy participants. The combination of a high-yield spin-exchange optical pumping (129)Xe polarizer, custom-built radiofrequency coils, and an optimized gradient-echo MR imaging protocol was used to achieve signal sensitivity sufficient to directly image hyperpolarized (129)Xe dissolved in the human brain...
August 31, 2017: Radiology
https://www.readbyqxmd.com/read/28804157/electron-microscopic-observations-of-rb-particles-and-pitting-in-129-xe-spin-exchange-optical-pumping-cells
#5
C Flower, M S Freeman, M Plue, B Driehuys
High-volume production of hyperpolarized (129)Xe by spin-exchange optical pumping (SEOP) has historically fallen short of theoretical predictions. Recently, this shortfall was proposed to be caused by the formation of alkali metal clusters during optical pumping. However, this hypothesis has yet to be verified experimentally. Here, we seek to detect the presence of alkali particles using a combination of both transmission (TEM) and scanning (SEM) electron microscopy. From TEM studies, we observe the presence of particles exhibiting sizes ranging from approximately 0...
July 14, 2017: Journal of Applied Physics
https://www.readbyqxmd.com/read/28800249/reply-from-authors-of-correlation-of-lci-with-hyperpolarized-129-xe-magnetic-resonance-imaging-in-pediatric-cf-subjects
#6
Nikhil Kanhere, Marcus J Couch, Jonathan H Rayment, Felix Ratjen, Giles Santyr
No abstract text is available yet for this article.
August 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28681470/spatial-fuzzy-c-means-thresholding-for-semiautomated-calculation-of-percentage-lung-ventilated-volume-from-hyperpolarized-gas-and-1-h-mri
#7
Paul J C Hughes, Felix C Horn, Guilhem J Collier, Alberto Biancardi, Helen Marshall, Jim M Wild
PURPOSE: To develop an image-processing pipeline for semiautomated (SA) and reproducible analysis of hyperpolarized gas lung ventilation and proton anatomical magnetic resonance imaging (MRI) scan pairs. To compare results from the software for total lung volume (TLV), ventilated volume (VV), and percentage lung ventilated volume (%VV) calculation to the current manual "basic" method and a K-means segmentation method. MATERIALS AND METHODS: Six patients were imaged with hyperpolarized (3) He and same-breath lung (1) H MRI at 1...
July 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28508450/simultaneous-assessment-of-both-lung-morphometry-and-gas-exchange-function-within-a-single-breath-hold-by-hyperpolarized-129-xe-mri
#8
Jianping Zhong, Huiting Zhang, Weiwei Ruan, Junshuai Xie, Haidong Li, He Deng, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou
During the measurement of hyperpolarized (129) Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application...
August 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28475947/depolarization-of-nuclear-spin-polarized-129-xe-gas-by-dark-rubidium-during-spin-exchange-optical-pumping
#9
M A Antonacci, Alex Burant, Wolfgang Wagner, Rosa T Branca
Continuous-flow spin-exchange optical pumping (SEOP) continues to serve as the most widespread method of polarizing (129)Xe for magnetic resonance experiments. Unfortunately, continuous-flow SEOP still suffers from as-yet unidentified inefficiencies that prevent the production of large volumes of xenon with a nuclear spin polarization close to theoretically calculated values. In this work we use a combination of ultra-low field nuclear magnetic resonance spectroscopy and atomic absorption spectroscopy (AAS) measurements to study the effects of dark Rb vapor on hyperpolarized (129)Xe in situ during continuous-flow SEOP...
June 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28384123/magnetic-resonance-imaging-with-hyperpolarized-agents-methods-and-applications
#10
Erin B Adamson, Kai D Ludwig, David G Mummy, Sean B Fain
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium ((3)He) and xenon ((129)Xe) gases have reached the stage where they are under study in clinical research. HP (129)Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases. With advances in polarizer technology and unique capabilities for imaging of (129)Xe gas exchange into lung tissue and blood, HP (129)Xe MRI is attracting new attention...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28382694/quantitative-analysis-of-hyperpolarized-129-xe-gas-transfer-mri
#11
Ziyi Wang, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Elianna A Bier, Sudarshan Rajagopal, Yuh Chin Huang, Thomas G O'Riordan, Craig R Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: Hyperpolarized (129) Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of (129) Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize information from these images of pulmonary gas transfer are lacking. Here, we introduce a novel method to transform these data into quantitative maps of pulmonary ventilation, and (129) Xe gas transfer to barrier and RBC compartments...
April 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28371091/novel-magnetic-resonance-imaging-for-assessment-of-bronchial-stenosis-in-lung-transplant-recipients
#12
K Mahmood, L Ebner, M He, S H Robertson, Z Wang, H P McAdams, M M Wahidi, S L Shofer, Y T Huang, B Driehuys
Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo time (UTE) scans and hyperpolarized (HP) (129) Xe gas can offer structural and functional assessment of bronchial stenosis seen after lung transplantation. Six patients with lung transplantation-related bronchial stenosis underwent HP (129) Xe MRI and UTE MRI in the same session...
