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https://www.readbyqxmd.com/read/27782313/cytotoxic-ebv-positive-large-b-cell-lymphoma-a-breg-derived-neoplasia
#1
Valentina Tabanelli, Vanessa Santiago-Pacheco, Mario Corbellino, Angelica Calleri, Claudio Agostinelli, Carlo Parravicini, Stefano A Pileri
AIMS: A new subtype of granzyme B (GrB) producing "regulatory B cells" (Bregs) has been recently described; these peculiar cytotoxic B-cells are significantly increased in interleukin-21 (IL-21)-rich settings, and in particular during HIV and EBV infection. Our aim is to report a unique case of an EBV-positive diffuse large B-cell lymphoma (DLBCL) with cytotoxic features arisen in an HIV+ patient, and to understand if this lesion may represent a proliferation of neoplastic cytotoxic Bregs...
October 26, 2016: Histopathology
https://www.readbyqxmd.com/read/27756777/hiv-infection-and-survival-of-lymphoma-patients-in-the-era-of-highly-active-antiretroviral-therapy
#2
Xuesong Han, Ahmedin Jemal, Erin Hulland, Edgar P Simard, Loretta Nastoupil, Elizabeth M Ward, Christopher R Flowers
BACKGROUND: Highly active antiretroviral therapy (HAART) has extended the life expectancy of HIV/AIDS patients to approach that of the general population. However, it remains unclear whether HIV infection affects the survival of lymphoma patients in the HAART era. METHODS: Patients diagnosed with Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), peripheral T-cell lymphoma (PTCL) or follicular lymphoma (FL) during 2004-2011 were identified from the National Cancer Database...
October 18, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27696080/determining-protein-biomarkers-for-dlbcl-using-ffpe-tissues-from-hiv-negative-and-hiv-positive-patients
#3
Pumza Magangane, Raveendra Sookhayi, Dhirendra Govender, Richard Naidoo
DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and specificity. In addition, these biomarkers have not been studied in the HIV context. Therefore, the identification of new biomarkers for HIV negative and HIV positive DLBCL, may lead to a better understanding of the disease pathology and better therapeutic design...
October 1, 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27688606/hiv-associated-hematologic-malignancies-experience-from-a-tertiary-cancer-center-in-india
#4
Rakesh Reddy, Ajay Gogia, Lalit Kumar, Atul Sharma, Sameer Bakhshi, Mehar C Sharma, Saumyaranjan Mallick, Ranjit Sahoo
CONTEXT AND AIM: Data on HIV associated hematologic malignancies is sparse from India. This study attempts to analyze the spectrum and features of this disease at a tertiary cancer center in India. SETTING AND METHODS: Retrospective study from case records of patients registered with a diagnosis of hematologic malignancy and HIV infection between January 2010 and June 2015. RESULTS: Thirteen cases of HIV associated hematologic malignancies were identified, six of them pediatric...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27418269/contributions-of-hiv-to-non-hodgkin-lymphoma-mortality-trends-in-the-united-states
#5
Nadia Howlader, Meredith S Shiels, Angela B Mariotto, Eric A Engels
BACKGROUND: The human immunodeficiency virus (HIV) epidemic has strongly influenced non-Hodgkin lymphoma (NHL) incidence in the U.S. general population, but its effects on NHL mortality trends are unknown. METHODS: Using SEER cancer registry data, we assessed NHL mortality rates in the United States (2005-2012) and mapped NHL deaths to prior incident cases. Data included HIV status at NHL diagnosis. We describe the proportion of NHL deaths linked to an HIV-infected case, for 3 AIDS-defining subtypes [diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma, and central nervous system (CNS) lymphoma] and within demographic categories...
September 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27271843/recent-advances-in-aggressive-large-b-cell-lymphomas-a-comprehensive-review
#6
Penelope Korkolopoulou, Theodoros Vassilakopoulos, Vassilios Milionis, Maria Ioannou
Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with considerable heterogeneity reflected in the 2008 World Health Organization classification. In recent years, genome-wide assessment of genetic and epigenetic alterations has shed light upon distinct molecular subsets linked to dysregulation of specific genes or pathways. Besides fostering our knowledge regarding the molecular complexity of DLBCL types, these studies have unraveled previously unappreciated genetic lesions, which may be exploited for prognostic and therapeutic purposes...
