Arya Kadukkattil Ramanunny, Sheetu Wadhwa, Sachin Kumar Singh, Bimlesh Kumar, Monica Gulati, Ankit Kumar, Saud Almawash, Ahmed Al Saqr, Kuppusamy Gowthamrajan, Kamal Dua, Harpreet Singh, Sukriti Vishwas, Rubiya Khursheed, Shaik Rahana Parveen, Aravindhanathan Venkatesan, Keshav R Paudel, Philip M Hansbro, Dinesh Kumar Chellappan
Non-aqueous nanoemulsion (NANE) of Alpinia galanga extract (AGE) was prepared using Palmester 3595 (MCT oil) as oil phase, Cremophor RH 40-Transcutol P® as surfactant-co-surfactant (Smix ), and glycerin as non-aqueous polar continuous phase. The composition was optimized by applying three-level, four factor Box-Behnken design (BBD). The mean droplet size and zeta potential of the optimized AGE NANE was found to be 60.81 ± 18.88 nm and -7.99 ± 4.14 mV, respectively. The ex vivo permeation studies of AGE NANE and AGE per se on porcine skin reported flux of 125...
June 4, 2022: International Journal of Pharmaceutics