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https://www.readbyqxmd.com/read/29783804/-acquired-cystic-kidney-disease-associated-renal-cell-carcinoma-a-clinicopathologic-study-of-three-cases
#1
W Zhang, L L Xu, W J Yu, Q Wang, Y X Jiang, Y Liu, Y J Li
Objective: To study the clinicopathologic, immunohistochemical (IHC), histogenetic and prognostic features of acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC). Methods: Three cases of ACKD-RCC, including two from 401 Hospital of PLA and one from the Affiliated Hospital of Qingdao University were studied by clinical, histological and IHC analysis with review of relevant literature. Results: All the three patients were male, ranging from 46 to 78 years old. All patients had history of chronic renal failure; two patients were treated with hemodialysis for 9 years and 11 years, respectively...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29736668/immunohistochemical-predictors-for-intestinal-and-pancreatobiliary-types-of-adenocarcinoma-of-the-ampulla-of-vater
#2
João Paulo Lemos da Silveira Santos, Carla Jorge Machado, Eduardo Paulino Junior, João Bernardo Sancio Rocha Rodrigues, Paula Teixeira Vidigal, Vivian Resende
OBJECTIVES: To investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival. METHODS: Immunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29729192/immunohistochemical-and-genetic-characteristics-of-a-colorectal-mucin-rich-variant-of-traditional-serrated-adenoma
#3
Takafumi Hiromoto, Takashi Murakami, Yoichi Akazawa, Noriko Sasahara, Tsuyoshi Saito, Naoto Sakamoto, Hiroyuki Mitomi, Akihito Nagahara, Takashi Yao
AIMS: Recently, several morphological variants of traditional serrated adenoma (TSA) of the colorectum have been recognized, and mucin-rich TSA (MR-TSA) and serrated tubulovillous adenoma (S-TVA) were introduced as distinct morphological variants separate from conventional TSA (C-TSA). This study aimed to elucidate the immunohistochemical and genetic characteristics of MR-TSAs. METHODS AND RESULTS: We performed immunostaining for cytokeratins (e.g. CK7 and CK20), mucins (e...
May 5, 2018: Histopathology
https://www.readbyqxmd.com/read/29724582/primary-intestinal-type-adenocarcinoma-of-the-tongue
#4
C Guo, M-Q Jia, L Wang, J Jia
Primary intestinal-type adenocarcinoma (ITAC) of the tongue is a rare neoplasm. The case of a 59-year-old male with a painless mass in the dorsum of the oral tongue diagnosed as primary ITAC is reported here. The particular characteristic of the case was the patient's long-term medical history of 40years. The patient underwent resection of the tongue carcinoma through a midline approach and direct suture, with postoperative chemoradiotherapy. Immunohistochemical staining indicated that the tumour was positive for CK20 and negative for CK7...
April 30, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29723459/-clinicopathological-features-of-primary-seminal-vesicle-adenocarcinoma-a-report-of-4-cases-and-review-of-the-literature
#5
Jia-Ning Guo, Hui Li, Zhan-Dong Hu, En-Li Liang, Ji-Wu Chang
Objective: To investigate the clinicopathological characteristics, diagnosis, and treatment of primary seminal vesicle adenocarcinoma (SVAC). METHODS: We analyzed the clinical data and clinicopathological characteristics of 4 cases of primary SVAC treated in the Department of Urology of the Second Hospital of Tianjin Medical University and reviewed relevant literature. RESULTS: All the 4 patients were treated by open radical resection of the seminal vesicle and prostate and pathologically diagnosed with SVAC...
