keyword
MENU ▼
Read by QxMD icon Read
search

CK7

keyword
https://www.readbyqxmd.com/read/28097642/adrenal-cyst-with-both-m%C3%A3-llerian-and-mesothelial-differentiation-a-clinicopathological-and-immunohistochemical-study-with-implications-for-histogenesis
#1
Łukasz Koperski, Benedykt Szczepankiewicz, Paweł Pihowicz, Łukasz Fus, Ewa Wolińska, Barbara Górnicka
True epithelial-lined cysts are rare forms of adrenal cystic lesions, the pathogenesis of which is still not fully understood. In this report we present a case of an adrenal cyst diagnosed incidentally on imaging in a 31-year-old, previously healthy, obese woman. Due to non-specific hormonal disorders and enlargement of the lesion, a right-sided laparoscopic adrenalectomy was performed. The cyst was lined predominantly by ciliated cuboidal-to-columnar, Müllerian-type epithelium, and focally by flat-to-cuboidal, mesothelium-like lining...
January 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28081573/-prostate-carcinoma-mimics-lung-carcinoma-a-case-report
#2
Konstantinos Drosos, Klaus Höfner
A PSA-negative, advanced adenocarcinoma of the prostate is a rare finding. Expression of thyroid transcription factor-1 (TTF-1) in the tumour in combination with a previous medical history of lung adenocarcinoma could complicate the final diagnosis. To the best of our knowledge, we present the second case of a TTF-1-positive, acinar adenocarcinoma of the prostate.We present the case of a 65-year-old male with surgically treated lung adenocarcinoma; 3 years later we diagnosed adenocarcinoma of the bladder and prostate...
January 12, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28078121/clinical-morphologic-and-immunophenotypic-characteristics-of-ampullary-carcinomas-with-an-emphasis-on-smad4-expression
#3
Ahmad Alkhasawneh, Lizette Vila Duckworth, Thomas J George, Neelam V Desai, Alex J Sommerfeld, Xiaomin Lu, Tania Zuluaga Toro
BACKGROUND: The purpose of our study was to examine the relationship between clinicopathologic variables and morphologic subtypes in ampullary carcinoma, with an emphasis on the expression of SMAD4 tumor suppressor gene. METHODS: Sixty-three cases of ampullary carcinomas resected between 2000-2011 were included in this study. Clinical characteristics and outcome data were recorded. Tumors were classified as pancreatobiliary or intestinal type based on morphology, and immunohistochemical (IHC) studies for cytokeratin 7 (CK7), cytokeratin 20 (CK20), cytokeratin 17 (CK17), and SMAD4 were performed...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28072972/-clinicopathologic-features-of-adenoid-cystic-carcinoma-of-breast
#4
S P Guo, Q L Li, Y M Wang, K X Zeng, Y Liu, W N Xu, X M Zhang
Objective: To investigate the clinicopathologic features and grading of adenoid cystic carcinoma (ACC) of the breast. Methods: Sixteen cases of ACC of the breast were analyzed and graded according to the previous report. Immunohistochemical (IHC) staining was used to detect the immunophenotype, Ki-67 proliferative index and expression of EZH2, and the association with tumor grade and outcome was analyzed. Results: Of the 16 cases, 11 were grade Ⅰ, with the epithelial and myoepithelial cells being arranged into tubular and cribriform structure with no solid component; three were grade Ⅱ, which were composed of mixed tubular, cribriform and solid component (<30%); and two were grade Ⅲ, which showed mainly solid component (>90%) and the tumor cells showed basaloid features with scanty cytoplasm and hyperchromatic nuclei, and mitotic count was>5/10 HPF...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28072477/recurrent-nab2-stat6-gene-fusions-and-estrogen-receptor-alpha-expression-in-pulmonary-adenofibromas
#5
Nicola Fusco, Elena Guerini-Rocco, Claudia Augello, Andrea Terrasi, Giulia Ercoli, Caterina Fumagalli, Davide Vacirca, Paola Braidotti, Antonina Parafioriti, Marta Jaconi, Letterio Runza, Vijayalakshmi Ananthanarayanan, Fabio Pagni, Silvano Bosari, Massimo Barberis, Stefano Ferrero
AIMS: Pulmonary adenofibromas are rare benign fibroepithelial tumours of the lung with unknown histogenesis and an indolent clinical behaviour. Their stroma resembles that of solitary fibrous tumours, while the glands are composed of respiratory epithelium organized in a phyllodes-like architecture. Differentiation of pulmonary adenofibromas from other more aggressive intrathoracic tumours is clinically relevant. However, their biology is unknown. Here, we sought to characterize pulmonary adenofibromas at a clinicopathologic level and to define whether they could be underpinned by a highly recurrent somatic genetic alteration akin to tumours with similar morphology...
