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Dengue zika flavivirus virus

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https://www.readbyqxmd.com/read/28320169/probable-zika-virus-associated-guillain-barr%C3%A3-syndrome-challenges-with-clinico-laboratory-diagnosis
#1
Eliza Miller, Zoe Becker, Daniel Shalev, Christopher T Lee, Comana Cioroiu, Kiran Thakur
A 55year old woman in New York City presented in May 2016 with progressive weakness, ataxia, paresthesia, and areflexia, shortly after returning from the Dominican Republic. Lumbar puncture revealed cytoalbuminological dissociation. Due to her recent travel, Zika-associated Guillain Barré syndrome (GBS) was suspected and she underwent evaluation for recent flavivirus exposure. Zika virus RNA was not detected in serum, but Zika virus immunoglobulin M (IgM) was detected in both serum and cerebrospinal fluid...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28306183/flavivirus-cross-reactivity-in-serological-tests-and-guillain-barr%C3%A3-syndrome-in-a-hematopoietic-stem-cell-transplant-patient-a-case-report
#2
Sonia M Raboni, Carmem Bonfim, Bernardo M Almeida, Camila Zanluca, Andrea C Koishi, Paula R V P Rodrigues, Claudia K Kay, Lisandro L Ribeiro, Rosana H Scola, Claudia N Duarte Dos Santos
Serological diagnosis of flavivirus infection is a challenge, particularly in the context of a disease associated with immune response enhancement in a transplant patient, where aspects such as previous flavivirus infections may be involved with the outcome. We report a case of a pediatric patient who developed Guillain-Barré syndrome (GBS) after matched-unrelated hematopoietic stem cell transplantation (HSCT). The patient lives in a Brazilian region that is experiencing an epidemic of Zika virus (ZIKV) and dengue virus (DENV)...
March 17, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28288094/identification-of-zika-virus-epitopes-reveals-immunodominant-and-protective-roles-for-dengue-virus-cross-reactive-cd8-t-cells
#3
Jinsheng Wen, William Weihao Tang, Nicholas Sheets, Julia Ellison, Alessandro Sette, Kenneth Kim, Sujan Shresta
CD8(+) T cells play an important role in controlling Flavivirus infection, including Zika virus (ZIKV). Here, we have identified 25 HLA-B*0702-restricted epitopes and 1 HLA-A*0101-restricted epitope using interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) and intracellular cytokine staining (ICS) in ZIKV-infected IFN-α/β receptor-deficient HLA transgenic mice. The cross-reactivity of ZIKV epitopes to dengue virus (DENV) was tested using IFN-γ-ELISPOT and IFN-γ-ICS on CD8(+) T cells from DENV-infected mice, and five cross-reactive HLA-B*0702-binding peptides were identified by both assays...
March 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28278327/chorioretinal-lesions-presumed-secondary-to-zika-virus-infection-in-an-immunocompromised-adult
#4
Christopher R Henry, Luma Al-Attar, Alexis M Cruz-Chacón, Janet L Davis
Importance: Zika virus has spread rapidly throughout the Americas since 2015. The public health implications of Zika virus infection lend special importance to identifying the virus in unsuspected hosts. Objective: To describe relevant imaging studies and clinical features of chorioretinal lesions that are presumably associated with Zika virus and that share analogous features with chorioretinal lesions reported in cases of Dengue fever and West Nile virus. Design, Setting, and Participants: This is a case report from an academic referral center in Miami, Florida, of a woman in her 60s from Guaynabo, Puerto Rico, who presented with reduced visual acuity and bilateral diffuse, subretinal, confluent, placoid, and multifocal chorioretinal lesions...
March 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28273394/inhibition-of-type-i-interferon-induction-and-signalling-by-mosquito-borne-flaviviruses
#5
REVIEW
Stephanie L Cumberworth, Jordan J Clark, Alain Kohl, Claire L Donald
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity...
