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https://www.readbyqxmd.com/read/29155512/efficacy-and-safety-of-cetuximab-plus-folfox-in-second-line-and-third-line-therapy-in-metastatic-colorectal-cancer
#1
Ersin Ozaslan, Ulas Serkan Topaloglu, Mevlude Inanc, Umut Gokmen Erdem, Hacer Demir, Erkan Arpaci, Mehmet Metin Seker, Mustafa Karaagac, Melih Kiziltepe, Baki Eker, Metin Ozkan
PURPOSE: To evaluate the efficacy and adverse events with cetuximab plus FOLFOX administered as second- and third-line therapy in metastatic colorectal cancer (mCRC) patients. METHODS: IPatients were administered cetuximab plus FOLFOX as second- and third-line therapy from January 2010 through October 2015. mCRC patients with wild type KRAS were alsï given irinïtecan and/ïr ïxaliplatin cïmbined with fluorïpyrimidine±bevacizumab. Tumor respïnse and survival were evaluated using RECIST and Kaplan-Meier methïd respectively...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29141520/a-simple-suture-guiding-device-for-minimally-invasive-achilles-tendon-repair
#2
Sinan Obut, Alper Gultekin, Meric Unal, Ulaş Serarslan, Ümit Tuhanioğlu
BACKGROUND: Our hypothesis is to utilize a simple suture-guiding device for minimally invasive repair of Achilles tendon without any extra cost with a minimal risk of rerupture. The purpose of this study is to investigate the results of our minimally invasive technique for Achilles tendon repair using a simple ovarian clamp for suture guiding. MATERIALS AND METHODS: Twenty patients with acute Achilles tendon rupture were treated with minimally invasive repair by an expert orthopaedic surgeon...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29140992/transcriptome-profile-of-lung-dendritic-cells-after-in-vitro-porcine-reproductive-and-respiratory-syndrome-virus-prrsv-infection
#3
Maren Julia Pröll, Christiane Neuhoff, Karl Schellander, Muhammad Jasim Uddin, Mehmet Ulas Cinar, Sudeep Sahadevan, Xueqi Qu, Md Aminul Islam, Mikhael Poirier, Marcel A Müller, Christian Drosten, Dawit Tesfaye, Ernst Tholen, Christine Große-Brinkhaus
The porcine reproductive and respiratory syndrome (PRRS) is an infectious disease that leads to high financial and production losses in the global swine industry. The pathogenesis of this disease is dependent on a multitude of factors, and its control remains problematic. The immune system generally defends against infectious diseases, especially dendritic cells (DCs), which play a crucial role in the activation of the immune response after viral infections. However, the understanding of the immune response and the genetic impact on the immune response to PRRS virus (PRRSV) remains incomplete...
2017: PloS One
https://www.readbyqxmd.com/read/29138489/a-dual-channel-endoscope-for-quantitative-imaging-monitoring-and-triggering-of-doxorubicin-release-from-liposomes-in-living-mice
#4
Jeremy Kress, Daniel J Rohrbach, Kevin A Carter, Dandan Luo, Chien Poon, Semra Aygun-Sunar, Shuai Shao, Shashikant Lele, Jonathan F Lovell, Ulas Sunar
Doxorubicin (Dox) is approved for use in liposomal form for the treatment of ovarian cancer. We previously developed a long-circulating Dox formulation in liposomes containing small amounts of porphyrin-phospholipid, which enables on-demand drug release with near-infrared irradiation. In this study, we present and evaluate a dual-modal, dual-channel light endoscope that allows quantitative reflectance and fluorescence imaging for monitoring of local Dox concentrations in target areas. The endoscope consists of two flexible imaging fibers; one to transmit diagnostic and therapeutic light to the target, and the other to detect fluorescent and reflected light...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138307/microdiversity-of-an-abundant-terrestrial-bacterium-encompasses-extensive-variation-in-ecologically-relevant-traits
#5
Alexander B Chase, Ulas Karaoz, Eoin L Brodie, Zulema Gomez-Lunar, Adam C Martiny, Jennifer B H Martiny
Much genetic diversity within a bacterial community is likely obscured by microdiversity within operational taxonomic units (OTUs) defined by 16S rRNA gene sequences. However, it is unclear how variation within this microdiversity influences ecologically relevant traits. Here, we employ a multifaceted approach to investigate microdiversity within the dominant leaf litter bacterium, Curtobacterium, which comprises 7.8% of the bacterial community at a grassland site undergoing global change manipulations. We use cultured bacterial isolates to interpret metagenomic data, collected in situ over 2 years, together with lab-based physiological assays to determine the extent of trait variation within this abundant OTU...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29123587/local-recurrence-of-sporadic-mesenteric-fibromatosis-following-radical-surgery-attacking-the-proximal-jejunum
#6
Selçuk Gülmez, Ebubekir Gündeş, Aziz Serkan Senger, Orhan Uzun, Ulaş Aday, Hüseyin Çiyiltepe, Durmuş Ali Çetin, Emre Bozdağ, Kamuran Cumhur Değer, Erdal Polat
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29123586/long-term-evolution-of-squamous-cell-cancer-in-plummer-vinson-syndrome
#7
Ulaş Aday, Ebubekir Gündeş, Durmuş Ali Çetin, Hüseyin Çiyiltepe, Kayhan Başak, Mustafa Duman
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29123585/cause-of-mortality-in-aortoesophageal-fistula-oesophageal-sepsis-a-case-report
#8
Ulaş Aday, Durmuş Ali Çetin, Hüseyin Çiyiltepe, Ebubekir Gündeş, Emre Bozdağ, Aziz Serkan Senger
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29122732/overcoming-end-to-end-vessel-mismatch-during-sta-radial-artery-m2-interposition-grafting-for-cerebral-ischemia-the-tapering-technique
#9
Ulaş Cıkla, Debraj Mukherjee, Mustafa K Başkaya
No abstract text is available yet for this article.
