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Dengue zika flavivirus virus

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https://www.readbyqxmd.com/read/29020226/innate-t-and-b-cell-responses-in-acute-human-zika-patients
#1
Lilin Lai, Nadine Rouphael, Yongxian Xu, Muktha S Natrajan, Allison Beck, Mari Hart, Matthew Feldhammer, Amanda Feldpausch, Charles Hill, Henry Wu, Jessica K Fairley, Pamela Lankford-Turner, Nicole Kasher, Patrick Rago, Yi-Juan Hu, Srilatha Edupuganti, Shital M Patel, Kristy O Murray, Mark J Mulligan
Background: There is an urgent need for studies of viral persistence and immunity during human Zika infections to inform planning and conduct of vaccine clinical trials. Methods: In five returned US travelers with acute symptomatic Zika infection, clinical features, viral RNA levels, and immune responses were characterized. Results: Two pregnant, flavivirus-experienced patients had viral RNA persist in plasma for >44 and >26 days. Three days after symptom onset transient increases in pro-inflammatory monocytes began followed at five days by transient decreases in myeloid dendritic cells...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28972551/sophoraflavenone-g-restricts-dengue-and-zika-virus-infection-via-rna-polymerase-interference
#2
Alexandre Sze, David Olagnier, Samar Bel Hadj, Xiaoying Han, Xiao Hong Tian, Hong-Tao Xu, Long Yang, Qingwen Shi, Penghua Wang, Mark A Wainberg, Jian Hui Wu, Rongtuan Lin
Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition...
October 3, 2017: Viruses
https://www.readbyqxmd.com/read/28968905/yellow-fever-virus-but-not-zika-or-dengue-virus-inhibits-t-cell-receptor-mediated-t-cell-function-by-an-rna-based-mechanism
#3
James H McLinden, Nirjal Bhattarai, Jack T Stapleton, Qing Chang, Thomas M Kaufman, Suzanne L Cassel, Fayyaz S Sutterwala, Hillel Haim, Jon Houtman, Jinhua Xiang
The Flavivirus genus within the Flaviviridae is comprised of many important human pathogens including Yellow Fever virus (YFV), Dengue virus (DENV) and Zika virus (ZKV), all of which are global public health concerns. Although the related flaviviruses hepatitis C virus and human pegivirus (formerly named GBV-C) interfere with T cell receptor (TCR) signaling by novel RNA and protein based mechanisms, the effect of other flaviviruses on TCR signaling is unknown. Here, we studied the effect of YFV, DENV, and ZKV on TCR signaling...
September 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968863/replication-of-zika-virus-in-human-prostate-cells-a-potential-source-of-sexually-transmitted-virus
#4
Jennifer L Spencer, Anismrita Lahon, Linda L Tran, Ravi P Arya, Alexander R Kneubehl, Megan B Vogt, Daniela Xavier, David R Rowley, Jason T Kimata, Rebecca R Rico-Hesse
Background: While Zika virus (ZIKV) is mainly transmitted by mosquitoes, numerous cases of sexual transmission have been reported during recent outbreaks. Little is known about which host cell types or entry factors aid in mediating this sexual transmission. Methods: In this study, we investigated ZIKV cell tropism by infecting two types of human prostate cells with three contemporary ZIKV isolates from persons infected in the Americas. We utilized qRT-PCR and immunofluorescence to measure infection and flow cytometry to detect entry factor expression...
August 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968838/cd-loop-extension-in-zika-virus-envelope-protein-key-for-stability-and-pathogenesis
#5
Emily N Gallichotte, Kenneth H Dinnon, Xin-Ni Lim, Thiam-Seng Ng, Elisa X Y Lim, Vineet D Menachery, Shee-Mei Lok, Ralph S Baric
With severe disease manifestations including microcephaly, congenital malformation, and Guillain-Barré syndrome, Zika virus (ZIKV) remains a persistent global public health threat. Despite antigenic similarities with dengue viruses, structural studies have suggested the extended CD-loop and hydrogen-bonding interaction network within the ZIKV envelope protein contribute to stability differences between the viral families. This enhanced stability may lead to the augmented infection, disease manifestation, and persistence in body fluids seen following ZIKV infection...
