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Yolk sac tumor

Turan Yıldız, Zekeriya İlçe, Yasemin Gündüz, Gözde Çakar Çakırsoy
Undescended testicle is the most common congenital anomaly among males. Testicular tumor develops in 3-5% of the boys with a complaint of undescended testicle. The clinical presentation of malignant intra-abdominal testicular tumors ranges from asymptomatic cases to acute abdomen. In this study, we present a child with testicular tumor rupture which is observed very rarely. A 16-year-old boy presented 24 hours after the sudden onset of right lower quadrant pain, nausea, vomiting and fever. On physical examination, extensive tenderness in the abdomen and abdominal guarding were found...
September 2016: Türk Pediatri Arşivi
Annikka Weissferdt, Neda Kalhor, Jaime Rodriguez Canales, Junya Fujimoto, Ignacio I Wistuba, Cesar A Moran
Primary mediastinal germ cell tumors are uncommon tumors that can pose diagnostic difficulties due to their morphologic spectrum and unusual site. Immunohistochemistry plays an increasing role in the diagnosis of these tumors. Whereas the immunophenotype of testicular yolk sac tumors (YST) is rather well known, the opposite is true for primary mediastinal YST leading us to investigate the immunohistochemical features of 14 such neoplasms. Fourteen cases of primary mediastinal YST were reviewed and representative whole tissue sections were selected for immunohistochemical analysis using antibodies directed against CAM5...
September 16, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Francesco Esposito, Marco Di Serafino, Patrizia Oresta
Malignant sacrococcygeal yolk sac tumor is a rare extra-gonadal germ cell tumor of infancy and childhood. We report the case of a 14-month-old white female infant with a rapidly growing supra-gluteal mass at first misdiagnosed as hemangioma after a clinical assessment. The lesion was then classified as extra-gonadal yolk sac tumor due to alarming ultrasound features, later confirmed at MRI and pathology. This report remarks the need of a rigorous methodology in the ultrasound exploration of the gluteal region...
September 2016: Journal of Ultrasound
Sanjita Ravishankar, Anais Malpica, Preetha Ramalingam, Elizabeth D Euscher
We present the clinicopathologic features of 15 cases of extragonadal yolk sac tumor (EGYST) detected in female patients and reviewed at our institution from 1988 to 2016. We recorded: patient age, clinical presentation, tumor location, FIGO stage (where applicable), histologic patterns including presence/absence of Schiller-Duval bodies, other germ cell or somatic components, immunoperoxidase results, treatment, and outcome. Patients' ages ranged from 17 to 87 (median, 62) years and presentation included: abnormal uterine bleeding, 12; hematuria, 1; labial mass, 1; abdominal pain, 1...
September 14, 2016: American Journal of Surgical Pathology
Manuel Nistal, Ricardo Paniagua, Pilar Gonzalez-Peramato, Miguel Reyes-Múgica
Testicular tumors in the prepubertal age are relatively rare, representing only 9.4% of the total testicular and paratesticular specimens from a 20 year review performed at a large pediatric hospital 1. They account for 1 to 2 % of all solid tumors in the pediatric age group, with an annual incidence between 0.5 and 2/100,000 boys according to Coppes et al. 2 and data from the Prepubertal Testicular Tumor Registry 3. Similar to other neoplasms afflicting children, a bimodal age distribution is observed. The first peak is between birth and 3 years of age, and a second one occurs at the onset of puberty,extending to the fourth decade...
September 14, 2016: Pediatric and Developmental Pathology
Snehal S Patel, Surender Nakka
BACKGROUND: Studies have shown the renin angiotensin system via angiogenesis is involved in tumor development. OBJECTIVE: Therefore, the objective of present study was to examine the effect of perindopril on tumor growth and angiogenesis in animal model of breast cancer. METHODS: In the present study, we investigated the effect of perindopril on tumor development of mammary gland cancer induced by 7,12-dimethylbenz[a]anthracene, mouse tumor xenograft and corneal micropocket model...
August 17, 2016: Anti-cancer Agents in Medicinal Chemistry
Bo Li, Qianqian Jiang, Shitai Zhang, Yang Zhou, Qing-Fu Zhang, Ling OuYang
Yolk sac tumor (YST) is a common malignant primitive germ cell tumor that often exhibits differentiation into endodermal structures. They most commonly occur in childhood and adolescence and are rare after the age of 40 years. Derived from the yolk sac during the embryonic period, YSTs can occur in the gonads and germ cells because the tumor cells migrate from the yolk sac toward the gonads. Here, we present a rare case of primary gluteus YST in a 3-year-old girl. She received BEP chemotherapy (bleomycin + etoposide + cisplatin) after surgical resection...
