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Drosophila class iv neuron

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https://www.readbyqxmd.com/read/29035200/small-conductance-ca-2-activated-k-channels-induce-the-firing-pause-periods-during-the-activation-of-drosophila-nociceptive-neurons
#1
Koun Onodera, Shumpei Baba, Akira Murakami, Tadashi Uemura, Tadao Usui
In Drosophila larvae, Class IV sensory neurons respond to noxious thermal stimuli and provoke heat avoidance behavior. Previously, we showed that the activated neurons displayed characteristic fluctuations of firing rates which consisted of repetitive high-frequency spike trains and subsequent pause periods, and we proposed that the firing rate fluctuations enhanced the heat avoidance (Terada et al., 2016). Here, we further substantiate this idea by showing that the pause periods and the frequency of fluctuations are regulated by small conductance Ca(2+)-activated K(+) (SK) channels, and the SK knockdown larvae display faster heat avoidance than control larvae...
October 16, 2017: ELife
https://www.readbyqxmd.com/read/28910410/the-function-of-drosophila-larval-class-iv-dendritic-arborization-sensory-neurons-in-the-larval-pupal-transition-is-separable-from-their-function-in-mechanical-nociception-responses
#2
Hannah E Brown, Trishna Desai, Allison J Murphy, Harshida Pancholi, Zachary W Schmidt, Hannah Swahn, Eric C Liebl
The sensory and physiological inputs which govern the larval-pupal transition in Drosophila, and the neuronal circuity that integrates them, are complex. Previous work from our laboratory identified a dosage-sensitive genetic interaction between the genes encoding the Rho-GEF Trio and the zinc-finger transcription factor Sequoia that interfered with the larval-pupal transition. Specifically, we reported heterozygous mutations in sequoia (seq) dominantly exacerbated the trio mutant phenotype, and this seq-enhanced trio mutant genotype blocked the transition of third instar larvae from foragers to wanderers, a requisite behavioral transition prior to pupation...
2017: PloS One
https://www.readbyqxmd.com/read/28855331/drosophila-nociceptive-sensitization-requires-bmp-signaling-via-the-canonical-smad-pathway
#3
Taylor L Follansbee, Kayla J Gjelsvik, Courtney L Brann, Aidan L McParland, Colin A Longhurst, Michael J Galko, Geoffrey K Ganter
Nociceptive sensitization is a common feature in chronic pain, but its basic cellular mechanisms are only partially understood. The present study used the Drosophila melanogaster model system and a candidate gene approach to identify novel components required for modulation of an injury-induced nociceptive sensitization pathway presumably downstream of Hedgehog. This study demonstrates that RNAi silencing of a member of the Bone Morphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifically in the Class IV multidendritic nociceptive neuron, significantly attenuated ultraviolet injury-induced sensitization...
August 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28837687/the-spliceosome-associated-protein-mfap1-binds-to-vcp-in-drosophila
#4
Sandra Rode, Henrike Ohm, Jaqueline Zipfel, Sebastian Rumpf
Posttranscriptional regulation of gene expression contributes to many developmental transitions. Previously, we found that the AAA chaperone Valosin-Containing Protein (VCP) regulates ecdysone-dependent dendrite pruning of Drosophila class IV dendritic arborization (c4da) neurons via an effect on RNA metabolism. In a search for RNA binding proteins associated with VCP, we identified the spliceosome-associated protein Mfap1, a component of the tri-snRNP complex. Mfap1 is a nucleolar protein in neurons and its levels are regulated by VCP...
2017: PloS One
https://www.readbyqxmd.com/read/28803873/neural-circuitry-that-evokes-escape-behavior-upon-activation-of-nociceptive-sensory-neurons-in-drosophila-larvae
#5
Jiro Yoshino, Rei K Morikawa, Eri Hasegawa, Kazuo Emoto
Noxious stimuli trigger a stereotyped escape response in animals. In Drosophila larvae, class IV dendrite arborization (C4 da) sensory neurons in the peripheral nervous system are responsible for perception of multiple nociceptive modalities, including noxious heat and harsh mechanical stimulation, through distinct receptors [1-9]. Silencing or ablation of C4 da neurons largely eliminates larval responses to noxious stimuli [10-12], whereas optogenetic activation of C4 da neurons is sufficient to provoke corkscrew-like rolling behavior similar to what is observed when larvae receive noxious stimuli, such as high temperature or harsh mechanical stimulation [10-12]...
