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https://www.readbyqxmd.com/read/27914862/neurotensin-regulation-induces-overexpression-and-activation-of-egfr-in-hcc-and-restores-response-to-erlotinib-and-sorafenib
#1
Zherui Wu, Antoine Galmiche, Jin Liu, Nicolas Stadler, Dominique Wendum, Evelyne Segal-Bendirdjian, Valerie Paradis, Patricia Forgez
Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer due to the combination of late diagnosis and a lack of curative treatments. The identification of factors which promote tumor aggressiveness, and those that predict treatment responses, are a means to optimize the management of HCC patients. The complex of Neurotensin (NTS) and its high affinity receptor (NTSR1) has been shown to induce tumor growth and metastasis process in various cancers. In this paper, we propose that NTS and NTSR1 can assist in the management of HCC...
November 30, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27902570/preprotachykinin-a-ppta-is-expressed-by-a-distinct-population-of-excitatory-neurons-in-the-mouse-superficial-spinal-dorsal-horn-including-cells-that-respond-to-noxious-and-pruritic-stimuli
#2
Maria Gutierrez-Mecinas, Andrew M Bell, Alina Marin, Rebecca Taylor, Kieran A Boyle, Takahiro Furuta, Masahiko Watanabe, Erika Polgár, Andrew J Todd
The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. We recently defined three non-overlapping populations among the excitatory neurons, based on the expression of neurotensin, neurokinin B (NKB) and gastrin-releasing peptide (GRP). Here we identify and characterise another population: neurons that express the tachykinin peptide substance P...
November 25, 2016: Pain
https://www.readbyqxmd.com/read/27891817/preliminary-study-of-personality-traits-in-chinese-lung-cancer-patients-modification-by-neurotensin-receptor-1-polymorphisms
#3
Hui Ma, Zhengtu Cong, Hongyu Zhang, Jiangang Tao, Chao Yang, Zhijie Song
This study recruited 148 lung cancer patients and 157 healthy Chinese individuals to evaluate the personality traits of Chinese lung cancer patients using the Tridimensional Personality Questionnaire and to investigate the associations between these traits and the rs6090453C/G and rs6011914C/G polymorphisms of the neurotensin receptor 1 gene. The results demonstrated significant differences in the Tridimensional Personality Questionnaire total and subscale scores between the 2 groups. Significant differences were found in the reward dependence 2 (RD2) score between the rs6090453C/G genotypes and in the total harm avoidance (HA), HA1, HA2, HA4, and RD2 scores between the rs6011914C/G genotypes...
November 28, 2016: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/27844204/analysis-of-enteroendocrine-cell-populations-in-the-human-colon
#4
Patricia Martins, Josiane Fakhry, Enio Chaves de Oliveira, Billie Hunne, Linda J Fothergill, Mitchell Ringuet, Débora d'Ávila Reis, Jens F Rehfeld, Brid Callaghan, John B Furness
Recent studies have shown that patterns of colocalisation of hormones in enteroendocrine cells are more complex than previously appreciated and that the patterns differ substantially between species. In this study, the human sigmoid colon is investigated by immunohistochemistry for the presence of gastrointestinal hormones and their colocalisation. The segments of colon were distant from the pathology that led to colectomy and appeared structurally normal. Only four hormones, 5-hydroxytryptamine (5-HT), glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and somatostatin, were common in enteroendocrine cells of the human colon...
November 14, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27842797/nts2-selective-neurotensin-mimetics-with-tetrahydrofuran-amino-acids
#5
Nadja A Simeth, Manuel Bause, Michael Dobmeier, Ralf C Kling, Daniel Lachmann, Harald Hübner, Jürgen Einsiedel, Peter Gmeiner, Burkhard König
Stimulation of the NTS2 neurotensin receptor causes antipsychotic effects and leads to a promotion of the μ-opioid-independent antinociception, which is important in the modulation of tonic pain sensitivity. We report the synthesis and properties of a small library of peptidic agonists based on the active neurotensin fragment NT(8-13). Two tetrahydrofuran amino acid derivatives were synthesized to replace Tyr(11) in NT(8-13). Additionally, Arg(8), Arg(9), and Ile(12) of the lead peptide were exchanged by Lys, Lys, and Gly, respectively...
