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https://www.readbyqxmd.com/read/28638113/clinical-significance-and-next-generation-sequencing-of-chinese-pulmonary-sarcomatoid-carcinoma
#1
Xin Li, Dan Wang, Qingchun Zhao, Dian Ren, Fan Ren, Gang Chen, Hongyu Liu, Jun Chen
Pulmonary Sarcomatoid Carcinoma (PSC) constitutes a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with a poor prognosis. In this study, a group of 7 patients with PSC was studied. Microscope analysis of all 7 cases revealed a pleomorphic carcinoma subtype. Moreover, 5 cases (71.4%) were composed entirely of malignant sarcomatoid-like elements, and 2 cases (28.6%) were composed of malignant sarcomatoid-like elements and at least 10% adenocarcinoma-like elements. Immunohistochemically, the PSC components of all 7 cases were positive for vimentin and cytokeratins, including cytokeratin (CK) and cytokeratin 7 (CK7)...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627210/lactobacillus-rhamnosusgg-reduces-hepatic-fibrosis-in-a-model-of-chronic-liver-disease-in-rats
#2
Thais Ortiz Hammes, Renata Leke, Thayssa Dalla Costa Escobar, Laisa Beduschi Fracasso, Fabiola Schons Meyer, Michael Éverton Andrades, Themis Reverbel da Silveira
BACKGROUND: The intestinal dysbiosis is common in chronic liver disease and can induce to inflammatory responses and mediate the collagen deposition in the liver. AIM: To evaluate the probiotic Lactobacillus rhamnosus GG (LGG) for the treatment of liver fibrosis in a model of chronic cholestatic liver disease in rats. METHODS: Male adult Wistar rats (n = 29) were submitted to common bile duct ligation (BDL groups) or manipulation of common bile duct without ligation (Ctrl groups)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28616595/a-rare-case-of-anal-carcinosarcoma-with-human-papilloma-virus-infection-in-both-biphasic-tumor-elements-an-immunohistochemical-molecular-and-ultrastructural-study
#3
Richard A Hickman, Azore-Dee Bradshaw, Nicholas Cassai, Antonio Galvao Neto, David Zhou, Tinghao Fu, Peng Lee, Zhiheng Pei, Rosemary Wieczorek
Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV). We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH) and further supported by electron microscopy (EM). Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/28612331/isolation-and-characterization-of-trophoblasts-from-enzymatic-explants-of-human-term-placenta
#4
Tamara D Kolokoltsova, Irina N Saburina, Irina M Zurina, Anastasia A Gorkun, Nastasia V Kosheleva, Vadim S Repin, Rimma A Poltavtseva, Gennady T Sukhikh
In the present study, we describe a new method of isolation and culture of human villous and extravillous trophoblasts from term placenta. The cultivation of trypsinized placental villous tissue explants, followed by the isolation of cells from outgrowth islets allows for obtaining a cytotrophoblast subpopulation that is free from contamination by other cell types. Compared to other methods, our protocol is mild, simple and effective, does not request costly reagents and provides isolation of the mononuclear cytotrophoblast cell populations free from contamination by other types of placental cells...
June 13, 2017: Human Cell
https://www.readbyqxmd.com/read/28607685/concurrent-braf-and-pten-mutations-in-melanoma-of-unknown-origin-presenting-as-a-breast-mass
#5
Emmanuel Agosto-Arroyo, Marilin Rosa, Alec Chau, Laila Khazai
BACKGROUND: Metastases represent a small percentage of the malignancies affecting the breast, and only 5% of melanomas originate from non-cutaneous sites. Multiple genetic aberrations have been associated with the development of melanocytic lesions, including BRAF V600E mutation. Mutations in PTEN gene have also been related to the pathogenesis of multiple malignancies. PURPOSE/METHOD: This is the case of a 28-year-old female who presented with a tender, palpable mass in the upper outer quadrant of the right breast...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28603942/primary-hepatic-choriocarcinoma-in-an-83-year-old-woman
#6
Akihiko Fukagawa, Naoto Fujita, Kenji Ohira, Hajime Fujimoto, Nobuaki Goto, Akinori Nozawa
We present a case of primary hepatic choriocarcinoma in an 83-year-old Japanese woman with gastric wall and lymph node metastases and a splenic vein tumor thrombus. Multiple irregular hepatic tumors with massive necrosis and hemorrhage were observed during autopsy. Syncytiotrophoblast-like and mononucleated cytotrophoblast-like cell morphology with focal hepatocellular carcinoma (HCC)-like trabecular structures was observed. In immunohistochemical analyses, the tumor cells expressed human chorionic gonadotropin (hCG) and cytokeratins (AE1/AE3, CK7, CK19) but were negative for alpha-fetoprotein (AFP), glypican-3, and vimentin...