January 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28069272/smarcb1-ini1-deficient-sinonasal-carcinoma-shows-methylation-of-rassf1-gene-a-clinicopathological-immunohistochemical-and-molecular-genetic-study-of-a-recently-described-entity
#6
Jan Laco, Marcela Chmelařová, Hana Vošmiková, Kateřina Sieglová, Ivana Bubancová, Pavel Dundr, Kristýna Němejcová, Jaroslav Michálek, Petr Čelakovský, Radovan Mottl, Igor Sirák, Milan Vošmik, Aleš Ryška
The aim of the study was detailed clinicopathological investigation of SMARCB1/INI1-deficient sinonasal carcinomas, including molecular genetic analysis of mutational status and DNA methylation of selected protooncogenes and tumor suppressor genes by means of next generation sequencing (NGS) and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). A total of 4/56 (7%) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas diagnosed over a 19year period using immunohistochemical screening...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28060246/unsuspected-conjunctival-orbital-dermoid-cyst-aids-in-diagnosis
#7
Frederick A Jakobiec, Fouad R Zakka, Alice Lorch
A 25-year-old man with Type 1 diabetes mellitus experienced rapid visual decline and was scheduled for right cataract surgery. At the time of administering an inferotemporal retrobulbar block, a white discharge appeared spontaneously on the surface of the globe. Superotemporally a cyst was found and its contents were subtotally evacuated. Microscopically, eosinophilic, acellular material with chatter artifact and small vacuoles was detected and initially thought to represent a lens choristoma. This material stained moderately with the periodic acid Schiff method and was focally Congo red positive without apple green birefringence; it also stained blue with the Masson trichrome method...
January 5, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28058099/adenomatoid-tumor-of-the-adrenal-gland-in-young-woman-from-clinical-and-radiological-to-pathological-study
#8
Brankica Krstevska, Sasha Jovanovska Mishevska, Rubens Jovanovic
Adenomatoid tumors are neoplasms of mesothelial origin, usually occurring in the male and female genital tracts. Extragenital localization sites such as adrenal glands are rare but have been reported. When found in the adrenals, they represent great clinical, radiological and pathological diagnostic challenge, with wide range of differential diagnoses to be considered. We present a case of a 30 years old female, with incidental ultrasound finding of unilateral tumor in the right adrenal gland. Multi slices CT scan was of value in localizing this tumor, but not in the precise diagnosis...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/28038793/histologic-characteristics-of-thymic-adenocarcinomas-clinicopathologic-study-of-a-nine-case-series-and-a-review-of-the-literature
#9
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Primary thymic adenocarcinoma is an extraordinarily rare malignancy; only 49 cases have been reported in the medical literature to date. Because of its rarity, clinical and pathologic characteristics of thymic adenocarcinoma are unclear. We present nine cases of primary thymic adenocarcinoma and discuss clinicopathologic findings in the context of the existing literature. Two-hundred twenty-six thymic carcinoma cases were diagnosed at Samsung Medical Center in Korea, from January, 2001 to July, 2016. Nine of these 226 cases were primary thymic adenocarcinomas...
November 15, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28035707/local-recurrence-of-cutaneous-mixed-tumor-chondroid-syringoma-as-malignant-mixed-tumor-of-the-thumb-20-years-after-initial-diagnosis
#10
Catherine M Nguyen, David S Cassarino
Benign cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of the benign mixed tumor (pleomorphic adenoma) of salivary glands, consisting of both epithelial and mesenchymal elements. The incidence of cutaneous mixed tumor is rare, composing < 0.01% of all primary skin tumors. Herein, we report a case of malignant mixed tumor which recurred in the right thumb 20 years after the reported initial diagnosis of a benign mixed tumor at this site. Histologically, the lesion consisted of highly atypical and infiltrative cells in cords and ductal structures, with an adjacent focus of residual benign mixed tumor present...