August 21, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28700938/golgi-outpost-synthesis-impaired-by-toxic-polyglutamine-proteins-contributes-to-dendritic-pathology-in-neurons
#6
Chang Geon Chung, Min Jee Kwon, Keun Hye Jeon, Do Young Hyeon, Myeong Hoon Han, Jeong Hyang Park, In Jun Cha, Jae Ho Cho, Kunhyung Kim, Sangchul Rho, Gyu Ree Kim, Hyobin Jeong, Jae Won Lee, TaeSoo Kim, Keetae Kim, Kwang Pyo Kim, Michael D Ehlers, Daehee Hwang, Sung Bae Lee
Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite elongation accompanied by a loss of Golgi outposts (GOPs) and a decreased supply of plasma membrane (PM) in Drosophila class IV dendritic arborization (da) (C4 da) neurons. mRNA sequencing revealed that genes downregulated by polyQ proteins included many secretory pathway-related genes, including COPII genes regulating GOP synthesis...
July 11, 2017: Cell Reports
https://www.readbyqxmd.com/read/28342875/the-nociception-genes-painless-and-piezo-are-required-for-the-cellular-immune-response-of-drosophila-larvae-to-wasp-parasitization
#7
Yumiko Tokusumi, Tsuyoshi Tokusumi, Robert A Schulz
In vertebrates, interaction between the nervous system and immune system is important to protect a challenged host from stress inputs from external sources. In this study, we demonstrate that sensory neurons are involved in the cellular immune response elicited by wasp infestation of Drosophila larvae. Multidendritic class IV neurons sense contacts from external stimuli and induce avoidance behaviors for host defense. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28209644/mitochondrial-dysfunction-induces-dendritic-loss-via-eif2%C3%AE-phosphorylation
#8
Taiichi Tsuyama, Asako Tsubouchi, Tadao Usui, Hiromi Imamura, Tadashi Uemura
Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still unclear. We here dissect the molecular mechanism by which mitochondrial dysfunction induced by Prel aberrant function mediates selective dendritic loss in Drosophila melanogaster class IV dendritic arborization neurons. Using in vivo ATP imaging, we found that neuronal cellular ATP levels during development are not correlated with the progression of dendritic loss...
March 6, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/27868313/nutrient-dependent-increased-dendritic-arborization-of-somatosensory-neurons
#9
Kaori Watanabe, Yuki Furumizo, Tadao Usui, Yukako Hattori, Tadashi Uemura
Suboptimal nutrition imposes developmental constraints on infant animals, which marshal adaptive responses to eventually become mature adults. Such responses are mounted at multiple levels from systemic to cellular. At the cellular level, the underlying mechanisms of cell proliferation control have been intensively studied. However, less is known about how growth of postmitotic and morphologically complex cells, such as neurons, is controlled by nutritional status. We address this question using Class I and Class IV dendritic arborization neurons in Drosophila larvae...
January 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27494275/drosophila-larval-to-pupal-switch-under-nutrient-stress-requires-ip3r-ca-2-signalling-in-glutamatergic-interneurons
#10
Siddharth Jayakumar, Shlesha Richhariya, O Venkateswara Reddy, Michael J Texada, Gaiti Hasan
Neuronal circuits are known to integrate nutritional information, but the identity of the circuit components is not completely understood. Amino acids are a class of nutrients that are vital for the growth and function of an organism. Here, we report a neuronal circuit that allows Drosophila larvae to overcome amino acid deprivation and pupariate. We find that nutrient stress is sensed by the class IV multidendritic cholinergic neurons. Through live calcium imaging experiments, we show that these cholinergic stimuli are conveyed to glutamatergic neurons in the ventral ganglion through mAChR...