November 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29121822/investigation-of-efficacy-of-treatment-in-spinal-cord-injury-erythropoietin-versus-methylprednisolone
#10
Okan Ozkunt, Kerim Sariyilmaz, Halil Can Gemalmaz, Seren Gülsen Gürgen, Ulaş Yener, Fatih Dikici
BACKGROUND: Investigation of the expression of platelet-derived growth factor (PDGF)-β and glial fibrillary acidic protein (GFAP) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (EPO) and methylprednisolone (MP). METHODS: Thirty adult female rats were randomly divided into three even groups. A laminectomy was applied to thoracic ninth vertebra and contusion injury was induced by extradural application of an aneurysm clip...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29115650/spontaneous-rectus-sheath-hematoma-in-cardiac-in-patients-a-single-center-experience
#11
Ebubekir Gündeş, Durmuş Ali Çetin, Ulaş Aday, Hüseyin Çiyiltepe, Kamuran Cumhur Değer, Orhan Uzun, Aziz Serkan Senger, Erdal Polat, Mustafa Duman
BACKGROUND: This study presents the relationship between mortality and spontaneous rectus sheath hematoma (RSH) in inpatients receiving anticoagulant and antiaggregant treatment for cardiac pathology at cardiology and cardiovascular surgery clinics. METHODS: Within the scope of our study, the cases of 27 patients who were diagnosed with spontaneous RSH between January 2010 and December 2015 at Kartal Kosuyolu High Speciality Training and Research Hospital were retrospectively evaluated...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29103414/using-music-to-reduce-anxiety-among-older-adults-in-the-emergency-department-a-randomized-pilot-study
#12
Laura Belland, Laura Rivera-Reyes, Ula Hwang
BACKGROUND: An emergency department (ED) visit may be distressing and anxiety-provoking for older adults (age > 65 years). No studies have specifically evaluated the effect of music listening on anxiety in older adults in the ED. OBJECTIVE: The objective of this pilot study was to evaluate the effect of music listening on anxiety levels in older ED patients. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This was a randomized pilot study in the geriatric ED of an urban academic tertiary medical center...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29082502/the-generation-of-three-dimensional-head-and-neck-cancer-models-for-drug-discovery-in-384-well-ultra-low-attachment-microplates
#13
David A Close, Daniel P Camarco, Feng Shan, Stanton J Kochanek, Paul A Johnston
The poor success rate of cancer drug discovery has prompted efforts to develop more physiologically relevant cellular models for early preclinical cancer lead discovery assays. For solid tumors, this would dictate the implementation of three-dimensional (3D) tumor models that more accurately recapitulate human solid tumor architecture and biology. A number of anchorage-dependent and anchorage-independent in vitro 3D cancer models have been developed together with homogeneous assay methods and high content imaging approaches to assess tumor spheroid morphology, growth, and viability...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29062448/arm-reduced-robotic-assisted-laparoscopic-hysterectomy-with-transvaginal-cuff-closure
#14
Serkan Bodur, Murat Dede, Ulas Fidan, Burcin F Firatligil, Mustafa Ulubay, Mustafa Ozturk, Mufit C Yenen
INTRODUCTION: The use of robotics for benign etiology in gynecology has not proven to be more beneficial when compared to traditional laparoscopy. The major concern regarding robotic hysterectomy stems from its high cost. AIM: To evaluate the clinical utility and effectiveness of one-arm reduced robotic-assisted laparoscopic hysterectomy as a cost-effective surgical option for total robotic hysterectomy. MATERIAL AND METHODS: A sample population of 54 women who underwent robotic-assisted laparoscopic surgery for benign gynecologic indications was evaluated, and two groups were identified: (1) the two-armed robotic-assisted laparoscopic surgery group (n = 38 patients), and (2) the three-armed robotic-assisted laparoscopic surgery group (n = 16 patients)...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29057191/small-town-america-s-despair-infected-substance-users-needing-outpatient-parenteral-therapy-and-risk-stratification
#15
Ulas M Camsari, Claudia R Libertin
Background  An active intravenous substance use disorder is often the primary cause of infectious diseases in this population of users and creates a barrier to successful parenteral antimicrobial management. The dilemma is compounded by dramatically limited resources in small US towns. Methods This retrospective review from January 2014 through July 2016 aimed to develop a risk stratification approach to aid rural healthcare providers in determining who among patients with addictive disorders could safely be discharged for outpatient antimicrobial therapy with a peripherally inserted central catheter (PICC)...
