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https://www.readbyqxmd.com/read/29328911/western-diet-triggers-nlrp3-dependent-innate-immune-reprogramming
#1
Anette Christ, Patrick Günther, Mario A R Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J C F M Moorlag, Vinod Kumar, Min Hi Park, Leo A B Joosten, Laszlo A Groh, Niels P Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L Fitzgerald, Mihai G Netea, Joachim L Schultze, Eicke Latz
Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undetectable in serum soon after mice were shifted back to a chow diet (CD). In contrast, myeloid cell responses toward innate stimuli remained broadly augmented...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29318583/geriatric-emergency-department-innovations-transitional-care-nurses-and-hospital-use
#2
Ula Hwang, Scott M Dresden, Mark S Rosenberg, Melissa M Garrido, George Loo, Jeremy Sze, Stephanie Gravenor, D Mark Courtney, Raymond Kang, Carolyn W Zhu, Carmen Vargas-Torres, Corita R Grudzen, Lynne D Richardson
OBJECTIVES: To examine the effect of an emergency department (ED)-based transitional care nurse (TCN) on hospital use. DESIGN: Prospective observational cohort. SETTING: Three U.S. (NY, IL, NJ) EDs from January 1, 2013, to June 30, 2015. PARTICIPANTS: Individuals aged 65 and older in the ED (N = 57,287). INTERVENTION: The intervention was first TCN contact. Controls never saw a TCN during the study period...
January 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29306499/an-alternative-treatment-for-osteoporotic-su-type-iii-periprosthetic-supracondylar-femur-fractures-double-locking-plate-fixation
#3
Hakan Çiçek, Ümit Tuhanioğlu, Hasan Ulaş Oğur, Fırat Seyfettinoğlu, Murat Bozkurt
INTRODUCTION: Patients with Su Type III fractures based on total knee arthroplasty (TKA) constitute a patient group with problematic treatment and management. Although it has difficulties, open reduction and internal fixation is one of the treatment options. METHOD: A retrospective evaluation was made of 22 patients surgically treated in our clinic with double locking, low contact titanium plate and screw for a Su Type III periprosthetic fracture based on TKA. The patients were evaluated with bone mineral densitometry, postoperative Knee Society Score (KSS), WOMAC and radiological evaluations...
January 3, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29298972/human-papilloma-viruses-and-their-genotype-distribution-in-women-with-high-socioeconomic-status-in-central-anatolia-turkey-a-pilot-study
#4
Mert Ulaş Barut, Engin Yildirim, Mehmet Kahraman, Murat Bozkurt, Necat Imirzalioğlu, Ayhan Kubar, Eray Çalişkan, Sibel Sak, Tarık Aksu
BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients with unhealthy cervix in the study were: erosion, chronic cervicitis, healed lacerations, hypertrophied cervix, and abnormal discharges from the cervix...