July 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28266629/an-optimized-microfabricated-platform-for-the-optical-generation-and-detection-of-hyperpolarized-129-xe
#13
Daniel J Kennedy, Scott J Seltzer, Ricardo Jiménez-Martínez, Hattie L Ring, Nicolas S Malecek, Svenja Knappe, Elizabeth A Donley, John Kitching, Vikram S Bajaj, Alexander Pines
Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized (129)Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of (129)Xe gas. This device was limited by (129)Xe polarizations less than 1%, (129)Xe NMR signals smaller than 20 nT, and transport of hyperpolarized (129)Xe over millimeter lengths...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28245140/correlation-of-lci-with-hyperpolarized-129-xe-magnetic-resonance-imaging-in-pediatric-cf-subjects
#14
Nikhil Kanhere, Marcus J Couch, Krzysztof Kowalik, Brandon Zanette, Jonathan H Rayment, David Manson, Padmaja Subbarao, Felix Ratjen, Giles Santyr
No abstract text is available yet for this article.
February 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28192930/mitochondria-targeted-and-intracellular-biothiol-triggered-hyperpolarized-129-xe-magnetofluorescent-biosensor
#15
Qingbin Zeng, Qianni Guo, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S Bouchard, Xin Zhou
Biothiols such as gluthathione (GSH), cysteine (Cys), homocysteine (Hcy), and thioredoxin (Trx) play vital roles in cellular metabolism. Various diseases are associated with abnormal cellular biothiol levels. Thus, the intracellular detection of biothiol levels could be a useful diagnostic tool. A number of methods have been developed to detect intracellular thiols, but sensitivity and specificity problems have limited their applications. To address these limitations, we have designed a new biosensor based on hyperpolarized xenon magnetic resonance detection, which can be used to detect biothiol levels noninvasively...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28065276/using-imaging-as-a-biomarker-for-asthma
#16
REVIEW
Abhaya Trivedi, Chase Hall, Eric A Hoffman, Jason C Woods, David S Gierada, Mario Castro
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28046370/th-cd-202-09-free-breathing-proton-mri-functional-lung-avoidance-maps-to-guide-radiation-therapy
#17
D Capaldi, K Sheikh, D Hoover, B Yaremko, D Palma, G Parraga
PURPOSE: Pulmonary functional MRI using inhaled gas contrast agents was previously investigated as a way to identify well-functioning lung in patients with NSCLC who are clinical candidates for radiotherapy. Hyperpolarized noble-gas ((3) He and (129) Xe) MRI has also been optimized to measure functional lung information, but for a number of reasons, the clinical translation of this approach to guide radiotherapy planning has been limited. As an alternative, free-breathing pulmonary 1H MRI using clinically available MRI systems and pulse sequences provides a non-contrast-enhanced method to generate both ventilation and perfusion maps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041987/retigabine-diminishes-the-effects-of-acetylcholine-adrenaline-and-adrenergic-agonists-on-the-spontaneous-activity-of-guinea-pig-smooth-muscle-strips-in-vitro
#18
Elisaveta Apostolova, Plamen Zagorchev, Vesela Kokova, Lyudmil Peychev
PURPOSE: The aim of this study is to evaluate the effect of retigabine on the smooth muscle response to acetylcholine, adrenaline, α-and β-adrenoceptor agonists. METHODS: We studied the change in the spontaneous smooth muscle contraction of guinea pig gastric corpus strips before and after 20-min treatment with 2μM retigabine. We also evaluated the effect of retigabine on the smooth muscle response to 10μM acetylcholine, 1 and 10μM adrenaline, 1μM methoxamine, 0...
March 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28026061/detection-of-smoke-induced-pulmonary-lesions-by-hyperpolarized-129-xe-diffusion-kurtosis-imaging-in-rat-models
#19
Weiwei Ruan, Jianping Zhong, Yu Guan, Yi Xia, Xiuchao Zhao, Yeqing Han, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou
PURPOSE: To demonstrate that hyperpolarized (HP) xenon diffusion kurtosis imaging (DKI) is able to detect smoke-induced pulmonary lesions in rat models. METHODS: Multi-b DKI with hyperpolarized xenon was used for the first time in five smoke-exposed rats and five healthy rats. Additionally, DKI with b values of up to 80 s/cm(2) were used in two healthy rats to probe the critical b value (a limit beyond which the DKI cannot describe the non-Gaussian diffusion). RESULTS: The mean apparent diffusion coefficient (Dapp ) and diffusion kurtosis (Kapp ) extracted by the DKI model revealed significant changes in the smoke-exposed rats compared with those in the control group (P = 0...
December 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27875871/remote-detection-of-hyperpolarized-129-xe-resonances-via-multiple-distant-dipolar-field-interactions-with-1-h
#20
Le Zhang, Michael Antonacci, Alex Burant, Karl M Koshlap, Rosa Tamara Branca
A remote detection scheme utilizing the distant dipolar field interaction between two different spin species was proposed by Granwehr et al. [J. Magn. Reson. 176(2), 125 (2005)]. In that sequence (1)H spins were detected indirectly via their dipolar field interaction with (129)Xe spins, which served as the sensing spins. Here we propose a modification of the proposed detection scheme that takes advantage of the longer T1 relaxation time of xenon to create a long lasting dipolar field with which the fast relaxing (1)H spins are allowed to interact many times during a single acquisition...
November 21, 2016: Journal of Chemical Physics
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