keyword
https://read.qxmd.com/read/35903011/efficacy-of-doxycycline-for-mild-to-moderate-community-acquired-pneumonia-in-adults-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
JOURNAL ARTICLE
Sang-Ho Choi, Antoni Cesar, Timothy Arthur Chandos Snow, Naveed Saleem, Nishkantha Arulkumaran, Mervyn Singer
BACKGROUND: Doxycycline has been recommended as a treatment option for non-severe community-acquired pneumonia (CAP) in adults. We sought to review the evidence for the efficacy of doxycycline in adult patients with mild-to-moderate CAP. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) of doxycycline versus comparator to assess the clinical efficacy. The primary outcome was the clinical cure rate. Random effects model meta-analyses were used to generate pooled odds ratio (OR) and evaluate heterogeneity (I2)...
February 18, 2023: Clinical Infectious Diseases
https://read.qxmd.com/read/35902536/therapeutic-effect-of-il-21-blockage-by-gene-therapy-in-experimental-autoimmune-encephalomyelitis
#2
JOURNAL ARTICLE
Ángel Edo, Laura Calvo-Barreiro, Herena Eixarch, Assumpció Bosch, Miguel Chillón, Carmen Espejo
The pathogenic role of the interleukin 21 (IL-21) in different autoimmune diseases, such as multiple sclerosis (MS), has been extensively studied. However, its pleiotropic nature makes it a cytokine that may exhibit different activity depending on the immunological stage of the disease. In this study, we developed a gene therapy strategy to block the interaction between IL-21 and its receptor (IL-21R) by using adeno-associated vectors (AAV) encoding a new soluble cytokine receptor (sIL21R) protein. We tested this strategy in a murine model of experimental autoimmune encephalomyelitis (EAE), obtaining different clinical effects depending on the time at which the treatment was applied...
July 28, 2022: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/35443454/role-of-potential-biomarkers-in-management-and-prognosis-of-corona-virus-disease
#3
JOURNAL ARTICLE
Ankita Khatri
Corona virus disease is a global pandemic. One of the key issues has been the very high volume of patients presenting to health centres or hospitals during the outbreak. It clearly overwhelms the human and mechanistic capacities available. Therefore, early and effective predictors of clinical outcomes are required for risk stratification. MATERIAL: This is hospital based retrospective study on patients who were admitted in Covid wards/ICU at IGGMC. Patients were divided into 3 groups- mild-moderate; severe; and critical based on their clinical presentation on admission...
April 2022: Journal of the Association of Physicians of India
https://read.qxmd.com/read/34057876/data-mining-for-detecting-signals-of-adverse-drug-reaction-of-doxycycline-using-the-korea-adverse-event-reporting-system-database
#4
JOURNAL ARTICLE
Jae Young Heo, Moon Kyun Cho, Sooyoung Kim
BACKGROUND: Doxycycline is one of the most prescribed antibiotics by dermatologists. However, the concern regarding adverse events of doxycyline has been rising. OBJECTIVE: To detect the adverse events of doxycycline using the Korea Adverse Events Reporting System (KAERS) database from January 2014 to December 2018 through a data mining method. METHODS: A signal was defined as one satisfying all three indices; a proportional reporting ratio, a reporting odds ratio, and an information component...
June 16, 2021: Journal of Dermatological Treatment
https://read.qxmd.com/read/33863772/one-man-three-tick-borne-illnesses
#5
Leah Grant, Imran Mohamedy, Laura Loertscher
A 70-year-old man presented to the emergency department with fevers, ankle edema and nausea following a presumed insect bite on his ankle 1 month prior. On examination, he was febrile and had left leg pain with passive range of motion. Laboratory studies revealed anemia, thrombocytopenia, acute kidney injury and elevated aminotransaminases. Due to his recent travel to the Northeastern United States, he was suspected of having a possible tick-borne illness. Serologies were positive for Borrelia burgdorferi , Anaplasma phagocytophilum and Babesia microti , and the patient was diagnosed with Lyme disease, babesiosis and anaplasmosis...