November 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27834811/focal-adhesion-kinase-dependent-role-of-the-soluble-form-of-neurotensin-receptor-3-sortilin-in-colorectal-cancer-cell-dissociation
#6
REVIEW
Sophie Béraud-Dufour, Chistelle Devader, Fabienne Massa, Morgane Roulot, Thierry Coppola, Jean Mazella
The aim of the present review is to unravel the mechanisms of action of the soluble form of the neurotensin (NT) receptor-3 (NTSR3), also called Sortilin, in numerous physiopathological processes including cancer development, cardiovascular diseases and depression. Sortilin/NTSR3 is a transmembrane protein thought to exert multiple functions both intracellularly and at the level of the plasma membrane. The Sortilin/NTSR3 extracellular domain is released by shedding from all the cells expressing the protein...
November 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27805786/neurotensin-conjugated-reduced-graphene-oxide-with-multi-stage-near-infrared-triggered-synergic-targeted-neuron-gene-transfection-in-vitro-and-in-vivo-for-neurodegenerative-disease-therapy
#7
Tsung-Ying Hsieh, Wei-Chen Huang, Yi-Da Kang, Chao-Yi Chu, Wen-Lin Liao, You-Yin Chen, San-Yuan Chen
Delivery efficiency with gene transfection is a pivotal point in achieving maximized therapeutic efficacy and has been an important challenge with central nervous system (CNS) diseases. In this study, neurotensin (NT, a neuro-specific peptide)-conjugated polyethylenimine (PEI)-modified reduced graphene oxide (rGO) nanoparticles with precisely controlled two-stage near-infrared (NIR)-laser photothermal treatment to enhance the ability to target neurons and achieve high gene transfection in neurons. First-stage NIR laser irradiation on the cells with nanoparticles attached on the surface can increase the permeability of the cell membrane, resulting in an apparent increase in cellular uptake compared to untreated cells...
November 2, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27803332/correction-for-patel-et-al-neurotensin-stimulates-sortilin-and-mtor-in-human-microglia-inhibitable-by-methoxyluteolin-a-potential-therapeutic-target-for-autism
#8
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27767183/molecular-characterization-of-thy1-expressing-fear-inhibiting-neurons-within-the-basolateral-amygdala
#9
Kenneth M McCullough, Dennis Choi, Jidong Guo, Kelsey Zimmerman, Jordan Walton, Donald G Rainnie, Kerry J Ressler
Molecular characterization of neuron populations, particularly those controlling threat responses, is essential for understanding the cellular basis of behaviour and identifying pharmacological agents acting selectively on fear-controlling circuitry. Here we demonstrate a comprehensive workflow for identification of pharmacologically tractable markers of behaviourally characterized cell populations. Thy1-eNpHR-, Thy1-Cre- and Thy1-eYFP-labelled neurons of the BLA consistently act as fear inhibiting or 'Fear-Off' neurons during behaviour...
October 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27765644/binge-like-intake-of-hfd-attenuates-alcohol-intake-in-rats
#10
Sunil Sirohi, Arriel Van Cleef, Jon F Davis
Binge eating and binge alcohol intake are behavioral manifestations of pathological feeding and alcohol use disorder (AUD), respectively. Binge-feeding and AUD have high comorbidity with other psychiatric disorders such as depression, which could have important implications for the management of these conditions. Importantly, these behaviors share many common features suggesting a singular etiology. However, the nature by which binge-feeding affects the development or maintenance of AUD is unclear. The present study examined the impact of a binge-feeding from a nutritionally complete high-fat diet (HFD) on initiation and maintenance of alcohol intake, anxiolytic behavior and central genetic changes in brain regions that control alcohol-reinforced behaviors...