August 5, 2016: ELife
https://www.readbyqxmd.com/read/27260999/a-genome-wide-screen-for-dendritically-localized-rnas-identifies-genes-required-for-dendrite-morphogenesis
#11
Mala Misra, Hendia Edmund, Darragh Ennis, Marissa A Schlueter, Jessica E Marot, Janet Tambasco, Ida Barlow, Sara Sigurbjornsdottir, Renjith Mathew, Ana Maria Vallés, Waldemar Wojciech, Siegfried Roth, Ilan Davis, Maria Leptin, Elizabeth R Gavis
Localizing messenger RNAs at specific subcellular sites is a conserved mechanism for targeting the synthesis of cytoplasmic proteins to distinct subcellular domains, thereby generating the asymmetric protein distributions necessary for cellular and developmental polarity. However, the full range of transcripts that are asymmetrically distributed in specialized cell types, and the significance of their localization, especially in the nervous system, are not known. We used the EP-MS2 method, which combines EP transposon insertion with the MS2/MCP in vivo fluorescent labeling system, to screen for novel localized transcripts in polarized cells, focusing on the highly branched Drosophila class IV dendritic arborization neurons...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27256879/nanos-mediated-repression-of-hid-protects-larval-sensory-neurons-after-a-global-switch-in-sensitivity-to-apoptotic-signals
#12
Balpreet Bhogal, Amara Plaza-Jennings, Elizabeth R Gavis
Dendritic arbor morphology is a key determinant of neuronal function. Once established, dendrite branching patterns must be maintained as the animal develops to ensure receptive field coverage. The translational repressors Nanos (Nos) and Pumilio (Pum) are required to maintain dendrite growth and branching of Drosophila larval class IV dendritic arborization (da) neurons, but their specific regulatory role remains unknown. We show that Nos-Pum-mediated repression of the pro-apoptotic gene head involution defective (hid) is required to maintain a balance of dendritic growth and retraction in class IV da neurons and that upregulation of hid results in decreased branching because of an increase in caspase activity...
June 15, 2016: Development
https://www.readbyqxmd.com/read/26978375/pseudopterosin-a-protection-of-synaptic-function-and-potential-as-a-neuromodulatory-agent
#13
Stacee Lee Caplan, Bo Zheng, Ken Dawson-Scully, Catherine A White, Lyndon M West
Natural products have provided an invaluable source of inspiration in the drug discovery pipeline. The oceans are a vast source of biological and chemical diversity. Recently, this untapped resource has been gaining attention in the search for novel structures and development of new classes of therapeutic agents. Pseudopterosins are group of marine diterpene glycosides that possess an array of potent biological activities in several therapeutic areas. Few studies have examined pseudopterosin effects during cellular stress and, to our knowledge, no studies have explored their ability to protect synaptic function...
March 10, 2016: Marine Drugs
https://www.readbyqxmd.com/read/26880554/neuronal-processing-of-noxious-thermal-stimuli-mediated-by-dendritic-ca-2-influx-in-drosophila-somatosensory-neurons
#14
Shin-Ichiro Terada, Daisuke Matsubara, Koun Onodera, Masanori Matsuzaki, Tadashi Uemura, Tadao Usui
Adequate responses to noxious stimuli causing tissue damages are essential for organismal survival. Class IV neurons in Drosophila larvae are polymodal nociceptors responsible for thermal, mechanical, and light sensation. Importantly, activation of Class IV provoked distinct avoidance behaviors, depending on the inputs. We found that noxious thermal stimuli, but not blue light stimulation, caused a unique pattern of Class IV, which were composed of pauses after high-frequency spike trains and a large Ca(2+) rise in the dendrite (the Ca(2+) transient)...
February 15, 2016: ELife
https://www.readbyqxmd.com/read/26495837/steroid-receptor-isoform-expression-in-drosophila-nociceptor-neurons-is-required-for-normal-dendritic-arbor-and-sensitivity
#15
Aidan L McParland, Taylor L Follansbee, Gwendolyn D Vesenka, Alexandra E Panaitiu, Geoffrey K Ganter
Steroid hormones organize many aspects of development, including that of the nervous system. Steroids also play neuromodulatory and other activational roles, including regulation of sensitivity to painful stimuli in mammals. In Drosophila, ecdysteroids are the only steroid hormones, and therefore the fly represents a simplified model system in which to explore mechanisms of steroid neuromodulation of nociception. In this report, we present evidence that ecdysteroids, acting through two isoforms of their nuclear ecdysone receptor (EcR), modulate sensitivity to noxious thermal and mechanical stimuli in the fly larva...
