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Dengue zika flavivirus virus

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https://www.readbyqxmd.com/read/29666784/the-immune-responses-of-the-animal-hosts-of-west-nile-virus-a-comparison-of-insects-birds-and-mammals
#1
REVIEW
Laura R H Ahlers, Alan G Goodman
Vector-borne diseases, including arboviruses, pose a serious threat to public health worldwide. Arboviruses of the flavivirus genus, such as Zika virus (ZIKV), dengue virus, yellow fever virus (YFV), and West Nile virus (WNV), are transmitted to humans from insect vectors and can cause serious disease. In 2017, over 2,000 reported cases of WNV virus infection occurred in the United States, with two-thirds of cases classified as neuroinvasive. WNV transmission cycles through two different animal populations: birds and mosquitoes...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29652486/biochemistry-and-molecular-biology-of-flaviviruses
#2
Nicholas J Barrows, Rafael K Campos, Kuo-Chieh Liao, K Reddisiva Prasanth, Ruben Soto-Acosta, Shih-Chia Yeh, Geraldine Schott-Lerner, Julien Pompon, October M Sessions, Shelton S Bradrick, Mariano A Garcia-Blanco
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Most of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move, their geographic reach is increasing. Flaviviruses are simple RNA-protein machines that carry out protein synthesis, genome replication, and virion packaging in close association with cellular lipid membranes...
April 13, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29618505/incorporation-of-igg-depletion-in-a-neutralization-assay-facilitates-differential-diagnosis-of-zika-and-dengue-in-secondary-flavivirus-infection-cases
#3
Amanda E Calvert, Karen L Boroughs, Janeen Laven, Janae L Stovall, Betty E Luy, Olga I Kosoy, Claire Y-H Huang
Zika virus (ZIKV) has emerged as a major global public health concern due to its link as a causative agent of human birth defects. Serological laboratory diagnosis of suspected ZIKV specimens collected a week or more after symptom onset primarily relies on detection of anti-ZIKV specific IgM antibodies by ELISA coupled with detection of ZIKV-specific neutralizing antibody by neutralization tests. A definitive diagnosis based on serology assays is possible during primary ZIKV infections; however, due to cross-reactivity of antibodies elicited during flaviviral infections a definitive diagnosis is not always possible, especially among individuals who have been previously exposed to closely related flaviviruses such as dengue virus (DENV)...
April 4, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29618091/longitudinal-analysis-of-antibody-cross-neutralization-following-zika-and-dengue-virus-infection-in-asia-and-the-americas
#4
Magelda Montoya, Matthew Collins, Wanwisa Dejnirattisai, Leah C Katzelnick, Henry Puerta-Guardo, Ramesh Jadi, Samuel Schildhauer, Piyada Supasa, Sirijitt Vasanawathana, Prida Malasit, Juthathip Mongkolsapaya, Aruna D de Silva, Hasitha Tissera, Angel Balmaseda, Gavin Screaton, Aravinda M de Silva, Eva Harris
Background: The four dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies and plasma from DENV-immune donors can neutralize or enhance ZIKV in vitro and in small animal models, and vice versa, the extent, duration, and significance of cross-reactivity remains unknown, particularly in flavivirus-endemic regions. Methods: We studied neutralizing antibodies to ZIKV and DENV1-4 in longitudinal serologic specimens through 3 years post-infection from people in Latin America and Asia with laboratory-confirmed DENV infections...
April 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29610346/flavivirus-internalization-is-regulated-by-a-size-dependent-endocytic-pathway
#5
Brent A Hackett, Sara Cherry
Flaviviruses enter host cells through the process of clathrin-mediated endocytosis, and the spectrum of host factors required for this process are incompletely understood. Here we found that lymphocyte antigen 6 locus E (LY6E) promotes the internalization of multiple flaviviruses, including West Nile virus, Zika virus, and dengue virus. Perhaps surprisingly, LY6E is dispensable for the internalization of the endogenous cargo transferrin, which is also dependent on clathrin-mediated endocytosis for uptake. Since viruses are substantially larger than transferrin, we reasoned that LY6E may be required for uptake of larger cargoes and tested this using transferrin-coated beads of similar size as flaviviruses...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29590614/oral-antibiotic-treatment-of-mice-exacerbates-the-disease-severity-of-multiple-flavivirus-infections
#6
Larissa B Thackray, Scott A Handley, Matthew J Gorman, Subhajit Poddar, Prachi Bagadia, Carlos G Briseño, Derek J Theisen, Qing Tan, Barry L Hykes, Hueylie Lin, Tiffany M Lucas, Chandni Desai, Jeffrey I Gordon, Kenneth M Murphy, Herbert W Virgin, Michael S Diamond
Although the outcome of flavivirus infection can vary from asymptomatic to lethal, environmental factors modulating disease severity are poorly defined. Here, we observed increased susceptibility of mice to severe West Nile (WNV), Dengue, and Zika virus infections after treatment with oral antibiotics (Abx) that depleted the gut microbiota. Abx treatment impaired the development of optimal T cell responses, with decreased levels of WNV-specific CD8+ T cells associated with increased infection and immunopathology...
