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https://www.readbyqxmd.com/read/29774520/implantation-of-bioresorbable-scaffolds-under-guidance-of-optical-coherence-tomography-feasibility-and-pilot-clinical-results-of-a-systematic-protocol
#1
Juan Luis Gutiérrez-Chico, Carlos Cortés, Michele Schincariol, Ula Limon, Meric Yalcinli, María-Alexandra Durán-Cortés, Milosz Jaguszewski
BACKGROUND: We hypothesise that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) might improve expansion and apposition, thus translating into better clinical outcomes, particularly reducing thrombotic events. METHODS: Patients considered suitable for BRS therapy in de novo coronary lesions underwent OCT. The predominant type of plaque was classified as lipidic, fibrous or calcific, undergoing tailored plaque preparation accordingly...
May 18, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29758000/degree-of-freedom-strengthened-cascade-array-for-dod-doa-estimation-in-mimo-array-systems
#2
Bobin Yao, Zhi Dong, Weile Zhang, Wei Wang, Qisheng Wu
In spatial spectrum estimation, difference co-array can provide extra degrees-of-freedom (DOFs) for promoting parameter identifiability and parameter estimation accuracy. For the sake of acquiring as more DOFs as possible with a given number of physical sensors, we herein design a novel sensor array geometry named cascade array. This structure is generated by systematically connecting a uniform linear array (ULA) and a non-uniform linear array, and can provide more DOFs than some exist array structures but less than the upper-bound indicated by minimum redundant array (MRA)...
May 14, 2018: Sensors
https://www.readbyqxmd.com/read/29749910/a-novel-low-cost-reusable-high-fidelity-neurosurgical-training-simulator-for-cerebrovascular-bypass-surgery
#3
Ulas Cikla, Balkan Sahin, Sahin Hanalioglu, Azam S Ahmed, David Niemann, Mustafa K Baskaya
OBJECTIVE Cerebrovascular bypass surgery is a challenging yet important neurosurgical procedure that is performed to restore circulation in the treatment of carotid occlusive diseases, giant/complex aneurysms, and skull base tumors. It requires advanced microsurgical skills and dedicated training in microsurgical techniques. Most available training tools, however, either lack the realism of the actual bypass surgery (e.g., artificial vessel, chicken wing models) or require special facilities and regulations (e...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29749326/pancreatic-stump-closure-using-only-stapler-is-associated-with-high-postoperative-fistula-rate-after-minimal-invasive-surgery
#4
Adem Yüksel, Erdal Birol Bostancı, Muhammet Kadri Çolakoğlu, Murat Ulaş, İlter Özer, Kerem Karaman, Musa Akoğlu
BACKGROUND/AIMS: Postoperative pancreatic fistula (POPF) is the most common cause of morbidity and mortality after distal pancreatectomy (DP). The aim of the present study is to determine the risk factors that can lead to POPF. MATERIALS AND METHODS: The study was conducted between January 2008 and December 2012. A total of 96 patients who underwent DP were retrospectively analyzed. RESULTS: Overall, 24 patients (25%) underwent laparoscopic distal pancreatectomy (LDP) and 72 patients (75%) open surgery...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29733805/il-17a-mcp-1-ccr-2-and-abca1-polymorphisms-in-children-with-non-alcoholic-fatty-liver-disease
#5
Ulas Emre Akbulut, Hamdi Cihan Emeksiz, Senol Citli, Hamdi Cihan Emeksiz, Hatice Ayca Ata Korkmaz, Gaye Baki
OBJECTIVE: The prevalence of non-alcoholic fatty liver disease in children has risen significantly, owing to the worldwide childhood obesity epidemic in the last two decades. Non-alcoholic fatty liver disease is closely linked to sedentary lifestyle, increased body mass index, and visceral adiposity. In addition, individual genetic variations also have a role in the development and progression of non-alcoholic fatty liver disease. The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease...