July 2016: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27197296/comprehensive-evaluation-of-medical-conditions-associated-with-risk-of-non-hodgkin-lymphoma-using-medicare-claims-medwas
#7
Eric A Engels, Ruth Parsons, Caroline Besson, Lindsay M Morton, Lindsey Enewold, Winnie Ricker, Elizabeth L Yanik, Hannah Arem, April A Austin, Ruth M Pfeiffer
BACKGROUND: Certain medical conditions affect risk of non-Hodgkin lymphoma (NHL), but the full range of associations is unknown. We implemented a novel method ("medical condition-wide association study," MedWAS) to comprehensively evaluate medical risk factors for NHL documented in administrative health claims. METHODS: Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we conducted a case-control study comparing NHL cases [N = 52,691, age 66+ years, with five subtypes: chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, marginal zone lymphoma (MZL), T-cell lymphoma (TCL)] to controls (N = 200,000)...
July 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/26875596/two-cases-of-primary-non-hodgkin-s-lymphoma-of-female-breast-role-of-fine-needle-aspiration-cytology-and-cell-block-immunohistochemistry
#8
Tarak Banik, Krishnendu Mondal, Rupali Mandal
Primary breast lymphoma (PBL) is an uncommon neoplastic condition. Though HIV-infection is a known risk factor for the development of extranodal lymphomas, mammary involvement is still a rarity. Radiologically, PBL appears as well circumscribed, heteroechoic, noncalcifying mass. Fine-needle aspiration cytology (FNAC) is commonly used to diagnose this neoplasm; however, subcategorization requires immunophenotypic characterization of the neoplastic cells. Herein, we report two cases of PBL, including a HIV-infected lady; in both the cases FNAC expressed features of non-Hodgkin's lymphoma...
March 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/26860883/unilateral-uveitis-masquerade-syndrome-caused-by-diffuse-large-b-cell-lymphoma-diagnosed-using-multiparametric-flow-cytometry-of-the-aqueous-humor
#9
Silvia Monsalvo, Cristina Serrano, Elena Prieto, Guillermo Fernández-Sanz, Maria-Camino Puente, Maria Rodriguez-Pinilla, Aranzazu Garcia Raso, Pilar Llamas, Raul Cordoba
BACKGROUND The uveitis masquerade syndromes (UMS) are a group of ocular diseases that may mimic chronic intraocular inflammation. Many malignant entities such as non-Hodgkin's lymphomas may masquerade as uveitis. We report a case of an HIV-positive patient with masquerade syndrome presenting unilateral uveitis. CASE REPORT 45-year-old Caucasian man with a diagnosis of diffuse large B-cell lymphoma (DLBCL). The patient was diagnosed by a biopsy of an abdominal mass which showed fragments of gastric mucosa with diffuse growth of neoplastic cells...
February 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/26715026/long-term-remission-in-a-case-of-plasmablastic-lymphoma-treated-with-comp-cyclophosphamide-liposomal-doxorubicin-vincristine-prednisone-and-bortezomib
#10
Emanuele Cencini, Alberto Fabbri, Susanna Guerrini, Maria Antonietta Mazzei, Vania Rossi, Monica Bocchia
Plasmablastic lymphoma (PBL) is a rare subtype of non-Hodgkin lymphomas (NHL) strongly associated with HIV infection, even if cases in other immunosuppressed patients such as solid organ transplant recipients and in immunocompetent individuals have been increasingly reported. Current treatment strategy for HIV-negative patients is similar to DLBCL as first-line treatment, but durable remissions are seldom observed. Anthracycline-containing regimens could be too toxic for elderly patients and/or with cardiac failure, because a non-pegylated liposomal doxorubicin (NLD) could be used in this field...