January 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29296485/analytical-models-for-time-domain-diffuse-correlation-spectroscopy-for-multi-layer-and-heterogeneous-turbid-media
#5
Jun Li, Lina Qiu, Chien-Sing Poon, Ulas Sunar
A novel approach for time-domain diffuse correlation spectroscopy (TD-DCS) has been recently proposed, which has the unique advantage by simultaneous measurements of optical and dynamical properties in a scattering medium. In this study, analytical models for calculating the time-resolved electric-field autocorrelation function is presented for a multi-layer turbid sample, as well as a semi-infinite medium embedded with a small dynamic heterogeneity. To verify the analytical models, we used Monte Carlo simulations, which demonstrated that the theoretical prediction for the time-resolved autocorrelation function was highly consistent with the Monte Carlo simulation, validating the proposed analytical models...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29296020/linking-soil-biology-and-chemistry-in-biological-soil-crust-using-isolate-exometabolomics
#6
Tami L Swenson, Ulas Karaoz, Joel M Swenson, Benjamin P Bowen, Trent R Northen
Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning among bacterial isolates from biological soil crust (biocrust). Here we examine native biocrust to determine if these patterns are reproduced in the environment. Overall, most soil metabolites display the expected relationship (positive or negative correlation) with four dominant bacteria following a wetting event and across biocrust developmental stages...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29277130/an-interdisciplinary-academic-detailing-approach-to-decrease-inappropriate-medication-prescribing-by-physician-residents-for-older-veterans-treated-in-the-emergency-department
#7
Jason M Moss, William E Bryan, Loren M Wilkerson, Heather A King, George L Jackson, Ryan K Owenby, Courtney H Van Houtven, Melissa B Stevens, James Powers, Camille P Vaughan, William W Hung, Ula Hwang, Alayne D Markland, Richard Sloane, William Knaack, Susan Nicole Hastings
OBJECTIVE: To evaluate the impact of an academic detailing intervention delivered as part of a quality improvement project by a physician-pharmacist pair on (1) self-reported confidence in prescribing for older adults and (2) rates of potentially inappropriate medications (PIMs) prescribed to older adults by physician residents in a Veteran Affairs emergency department (ED). METHODS: This quality improvement project at a single site utilized a questionnaire that assessed knowledge of Beers Criteria, self-perceived barriers to appropriate prescribing in older adults, and self-rated confidence in ability to prescribe in older adults which was administered to physician residents before and after academic detailing delivered during their emergency medicine rotation...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29275859/microbiome-influences-prenatal-and-adult-microglia-in-a-sex-specific-manner
#8
Morgane Sonia Thion, Donovan Low, Aymeric Silvin, Jinmiao Chen, Pauline Grisel, Jonas Schulte-Schrepping, Ronnie Blecher, Thomas Ulas, Paola Squarzoni, Guillaume Hoeffel, Fanny Coulpier, Eleni Siopi, Friederike Sophie David, Claus Scholz, Foo Shihui, Josephine Lum, Arlaine Anne Amoyo, Anis Larbi, Michael Poidinger, Anne Buttgereit, Pierre-Marie Lledo, Melanie Greter, Jerry Kok Yen Chan, Ido Amit, Marc Beyer, Joachim Ludwig Schultze, Andreas Schlitzer, Sven Pettersson, Florent Ginhoux, Sonia Garel
Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults...
December 21, 2017: Cell
https://www.readbyqxmd.com/read/29262348/cellular-differentiation-of-human-monocytes-is-regulated-by-time-dependent-interleukin-4-signaling-and-the-transcriptional-regulator-ncor2
#9
Jil Sander, Susanne V Schmidt, Branko Cirovic, Naomi McGovern, Olympia Papantonopoulou, Anna-Lena Hardt, Anna C Aschenbrenner, Christoph Kreer, Thomas Quast, Alexander M Xu, Lisa M Schmidleithner, Heidi Theis, Lan Do Thi Huong, Hermi Rizal Bin Sumatoh, Mario A R Lauterbach, Jonas Schulte-Schrepping, Patrick Günther, Jia Xue, Kevin Baßler, Thomas Ulas, Kathrin Klee, Natalie Katzmarski, Stefanie Herresthal, Wolfgang Krebs, Bianca Martin, Eicke Latz, Kristian Händler, Michael Kraut, Waldemar Kolanus, Marc Beyer, Christine S Falk, Bettina Wiegmann, Sven Burgdorf, Nicholas A Melosh, Evan W Newell, Florent Ginhoux, Andreas Schlitzer, Joachim L Schultze
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and heterogeneity remains largely unknown, hampering their clinical use. High-dimensional techniques were used to elucidate transcriptional, phenotypic, and functional differences between human in vivo and in vitro generated mononuclear phagocytes to facilitate their full potential in the clinic...