March 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29583121/a-quinoline-compound-inhibits-the-replication-of-dengue-virus-serotypes-1-4-in-vero-cells
#7
Hemalatha Beesetti, Poornima Tyagi, Brahmam Medapi, Vagolu Siva Krishna, Dharmarajan Sriram, Navin Khanna, Sathyamangalam Swaminathan
BACKGROUND: The global occurrence of dengue, a mosquito-borne viral disease caused by four distinct dengue viruses (DENV-1, -2, -3 and -4), is reported to have increased ~30-fold in the last fifty years, causing ~400 million infections a year. A limited use, sub-optimal live attenuated dengue vaccine has become available recently. It is becoming apparent that antibodies to DENVs can promote infection by Zika virus (ZIKV), a related mosquito-borne flavivirus. A drug to treat these flaviviral infections continues to be an unmet public health need...
March 27, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29560461/development-of-single-step-rt-pcr-for-detection-of-kyasanur-forest-disease-virus-from-clinical-samples
#8
Gouri Chaubal, Prasad Sarkale, Pravin Kore, Pragya Yadav
Background: Kyasanur Forest Disease (KFD), a tick borne flavivirus, which was earlier endemic to Karnataka state, India, has been confirmed and detected from neighboring states of Tamil Nadu, Maharashtra, Goa and Kerala states in India. Increased human and vector surveillance therefore becomes essential for the identification of KFD affected regions and control of further spread of the disease. Currently, available KFD detection assays include realtime RT-PCR and nested RT-PCR assays...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29555345/rapid-response-to-an-emerging-infectious-disease-lessons-learned-from-development-of-a-synthetic-dna-vaccine-targeting-zika-virus
#9
Sagar B Kudchodkar, Hyeree Choi, Emma L Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N Maslow, Charles C Reed, Scott White, J Joseph Kim, Gary P Kobinger, Pablo Tebas, David B Weiner, Kar Muthumani
Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective vaccines against infectious pathogens such as influenza, HIV, dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging. Zika virus is a mosquito-vectored flavivirus responsible for periodic outbreaks of disease in Africa, Southeast Asia, and the Pacific Islands dating back over 50 years...
March 16, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29543803/development-and-evaluation-of-a-novel-high-throughput-image-based-fluorescent-neutralization-test-for-detection-of-zika-virus-infection
#10
Andrea Cristine Koishi, Andréia Akemi Suzukawa, Camila Zanluca, Daria Elena Camacho, Guillermo Comach, Claudia Nunes Duarte Dos Santos
Zika virus (ZIKV) is an emerging arbovirus belonging to the genus flavivirus that comprises other important public health viruses, such as dengue (DENV) and yellow fever (YFV). In general, ZIKV infection is a self-limiting disease, however cases of Guillain-Barré syndrome and congenital brain abnormalities in newborn infants have been reported. Diagnosing ZIKV infection remains a challenge, as viral RNA detection is only applicable until a few days after the onset of symptoms. After that, serological tests must be applied, and, as expected, high cross-reactivity between ZIKV and other flavivirus serology is observed...