July 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29721106/biomarkers-in-urachal-cancer-and-adenocarcinomas-in-the-bladder-a-comprehensive-review-supplemented-by-own-data
#6
REVIEW
Henning Reis, Ulrich Krafft, Christian Niedworok, Orsolya Módos, Thomas Herold, Mark Behrendt, Hikmat Al-Ahmadie, Boris Hadaschik, Peter Nyirady, Tibor Szarvas
Urachal cancer (UrC) is a rare but aggressive cancer. Due to overlapping histomorphology, discrimination of urachal from primary bladder adenocarcinomas (PBAC) and adenocarcinomas secondarily involving the bladder (particularly colorectal adenocarcinomas, CRC) can be challenging. Therefore, we aimed to give an overview of helpful (immunohistochemical) biomarkers and clinicopathological factors in addition to survival analyses and included institutional data from 12 urachal adenocarcinomas. A PubMed search yielded 319 suitable studies since 1930 in the English literature with 1984 cases of UrC including 1834 adenocarcinomas (92%) and 150 nonadenocarcinomas (8%)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29720004/pulmonary-adenocarcinoma-mimicking-desquamative-interstitial-pneumonia-report-of-2-cases-with-genetic-analysis
#7
Masashi Miyaoka, Kazuhito Hatanaka, Masayuki Iwazaki, Naoya Nakamura
We report 2 cases of pulmonary adenocarcinoma mimicking desquamative interstitial pneumonia (DIP) with genetic analysis occurring in a 74-year-old woman and a 76-year-old woman. In both cases, the tumor was mainly composed of discohesive tumor cells, which filled and floated in the alveolar space in a DIP-like pattern. The tumor cells had abnormally large round to oval nuclei with fine chromatin and relatively abundant eosinophilic cytoplasm lacking pigmentation. Immunohistochemically, tumor cells in both cases were positive for CK7, TTF-1, napsin A, E-cadherin, β-catenin, and PD-L1 (one case had high expression and the other had low expression), and negative for CK5/6, CK20, p40, and ALK...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29698884/primary-intrahepatic-mesotheliomas-a-case-presentation-and-literature-review
#8
Hishaam Ismael, Steven Cox
INTRODUCTION: Primary Intrahepatic mesotheliomas are malignant tumors arising from the mesothelial cell layer covering Glisson's capsule of the liver. They are exceedingly rare with only fourteen cases reported in the literature. They have nonspecific signs and symptoms and need a high index of suspicion and an extensive workup prior to surgery. Surgery remains the mainstay of treatment. PRESENTATION OF CASE: 48 year old male presented with a 3 months history of abdominal pain, productive cough, anemia and weight loss...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29698701/mucinous-intrahepatic-cholangiocarcinoma-a-distinct-variant
#9
Zhikai Chi, Amarpreet Bhalla, Omer Saeed, Liang Cheng, Kendra Curless, Hanlin L Wang, Deepa T Patil, Jingmei Lin
Mucinous variant of intrahepatic cholangiocarcinoma (iCC) is rare, and its clinicopathological features and prognosis are far less clear. Six patients who had iCCs with more than 50% of mucinous component and 79 conventional iCCs were included in the study. The mean size of mucinous and conventional iCCs was 6.2cm and 6.0cm, respectively. The majority of patients (83%) with mucinous iCC presented at T3 stage or above, compared to 28% of the conventional group (p<0.01). Three patients with mucinous iCC (50%) died within 1year...