June 11, 2017: Pathology International
https://www.readbyqxmd.com/read/28599465/pulmonary-enteric-adenocarcinoma-with-pancreatic-metastasis-a-case-report
#7
Wen-Wen Sun, Zhi-Hong Xu, Chao-Fu Wang, Fang Wu, Jiu-Mei Cao, Pei-Jing Cui, Wei Huang, Xiao-Long Jin, Biao Li, Ke-Min Chen, Bei-Li Gao, Jia-An Hu
Pulmonary enteric adenocarcinoma is a markedly rare pathological type of lung adenocarcinoma. As the pancreas is a relatively uncommon site for metastasis, the present case is even more unusual. A 62-year-old male was admitted to hospital following the identification of masses in the left chest wall, right abdominal wall and right upper limb, but with no respiratory symptoms. Computed tomography (CT) of the chest revealed a lump in the lung and a mass in the left chest wall, and (18)F-fluorodeoxyglucose ((18)F-FDG) uptake by the lumps was increased...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28596515/characterization-of-a-new-murine-cell-line-of-sarcomatoid-hepatocellular-carcinoma-and-its-application-for-biomarker-therapy-development
#8
Chia-Hung Yen, Chih-Chung Lai, Chen-Chung Liao, Sheng-Fan Wang, Yi-Jen Liao, Chien-Yi Tung, Jung-Hsien Hung, Shiu-Feng Huang, Yi-Ming Arthur Chen
Sarcomatoid hepatocellular carcinoma (SHC) is a rare type of HCC with significantly poorer survival than ordinary HCC. Little is known about the mechanism associated with SHC and its biomarkers and therapy. Here, we established a mouse liver cancer cell line and designated as Ymac-1. A sarcomatous appearance was observed in the allograft tumor arose from Ymac-1. Liver-secreted plasma proteins were found in Ymac-1 cultured supernatant by proteomics analysis. The positive staining of CK7, CK8, Vimentin and the suppressed expression of AFP indicated that Ymac-1 is a SHC cell line...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28593937/basaloid-squamous-cell-carcinoma-of-the-head-and-neck-subclassification-into-basal-ductal-and-mixed-subtypes-based-on-comparison-of-clinico-pathologic-features-and-expression-of-p53-cyclin-d1-epidermal-growth-factor-receptor-p16-and-human-papillomavirus
#9
Kyung-Ja Cho, Se-Un Jeong, Sung Bae Kim, Sang-Wook Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
Background: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands. Materials and Methods: Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63) or ductal markers (CK7, CK8/18)...