May 4, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29726737/delayed-diagnosis-of-a-case-of-zenker-s-diverticulum-what-may-happen-when-a-family-physician-does-not-visit-his-family-physician
#6
Zekeriya Akturk, Ali Bilal Ulas, Atila Eroglu
INTRODUCTION: Zenker's diverticulum is a diverticulum of the mucosa of the pharynx, just above the cricopharyngeal muscle. It occurs commonly in elderly patients (over 70 years) and the typical symptoms include dysphagia, regurgitation, chronic cough, aspiration and weight loss. CASE: We are reporting dysphagia in a 49-years old man who was treated as having Helicobacter Pylori gastritis for three years. Being a family physician himself, the patient applied to specialists in gastroenterology, bypassing primary care...
December 2018: European Journal of General Practice
https://www.readbyqxmd.com/read/29709611/the-effects-of-acute-foot-shock-stress-on-empathy-levels-in-rats
#7
Aslı Karakilic, Servet Kizildag, Sevim Kandis, Guven Guvendi, Basar Koc, Gamze B Camsari, Ulas M Camsari, Mehmet Ates, Sevil Gonenc Arda, Nazan Uysal
Empathy defined as the ability to understand and the share the feelings, thoughts, and attitudes of another, is an important skill in survival and reproduction. Among many factors that affect empathy include psychological stress, anxiety states. The aim of this study was to investigate the impact of acute psychological stress on empathic behavior and its association with oxytocin and vasopressin levels in amygdala and prefrontal cortex. Rats were subjected to 0.2 mA (low) and 1.6 mA (high) intensity of foot shock stress for duration of 20 minutes...
April 27, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29693218/preventing-wernicke-encephalopathy-after-bariatric-surgery
#8
REVIEW
Erik Oudman, Jan W Wijnia, Mirjam van Dam, Laser Ulas Biter, Albert Postma
Half a million bariatric procedures are performed annually worldwide. Our aim was to review the signs and symptoms of Wernicke's encephalopathy (WE) after bariatric surgery. We included 118 WE cases. Descriptions involved gastric bypass (52%), but also newer procedures like the gastric sleeve. Bariatric WE patients were younger (median = 33 years) than those in a recent meta-analysis of medical procedures (mean = 39.5 years), and often presented with vomiting (87.3%), ataxia (84.7%), altered mental status (76...
April 24, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29679349/timeline-bioavailability-of-magnesium-compounds-in-hours-which-magnesium-compound-works-best
#9
Nazan Uysal, Servet Kizildag, Zeynep Yuce, Guven Guvendi, Sevim Kandis, Basar Koc, Aslı Karakilic, Ulas M Camsari, Mehmet Ates
Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues...
April 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29678729/statins-reduce-testicular-and-ocular-vegf-a-potential-compromise-to-microcirculation
#10
Nuran Ekerbiçer, Tugba Gurpinar, Ali Riza Sisman, Guven Guvendi, Ulas M Camsari, Nazan Uysal
Microcirculation has great importance in eye and testicular tissue and is necessary to have adequate and appropriate amount of angiogenesis. It is known that high levels of Vascular Endothelial Growth Factor (VEGF) trigger uncontrolled angiogenesis, whereas inadequate VEGF can lead to decreased tissue perfusion and oxygenation. The aim of this study was to investigate effects of VEGF in testicular and ocular tissues in both non-diabetic and diabetic rats treated by statin. Atorvastatin (10 mg/kg daily given by orally gavage) was administered for two weeks...
April 17, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29677003/identification-of-a-novel-tcf4-isoform-in-the-human-corneal-endothelium
#11
Allen O Eghrari, Shivakumar Vasanth, Briana C Gapsis, Henry Bison, Ula Jurkunas, S Amer Riazuddin, John D Gottsch
PURPOSE: Alternative splice isoforms of TCF4, a gene implicated in Fuchs corneal dystrophy, have been identified in multiple human tissues outside of the eye. The aim of this study was to identify the transcriptional profile of TCF4 in the corneal endothelium. METHODS: We extracted RNA from the donor corneal endothelium and performed rapid amplification of cDNA ends. We tested the expression pattern of 1 newly identified isoform (7b) in a panel of cDNA derived from multiple human tissues and included cDNA from corneal endothelial (CE) and retinal pigment epithelial cell lines...