April 23, 2018: Human Pathology
https://www.readbyqxmd.com/read/29692901/primary-high-grade-calcitonin-negative-neuroendocrine-carcinoma-of-the-thyroid-a-very-rare-cancer
#10
Joseph A Chorny, John J Orrego, José Manuel Cameselle-Teijeiro
Most medullary thyroid carcinomas (MTCs) are low grade and produce calcitonin. There are some calcitonin-negative MTCs that produce only calcitonin gene-related peptide (CGRP). Rarely, MTCs are negative for calcitonin and CGRP peptides, but contain their corresponding mRNAs. Primary thyroid neuroendocrine neoplasms other than MTCs are extremely rare. We describe a primary high-grade neuroendocrine carcinoma that was negative for CGRP and calcitonin at both the protein and mRNA levels. A 42-year-old woman presented with a rapidly enlarging thyroid mass replacing most of the left lobe and isthmus...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29690667/-clinicopathologic-characterisitics-of-pancreatic-acinar-cell-carcinomas
#11
X H Ding, Z B Wang, X M Qiu
Objective: To investigate clinical, pathological and immunohistochemical features of pancreatic acinar cell carcinoma. Methods: A retrospective review of surgical and pathological databases between 2011 and 2016 at PLA General Hospital was collected and 14 cases of acinar cell carcinoma (ACC) of the pancreas were identified. EnVision immunohistochemistry was used to detect the expression of Trypsin, bcl-10 and cytokeratin(CK) proteins. Results: The patients included nine cases of pure ACC, 3 cases of mixed acinar ductal carcinoma, 1 case of mixed acinar-neuroendocrine carcinoma and acinar-ductal-neuroendocrine carcinoma, respectively...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29680777/stromal-cells-telocytes-and-endothelial-progenitors-in-the-perivascular-niches-of-the-trigeminal-ganglion
#12
M C Rusu, V S Mănoiu, D Creţoiu, S M Creţoiu, A D Vrapciu
Stromal cells/telocytes (SCs/TCs) were recently described in the human adult trigeminal ganglion (TG). As some markers are equally expressed in SCs/TCs and endothelial cells, we hypothesized that a subset of the TG SCs/TCs is in fact represented by endothelial progenitor cells of a myelomonocytic origin. This study aimed to evaluate whether the interstitial cells of the human adult TG correlate with the myelomonocytic lineage. We used primary antibodies for c-erbB2/HER-2, CD31, nestin, CD10, CD117/c-kit, von Willebrand factor (vWF), CD34, Stro-1, CD146, α-smooth muscle actin (α-SMA), CD68, VEGFR-2 and cytokeratin 7 (CK7)...
April 19, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29680194/the-challenge-of-evaluating-adnexal-masses-in-patients-with-breast-cancer
#13
REVIEW
Tomás Reinert, Angélica Nogueira-Rodrigues, Fabiola Procacci Kestelman, Patricia Ashton-Prolla, Márcia Silveira Graudenz, José Bines
This narrative literature review addresses the problem of an adnexal mass discovered during the course of breast cancer (BC) care, which may represent a benign condition, a metastatic process, or a primary ovarian cancer (OC), clinical scenarios associated with distinct physiopathology and prognosis. Furthermore, the coexistence of BC and OC in the same patient may be owing to a hereditary disorder, deserving specific management strategies and counseling. The initial detection and evaluation of an adnexal mass in a patient with BC requires a high index of suspicion, and the initial workup should include a thorough medical history and physical examination, measurement of tumor markers, complete blood count, and imaging tests...
March 12, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29675349/primary-ductal-adenocarcinoma-of-lacrimal-gland-two-case-reports-and-review-of-the-literature
#14
Hsin-Yu Yang, Cheng-Hsien Wu, Chieh-Chih Tsai, Wei-Kuang Yu, Shu-Ching Kao, Catherine Jui-Ling Liu
A 64-year-old male presented with progressive proptosis of the left eye for 3 months. Orbital computed tomography (CT) demonstrated a 3.9 cm infiltrative mass over the superotemporal quadrant of the left orbit. Pathology of biopsy revealed a ductal adenocarcinoma of lacrimal gland with positive immunohistochemical staining for androgen receptor (AR), cytokeratin-7 (CK7), and gross cystic disease fluid protein 15 (GCDFP-15). The patient received orbital exenteration and adjuvant chemoradiotherapy. No recurrence or metastasis was noted 27 months after treatment...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29672360/cutaneous-metastasis-of-adenocarcinoma-of-the-ampulla-of-vater
#15
Angel Fernandez-Flores, David S Cassarino
Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. The scalp biopsy showed a dermal and epidermotropic well-differentiated glandular neoplasm with abundant neutrophils within the luminae of the tumoral glands...