September 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28959858/-progress-in-zika-virus-and-its-vaccines
#6
Deqiao Tian, Wei Chen
Like Yellow fever virus, Dengue virus, Japanese encephalitis virus and West Nile virus, Zika virus is also a mosquito-borne flavivirus. Since it was isolated in 1947, there has been little concern over Zika virus due to its limited distribution and mild symptoms. In recent years, especially since 2015, Zika virus has become a global concern because of its outbreak in Brazil and associated microcephaly. Vaccines against Zika virus, regarded as the effective measures to control Zika fever epidemic, are being developed in nearly thirty institutions worldwide...
January 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28959246/recent-perspectives-on-genome-transmission-clinical-manifestation-diagnosis-therapeutic-strategies-vaccine-developments-and-challenges-of-zika-virus-research
#7
REVIEW
Apoorva Shankar, Amulya A Patil, Sinosh Skariyachan
One of the potential threats to public health microbiology in 21st century is the increased mortality rate caused by Zika virus (ZIKV), a mosquito-borne flavivirus. The severity of ZIKV infection urged World Health Organization (WHO) to declare this virus as a global concern. The limited knowledge on the structure, virulent factors, and replication mechanism of the virus posed as hindrance for vaccine development. Several vector and non-vector-borne mode of transmission are observed for spreading the disease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28956764/envelope-modified-tetravalent-dengue-virus-like-particle-vaccine-implication-for-flavivirus-vaccine-design
#8
Akane Urakami, Mya Myat Ngwe Tun, Meng Ling Moi, Atsuko Sakurai, Momoko Ishikawa, Sachiko Kuno, Ryuji Ueno, Kouichi Morita, Wataru Akahata
Dengue viruses (DENV) infect 50-100 million people each year. The spread of DENV-associated infections is one of the most serious public health problems worldwide, as there is no widely available vaccine or specific therapeutic for DENV infections. To address this, we developed a novel tetravalent dengue vaccine utilizing virus-like particle (VLP) technology. We created recombinant DENV1-4 VLPs by co-expressing precursor membrane (prM) and envelope (E) proteins, with a F108A mutation in the fusion loop structure of E to increase the production of VLPs in mammalian cells...
September 27, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28954927/rapid-antigen-tests-for-dengue-virus-serotypes-and-zika-virus-in-patient-serum
#9
Irene Bosch, Helena de Puig, Megan Hiley, Marc Carré-Camps, Federico Perdomo-Celis, Carlos F Narváez, Doris M Salgado, Dewahar Senthoor, Madeline O'Grady, Elizabeth Phillips, Ann Durbin, Diana Fandos, Hikaru Miyazaki, Chun-Wan Yen, Margarita Gélvez-Ramírez, Rajas V Warke, Lucas S Ribeiro, Mauro M Teixeira, Roque P Almeida, José E Muñóz-Medina, Juan E Ludert, Mauricio L Nogueira, Tatiana E Colombo, Ana C B Terzian, Patricia T Bozza, Andrea S Calheiros, Yasmine R Vieira, Giselle Barbosa-Lima, Alexandre Vizzoni, José Cerbino-Neto, Fernando A Bozza, Thiago M L Souza, Monique R O Trugilho, Ana M B de Filippis, Patricia C de Sequeira, Ernesto T A Marques, Tereza Magalhaes, Francisco J Díaz, Berta N Restrepo, Katerine Marín, Salim Mattar, Daniel Olson, Edwin J Asturias, Mark Lucera, Mohit Singla, Guruprasad R Medigeshi, Norma de Bosch, Justina Tam, Jose Gómez-Márquez, Charles Clavet, Luis Villar, Kimberly Hamad-Schifferli, Lee Gehrke
The recent Zika virus (ZIKV) outbreak demonstrates that cost-effective clinical diagnostics are urgently needed to detect and distinguish viral infections to improve patient care. Unlike dengue virus (DENV), ZIKV infections during pregnancy correlate with severe birth defects, including microcephaly and neurological disorders. Because ZIKV and DENV are related flaviviruses, their homologous proteins and nucleic acids can cause cross-reactions and false-positive results in molecular, antigenic, and serologic diagnostics...