June 8, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28582341/invasive-extramammary-paget-disease-of-the-vulva-with-signet-ring-cell-morphology-in-a-patient-with-signet-ring-cell-carcinoma-of-the-stomach-report-of-a-case
#10
Byung-Kwan Jeong, Kyu-Rae Kim
This report describes a rare case of invasive extramammary Paget disease of the vulva with signet ring cell morphology in a 58-yr-old woman with a history of signet ring cell carcinoma of the stomach. This case was initially misinterpreted as a metastatic gastric carcinoma to the vulva because an initial small, superficial biopsy specimen showed infiltration of signet ring cells in the dermis without intraepidermal Paget cells. However, a surgically resected specimen showed concordant immunophenotypes in both intraepidermal Paget cells and intradermal signet ring cell components with immunoreactivity to cytokeratin (CK) 7, CEA, and gross cystic disease fluid protein-15, and immunonegativity for CK20, MUC5AC, and MUC6...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28565920/vulvar-basal-cell-carcinoma-four-case-reports-with-immunohistochemical-study
#11
Mª Reyes García-de-la-Fuente, Maria Santacana, Felip Vilardell, R M Pujol, Eloi Gari, J M Casanova
Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semimucous area, a nonphotoexposed area, and a nonhairy area. We have determined the CK7 and CK19 profile of all cases; both are markers of simple epithelium with glandular differentiation. Interestingly, all cases were positively stained for CK7 and CK19...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28555282/smarca4-deficient-pulmonary-adenocarcinoma-clinicopathological-immunohistochemical-and-molecular-characteristics-of-a-novel-aggressive-neoplasm-with-a-consistent-ttf1-neg-ck7-pos-heppar-1-pos-immunophenotype
#12
Abbas Agaimy, Florian Fuchs, Evgeny A Moskalev, Horia Sirbu, Arndt Hartmann, Florian Haller
Alterations in SMARCA4, a member of the chromatin remodeling Switch Sucrose Non-Fermentable (SWI/SNF) complex, characterize a subset of non-small cell lung cancer (NSCLC), but detailed morphological and immunophenotypic description of this tumor type is lacking. We describe 20 NSCLC cases found on routine screening not to express SMARCA4 by immunohistochemistry (IHC). These tumors were stained for CK7, TTF1, SMARCA2, SMARCA4, SMARCB1, and HepPar-1 and analyzed for molecular alterations, using a 160 cancer-related gene panel including the full coding sequence of SMARCA4...
May 30, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28554748/nephrogenic-adenoma-of-the-urinary-tract-a-6-year-single-center-experience
#13
Didem Turcan, Mustafa Fuat Acikalin, Evrim Yilmaz, Funda Canaz, Deniz Arik
BACKGROUND: Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers. MATERIALS AND METHODS: A retrospective series of 21 cases of nephrogenic adenoma in 18 patients, which were diagnosed in our department between 2010 and 2016, were analyzed...
March 25, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28554573/clinical-significance-of-ck7-hpv-l1-and-koilocytosis-for-patients-with-cervical-low-grade-squamous-intraepithelial-lesions-a-retrospective-analysis
#14
Lanqing Cao, Ping-Li Sun, Min Yao, Shifan Chen, Hongwen Gao
Most cervical low-grade squamous intraepithelial lesions (LSILs) do not progress to high-grade squamous intraepithelial lesions (HSILs); however, reliable biomarkers that predict LSIL progression are lacking. We investigated the association of cytokeratin 7 (CK7), human papillomavirus-L1 capsid protein (HPV-L1), and koilocytosis with clinical outcomes of patients with LSIL. CK7, HPV-L1, Ki67, and p16-INK4A expression was determined in 72 cervical LSIL and 28 HSIL biopsy samples; koilocytosis was evaluated by reviewing biopsy slides...
May 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28540449/epidermoid-cysts-are-a-characteristic-feature-of-intrapancreatic-but-not-of-extrapancreatic-accessory-spleens
#15
Kenichi Hirabayashi, Misuzu Yamada, Hirotaka Kono, Atsuko Hadano, Aya Kawanishi, Yumi Takanashi, Yoshiaki Kawaguchi, Toshio Nakagohri, Tetsuya Mine, Naoya Nakamura
Accessory spleens (ASs), ectopic splenic tissue at intrapancreatic and extrapancreatic sites, rarely contain epidermoid cysts. Our aim was to analyze the incidence of epidermoid cysts in ASs and perform an immunohistochemical analysis of its epithelial lining. We included in the study 148 ASs from 135 patients, for which pathological data were available. Eleven were intrapancreatic ASs (IPASs) and 137 were extrapancreatic ASs (EPASs). Six of the eleven (55%) IPASs contained epidermoid cysts, but they were not detected in EPASs...