March 8, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28264033/dengue-virus-genomic-variation-associated-with-mosquito-adaptation-defines-the-pattern-of-viral-non-coding-rnas-and-fitness-in-human-cells
#6
Claudia V Filomatori, Juan M Carballeda, Sergio M Villordo, Sebastian Aguirre, Horacio M Pallarés, Ana M Maestre, Irma Sánchez-Vargas, Carol D Blair, Cintia Fabri, Maria A Morales, Ana Fernandez-Sesma, Andrea V Gamarnik
The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved a mechanism to differentially regulate the production of viral non-coding RNAs in mosquitos and humans, with a significant impact on viral fitness in each host. Flavivirus infections accumulate non-coding RNAs derived from the viral 3'UTRs (known as sfRNAs), relevant in viral pathogenesis and immune evasion...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28261172/the-complement-system-in-flavivirus-infections
#7
Jonas N Conde, Emiliana M Silva, Angela S Barbosa, Ronaldo Mohana-Borges
The incidence of flavivirus infections has increased dramatically in recent decades in tropical and sub-tropical climates worldwide, affecting hundreds of millions of people each year. The Flaviviridae family includes dengue, West Nile, Zika, Japanese encephalitis, and yellow fever viruses that are typically transmitted by mosquitoes or ticks, and cause a wide range of symptoms, such as fever, shock, meningitis, paralysis, birth defects, and death. The flavivirus genome is composed of a single positive-sense RNA molecule encoding a single viral polyprotein...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28254839/the-crystal-structure-of-zika-virus-ns5-reveals-conserved-drug-targets
#8
Wenqian Duan, Hao Song, Haiyuan Wang, Yan Chai, Chao Su, Jianxun Qi, Yi Shi, George F Gao
Zika virus (ZIKV) has emerged as major health concern, as ZIKV infection has been shown to be associated with microcephaly, severe neurological disease and possibly male sterility. As the largest protein component within the ZIKV replication complex, NS5 plays key roles in the life cycle and survival of the virus through its N-terminal methyltransferase (MTase) and C-terminal RNA-dependent RNA polymerase (RdRp) domains. Here, we present the crystal structures of ZIKV NS5 MTase in complex with an RNA cap analogue ((m7)GpppA) and the free NS5 RdRp...
March 2, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28243937/zika-virus-an-emerging-flavivirus
#9
REVIEW
Sang-Im Yun, Young-Min Lee
Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific Islands, then further afield to South and Central America and the Caribbean. Currently, ZIKV is actively circulating not only in much of Latin America and its neighbors but also in parts of the Pacific Islands and Southeast Asia...
March 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28229481/cross-reactivity-of-commercial-anti-dengue-immunoassays-in-patients-with-acute-zika-virus-infection
#10
Alvina Clara Felix, Nathalia C Santiago Souza, Walter M Figueiredo, Angela A Costa, Marta Inenami, Rosangela M G da Silva, José Eduardo Levi, Claudio Sergio Pannuti, Camila Malta Romano
Several countries have local transmission of multiple arboviruses, in particular, dengue and Zika viruses, which have recently spread through many American countries. Cross reactivity among Flaviviruses is high and present a challenge for accurate identification of the infecting agent. Thus, we evaluated the level of cross reactivity of anti-dengue IgM/G Enzyme-Linked Immunosorbent Assays (ELISA) from three manufacturers against 122 serum samples obtained at two time-points from 61 patients with non-dengue confirmed Zika virus infection...
February 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28228395/antibody-responses-to-zika-virus-infections-in-flavivirus-endemic-environments
#11
Sarah L Keasey, Christine L Pugh, Stig M R Jensen, Jessica L Smith, Robert D Hontz, Anna P Durbin, Dawn M Dudley, David H O'Connor, Robert G Ulrich
Zika virus (ZIKV) infections occur in areas where dengue (DENV), West Nile (WNV), yellow fever (YFV), and other viruses of the genus Flavivirus co-circulate. The envelope protein (E) of these closely related flaviviruses induces specific long-term immunity, yet subsequent infections are associated with cross-reactive antibody responses that may enhance disease susceptibility and severity. To gain a better understanding of ZIKV infections against a background of similar viral diseases, we examined serological immune responses to ZIKV, WNV, DENV and YFV infections of humans and non-human primates (NHP)...