September 27, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28934431/genetic-profiling-and-comorbidities-of-zika-infection
#10
Mohammad Ali Moni, Pietro Lio'
Background: The difficulty in distinguishing infection by Zika virus (ZIKV) from other flaviviruses is a global health concern, particularly given the high risk of neurologic complications (including Guillain-Barré syndrome [GBS]) with ZIKV infection. Methods: We developed quantitative frameworks to compare and explore infectome, diseasome, and comorbidity of ZIKV infections. We analyzed gene expression microarray and RNA-Seq data from ZIKV, West Nile fever (WNF), chikungunya, dengue, yellow fever, Japanese encephalitis virus, GBS, and control datasets...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28932235/zika-virus-congenital-syndrome-experimental-models-and-clinical-aspects
#11
REVIEW
Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui, Jean Pierre Schatzmann Peron
Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28916719/kir2ds2-recognizes-conserved-peptides-derived-from-viral-helicases-in-the-context-of-hla-c
#12
Mohammed M Naiyer, Sorcha A Cassidy, Andrea Magri, Vanessa Cowton, Kevin Chen, Salah Mansour, Hariklia Kranidioti, Berenice Mbirbindi, Pauline Rettman, Scott Harris, Liam J Fanning, Arend Mulder, Franz H J Claas, Andrew D Davidson, Arvind H Patel, Marco A Purbhoo, Salim I Khakoo
Killer cell immunoglobulin-like receptors (KIRs) are rapidly evolving species-specific natural killer (NK) cell receptors associated with protection against multiple different human viral infections. We report that the activating receptor KIR2DS2 directly recognizes viral peptides derived from conserved regions of flaviviral superfamily 2 RNA helicases in the context of major histocompatibility complex class I. We started by documenting that peptide LNPSVAATL from the hepatitis C virus (HCV) helicase binds HLA-C*0102, leading to NK cell activation through engagement of KIR2DS2...
September 15, 2017: Science Immunology
https://www.readbyqxmd.com/read/28916391/zika-virus-structural-biology-and-progress-in-vaccine-development
#13
REVIEW
Hsiao-Han Lin, Bak-Sau Yip, Li-Min Huang, Suh-Chin Wu
The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal microcephaly in newborns in Brazil have raised alarms in many countries regarding the threat to pregnant women. Instances of microcephaly and central nervous system malformations continue to increase in ZIKV outbreak regions. ZIKV is a small enveloped positive-strand RNA virus belonging to the Flavivirus genus of the Flaviviridae family. High-resolution ZIKV structures recently identified by cryo-electron microscopy indicate that the overall ZIKV structure is similar to those of other flaviviruses...
September 12, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28878076/zika-virus-infects-human-sertoli-cells-and-modulates-the-integrity-of-the-in-vitro-blood-testis-barrier-model
#14
David N Siemann, Daniel P Strange, Payal N Maharaj, Pei-Yong Shi, Saguna Verma
Confirmed reports of ZIKV in human seminal fluid for months after the clearance of viremia suggest the ability of ZIKV to establish persistent infection in the seminiferous tubules, an immune privileged site in the testis protected by the blood-testis barrier, also called the Sertoli cell barrier (SCB). However, cellular targets of ZIKV in human testis and mechanisms by which the virus enters seminiferous tubules remain unclear. We demonstrate that primary human SCs were highly susceptible to ZIKV as compared to the closely related dengue virus and induced expression of IFN-α, key cytokines and cell-adhesion molecules (VCAM-1 and ICAM-1)...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28877637/ghost-probiotics-with-a-combined-regimen-a-novel-therapeutic-approach-against-the-zika-virus-an-emerging-world-threat
#15
Vivek K Bajpai, Vishal Chandra, Na-Hyung Kim, Rajni Rai, Pradeep Kumar, Kangmin Kim, Abhinav Aeron, Sun Chul Kang, D K Maheshwari, MinKyun Na, Irfan A Rather, Yong-Ha Park
The Zika virus (ZIKV) used to be an obscure flavivirus closely related to dengue virus (DENV). Transmission of this epidemic pathogen occurs mainly via mosquitoes, but it is also capable of placental and sexual transmission. Although the characteristics of these viruses are well defined, infections are unpredictable in terms of disease severity, unusual clinical manifestations, unexpected methods of transmission, long-term persistence, and the development of new strains. Recently, ZIKV has gained huge medical attention following the large-scale epidemics around the world, and reported cases of congenital abnormalities associated with Zika virus infections which have created a public health emergency of international concern...