2015: PloS One
https://www.readbyqxmd.com/read/26302791/adult-drosophila-sensory-neurons-specify-dendritic-territories-independently-of-dendritic-contacts-through-the-wnt5-drl-signaling-pathway
#16
Kei-ichiro Yasunaga, Akane Tezuka, Natsuko Ishikawa, Yusuke Dairyo, Kazuya Togashi, Hiroyuki Koizumi, Kazuo Emoto
Sensory neurons with common functions are often nonrandomly arranged and form dendritic territories in stereotypic spatial patterns throughout the nervous system, yet molecular mechanisms of how neurons specify dendritic territories remain largely unknown. In Drosophila larvae, dendrites of class IV sensory (C4da) neurons completely but nonredundantly cover the whole epidermis, and the boundaries of these tiled dendritic fields are specified through repulsive interactions between homotypic dendrites. Here we report that, unlike the larval C4da neurons, adult C4da neurons rely on both dendritic repulsive interactions and external positional cues to delimit the boundaries of their dendritic fields...
August 15, 2015: Genes & Development
https://www.readbyqxmd.com/read/26108333/importance-of-gene-dosage-in-controlling-dendritic-arbor-formation-during-development
#17
REVIEW
Tijana Copf
Proper dendrite morphology is crucial for normal nervous system functioning. While a number of genes have been implicated in dendrite morphogenesis in both invertebrates and mammals, it remains unclear how developing dendrites respond to changes in gene dosage and what type of patterns their responses may follow. To understand this, I review here evidence from the recent literature, focusing on the genetic studies performed in the Drosophila larval dendritic arborization class IV neuron, an excellent cell type to understand dendrite morphogenesis...
September 2015: European Journal of Neuroscience
https://www.readbyqxmd.com/read/25764303/the-ret-receptor-regulates-sensory-neuron-dendrite-growth-and-integrin-mediated-adhesion
#18
Peter Soba, Chun Han, Yi Zheng, Daniel Perea, Irene Miguel-Aliaga, Lily Yeh Jan, Yuh Nung Jan
Neurons develop highly stereotyped receptive fields by coordinated growth of their dendrites. Although cell surface cues play a major role in this process, few dendrite specific signals have been identified to date. We conducted an in vivo RNAi screen in Drosophila class IV dendritic arborization (C4da) neurons and identified the conserved Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite development. The loss of Ret results in severe dendrite defects due to loss of extracellular matrix adhesion, thus impairing growth within a 2D plane...
March 12, 2015: ELife
https://www.readbyqxmd.com/read/25506553/cell-type-specific-transcriptomic-profiling-to-dissect-mechanisms-of-differential-dendritogenesis
#19
Surajit Bhattacharya, Eswar Prasad R Iyer, Srividya Chandramouli Iyer, Daniel N Cox
The establishment, maintenance and modulation of cell-type specific neural architectures is critically important to the formation of functional neural networks. At the neuroanatomical level, differential patterns of dendritic arborization directly impact neural function and connectivity, however the molecular mechanisms underlying the specification of distinct dendrite morphologies remains incompletely understood. To address this question, we analyzed global gene expression from purified populations of wild-type class I and class IV Drosophila melanogaster dendritic arborization (da) sensory neurons compared to wild-type whole larval RNA using oligo DNA microarray expression profiling...
December 1, 2014: Genomics Data
https://www.readbyqxmd.com/read/25457610/the-role-of-ppk26-in-drosophila-larval-mechanical-nociception
#20
Yanmeng Guo, Yuping Wang, Qingxiu Wang, Zuoren Wang
In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical nociception in class IV da neurons. Our immunohistochemical and functional results demonstrate that ppk26 is specifically expressed in class IV da neurons. Larvae with mutant ppk26 showed severe behavioral defects in a mechanical nociception behavioral test but responded to noxious heat stimuli comparably to wild-type larvae. In addition, functional studies suggest that ppk26 and ppk (also called ppk1) function in the same pathway, whereas piezo functions in a parallel pathway...
November 20, 2014: Cell Reports
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