August 18, 2017: Curēus
https://www.readbyqxmd.com/read/29056994/factors-affecting-treatment-management-and-mortality-in-cases-of-retroperitoneal-hematoma-after-cardiac-catheterization-a-single-center-experience
#16
Ebubekir Gündeş, Ulaş Aday, Mustafa Bulut, Hüseyin Çiyiltepe, Durmuş Ali Çetin, Selçuk Gülmez, Aziz Serkan Senger, Kamuran Cumhur Değer, Erdal Polat, Mustafa Duman
INTRODUCTION: There is little information available on the clinical aspects, results, treatment and management of cardiac catheterization-related retroperitoneal hematoma. Data on the subject are rather limited, and current publications are based on a limited number of retrospective cohort studies and case reports. AIM: To perform a retrospective analysis of the demographic, clinical, and in-hospital results of patients who developed retroperitoneal hematoma (RPH) after cardiac catheterization (CC)...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29053562/predictive-factors-for-corneal-clearance-after-descemetorhexis-without-endothelial-keratoplasty
#17
Emma Davies, Ula Jurkunas, Roberto Pineda
PURPOSE: To study preoperative factors that possibly contribute to corneal clearance after Descemetorhexis without endothelial keratoplasty (DWEK) and to determine the most successful surgical technique for the procedure. METHODS: Retrospective chart review of 17 eyes of 13 patients with Fuchs corneal endothelial dystrophy that underwent central 4-mm DWEK. RESULTS: Baseline age, pachymetry, and endothelial cell count were not statistically significantly different between eyes that cleared 0 to 2 months, 3 to 5 months, 6 to 8 months, or that failed to clear...
October 17, 2017: Cornea
https://www.readbyqxmd.com/read/29040186/the-effect-of-adenomyosis-in-myometrial-invasion-and-overall-survival-in-endometrial-cancer
#18
Selçuk Erkilinç, Enes Taylan, Varol Gülseren, Gamze Erkilinç, Tuğba Karadeniz, Mustafa Bağci, Orhan Temel, Ulaş Solmaz, Mehmet Gökçü, Muzaffer Sanci
AIM: The aim of this study was to evaluate whether adenomyosis had an effect on myometrial tumor invasion, stage of the disease, and survival in endometrial cancer. METHODS: Endometrial cancer patients encountered between 2007 and 2016 were identified from pathology records. Patients who underwent suboptimal surgical or medical treatment or with insufficient clinical or surgical data were excluded. Patients diagnosed as having concurrent adenomyosis constituted the study group...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#19
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29029292/minimizing-retraction-by-pia-arachnoidal-10-0-sutures-in-intrasulcal-dissection
#20
Kutluay Uluc, Ulas Cikla, Deniz B Morkan, Alperen Sirin, Azam S Ahmed, Kyle Swanson, Mustafa K Baskaya
BACKGROUND: In contemporary microneurosurgery reducing retraction-induced injury to the brain is essential. Self-retaining retractor systems are commonly used to improve visualization and decrease the repetitive microtrauma, but sometimes self-retaining retractor systems can be cumbersome and the force applied can cause focal ischemia or contusions. This may increase the morbidity and mortality. Here, we describe a technique of retraction using 10-0 sutures in the arachnoid. OBJECTIVE: To evaluate the imaging and clinical results in patients where 10-0 suture retraction was used to aid the surgical procedure...
September 19, 2017: Operative Neurosurgery (Hagerstown, Md.)
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