February 22, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28207910/a-single-mutation-in-the-envelope-protein-modulates-flavivirus-antigenicity-stability-and-pathogenesis
#12
Leslie Goo, Laura A VanBlargan, Kimberly A Dowd, Michael S Diamond, Theodore C Pierson
The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F) of the West Nile virus (WNV) E protein domain I-II hinge that regulates virus breathing. The T198F mutation resulted in a ~70-fold increase in sensitivity to neutralization by a monoclonal antibody targeting a cryptic epitope in the fusion loop...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28198548/phylogenetic-characterization-of-circulating-dengue-and-alkhumra-hemorrhagic-fever-viruses-in-western-saudi-arabia-and-lack-of-evidence-of-zika-virus-in-the-region-a-retrospective-study-2010-2015
#13
Moneerah S Al-Saeed, Sherif A El-Kafrawy, Suha A Farraj, Tagreed L Al-Subhi, Norah A Othman, Arwa Alsultan, Huda G Ben Helaby, Mustafa M Alshawdari, Ahmed M Hassan, Remi N Charrel, Esam I Azhar, Anwar M Hashem
Flaviviruses represent a global public health concern. They consist of ∼70 viruses with almost half of them causing human diseases with unspecified febrile illnesses. Cities in western Saudi Arabia are endemic for viruses (DENV) with sporadic infections due to Alkhumra hemorrhagic fever virus (AHFV). They also represent a major destination for travelers coming for annual religious pilgrimages (Hajj and Umrah) from all over the world. However, whether other flaviviruses are circulating is not known because of the limited number of surveillance studies...
February 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28179396/the-antigenic-structure-of-zika-virus-and-its-relation-to-other-flaviviruses-implications-for-infection-and-immunoprophylaxis
#14
REVIEW
Franz X Heinz, Karin Stiasny
Zika virus was discovered ∼70 years ago in Uganda and maintained a low profile as a human disease agent in Africa and Asia. Only recently has it caused explosive outbreaks in previously unaffected regions, first in Oceania and then in the Americas since 2015. Of special concern is the newly identified link between congenital malformations (especially microcephaly) and Zika virus infections during pregnancy. At present, it is unclear whether Zika virus changed its pathogenicity or whether the huge number of infections allowed the recognition of a previously cryptic pathogenic property...
March 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28174309/understanding-zika-virus-stability-and-developing-a-chimeric-vaccine-through-functional-analysis
#15
Xuping Xie, Yujiao Yang, Antonio E Muruato, Jing Zou, Chao Shan, Bruno T D Nunes, Daniele B A Medeiros, Pedro F C Vasconcelos, Scott C Weaver, Shannan L Rossi, Pei-Yong Shi
Compared with other flaviviruses, Zika virus (ZIKV) is uniquely associated with congenital diseases in pregnant women. One recent study reported that (i) ZIKV has higher thermostability than dengue virus (DENV [a flavivirus closely related to ZIKV]), which might contribute to the disease outcome; (ii) the higher thermostability of ZIKV could arise from an extended loop structure in domain III of the viral envelope (E) protein and an extra hydrogen-bond interaction between E molecules (V. A. Kostyuchenko, E...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28167751/axl-dependent-infection-of-human-fetal-endothelial-cells-distinguishes-zika-virus-from-other-pathogenic-flaviviruses
#16
Audrey Stéphanie Richard, Byoung-Shik Shim, Young-Chan Kwon, Rong Zhang, Yuka Otsuka, Kimberly Schmitt, Fatma Berri, Michael S Diamond, Hyeryun Choe
Although a causal relationship between Zika virus (ZIKV) and microcephaly has been established, it remains unclear why ZIKV, but not other pathogenic flaviviruses, causes congenital defects. Here we show that when viruses are produced in mammalian cells, ZIKV, but not the closely related dengue virus (DENV) or West Nile virus (WNV), can efficiently infect key placental barrier cells that directly contact the fetal bloodstream. We show that AXL, a receptor tyrosine kinase, is the primary ZIKV entry cofactor on human umbilical vein endothelial cells (HUVECs), and that ZIKV uses AXL with much greater efficiency than does DENV or WNV...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28152048/zika-virus-antagonizes-type-i-interferon-responses-during-infection-of-human-dendritic-cells