April 17, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29664741/primary-vaginal-gastric-type-adenocarcinoma-and-vaginal-adenosis-exhibiting-gastric-differentiation-report-of-a-series-with-detailed-immunohistochemical-analysis
#16
Richard Wing-Cheuk Wong, Michelle Moore, Karen L Talia, Raji Ganesan, W Glenn McCluggage
So-called gastric-type adenocarcinoma and related premalignant lesions have been characterized in the cervix, but similar lesions are not widely recognized in the vagina. We report a series of 11 vaginal glandular lesions exhibiting gastric differentiation, comprising 5 cases of adenocarcinoma and 6 of adenosis. All cases occurred in adults (aged 33 to 69) with no known history of diethylstilboestrol exposure. The vaginal adenocarcinomas exhibited morphologic features identical to gastric-type adenocarcinoma of the cervix, but 1 case additionally demonstrated basaloid and sarcomatoid components, which have not been previously reported in cervical gastric-type adenocarcinoma...
April 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29660830/cytologic-diagnosis-of-primary-peritoneal-high-grade-serous-carcinoma-in-a-man
#17
Brandon Umphress, John Philip, Yaxia Zhang, Xiaoqi Lin
Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm histologically indistinguishable from ovarian serous carcinoma primarily occurring in the female population. To date, extremely rare cases of PPSC have been reported in men; however, diagnosis by cytology has yet to be described. Here we present the clinical, radiographic, cytomorphologic, histologic and immunohistochemical (IHC) findings of a high-grade (HG) PPSC in a 70-year-old man with a history of prostatic adenocarcinoma. Core needle biopsy (CNB) touch preparation smears showed pleomorphic, round, columnar and polygonal epithelioid cells present singly or arranged in loosely cohesive three-dimensional clusters...
April 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29652189/a-review-and-update-on-papillary-immature-metaplasia-of-the-uterine-cervix-a-distinct-subset-of-low-grade-squamous-intraepithelial-lesion-proposing-a-possible-cell-of-origin
#18
Soon Auck Hong, Su Hyun Yoo, Jene Choi, Stanley J Robboy, Kyu-Rae Kim
CONTEXT: - Papillary immature metaplasia (PIM) is a known papillary cervical lesion associated with low-risk human papilloma virus (LR-HPV). OBJECTIVE: - To evaluate additional clinicopathologic features and the HPV genotypes of PIM and discuss the presumptive cell of origin. DESIGN: - A total of 26 PIM cases were evaluated by p16INK4a , cytokeratin (CK) 7, and CK17 immunohistochemical stainings. Human papilloma virus genotyping was performed, by using HPV DNA Chip, HPV polymerase chain reaction (PCR), and real-time PCR...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29643652/utility-of-cytokeratin7-immunocytochemistry-in-the-cytopathological-diagnosis-of-fibrolamellar-hepatocellular-carcinoma
#19
Rashi Garg, Radhika Srinivasan, Pranab Dey, Priya Singh, Nalini Gupta, Arvind Rajwanshi
Objective: To distinguish fibrolamellar hepatocellular carcinoma (FL-HCC) variant from the conventional hepatocellular carcinoma (HCC) by cytology, immunocytochemistry, and morphometry. Study Design: Retrospective detailed cytomorphological, immunocytochemical, and morphometric analysis was performed in 6 cases of FL-HCC reported on fine needle aspiration. Cell block immunocytochemistry (CB-ICC) for CK7 and CD68 was performed in four cases. Morphometry was carried out with Cell A software...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643136/orbital-metastasis-from-an-occult-breast-carcinoma-t0-n1-m1
#20
Rita Pinto Proença, Júlia Fernandes, Miguel N Burnier, Rui Proença
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour...
April 11, 2018: BMJ Case Reports
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