2016: OncoTargets and Therapy
Teng Zhang, Yufeng Yao, Jingjing Wang, Yong Li, Ping He, Vinay Pasupuleti, Zhengkun Hu, Xinzhen Jia, Qixue Song, Xiaoli Tian, Changqin Hu, Qiuyun Chen, Qing Kenneth Wang
Aggf1 is the first gene identified for Klippel-Trenaunay syndrome (KTS), and encodes an angiogenic factor. However, the in vivo roles of Aggf1 are incompletely defined. Here we demonstrate that Aggf1 is essential for both physiological angiogenesis and pathological tumor angiogenesis in vivo Two lines of Aggf1 knockout (KO) mice showed particularly severe phenotype as no homozygous embryos were observed and heterozygous mice also showed embryonic lethality (haploinsufficient lethality) observed only for Vegfa and Dll4 Aggf1(+/-) KO caused defective angiogenesis in yolk sacs and embryos...
August 13, 2016: Human Molecular Genetics
Robert E Emerson, Chia-Sui Kao, John N Eble, David J Grignon, Mingsheng Wang, Shaobo Zhang, Xiaoyan Wang, Rong Fan, Timothy A Masterson, Lawrence M Roth, Liang Cheng
AIMS: Sacrococcygeal teratomas are rare tumours that occur most frequently in neonates, although adult cases also occur. The molecular pathogenesis of these tumours and their long-term prognosis is uncertain. We investigated the i(12p) status of a large number of primary sacrococcygeal teratomas in both children and adults, including cases with malignant germ cell tumour elements. METHODS AND RESULTS: Fifty-four sacrococcygeal teratoma specimens from 52 patients were identified, and available follow-up information was obtained...
August 13, 2016: Histopathology
F Bremmer, P Ströbel
The mediastinum is among the most frequent anatomic region in which germ cell tumors (GCT) arise, second only to the gonads. Mediastinal GCT (mGCT) account for 16 % of all mediastinal neoplasms. Although the morphology and (according to all available data) the molecular genetics of mediastinal and gonadal GCT are identical, a number of unique aspects exist. There is a highly relevant bi-modal age distribution. In pre-pubertal children of both sexes, mGCT consist exclusively of teratomas and yolk sac tumors...
September 2016: Der Pathologe
Ting Zhao, Yan Liu, Hongyuan Jiang, Hao Zhang, Yuan Lu
Bilateral malignant ovarian germ cell tumors (MOGCTs) are rare. Determination of the optimal treatment modalities is crucial, as these malignancies mainly affect girls and young women who may wish to preserve their fertility. In order to review the prevalence, clinical characteristics, treatment and outcome of bilateral MOGCTs, we performed a retrospective review of patients who were diagnosed with bilateral MOGCTs and underwent primary surgery at the Obstetrics and Gynecology Hospital of Fudan University (Shanghai, China) between January, 2001 and December, 2014...
August 2016: Molecular and Clinical Oncology
Hadi Shojaei, Hong Hong, Raymond W Redline
Yolk sac tumors occur at both gonadal and extra-gonadal sites. A recent case of ovarian endometrioid-pattern yolk sac tumor with strong diffuse expression of TTF-1 illustrated the potential for misdiagnosis due to divergent expression of endodermal lineage markers. The aim of this study was to investigate the expression of four divergent endodermal lineage markers, TTF-1, CDX2, Hep Par 1, and Napsin A, in gonadal and extra-gonadal yolk sac tumors of differing age, sex, and location (excluding foci of overt hepatoid differentiation)...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Dhanalakshmi Arumugam, Pavithra Thandavarayan, Lalitha Chidambaram, Sudha Boj, Sumathi Marudasalam
Yolk sac tumour also known as primitive endodermal tumour is the most common malignant germ cell tumour (GCT) in the paediatric age group. Most common sites of involvement are ovaries and testes, but rarely can occur in the extragonadal sites. In the head and neck region, yolk sac tumours have been reported in the nasopharynx, sinonasal tract, orbit, ear and parotid gland. Nasopharynx is an uncommon site for yolk sac tumour and very few cases of nasopharngeal pure yolk sac tumour have been reported so far. Yolk sac tumours are highly malignant and have a poor prognosis...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Jiang-ze Wang, Shan-shan Hu, Lin-mei Zhang, Teng-feng Chen
OBJECTIVE: To investigate different treatment methods for stage-Is testicular mixed germ cell tumors (TMGCTs). METHODS: We retrospectively analyzed the clinical data about 3'cases of stage-Is TMGCTs (aged 26-39 years) treated in the 175th Hospital of PLA, reviewed relevant literature, and explored the clinical characteristics of TMGCTs. RESULTS: Of the 3 patients, 1 was treated by radical orchiectomy, 1 by radical orchiectomy + retroperitoneal lymph node dissection + BEP chemotherapy scheme, and the other by radical orchiectomy + radiotherapy...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
Isidro Machado, María Victoria López-Soto, Albadio Samir Pérez-López, Carlos Domínguez-Álvarez, Antonio Llombart-Bosch
Hyaline globules and papillary fragments in cytologic samples from two intra-abdominal tumors in young females are presented including the cytological features and the correlation with the histopathologic and immunohistochemical findings. In the first case a cytologic study from an ovarian mass showed papillary structures and isolated tumor cells with epithelioid morphology, irregular reniform-like nuclear contour, pale or vacuolated cytoplasm, abundant hyaline globules and occasional glomeruloid structures resembling Schiller-Duval bodies...