April 19, 2018: Cornea
https://www.readbyqxmd.com/read/29659737/feeding-related-gut-microbial-composition-associates-with-peripheral-t-cell-activation-and-mucosal-gene-expression-in-african-infants
#12
Lianna F Wood, Bryan P Brown, Katie Lennard, Ulas Karaoz, Enock Havyarimana, Jo-Ann S Passmore, Anneke C Hesseling, Paul T Edlefsen, Louise Kuhn, Nicola Mulder, Eoin L Brodie, Donald L Sodora, Heather B Jaspan
Background: Exclusive breastfeeding reduces the rate of postnatal HIV transmission compared to non-exclusive breastfeeding, however the mechanisms of this protection are unknown. Our study was designed to interrogate the mechanisms underlying the protective effect of exclusive breastfeeding (EBF). Methods: A prospective, longitudinal study of infants from a high HIV prevalence, low-income setting in South Africa. We evaluated the role of any non-breastmilk feeds excluding prescribed medicines...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29657611/gastric-cancer-with-situs-inversus-totalis-does-it-really-create-difficulties-for-surgeons
#13
Ebubekir Gündeş, Durmuş Ali Çetin, Ulaş Aday, Hüseyin Çiyiltepe, Emre Bozdağ, Aziz Serkan Senger, Selçuk Gülmez, Kamuran Cumhur Değer, Orhan Uzun, Erdal Polat
Introduction: Situs inversus totalis (SIT) is a very rare condition that is seen at a rate of one in about 6000-8000 births. Aim: To offer a general view on the coexistence of SIT and gastric cancer, accompanied by a literature review. Material and methods: Within the scope of this study, the case of a patient with gastric adenocarcinoma and SIT has been presented. Previous research on gastric cancer cases with SIT was reviewed through a comprehensive search of the PubMed, Medline, and Google Scholar databases...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29653252/inactivation-of-ceramide-synthase-2-catalytic-activity-in-mice-affects-transcription-of-genes-involved-in-lipid-metabolism-and-cell-division
#14
Andreas Bickert, Paul Kern, Martina van Uelft, Stefanie Herresthal, Thomas Ulas, Katharina Gutbrod, Bernadette Breiden, Joachim Degen, Konrad Sandhoff, Joachim L Schultze, Peter Dörmann, Dieter Hartmann, Reinhard Bauer, Klaus Willecke
The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level. We show here by qRT-PCR and transcriptome analyses that several transcripts of genes involved in lipid metabolism and cell division are differentially regulated in livers of CerS2 H/A mice. Thus, very long chain ceramides produced by CerS2 are required for transcriptional regulation of target genes...
April 10, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29643512/innate-immune-memory-in-the-brain-shapes-neurological-disease-hallmarks
#15
Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani, Michael Gertig, Thomas Ulas, Gaurav Jain, Jessica Wagner, Lisa M Häsler, Katleen Wild, Angelos Skodras, Thomas Blank, Ori Staszewski, Moumita Datta, Tonatiuh Pena Centeno, Vincenzo Capece, Md Rezaul Islam, Cemil Kerimoglu, Matthias Staufenbiel, Joachim L Schultze, Marc Beyer, Marco Prinz, Mathias Jucker, André Fischer, Jonas J Neher
Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months...