December 30, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28035705/a-rare-case-of-cutaneous-oncocytic-hidradenoma
#11
Shivani P Reddy, Kim Chong, David S Cassarino
Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Oncocytomas, or tumors composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. Oncocytic metaplasia has only been rarely reported in various cutaneous neoplasms. We report a case of an elderly male presenting with a 5 millimeter erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based adnexal tumor with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged, bland-appearing epithelioid cells...
December 30, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28029685/immunoprofile-of-metaplastic-carcinomas-of-the-breast
#12
Emad A Rakha, Nuno D M Coimbra, Zsolt Hodi, Enaam Juneinah, Ian O Ellis, Andrew H S Lee
BACKGROUND: Metaplastic breast carcinoma (MBC) is a rare type of breast cancer and its diagnosis in routine practice can be challenging and may require immunohistochemical (IHC) characterisation if no conventional invasive or in situ carcinoma is present. Previous IHC studies of MBC often had a small sample size and did not investigate the different histological subtypes. This study aimed to assess the immunoprofile of MBC subtypes in a large series. METHODS: 172 MBC diagnosed in routine and referral practice in Nottingham over 26 years were reviewed by 3 breast pathologists...
December 28, 2016: Histopathology
https://www.readbyqxmd.com/read/28024950/detection-and-clinical-significance-of-circulating-tumor-cells-in-patients-undergoing-radical-cystectomy-for-urothelial-bladder-cancer
#13
Vincenzo Pagliarulo, Patrizia Ancona, Tommasangelo Petitti, Annamaria Salerno, Rossana Spadavecchia, Savino Di Stasi, Luigi Cormio, Buscarini Maurizio, Giuseppe Carrieri, Pasquale Ditonno
INTRODUCTION: Estimation of prognosis is patients undergoing radical cystectomy is often unreliable, as occult disease remains undetected by conventional diagnostic tools. The purpose of this study was to evaluate the feasibility and the clinical significance of a polymerase chain reaction assay to detect cytokeratin 7 (CK7) mRNA expression in peripheral blood cells of patients undergoing radical cystectomy for clinically nonmetastatic bladder cancer. PATIENTS AND METHODS: From 2005 to 2009, 59 patients undergoing radical cystectomy and pelvic lymph node dissection were prospectively investigated...
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28000303/primary-cutaneous-histiocytoid-carcinoma-with-distant-metastasis
#14
Rebecca Philips, Leila Langston, Helena Hwang, Travis Vandergriff, Tanya Trynosky, Alma C Berlingeri-Ramos
Distinguishing primary cutaneous adnexal carcinoma from metastatic carcinoma of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old man presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. Tumor cells had a histiocytoid appearance and displayed mild pleomorphism. The tumor was discohesive and had areas with a single file pattern...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27999702/serous-cystadenocarcinoma-arising-in-presumed-vitelline-duct-remnant-a-case-report-and-implications-in-the-management-of-cancer-of-unknown-primary
#15
Li Lei, Jeremy K Deisch
Background. Malignant neoplasms arising in Meckel's diverticulum, a vitelline duct remnant, are rare yet well-documented. Case Presentation. A 53-year-old previously healthy female presented with an enlarging midline abdominal wall mass. A computed tomography scan revealed a mass involving the linea alba, bilateral rectus abdominis, and subcutaneous fat. Extensive clinical workup failed to demonstrate other lesions, except local and paratracheal/hilar lymphadenopathy. Histopathologic examination of the resected tumor demonstrated a spectrum of serous neoplasia including serous cystadenoma, papillary serous carcinoma with numerous Psammoma bodies, and a poorly differentiated component...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27993885/pulmonary-adenofibroma-report-of-a-case-with-multiple-masses
#16
Junmei Hao, Cuiping Zhang, Qinghua Cao, Jiarui Zou, Chaofu Wang