March 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29536828/zika-virus-epidemiology-from-uganda-to-world-pandemic-an-update
#11
C Talero-Gutiérrez, A Rivera-Molina, C Pérez-Pavajeau, I Ossa-Ospina, C Santos-García, M C Rojas-Anaya, A de-la-Torre
Zika virus (ZIKV) infection is an emergent worldwide public health problem. Historically, 84 countries have reported vector-borne ZIKV transmission, 61 of which report on-going transmission. It is a Flavivirus transmitted through arthropods belonging to the Aedes genus. Since 2015, ZIKV infections have increased dramatically; with 1.3 million people infected during 2015 in Brazil alone. This paper's objective is to highlight the conjectural epidemiological points of the virus' dissemination. The digital archives Pubmed, MEDLINE, EMBASE and Cochrane were searched for papers that assessed aspects of ZIKV transmission and epidemiology...
March 14, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29527300/the-immunology-of-zika-virus
#12
REVIEW
Abigail Culshaw, Juthathip Mongkolsapaya, Gavin Screaton
Zika virus (ZIKV) was initially thought to cause only mild, self-limiting symptoms. However, recent outbreaks have been associated with the autoimmune disease Guillain-Barré syndrome and causally linked to a congenital malformation known as microcephaly. This has led to an urgent need for a safe and effective vaccine. A comprehensive understanding of the immunology of ZIKV infection is required to aid in the design of such a vaccine. Whilst details of both innate and adaptive immune responses to ZIKV are emerging, further research is needed...
2018: F1000Research
https://www.readbyqxmd.com/read/29513820/improved-reverse-transcription-polymerase-chain-reaction-assay-for-the-detection-of-flaviviruses-with-semi-nested-primers-for-discrimination-between-dengue-virus-serotypes-and-zika-virus
#13
Allan Rd Nunes, Brenda Elen B Alves, Hannaly Wb Pereira, Yasmin M Nascimento, Ingryd C Morais, José Veríssimo Fernandes, Josélio Mg Araújo, Daniel Cf Lanza
BACKGROUND The genus Flavivirus includes a variety of medically important viruses, including dengue virus (DENV) and Zika virus (ZIKV), which are most prevalent in Brazil. Because the clinical profile of patients affected by different DENV serotypes or ZIKV may be similar, the development of new methods that facilitate a rapid and accurate diagnosis is crucial. OBJECTIVES The current study aimed to develop an improved reverse transcription-polymerase chain reaction (RT-PCR) protocol for universal detection of flaviviruses by using semi-nested primers that discriminate between DENV serotypes and ZIKV...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29511459/neutralizing-antibodies-against-flaviviruses-babanki-virus-and-rift-valley-fever-virus-in-ugandan-bats
#14
Rebekah C Kading, Robert M Kityo, Eric C Mossel, Erin M Borland, Teddie Nakayiki, Betty Nalikka, Luke Nyakarahuka, Jeremy P Ledermann, Nicholas A Panella, Amy T Gilbert, Mary B Crabtree, Julian Kerbis Peterhans, Jonathan S Towner, Brian R Amman, Tara K Sealy, Stuart T Nichol, Ann M Powers, Julius J Lutwama, Barry R Miller
Introduction: A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role of bats in arbovirus maintenance is poorly understood. The aim of this study was to investigate the exposure history of Ugandan bats to a panel of arboviruses. Materials and methods: Insectivorous and fruit bats were captured from multiple locations throughout Uganda during 2009 and 2011-2013. All serum samples were tested for neutralizing antibodies against West Nile virus (WNV), yellow fever virus (YFV), dengue 2 virus (DENV-2), Zika virus (ZIKV), Babanki virus (BBKV), and Rift Valley fever virus (RVFV) by plaque reduction neutralization test (PRNT)...
2018: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/29511073/diagnosis-of-zika-virus-infection-by-peptide-array-and-enzyme-linked-immunosorbent-assay
#15
Nischay Mishra, Adrian Caciula, Adam Price, Riddhi Thakkar, James Ng, Lokendra V Chauhan, Komal Jain, Xiaoyu Che, Diego A Espinosa, Magelda Montoya Cruz, Angel Balmaseda, Eric H Sullivan, Jigar J Patel, Richard G Jarman, Jennifer L Rakeman, Christina T Egan, Chantal B E M Reusken, Marion P G Koopmans, Eva Harris, Rafal Tokarz, Thomas Briese, W Ian Lipkin
Zika virus (ZIKV) is implicated in fetal stillbirth, microcephaly, intracranial calcifications, and ocular anomalies following vertical transmission from infected mothers. In adults, infection may trigger autoimmune inflammatory polyneuropathy. Transmission most commonly follows the bite of infected Aedes mosquitoes but may also occur through sexual intercourse or receipt of blood products. Definitive diagnosis through detection of viral RNA is possible in serum or plasma within 10 days of disease onset, in whole blood within 3 weeks of onset, and in semen for up to 3 months...