April 16, 2021: BMJ Case Reports
https://read.qxmd.com/read/32062289/ureaplasma-parvum-causes-hyperammonemia-presenting-as-refractory-status-epilepticus-after-kidney-transplant
#6
JOURNAL ARTICLE
Camille Legouy, Alice Hu, Fanny Mochel, Nicolas Weiss, Adrien Collin, Sabine Pereyre, Mathilde Perrin, Nicolas Engrand
PURPOSE: Alert intensivists about the diagnostic pitfalls arising from hyperammonemia due to Ureaplasma infections in post-transplant patients. MATERIALS AND METHODS: Clinical observation of one patient. CASE REPORT: A 65-year-old female with a medical history of semi-recent kidney transplant was admitted to the Intensive Care Unit for refractory status epilepticus. There were no lesions on brain imaging. Bacterial cultures and viral PCR of cerebrospinal fluid were negative...
June 2020: Journal of Critical Care
https://read.qxmd.com/read/31980789/correction-to-periodontal-care-in-general-practice-20-important-faqs-part-two
#7
(no author information available yet)
Author's correction note: When this article was initially published, the following boxes in Table 1 were incorrect: In the top row of the Dosage column, 'Doxycyline 200 mg (loading dose), 100 mg OD for 14 days' should have read 'Doxycyline 200 mg (loading dose), 100 mg OD for 21 days' In the top r...
January 2020: British Dental Journal
https://read.qxmd.com/read/31440463/dodecyl-tpp-targets-mitochondria-and-potently-eradicates-cancer-stem-cells-cscs-synergy-with-fda-approved-drugs-and-natural-compounds-vitamin-c-and-berberine
#8
JOURNAL ARTICLE
Ernestina Marianna De Francesco, Béla Ózsvári, Federica Sotgia, Michael P Lisanti
Elevated mitochondrial biogenesis and/or metabolism are distinguishing features of cancer cells, as well as Cancer Stem Cells (CSCs), which are involved in tumor initiation, metastatic dissemination, and therapy resistance. In fact, mitochondria-impairing agents can be used to hamper CSCs maintenance and propagation, toward better control of neoplastic disease. Tri-Phenyl-Phosphonium (TPP)-based mitochondrially-targeted compounds are small non-toxic and biologically active molecules that are delivered to and accumulated within the mitochondria of living cells...
2019: Frontiers in Oncology
https://read.qxmd.com/read/31349003/effect-of-doxycyline-in-chronic-obstructive-pulmonary-disease-an-exploratory-study
#9
JOURNAL ARTICLE
Brajesh Singh, Nilanjana Ghosh, Dipanjan Saha, Surita Sarkar, Parthasarathi Bhattacharyya, Koel Chaudhury
PURPOSE: Various mechanisms, including oxidative stress, inflammation, and protease-antiprotease imbalance are proposed for the progressive decline in lung function in chronic obstructive pulmonary disease (COPD). Doxycycline, a broad spectrum tetracycline antibiotic, is reported to have non-antimicrobial matrix metalloproteinases (MMP) inhibitory action in various inflammatory conditions. The effect of doxycycline in COPD is hereby assessed in the present randomized prospective study...
October 2019: Pulmonary Pharmacology & Therapeutics
https://read.qxmd.com/read/30562480/monocyte-phagocytosis-of-malaria-%C3%AE-haematin-in-the-presence-of-artemisinin-amodiaquine-chloroquine-doxycycline-primaquine-pyrimethamine-and-quinine
#10
JOURNAL ARTICLE
Bridgette M Cumming, J P Dean Goldring
The intraerythrocytic malaria parasite digests haemoglobin to provide amino acids for metabolism and releases toxic haem that is sequestered into haemozoin, a non-toxic, insoluble, crystalline pigment. Following erythrocyte rupture, haemozoin is released into circulation and phagocytosed by monocytes. Phagocytosed haemozoin and antimalarial drugs have both been reported to modulate monocyte functions. This study determined the effects of therapeutic concentrations of seven antimalarial drugs; amodiaquine, artemisinin, chloroquine, doxycycline, primaquine, pyrimethamine and quinine, on the phagocytosis of β-haematin (synthetic haemozoin) by two monocytic cell lines, J774A...