We are reporting one case of multiple pulmonary adenofibromas in a 57-year-old non-smoking female. Ten well-circumscribed masses were identified in both lungs. The masses are characterized by gland-like structures lined by a single layer of simple cuboidal or columnar epithelium. The stroma is abundant and demonstrates compact spindle-cells. The epithelial component is generally positive for CK7, TTF-1, Napsin A. The stromal component displays expression of vimentin, desmin, SMA, h-CALD, ER, PR, Bcl-2, and is negative for CD34, CD117, CD99...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27984235/intraductal-tubulopapillary-neoplasm-of-the-pancreas-a-clinicopathologic-and-immunohistochemical-analysis-of-33-cases
#17
Olca Basturk, Volkan Adsay, Gokce Askan, Deepti Dhall, Giuseppe Zamboni, Michio Shimizu, Karina Cymes, Fatima Carneiro, Serdar Balci, Carlie Sigel, Michelle D Reid, Irene Esposito, Helena Baldaia, Peter Allen, Günter Klöppel, David S Klimstra
Intraductal tubulopapillary neoplasm (ITPN) is a relatively recently described member of the pancreatic intraductal neoplasm family. Thus, the literature on its histologic and immunohistochemical features, clinical behavior, and its similarities and differences from other pancreatic neoplasms is limited. Thirty-three cases of ITPN, the largest series to date, were identified. Immunohistochemical labeling for cytokeratins, glycoproteins, pancreatic enzymes, markers for intestinal and neuroendocrine differentiation, and antibodies associated with genetic alterations previously described in pancreatic neoplasms was performed...
December 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27982195/oral-adenosquamous-carcinoma-mimicking-a-pyogenic-granuloma-a-challenging-diagnosis
#18
Celina Faig Lima, Renata Acay, Ana Lia Anbinder, Janete Dias Almeida, Yasmin Rodarte Carvalho
Adenosquamous carcinoma is an aggressive variant of squamous cell carcinoma. This report describes a case of adenosquamous carcinoma with clinical features of a benign lesion and discusses the differential diagnoses, especially regarding histopathological and immunohistochemical analyses. A 45-year-old male was referred to our outpatient clinic complaining about a rapid-growing enlargement in hard palate. Clinical examination revealed an erythematous and pedunculated nodule with lobulated non-ulcerated surface...
October 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27934879/xp11-2-translocation-renal-cell-carcinoma-with-nono-tfe3-gene-fusion-morphology-prognosis-and-potential-pitfall-in-detecting-tfe3-gene-rearrangement
#19
Qiu-Yuan Xia, Zhe Wang, Ni Chen, Hua-Lei Gan, Xiao-Dong Teng, Shan-Shan Shi, Xuan Wang, Xue Wei, Sheng-Bing Ye, Rui Li, Heng-Hui Ma, Zhen-Feng Lu, Xiao-Jun Zhou, Qiu Rao
Xp11 translocation renal cell carcinomas are characterized by several different translocations involving the TFE3 gene. Tumors with different specific gene fusions may have different clinicopathological manifestations. Fewer than 10 renal cell carcinoma cases with NONO-TFE3 have been described. Here we examined eight additional cases of this rare tumor using clinicopathological, immunohistochemical, and molecular analyses. The male-to-female ratio of our study cohort was 1:1, and the median age was 30 years...
December 9, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27931799/oncocytic-papillary-renal-cell-carcinoma-a-clinicopathological-and-genetic-analysis-and-indolent-clinical-course-in-14-cases
#20
Guiyan Han, Wenjuan Yu, Jing Chu, Yan Liu, Yanxia Jiang, Yujun Li, Wei Zhang
A sort of PRCC with distinct eosinophilic cytoplasm named Oncocytic Papillary Renal Cell Carcinoma (OPRCC) has been increasingly attracting the attention of researchers recently. However, owing to the rarity of OPRCC, the clinicopathological and genetic features of the tumor have still not been well elucidated and whether it should be regarded as an independent subtype of PRCC remains controversial. Herein, a cohort of 14 OPRCCs was studied with the aim of revealing the distinct clinicopathological features, facilitating the classification and correct diagnosis of OPRCC...
January 2017: Pathology, Research and Practice
keyword
keyword
119379
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"