June 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/26666614/rituximab-containing-chemotherapy-r-chop-induced-kaposi-s-sarcoma-in-an-hiv-negative-patient-with-diffuse-large-b-cell-lymphoma
#11
Hiroshi Ureshino, Toshihiko Ando, Kensuke Kojima, Hidekazu Itamura, Shunichi Jinnai, Kazuko Doi, Koichi Ohshima, Kazuya Kurogi, Masaharu Miyahara, Shinya Kimura
Rituximab treatment may cause or exacerbate Kaposi's sarcoma (KS) in patients with human immunodeficiency virus (HIV)-associated multicentric Castleman's disease. Despite the widespread use of rituximab, rituximab-induced KS has not yet been reported in HIV-negative patients with diffuse large B cell lymphoma (DLBCL). We herein report a case of KS that developed after undergoing rituximab-containing chemotherapy in an HIV-negative patient with DLBCL. An 84-year-old man who received rituximab-containing chemotherapy for the treatment of DLBCL developed severe infection, and subsequently KS...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26458141/whole-blood-ebv-dna-predicts-outcome-in-diffuse-large-b-cell-lymphoma
#12
Maria Chiara Tisi, Elisa Cupelli, Rosaria Santangelo, Elena Maiolo, Eleonora Alma, Manuela Giachelia, Maurizio Martini, Silvia Bellesi, Francesco D'Alò, Maria Teresa Voso, Maurizio Pompili, Giuseppe Leone, Luigi Maria Larocca, Stefan Hohaus
An association between Epstein-Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity. In a cohort of 218 human immunodeficiency virus (HIV)-negative patients with diffuse large B-cell lymphomas, we detected EBV-DNA in 25% of whole blood (WB) samples at diagnosis. Presence and viral load in WB, mononuclear cells or plasma did not predict the presence of EBV in the tumor biopsy. Positive Hepatitis C virus (HCV) serology was associated with a higher frequency of EBV in WB...
2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26355571/stromal-immune-infiltration-in-hiv-related-diffuse-large-b-cell-lymphoma-is-associated-with-hiv-disease-history-and-patient-survival
#13
Chun Chao, Lanfang Xu, Michael J Silverberg, Otoniel Martínez-Maza, Lie-Hong Chen, Brandon Castor, Donald I Abrams, Hongbin D Zha, Reina Haque, Jonathan Said
OBJECTIVE: Understanding tumor microenvironment and its impact on prognosis of HIV-related lymphomas may provide insight into novel therapeutic strategies. DESIGN: We characterized the relationship between infiltrating immune cells with tumor characteristics, HIV disease history and survival in 80 patients with HIV-related diffuse large B-cell lymphoma (DLBCL) diagnosed in the era of combined antiretroviral therapy (1996-2007) at Kaiser Permanente California. Eighty patients with HIV-unrelated DLBCL were included for comparison...
September 24, 2015: AIDS
https://www.readbyqxmd.com/read/25964853/reversible-methotrexate-associated-lymphoma-of-the-liver-in-rheumatoid-arthritis-a-unique-case-of-primary-hepatic-lymphoma
#14
Ai Kawahara, Junichi Tsukada, Takahiro Yamaguchi, Takefumi Katsuragi, Takehiro Higashi
Primary hepatic lymphoma (PHL) is an extremely rare disease, frequently associated with viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immune deficiency virus (HIV). On the other hand, an increased risk of lymphoproliferative disorders (LPD) has been demonstrated in patients treated with immunosuppressive drugs such as methotrexate (MTX) for rheumatoid arthritis (RA). The role of Epstein-Barr virus (EBV) has been discussed in the pathogenesis of the immunodeficiency-associated LPDs...
2015: Biomarker Research
https://www.readbyqxmd.com/read/25843016/burkitt-leukaemia-lymphoma-r-codox-m-r-ivac-remains-gold-standard-treatment-in-bl
#15
L Smyth, P V Browne, E Conneally, C Flynn, P Hayden, M Jeffers, D O'Brien, F Quinn, J Kelly, M Perera, G M Crotty, M Leahy, B Hennessy, F Jackson, M Ryan, E Vandenberghe
BACKGROUND: Sporadic Burkitt lymphoma (BL), characterised by translocation-associated C-MYC upregulation is a rare, aggressive lymphoma with a cure rate up to 90 % using the R-CODOX-M/R-IVAC (RCRI) protocol. RCRI is active in HIV-associated BL in combination with HAART. The WHO classification system defines lymphomas intermediate between DLBCL and BL, in which lymphomas with t(14;18)(q32;q21) and C-MYC-carrying translocation, i.e. 'double-hit' are included (BL-DH), and these patients are conventionally treated with RCRI...
November 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/25745961/-cardiac-and-breast-diffuse-large-b-cell-lymphoma-with-pericardial-effusion-and-av-block
#16
Tatsuki Tomikawa, Takayuki Tabayashi, Michihide Tokuhira, Reiko Watanabe, Morihiko Sagawa, Tomoe Nemoto, Yuta Kimura, Yasuyuki Takahashi, Shigehisa Mori, Morihiro Higashi, Jun-Ichi Tamaru, Masahiro Kizaki
Primary cardiac lymphoma is extremely rare and is associated with a poor prognosis. In most cases, cardiac involvement occurs as a late symptom and the diagnosis is thus delayed. We herein report a 35-year-old woman with cardiac diffuse large B-cell lymphoma (DLBCL) with breast infiltration. The patient was admitted to our hospital based on an initial presentation with dyspnea on exertion, chest pain, and a hard mass of the left breast. Echocardiography revealed a mass in the right atrium wall and interatrial septum, and massive pericardial effusion...