February 2019: Experimental Parasitology
https://read.qxmd.com/read/30376188/prophylactic-antibiotic-therapy-for-chronic-obstructive-pulmonary-disease-copd
#11
JOURNAL ARTICLE
Samantha C Herath, Rebecca Normansell, Samantha Maisey, Phillippa Poole
BACKGROUND: There has been renewal of interest in the use of prophylactic antibiotics to reduce the frequency of exacerbations and improve quality of life in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine whether or not regular (continuous, intermittent or pulsed) treatment of COPD patients with prophylactic antibiotics reduces exacerbations or affects quality of life. SEARCH METHODS: We searched the Cochrane Airways Group Trials Register and bibliographies of relevant studies...
October 30, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29360920/evita-a-double-blind-vehicle-controlled-randomized-phase-ii-trial-of-vitamin-k1-cream-as-prophylaxis-for-cetuximab-induced-skin-toxicity
#12
RANDOMIZED CONTROLLED TRIAL
R-D Hofheinz, S Lorenzen, J Trojan, J Ocvirk, T J Ettrich, S-E Al-Batran, H Schulz, N Homann, H-P Feustel, M Schatz, M Kripp, N Schulte, M Tetyusheva, S Heeger, S Vlassak, K Merx
Background: Acne-like skin rash is a frequently occurring adverse event associated with drugs against the epidermal growth factor receptor. This randomized vehicle-controlled study investigated the addition of vitamin K1 cream to doxycycline in patients with metastatic colorectal cancer treated with cetuximab. Patients and methods: Patients receiving first-line cetuximab + FOLFIRI were randomly assigned to prophylactic treatment with doxycylin and vitamin K1 cream or doxycycline and the vehicle...
April 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/29083100/mefloquine-for-preventing-malaria-during-travel-to-endemic-areas
#13
REVIEW
Maya Tickell-Painter, Nicola Maayan, Rachel Saunders, Cheryl Pace, David Sinclair
BACKGROUND: Mefloquine is one of four antimalarial agents commonly recommended for preventing malaria in travellers to malaria-endemic areas. Despite its high efficacy, there is controversy about its psychological side effects. OBJECTIVES: To summarize the efficacy and safety of mefloquine used as prophylaxis for malaria in travellers. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials (CENTRAL), published on the Cochrane Library; MEDLINE; Embase (OVID); TOXLINE (https://toxnet...
October 30, 2017: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/28942680/brain-targeted-oral-delivery-of-doxycycline-hydrochloride-encapsulated-tween-80-coated-chitosan-nanoparticles-against-ketamine-induced-psychosis-behavioral-biochemical-neurochemical-and-histological-alterations-in-mice
#14
JOURNAL ARTICLE
Monu Yadav, Milind Parle, Nidhi Sharma, Sameer Dhingra, Neha Raina, Deepak Kumar Jindal
To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 full factorial design was used to optimize the nanoparticulate formulation to minimize particle size and maximize entrapment efficiency, while independent variables chosen were concentration of chitosan and Tween 80...
November 2017: Drug Delivery
https://read.qxmd.com/read/28834334/enhanced-hepatic-functions-of-genetically-modified-mouse-hepatoma-cells-by-spheroid-culture-for-drug-toxicity-screening
#15
JOURNAL ARTICLE
Joyita Sarkar, Jyoti Kumari, Jane M Tonello, Masamichi Kamihira, Ashok Kumar
While hepatic cell lines are mainly used for in vitro drug induced toxicity studies, they exhibit limited functionalities. To overcome this, the authors have employed genetically engineered mouse hepatoma cells, Hepa/8F5, wherein expression of liver enriched transcription factors is induced by doxycycline leading to increased functionality. Further enhancement in functionality is achieved by spheroid culture in a previously developed 3D cell culture platform. Cells are seeded in presence of temperature-responsive poly(N-isopropylacrylamide) on poly(N-isopropylacrylamide--co-gelatin) cryogel scaffold based high throughput platform...