December 19, 2017: Immunity
https://www.readbyqxmd.com/read/29260128/emergency-cases-following-elective-colonoscopy-iatrogenic-colonic-perforation
#10
Ebubekir Gündeş, Hüseyin Çiyiltepe, Ulaş Aday, Durmuş Ali Çetin, Aziz Serkan Senger, Orhan Uzun, Kamuran Cumhur Değer, Mustafa Duman, Erdal Polat
Objective: Our aim in this study was to present the cases of our patients who contracted colonic perforation during elective colonoscopy and became emergency cases; we also discuss treatment modalities along with literature reports on the subject. Material and Methods: Cases of patients who contracted iatrogenic colonic perforation following endoscopy of the colorectal system between January 2009 and December 2015 at Kartal Koşuyolu Yüksek İhtisas Training and Research Hospital's Endoscopy Unit were reviewed retrospectively...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29242841/unexpected-diagnosis-in-a-patient-with-a-left-ventricular-assist-device-rectal-cancer
#11
Ulaş Aday, Ebubekir Gündeş, Durmuş Ali Çetin, Hüseyin Çiyiltepe, Erdal Polat
No abstract text is available yet for this article.
2017: Archives of medical sciences. Atherosclerotic diseases
https://www.readbyqxmd.com/read/29219046/molecular-cloning-and-functional-characterization-of-antimicrobial-peptides-brevinin-1ulf-and-ulmin-1ula-in-the-skin-of-the-newly-classified-ryukyu-brown-frog-rana-ulma
#12
Daisuke Ogawa, Maki Mochitate, Maho Furukawa, Itaru Hasunuma, Tetsuya Kobayashi, Sakae Kikuyama, Shawichi Iwamuro
Antimicrobial peptides (AMPs) were previously isolated from the skin of the Ryukyu brown frog Rana okinavana. However, this species has recently been reclassified as two species, i.e., Rana kobai and Rana ulma. As a result, it was determined that AMPs isolated from R. okinavana were in fact products of R. kobai, but not of R. ulma. In the present study, we collected skin samples from the species R. ulma and cloned twelve cDNAs encoding AMP precursors for the acyclic brevinin-1ULa--1ULf, the temporin-ULa-ULc, ranatuerin-2ULa, japonicin-1ULa, and a novel peptide using reverse-transcription polymerase chain reaction techniques...
December 2017: Zoological Science
https://www.readbyqxmd.com/read/29216050/spatial-intensity-profiling-of-elastic-and-inelastic-scattering-in-isotropic-and-anisotropic-liquids-by-immersion-of-a-spherical-silicon-photocell
#13
Muhammad Hamza Humayun, Syed Sultan Shah Bukhari, Muhammad Zakwan, Mustafa Mert Bayer, Ulaş Sabahattin Gökay, Ali Serpengüzel, Kenichi Taira, Etsuji Omura, Josuke Nakata
The transverse spatial intensity distribution of elastic and inelastic light scattering in passive and active as well as weak and strong scattering liquid media has been studied by using Sphelar One p-n junction silicon spherical photocells. We immersed a Sphelar One in these scattering solutions and measured the photoconductive response in reverse biased photodiode (PD) configuration. The passive weak scattering medium was pure ethanol (EtOH), whereas the passive strong scattering medium was 5CB nematic liquid crystal (NLC)...
December 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29215344/a-new-laparoscopic-manoeuvre-in-median-arcuate-ligament-syndrome
#14
Selçuk Gülmez, Ulaş Aday, Aziz Serkan Senger, Ebubekir Gündeş
No abstract text is available yet for this article.
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29212138/direction-of-arrival-estimation-and-tracking-based-on-a-sequential-implementation-of-c-spice-with-an-off-grid-model
#15
Shu Cai, Xiaoye Shi, Hongbo Zhu
This paper focuses on the problem of estimating and tracking time-varying direction-of-arrivals (DoAs) with an antenna array. A sequential DoA estimation method is proposed by extending the capon and sparse iterative covariance-based estimation (C-SPICE) method, which is an iterative off-grid method for estimating constant DoAs. Then, a moving average initialization technique is introduced such that the spatial spectrum information estimated in this snapshot can be utilized in the next one. In uniform linear arrays (ULAs), we replace the uniform grid in direction domain with that in a "frequency" domain, to improve estimation accuracy without additional complexity in practical applications...