March 6, 2018: MBio
https://www.readbyqxmd.com/read/29490880/a-plant-produced-vaccine-protects-mice-against-lethal-west-nile-virus-infection-without-enhancing-zika-or-dengue-virus-infectivity
#16
Huafang Lai, Amber M Paul, Haiyan Sun, Junyun He, Ming Yang, Fengwei Bai, Qiang Chen
West Nile virus (WNV) has caused multiple global outbreaks with increased frequency of neuroinvasive disease in recent years. Despite many years of research, there are no licensed therapeutics or vaccines available for human use. One of the major impediments of vaccine development against WNV is the potential enhancement of infection by related flaviviruses in vaccinated subjects through the mechanism of antibody-dependent enhancement of infection (ADE). For instance, the recent finding of enhancement of Zika virus (ZIKV) infection by pre-exposure to WNV further complicates the development of WNV vaccines...
February 26, 2018: Vaccine
https://www.readbyqxmd.com/read/29473907/pharmacological-inhibition-of-protein-kinase-c-reduces-west-nile-virus-replication
#17
Ana B Blázquez, Ángela Vázquez-Calvo, Miguel A Martín-Acebes, Juan-Carlos Saiz
Flaviviruses are relevant animal and human pathogens that include West Nile virus (WNV), Japanese encephalitis virus, dengue virus, or Zika virus, among others. Currently, no licensed therapy is available to fight flaviviral infections. Protein kinases C (PKCs) constitute a family of multifunctional lipid-dependent isoenzymes that regulate a wide variety of cellular processes (apoptosis, differentiation, proliferation, cellular transformation, motility, adhesion, etc.) being currently considered at the front line of drug development for the treatment of diverse human disorders...
February 23, 2018: Viruses
https://www.readbyqxmd.com/read/29470500/glutathionylation-of-dengue-and-zika-ns5-proteins-affects-guanylyltransferase-and-rna-dependent-rna-polymerase-activities
#18
Chonticha Saisawang, Atichat Kuadkitkan, Prasert Auewarakul, Duncan R Smith, Albert J Ketterman
It has been estimated for dengue infection that the global population at risk is 3.5 billion people, which makes dengue an important public health problem. The causative agents of dengue are dengue viruses. For dengue virus replication, the dengue virus NS5 protein is of special importance as it has several enzyme activities important for viral replication. Previous reports of phosphorylation and SUMOylation of dengue NS5 have shown these protein modifications have important consequences for NS5 functions. In this report we identify glutathionylation, another reversible post translation modification that impacts on NS5 enzyme activity...
2018: PloS One
https://www.readbyqxmd.com/read/29466521/prolonged-zika-virus-viremia-in-a-patient-with-guillain-barr%C3%A3-syndrome-in-trinidad-and-tobago
#19
Gabriel Gonzalez-Escobar, Anne Marie Valadere, Rosmond Adams, Karen Polson-Edwards, Avery Q J Hinds, Akenath Misir, C James Hospedales
An emerging mosquito-borne flavivirus, Zika virus (ZIKV) is a significant public health concern because of the syndromes associated with the infection. In addition, ZIKV is considered a major problem due to large-scale spread of the disease and the possible clinical complications for the central nervous system, especially Guillain-Barré syndrome (GBS) and microcephaly. Since the introduction of ZIKV in the Caribbean, molecular detection of the viral RNA has been utilized as a more specific and sensitive approach to demonstrating acute infection...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/29454707/crystal-structure-of-the-capsid-protein-from-zika-virus
#20
Zifang Shang, Hao Song, Yi Shi, Jianxun Qi, George F Gao
Recently, Zika virus (ZIKV) emerged as a global public health concern, and is distinct from other flaviviruses in many aspects, e.g., causing transplacental infection, fetal abnormalities and vector-independent transmission through body fluids in humans. The capsid (C) protein is a multifunctional protein, since it binds to viral RNA in the process of nucleocapsid assembly and plays important roles in virus infection processes by interacting with cellular proteins, modulating cellular metabolism, apoptosis and immune response...
February 15, 2018: Journal of Molecular Biology
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