January 2015: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/25730510/hiv-infection-impact-on-clinical-biological-features-and-outcome-of-diffuse-large-b-cell-lymphoma-treated-with-r-chop-in-the-combination-antiretroviral-therapy-era
#17
MULTICENTER STUDY
Maria Joao Baptista, Olga Garcia, Mireia Morgades, Eva Gonzalez-Barca, Pilar Miralles, Armando Lopez-Guillermo, Eugenia Abella, Miriam Moreno, Juan-Manuel Sancho, Evarist Feliu, Josep-Maria Ribera, Jose-Tomas Navarro
OBJECTIVE: Since the introduction of combination antiretroviral therapy (cART) patients with HIV-related diffuse large B-cell lymphoma (DLBCL) show better control of immunosuppression, which may have an impact on the characteristics and prognosis of the disease. We aimed to compare the clinical presentation and prognosis of patients with HIV-related and HIV-unrelated DLBCL treated with rituximab, cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP) in the cART era. METHODS AND DESIGN: Eighty-one HIV-infected patients included in a Spanish multicentre trial were compared with 84 HIV-uninfected patients diagnosed in a Spanish institution in the same period all treated with R-CHOP...
April 24, 2015: AIDS
https://www.readbyqxmd.com/read/25709547/promising-role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-human-immunodeficiency-virus-associated-non-hodgkin-s-lymphoma
#18
Boom Ting Kung, W S Mak, S M J Lau, T K Auyong, C M Tong
This case report explores the potential role of FDG PET/CT in HIV -associated systemic non-Hodgkin's lymphoma (HIV-NHLs). In our locality, there are a cumulative total of 5523 reported HIV infections cases since 1984. We reported a case of HIV-related Burkitt's lymphoma (BL) and a case of diffuse large B-cell lymphoma (DLBCL) that underwent PET/CT examination in our PET centre. In HIV-NHLs patients, we must be reminded that not all hypermetabolic foci represent lymphomatous lesions. There is a close correlation between the pattern of lymphoid tissue activation in FDG PET/CT and HIV progression in patients without HIV-related malignancy...
January 2015: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/25678011/primary-lymphomas-in-the-gastrointestinal-tract
#19
REVIEW
Jiang Chen Peng, Lu Zhong, Zhi Hua Ran
Primary gastrointestinal (GI) lymphomas are uncommon diseases that can involve the whole GI tract. The etiologies of the disease remain unclear, and potential risk factors include celiac disease, Helicobacter pylori infection, use of immunosuppressive agents, human immunodeficiency virus (HIV) or Epstein-Barr virus (EBV) infection and inflammatory bowel disease, etc. Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma are the most common subtypes of GI lymphomas. B-cell lymphomas of the GI tract are more common in Western countries, while in Asia-Pacific region T-cell lymphomas are more frequently reported...
April 2015: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/25589617/a-comparative-study-of-molecular-characteristics-of-diffuse-large-b-cell-lymphoma-from-patients-with-and-without-human-immunodeficiency-virus-infection
#20
COMPARATIVE STUDY
Chun Chao, Michael J Silverberg, Lanfang Xu, Lie-Hong Chen, Brandon Castor, Otoniel Martínez-Maza, Donald I Abrams, Hongbin D Zha, Reina Haque, Jonathan Said
PURPOSE: HIV-related diffuse large B-cell lymphoma (DLBCL) may be biologically different from DLBCL in the general population. We compared, by HIV status, the expression and prognostic significance of selected oncogenic markers in DLBCL diagnosed at Kaiser Permanente in California, between 1996 and 2007. EXPERIMENTAL DESIGN: Eighty HIV-infected DLBCL patients were 1:1 matched to 80 HIV-uninfected DLBCL patients by age, gender, and race. Twenty-three markers in the following categories were examined using IHC: (i) cell-cycle regulators, (ii) B-cell activators, (iii) antiapoptotic proteins, and (iv) others, such as IgM...
March 15, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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