November 24, 2017: Sensors
https://www.readbyqxmd.com/read/29211709/an-800-million-solar-mass-black-hole-in-a-significantly-neutral-universe-at-a-redshift-of-7-5
#16
Eduardo Bañados, Bram P Venemans, Chiara Mazzucchelli, Emanuele P Farina, Fabian Walter, Feige Wang, Roberto Decarli, Daniel Stern, Xiaohui Fan, Fred Davies, Joseph F Hennawi, Rob Simcoe, Monica L Turner, Hans-Walter Rix, Jinyi Yang, Daniel D Kelson, Gwen Rudie, Jan Martin Winters
Quasars are the most luminous non-transient objects known, and as such they enable studies of the Universe at the earliest cosmic epochs. Despite extensive efforts, however, the quasar ULAS J1120+0641 at redshift z = 7.09 (hereafter J1120+0641) has remained the only one known at z > 7 for more than half a decade1. Here we report observations of the quasar ULAS J134208.10+092838.61 (hereafter J1342+0928) at a redshift of z = 7.54. This quasar has a bolometric luminosity of 4 × 1014L⊙ and a black hole mass of 8 × 108M⊙...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29205688/integration-of-radiological-findings-and-a-clinical-score-in-pediatric-appendicitis
#17
Derya Aydin, Caner Turan, Ali Yurtseven, Petek Bayindir, Bade Toker, Zafer Dokumcu, Murat Sezak, Eylem Ulas Saz
BACKGROUND: The efficacy of ultrasonography (US) and abdominal X-ray in combination with PAS is complicated in the diagnosis of acute appendicitis. Abdominal X-ray is as useful as US with clinical assessment when evaluated by experienced pediatric radiologist in acute appendicitis. We aimed to determine the value of US and abdominal X-ray for appendicitis in children when combined with clinical assessment based on the Pediatric Appendicitis Score (PAS). We also aimed to establish a practical pathway for acute appendicitis in childhood...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29195430/comparing-the-effect-of-aperture-extension-on-the-peak-sidelobe-level-of-sparse-arrays
#18
Ferdousi Sabera Rawnaque, John R Buck
The reduced number of sensors in sparse arrays create high peak sidelobe levels (PSLs). This letter compares the PSLs of minimum redundancy arrays (MRAs), minimum hole arrays (MHAs), and co-prime sensor arrays (CSAs) (conventionally beamformed and product processed) with fully populated uniform linear arrays (ULAs) as a function of aperture using both numerical simulations and experimental data. This letter finds that PSLs of MRAs, MHAs, and conventionally processed CSAs are much higher than the ULA PSL and are largely insensitive to aperture extension...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29192948/-letter-to-the-editor-addiction-psychiatry-fellowship-training-in-the-united-states
#19
Ulaş Mehmet Çamsarı
No abstract text is available yet for this article.
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29192414/outcomes-of-patients-with-advanced-stage-ovarian-cancer-with-intestinal-metastasis
#20
Eyüp Kebapcı, Varol Gülseren, Cem Tuğmen, Mehmet Gökçü, Ulaş Solmaz, İsmail Sert, Mustafa Kocaer, Mehmet Özer, Mustafa Ölmez, Muzaffer Sancı
OBJECTIVES: The aim of this study is to evaluate the results of advanced stage (stage IIIB-IVB) ovarian cancer (OC) patients with intestinal metastasis, and to investigate the factors that affect survival. MATERIAL AND METHODS: Patients who underwent cytoreductive surgery (CS) for FIGO stage IIIB-IVB OC with metastasis in the intestinal system, at Tepecik Research and Treatment Hospital between 2008-2014, were analyzed retrospectively. Patients with borderline ovarian tumor; those who had previously undergone radiation therapy and/or hysterectomy and patients having secondary or tertiary cytoreduction were excluded and 49 patients were included and analyzed in this study...
2017: Ginekologia Polska
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