October 17, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27666481/phosphatidylinositol-3-4-5-trisphosphate-binds-to-sortilin-and-competes-with-neurotensin-implications-for-very-low-density-lipoprotein-binding
#11
Robert P Sparks, Jermaine L Jenkins, Gregory E Miner, Yan Wang, Wayne C Guida, Charles E Sparks, Rutilio A Fratti, Janet D Sparks
Sortilin is a multi-ligand sorting receptor that interacts with B100-containing VLDL and LDL as well as other ligands including neurotensin (NT). The current study investigates the hypothesis that phosphatidylinositol (3,4,5)-trisphosphate (PIP3) generated downstream of insulin action can directly bind to sortilin. NT binds to sortilin at a well characterized site via its carboxy terminus (C-term). Using a crystal structure of human sortilin (hsortilin), PIP3 is predicted to bind at this C-term site. Binding of PIP3 to hsortilin is demonstrated using surface plasmon resonance (SPR) flowing PIP3 nanodiscs over immobilized hsortilin...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27663735/neurotensin-stimulates-sortilin-and-mtor-in-human-microglia-inhibitable-by-methoxyluteolin-a-potential-therapeutic-target-for-autism
#12
Arti B Patel, Irene Tsilioni, Susan E Leeman, Theoharis C Theoharides
We had reported elevated serum levels of the peptide neurotensin (NT) in children with autism spectrum disorders (ASD). Here, we show that NT stimulates primary human microglia, the resident immune cells of the brain, and the immortalized cell line of human microglia-SV40. NT (10 nM) increases the gene expression and release (P < 0.001) of the proinflammatory cytokine IL-1β and chemokine (C-X-C motif) ligand 8 (CXCL8), chemokine (C-C motif) ligand 2 (CCL2), and CCL5 from human microglia. NT also stimulates proliferation (P < 0...
September 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27661393/investigation-of-the-biological-impact-of-charge-distribution-on-a-ntr1-targeted-peptide
#13
Yinnong Jia, Wenting Zhang, Wei Fan, Susan Brusnahan, Jered Garrison
The neurotensin receptor 1 (NTR1) has been shown to be a promising target, due to its increased level of expression relative to normal tissue, for pancreatic and colon cancers. This has prompted the development of a variety of NTR1-targeted radiopharmaceuticals, based on the neurotensin (NT) peptide, for diagnostic and radiotherapeutic applications. A major obstacle for the clinical translation of NTR1-targeted radiotherapeutics would likely be nephrotoxicity due to the high levels of kidney retention. It is well-known that for many peptide-based agents, renal uptake is influenced by the overall molecular charge...
October 21, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27659107/regulation-of-therapeutic-hypothermia-on-inflammatory-cytokines-microglia-polarization-migration-and-functional-recovery-after-ischemic-stroke-in-mice
#14
Jin Hwan Lee, Zheng Z Wei, Wenyuan Cao, Soonmi Won, Xiaohuan Gu, Megan Winter, Thomas A Dix, Ling Wei, Shan Ping Yu
Stroke is a leading threat to human life and health in the US and around the globe, while very few effective treatments are available for stroke patients. Preclinical and clinical studies have shown that therapeutic hypothermia (TH) is a potential treatment for stroke. Using novel neurotensin receptor 1 (NTR1) agonists, we have demonstrated pharmacologically induced hypothermia and protective effects against brain damages after ischemic stroke, hemorrhage stroke, and traumatic brain injury (TBI) in rodent models...
December 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27643666/gut-hormone-gpcrs-structure-function-drug-discovery
#15
Arnau Cordomí, Daniel Fourmy, Irina G Tikhonova
Crystallization and determination of the high resolution three-dimensional structure of the β2-adrenergic receptor in 2007 was followed by structure elucidation of a number of other receptors, including those for neurotensin and glucagon. These major advances foster the understanding of structure-activity relationship of these receptors and structure-based rational design of new ligands having more predictable activity. At present, structure determination of gut hormone receptors in complex with their ligands (natural, synthetic) and interacting signalling proteins, for example, G-proteins, arrestins, represents a challenge which promises to revolutionize gut hormone endocrinonology...