#17
James R Bowen, Kendra M Quicke, Mohan S Maddur, Justin T O'Neal, Circe E McDonald, Nadia B Fedorova, Vinita Puri, Reed S Shabman, Bali Pulendran, Mehul S Suthar
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that is causally linked to severe neonatal birth defects, including microcephaly, and is associated with Guillain-Barre syndrome in adults. Dendritic cells (DCs) are an important cell type during infection by multiple mosquito-borne flaviviruses, including dengue virus, West Nile virus, Japanese encephalitis virus, and yellow fever virus. Despite this, the interplay between ZIKV and DCs remains poorly defined. Here, we found human DCs supported productive infection by a contemporary Puerto Rican isolate with considerable variability in viral replication, but not viral binding, between DCs from different donors...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28151637/interaction-of-zika-virus-envelope-protein-with-glycosaminoglycans
#18
So Young Kim, Jing Zhao, Xinyue Liu, Keith Fraser, Lei Lin, Xing Zhang, Fuming Zhang, Jonathan S Dordick, Robert J Linhardt
In February 2016, the World Health Organization declared a Public Health Emergency of International Concern on Zika Virus (ZIKV), due to its association with severe fetal anomalies of congenitally infected humans. This has led to urgent efforts by academic, federal, and industry research groups to better understand pathogenesis of ZIKV and to developing detection methods, therapeutic strategies and vaccines. Although we still do not have the entire picture of the pathogenesis of ZIKV, extensive research has been conducted on related pathogenic flaviviruses (i...
February 2, 2017: Biochemistry
https://www.readbyqxmd.com/read/28148804/a-microrna-screen-identifies-the-wnt-signaling-pathway-as-a-regulator-of-the-interferon-response-during-flavivirus-infection
#19
Jessica L Smith, Sophia Jeng, Shannon K McWeeney, Alec J Hirsch
The impact of mosquito-borne flavivirus infections worldwide is significant, and many critical aspects of these viruses' biology, including virus-host interactions, host cell requirements for replication, and how virus-host interactions impact pathology, remain to be fully understood. The recent re-emergence and spread of flaviviruses, including dengue virus (DENV), West Nile virus (WNV), and Zika virus (ZIKV), highlights the importance of performing basic research on this important group of pathogens. MicroRNAs (miRNAs) are small, noncoding RNAs that modulate gene expression post-transcriptionally and have been demonstrated to regulate a broad range of cellular processes...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28126366/testing-for-zika-virus-infection-in-pregnancy-key-concepts-to-deal-with-an-emerging-epidemic
#20
REVIEW
Catherine Eppes, Martha Rac, James Dunn, James Versalovic, Kristy O Murray, Melissa A Suter, Magda Sanz Cortes, Jimmy Espinoza, Maxim D Seferovic, Wesley Lee, Peter Hotez, Joan Mastrobattista, Steven L Clark, Michael A Belfort, Kjersti M Aagaard
Zika virus is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Following epidemics in Micronesia and French Polynesia during the past decade, more recent Zika virus infection outbreaks were first reported in South America as early as May 2013 and spread to now 50 countries throughout the Americas. Although no other flavivirus has previously been known to cause major fetal malformations following perinatal infection, reports of a causal link between Zika virus and microcephaly, brain and ocular malformations, and fetal loss emerged from hard-hit regions of Brazil by October 2015...
March 2017: American Journal of Obstetrics and Gynecology
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