April 11, 2018: Nature
https://www.readbyqxmd.com/read/29627687/joint-solution-for-pet-image-segmentation-denoising-and-partial-volume-correction
#16
Ziyue Xu, Mingchen Gao, Georgios Z Papadakis, Brian Luna, Sanjay Jain, Daniel J Mollura, Ulas Bagci
Segmentation, denoising, and partial volume correction (PVC) are three major processes in the quantification of uptake regions in post-reconstruction PET images. These problems are conventionally addressed by independent steps. In this study, we hypothesize that these three processes are dependent; therefore, jointly solving them can provide optimal support for quantification of the PET images. To achieve this, we utilize interactions among these processes when designing solutions for each challenge. We also demonstrate that segmentation can help in denoising and PVC by locally constraining the smoothness and correction criteria...
March 28, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29623248/holistic-classification-of-ct-attenuation-patterns-for-interstitial-lung-diseases-via-deep-convolutional-neural-networks
#17
Mingchen Gao, Ulas Bagci, Le Lu, Aaron Wu, Mario Buty, Hoo-Chang Shin, Holger Roth, Georgios Z Papadakis, Adrien Depeursinge, Ronald M Summers, Ziyue Xu, Daniel J Mollura
Interstitial lung diseases (ILD) involve several abnormal imaging patterns observed in computed tomography (CT) images. Accurate classification of these patterns plays a significant role in precise clinical decision making of the extent and nature of the diseases. Therefore, it is important for developing automated pulmonary computer-aided detection systems. Conventionally, this task relies on experts' manual identification of regions of interest (ROIs) as a prerequisite to diagnose potential diseases. This protocol is time consuming and inhibits fully automatic assessment...
2018: Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization
https://www.readbyqxmd.com/read/29620729/lens-regeneration-in-children
#18
Demetrios G Vavvas, Thaddeus P Dryja, M Edward Wilson, Timothy W Olsen, Ankoor Shah, Ula Jurkunas, Roberto Pineda, Vasiliki Poulaki, Sotiria Palioura, Peter Veldman, Javier Moreno-Montañés, Maria D Pinazo-Duran, José Carlos Pastor, Miltiadis Tsilimbaris, Douglas Rhee, Kathryn Colby, David G Hunter, Solon Thanos, Taiji Sakamoto, Louis R Pasquale, Joan W Miller, Deborah VanderVeen, Scott R Lambert
No abstract text is available yet for this article.
April 4, 2018: Nature
https://www.readbyqxmd.com/read/29609087/the-tonsillouvular-fissure-approach-access-to-dorsal-and-lateral-aspects-of-the-fourth-ventricle
#19
Ilhan Aydin, Sahin Hanalioglu, Halil Olgun Peker, Yahya Turan, Hakan Kina, Ulas Cikla, Mustafa K Baskaya
OBJECTIVE: Although approaches to the fourth ventricle (FV) have been studied well, approaches to the lesions located in the dorsal and lateral aspects of the FV have not been demonstrated in anatomical or clinical studies. The aim of present study is to demonstrate the tonsillouvular fissure approach (TUFA) in anatomical dissections and its utilization in surgical series for the first time in the literature. METHODS: For anatomical studies, four formalin-fixed human cadaveric heads infused with colored silicone and ten cerebellar specimens were dissected in a stepwise manner...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29565644/deep-learning-beyond-cats-and-dogs-recent-advances-in-diagnosing-breast-cancer-with-deep-neural-networks
#20
Jeremy R Burt, Neslisah Torosdagli, Naji Khosravan, Harish RaviPrakash, Aliasghar Mortazi, Fiona Tissavirasingham, Sarfaraz Hussein, Ulas Bagci
Deep Learning has demonstrated tremendous revolutionary changes in the computing industry and its effects in radiology and imaging sciences have begun to dramatically change screening paradigms. Specifically, these advances have influenced the development of computer aided detection and diagnosis (CAD) systems. These technologies have long been thought of as "second-opinion" tools for radiologists and clinicians. However, with significant improvements in deep neural networks, the diagnostic capabilities of learning algorithms are approaching levels of human expertise (radiologists, clinicians, etc...
March 22, 2018: British Journal of Radiology
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