May 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28533583/high-grade-urothelial-carcinoma-of-bladder-transforming-to-micropapillary-variant-on-follow-up
#16
Nitu Kumari, Anupama Jha, Pawan Vasudeva, Usha Agrawal
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinoma and returned with recurrence after 16 months. Histopathology after transurethral biopsy revealed a non-muscle invasive high-grade bladder tumour at first presentation, whereas tumour recurrence was reported after 1...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28526245/lymphogenous-metastasis-to-the-transverse-colon-that-originated-from-signet-ring-cell-gastric-cancer-a-case-report-and-review-of-the-literature
#17
Hirofumi Sonoda, Kazushige Kawai, Hironori Yamaguchi, Koji Murono, Manabu Kaneko, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Soichiro Ishihara, Susumu Aikou, Hiroharu Yamashita, Tetsuo Ushiku, Yasuyuki Seto, Masashi Fukayama, Toshiaki Watanabe
Metastases to the colon are rare and a high-frequency primary region is the stomach. In cases of metastases to the colon, the morphological type of the metastatic region is mostly the infiltrating type of poorly differentiated or undifferentiated adenocarcinoma with lymph and blood vessel invasion. A case of cancer metastasis to the transverse colon that originated from advanced gastric cancer, which shows the difficulties in the precise diagnosis of metastases to the colon, is presented. In the present case, the gastric carcinoma was determined to be an advanced infiltrative ulcerative adenocarcinoma and the colon carcinoma was determined to be a superficial depressed adenocarcinoma...
May 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28506732/primary-seminal-vesicle-carcinoma-the-usefulness-of-pax8-immunohistochemical-expression-for-the-differential-diagnosis
#18
Ilaria Posenato, Anna Caliò, Diego Segala, Salvatore Sgroi, Andrea Polara, Matteo Brunelli, Guido Martignoni
Primary seminal vesicle carcinoma is a rare entity whose diagnosis can be achieved ruling out the main carcinomas that commonly invade the seminal vesicles. Although a panel of immunohistochemical markers (CA125, CK7, CK20, PSA and PSAP) has been proposed as unique for primary seminal vesicle carcinoma, a reliable positive marker is lacking. In this article, we report a case of primary seminal vesicle carcinoma in a 57-years-old man. The tumor was localized to the left seminal vesicle and histologically characterized by papillae lined by broad eosinophilic cells with pleomorphic nuclei...
May 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28505002/immunohistochemical-classification-of-ampullary-carcinomas-critical-reappraisal-fails-to-confirm-prognostic-relevance-for-recently-proposed-panels-and-highlights-muc5ac-as-a-strong-prognosticator
#19
Yue Xue, Michelle D Reid, Serdar Balci, Brian Quigley, Takashi Muraki, Bahar Memis, Jun Xia, Ezgi Hacihasanoglu, Gabriela Bedolla, Burcin Pehlivanoglu, Grace E Kim, Takuma Tajiri, Nobuyike Ohike, Ritu Aneja, Alyssa M Krasinskas, Volkan Adsay
Recently, immunohistochemistry-based classifications of ampullary carcinomas have been proposed (Ang and colleagues [PMID: 24832159]; Chang and colleagues [PMID: 23439753]). In this study, the prognostic value of Ang/Chang panel markers (CK20, MUC1, MUC2, CDX2) as well as other markers (CK7, MUC5AC, and MUC6) were tested on full-faced sections of 136 ampullary carcinoma resections with substantial (>5 mm) invasion. Immunohistochemistry was correlated with both histologic classification (intestinal [INT], pancreatobiliary [PB], or nontubular based on ≥3/5 observer agreement) and clinical outcome...
July 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28495851/different-macrophages-equally-induce-emt-in-endometria-of-adenomyosis-and-normal
#20
Min An, Dong Li, Ming Yuan, Qiuju Li, Lu Zhang, Guo Yun Wang
Endometrial cells and microenvironment are two important factors in the pathogenesis of adenomyosis. Our previous study demonstrated that macrophages can induce eutopic epithelial cells of adenomyosis suffering from epithelial-mesenchymal transition (EMT). The aim of this study is to detect whether macrophages interacting with epithelial cells equally induce the EMT process in normal and eutopic endometria of healthy and adenomyotic patients; and macrophages parallelly polarize to M2. We investigated expressions of epithelial cadherin (E-cadherin), neural cadherin (N-cadherin), cytokeratin7 (CK7), vimentin, transforming growth factor-β1 (TGFB1), SMAD3 and pSMAD3 using Immunohistochemistry and Western Blot, then estimated genetic levels of CD163, IL10 and MMP12 using real-time quantitative polymerase chain reaction (RT-PCR) in macrophages...
May 11, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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