September 16, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27643557/discovery-of-novel-antagonists-of-human-neurotensin-receptor-1-on-the-basis-of-ligand-and-protein-structure
#16
Guo Zhang, Kun Wang, Xiao-Dan Li, Dong-Ling Zhang, Feng Xu
Neurotensin receptor 1 (NTR1) is a cell surface receptor belonging to the G protein-coupled receptor (GPCR) A superfamily. NTR1 plays an important role in neuronal and non-neuronal systems. Using the previously identified crystal structure of rat NTR1 (rNTR1), we screened for potential candidates of human NTR1 (hNTR1) ligand. Approximately 10,000 compounds were selected using the docking score, followed by pharmacophore-based virtual screening and a two-dimensional (2D)-fingerprint structural similarity search...
September 16, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27614972/song-in-an-affiliative-context-relates-to-the-neural-expression-of-dopamine-and-neurotensin-related-genes-in-male-european-starlings
#17
Devin P Merullo, Caroline S Angyal, Sharon A Stevenson, Lauren V Riters
Some animals, including songbirds, vocalize at high rates when alone or in large groups. In songbirds, vocal behavior in these contexts is important for song learning and group cohesion. It is not obviously targeted at any particular individual and is described as 'undirected'. Studies suggest a role for dopamine (DA) in undirected song. The neuropeptide neurotensin (NT) can enhance dopaminergic signaling upon binding to the NT receptor 1 (NTR1) and is found in regions where DA can influence song, including the ventral tegmental area (VTA), septum, and the song control nucleus Area X...
2016: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/27612962/role-of-proneurotensin-as-marker-of-paediatric-coeliac-disease
#18
C Montén, Å Torinsson Naluai, D Agardh
Neurotensin (NT) is a gut hormone functioning proinflammatory through nuclear factor kappa B (NF-κB) and interleukin (IL)-8 secretion or anti-inflammatory through epidermal growth factor receptors. NT mRNA is down-regulated in duodenal biopsies of children with untreated coeliac disease. The aim of this study was to investigate if plasma pro-NT levels correlated with the degree of intestinal mucosal damage and tissue transglutaminase autoantibody (tTGA) levels in children with coeliac disease. Fasting plasma samples from 96 children with coeliac disease and 89 non-coeliac disease controls were analysed for NT precursor fragment pro-NT 1-117 by a chemiluminometric immunoassay...
December 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27611941/nts-ntr1-co-expression-enhances-epithelial-to-mesenchymal-transition-and-promotes-tumor-metastasis-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway-in-hepatocellular-carcinoma
#19
Yingnan Ye, Xinxin Long, Lijie Zhang, Jieying Chen, Pengpeng Liu, Hui Li, Feng Wei, Wenwen Yu, Xiubao Ren, Jinpu Yu
Neurotensin (NTS) is a neuropeptide distributed in central nervous and digestive systems. In this study, the significant association between ectopic NTS expression and tumor invasion was confirmed in hepatocellular carcinoma (HCC). In primary HCC tissues, the NTS and neurotensin receptor 1 (NTR1) co-expression (NTS+NTR1+) is a poor prognostic factor correlated with aggressive biological behaviors and poor clinical prognosis. Enhanced epithelial-to-mesenchymal transition (EMT) features, including decreased E-cadherin, increased β-catenin translocation and N-cadherin expression, were identified in NTS+NTR1+ HCC tissues...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27591418/quantification-of-peptides-using-n-terminal-isotope-coding-and-c-terminal-derivatization-for-sensitive-analysis-by-micro-liquid-chromatography-tandem-mass-spectrometry
#20
Yohei Sakaguchi, Tomoya Kinumi, Akiko Takatsu
Stable isotope-coding coupled with mass spectrometry is a popular method for quantitative proteomics and peptide quantification. However, the efficiency of the derivatization reaction at a particular functional group, especially in complex structures, can affect accuracy. Here, we present a dual functional-group derivatization of bioactive peptides followed by micro liquid chromatography-tandem mass spectrometry (LC-MS/MS). By separating the sensitivity-enhancement and isotope-coding derivatization reactions, suitable chemistries can be chosen...
September 3, 2016: Journal of Mass Spectrometry: JMS
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