October 2017: Biotechnology Journal
https://read.qxmd.com/read/28373691/blocking-human-fear-memory-with-the-matrix-metalloproteinase-inhibitor-doxycycline
#16
RANDOMIZED CONTROLLED TRIAL
D R Bach, A Tzovara, J Vunder
Learning to predict threat is a fundamental ability of many biological organisms, and a laboratory model for anxiety disorders. Interfering with such memories in humans would be of high clinical relevance. On the basis of studies in cell cultures and slice preparations, it is hypothesised that synaptic remodelling required for threat learning involves the extracellular enzyme matrix metalloproteinase (MMP) 9. However, in vivo evidence for this proposal is lacking. Here we investigate human Pavlovian fear conditioning under the blood-brain barrier crossing MMP inhibitor doxycyline in a pre-registered, randomised, double-blind, placebo-controlled trial...
July 2018: Molecular Psychiatry
https://read.qxmd.com/read/28339766/higher-bioavailability-of-doxycycline-in-broiler-chickens-with-a-novel-in-feed-pharmaceutical-formulation
#17
JOURNAL ARTICLE
Lilia Gutiérrez, Juan Zermeño, Yazmín Alcalá, Héctor Sumano
Bioavailability of a new, long-acting (LA) pharmaceutical preparation for administering doxycycline as in-feed medication to broiler chickens was compared to the standard in-feed administration of doxycycline. A commercial poultry house harboring Ross-308 broiler chickens, weighing 450 g, was divided into 7 sections as follows: doxy-FOLA group (n = 6,000 chickens divided into 3 replicates) medicated with 10% doxycyline, long-acting pellets at a dose of 400 g of doxycycline HCl/ton of food, resulting in a calculated dose of 48 mg/kg for 5 d; doxy-ref group (n = 6,000, divided into 3 replicates) medicated as for doxy-FOLA, but using a 20% commercial preparation of doxycycline...
August 1, 2017: Poultry Science
https://read.qxmd.com/read/28052851/population-pharmacokinetic-model-of-doxycycline-plasma-concentrations-using-pooled-study-data
#18
JOURNAL ARTICLE
Ashley M Hopkins, Jessica Wojciechowski, Ahmad Y Abuhelwa, Stuart Mudge, Richard N Upton, David J R Foster
The literature presently lacks a population pharmacokinetic analysis of doxycycline. This study aimed to develop a population pharmacokinetic model of doxycycline plasma concentrations that could be used to assess the power of bioequivalence between Doryx delayed-release tablets and Doryx MPC. Doxycycline pharmacokinetic data were available from eight phase 1 clinical trials following single/multiple doses of conventional-release doxycycline capsules, Doryx delayed-release tablets, and Doryx MPC under fed and fasted conditions...
March 2017: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/27980856/effect-of-rpon-rpos-and-luxs-pathways-on-the-biofilm-formation-and-antibiotic-sensitivity-of-borrelia-burgdorferi
#19
JOURNAL ARTICLE
Eva Sapi, Priyanka A S Theophilus, Truc V Pham, Divya Burugu, David F Luecke
Borrelia burgdorferi , the causative agent of Lyme disease, is capable of forming biofilm in vivo and in vitro , a structure well known for its resistance to antimicrobial agents. For the formation of biofilm, signaling processes are required to communicate with the surrounding environment such as it was shown for the RpoN-RpoS alternative sigma factor and for the LuxS quorum-sensing pathways. Therefore, in this study, the wild-type B. burgdorferi and different mutant strains lacking RpoN, RpoS, and LuxS genes were studied for their growth characteristic and development of biofilm structures and markers as well as for their antibiotic sensitivity...
December 1, 2016: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/27909484/lyme-arrhythmia-in-an-avid-golfer-a-diagnostic-challenge-and-a-therapeutic-dilemma
#20
JOURNAL ARTICLE
Ujjwal Rastogi, Nidhi Kumars
Lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. Cardiac manifestations occur in about 5% of Lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. Occasionally, Lyme infection may also present with myopericarditis. Unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. We report the case of a 68 year-old male cardiologist who presented with new onset exertional dyspnea and palpitations...
February 2016: Journal of Atrial Fibrillation
keyword
keyword
119409
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.