September 7, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28869941/identifying-attenuating-mutations-tools-for-a-new-vaccine-design-against-flaviviruses
#16
Cécile Khou, Nathalie Pardigon
Emerging Flaviviruses pose an increasing threat to global human health. To date, human vaccines against yellow fever virus (YFV), Japanese encephalitis virus (JEV), dengue virus (DV), and tick-borne encephalitis virus (TBEV) exist. However, there is no human vaccine against other Flaviviruses such as Zika virus (ZIKV) and West Nile virus (WNV). In order to restrict their spread and to protect populations against the diseases they induce, vaccines against these emerging viruses must be designed. Obtaining new live attenuated Flavivirus vaccines using molecular biology methods is now possible...
2017: Intervirology
https://www.readbyqxmd.com/read/28852878/compensating-for-cross-reactions-using-avidity-and-computation-in-a-suspension-multiplex-immunoassay-for-serotyping-of-zika-versus-other-flavivirus-infections
#17
Bengt Rönnberg, Åke Gustafsson, Olli Vapalahti, Petra Emmerich, Åke Lundkvist, Jonas Schmidt-Chanasit, Jonas Blomberg
The recent spread of Zika virus (ZIKV) in the Americas and Asia necessitates an increased preparedness for improved maternal and perinatal health and blood safety. However, serological cross-reactions, especially to Dengue virus (DENV), complicate ZIKV antibody serodiagnosis. A novel "pan-Flavi" suspension multiplex immunoassay (PFSMIA) using 25 antigens, whole virus (WV), non-structural protein 1 (NS1), and envelope (E) proteins, from 7 zoonotic flaviviruses for specific detection of ZIKV and DENV IgM and IgG was developed...
August 29, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28835931/t-cell-responses-in-individuals-infected-with-zika-virus-and-in-those-vaccinated-against-dengue-virus
#18
Dominic Paquin-Proulx, Fabio E Leal, Cassia G Terrassani Silveira, Alvino Maestri, Claudia Brockmeyer, Shannon M Kitchen, Vinicius D Cabido, Esper G Kallas, Douglas F Nixon
BACKGROUND: The outbreak of Zika virus (ZIKV) infection in Brazil has raised concerns that infection during pregnancy could cause microcephaly and other severe neurodevelopmental malformations in the fetus. The mechanisms by which ZIKV causes fetal abnormalities are largely unknown. The importance of pre-infection with dengue virus (DENV), or other flaviviruses endemic to Brazil, remains to be investigated. It has been reported that antibodies directed against DENV can increase ZIKV infectivity by antibody dependent enhancement (ADE), suggesting that a history of prior DENV infection might worsen the outcome of ZIKV infection...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28815931/organization-of-the-flavivirus-rna-replicase-complex
#19
REVIEW
Carolin Brand, Martin Bisaillon, Brian J Geiss
Flaviviruses, such as dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses, are serious human pathogens that cause significant morbidity and mortality globally each year. Flaviviruses are single-stranded, positive-sense RNA viruses, and encode two multidomain proteins, NS3 and NS5, that possess all enzymatic activities required for genome replication and capping. NS3 and NS5 interact within virus-induced replication compartments to form the RNA genome replicase complex. Although the individual enzymatic activities of both proteins have been extensively studied and are well characterized, there are still gaps in our understanding of how they interact to efficiently coordinate their respective activities during positive-strand RNA synthesis and capping...
August 16, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28798738/zika-virus-an-emerging-worldwide-threat
#20
Irfan A Rather, Jameel B Lone, Vivek K Bajpai, Woon K Paek, Jeongheui Lim
ZIKA virus (ZIKV) poses a severe threat to the world. Recent outbreaks of ZIKV after 2007 along with its quick transmission have made this virus a matter of international concern. The virus shows symptoms that are similar to those caused in the wake of dengue virus (DENV) and other flaviviruses, which makes it difficult to discern the viral infection. Diagnosis is further complicated as the virus cross-reacts with antibodies of other viruses. Currently, molecular diagnosis of the virus is being performed by RT-PCR and IgM-captured enzyme-linked immunosorbent assay (MAC-ELISA)...
2017: Frontiers in Microbiology
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