July 13, 2016: Diagnostic Cytopathology
Thibault de la Motte Rouge, Patricia Pautier, Catherine Genestie, Annie Rey, Sébastien Gouy, Alexandra Leary, Christine Haie-Meder, Pierre Kerbrat, Stéphane Culine, Karim Fizazi, Catherine Lhommé
BACKGROUND: The ovarian yolk sac tumor (OYST) is a very rare malignancy arising in young women. Our objective was to determine whether an early decline in serum alpha-fetoprotein (AFP) during chemotherapy has a prognostic impact. METHODS: This retrospective study is based on prospectively recorded OYST cases at Gustave Roussy (Cancer Treatment Center). Survival curves were estimated using the Kaplan-Meier method. The serum AFP decline was calculated with the formula previously developed and validated in male patients with poor prognosis non-seminomatous germ cell tumors...
September 2016: Gynecologic Oncology
Shaoguang Feng, Songsong Huang, Yulong Tong, Zhongliang Chen, Delei Shen, Dazhou Wu, Xin-He Lai, Xiaoming Chen
BACKGROUND: RNA-binding protein LIN28 is involved in maintaining the pluripotency of embryonic stem cells. It has been detected in different types of testicular and ovarian germ cell tumors (GCTs), but its status in pediatric YSTs (yolk sac tumors) is still unknown. The aim of this study was to determine the immunohistochemical profile of LIN28 in pediatric YSTs. METHODS AND RESULTS: Immunohistochemistry detection of LIN28 was performed in 22 cases of pediatric YSTs and 10 mature teratomas...
August 2016: Pediatric Surgery International
X Wang, J He, Y Li
PURPOSE OF INVESTIGATION: Little is known regarding ovarian yolk sac tumor (YST) in postmenopausal females. The authors aimed to investigate the clinical features and prognosis of postmenopausal patients with ovarian YST. MATERIALS AND METHODS: Five cases of ovarian YST in postmenopausal females were retrospectively reviewed. A MEDLINE search was performed to identify postmenopausal patients with ovarian YST. RESULTS: Four patients had Stage I or II disease (Stage IC, IIC, and IIB in one, two, and one patient, respectively), and one patient demonstrated an unclear stage...
2016: European Journal of Gynaecological Oncology
T L Suma, Subramaniam Ramanathan, M Padma, L Appaji, M N Suma
Tumors arising from urachus in children are exceedingly rare and sporadically reported in literature. Being a midline structure, the urachus may harbor neoplastic germ cell elements and can occasionally present as a case of acute abdomen. A 20-month-old toddler presented with spontaneous rupture of an urachal yolk sac tumor causing hemoperitoneum. He underwent resection, received platinum-based chemotherapy and presently remains well on follow-up. Despite its rarity, urachal germ cell tumors must be considered in a child with acute abdomen and tumor markers must be measured preemptively in such cases...
June 17, 2016: Journal of Pediatric Hematology/oncology
Hyun-Jin Lee, Yeon Ju Yang, Sewon Jeong, Jong Dae Lee, Seok-Yong Choi, Da-Woon Jung, In Seok Moon
OBJECTIVES/HYPOTHESIS: The development of a simple, reliable, and cost-effective animal model greatly facilitates disease treatment. We aimed to establish a rapid, simple, and reproducible live zebrafish vestibular schwannoma xenograft model for antitumor drug screening. METHODS: We optimized each of the following conditions for tumor cell xenografts in zebrafish larvae: larval stage, incubation temperature, and injected cell number. We used NF2-/-mouse Schwann (SC4) cells and generated mCherry fluorescent protein-expressing cells prior to injection into zebrafish larvae...
May 31, 2016: Laryngoscope
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