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Yolk sac tumor

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https://www.readbyqxmd.com/read/29768344/synchronous-adrenocortical-carcinoma-and-ovarian-malignant-mixed-germ-cell-tumor-a-case-report-and-literature-review
#1
Ying He, Lian Xu, Qingli Li, Min Feng, Wei Wang
RATIONALE: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors. PATIENT CONCERNS: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. We describe the clinical, histopathological, and immunohistochemical findings and review the English literatures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29753846/role-of-hnf1%C3%AE-in-the-differential-diagnosis-from-other-germ-cell-tumors
#2
Anne-Laure Rougemont, Jean-Christophe Tille
Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1β...
May 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29705139/characteristics-treatment-decisions-and-outcomes-of-prepubertal-testicular-germ-cell-tumor-a-descriptive-analysis-from-a-large-chinese-center
#3
P Liu, W Li, H C Song, L L Jiao, W P Zhang, N Sun
INTRODUCTION: Prepubertal testicular tumors are fundamentally distinct from their postpubertal and adult counterparts. Racial and ethnic differences contribute to the incidence, characteristics, and histological distribution of prepubertal testicular germ cell tumors (PTGCTs). OBJECTIVE: To elucidate the characteristics and treatment outcomes of PTGCTs in a Chinese cohort. STUDY DESIGN: Data were retrospectively reviewed from consecutive PTGCT patients aged <12 years who received treatment at the current institution from January 2007 to December 2015...
April 3, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29677525/insights-from-diversified-anti-angiogenic-models-role-of-%C3%AE-interferon-inducer-deae-dextran
#4
Anita K Bakrania, Bhavesh C Variya, Snehal S Patel
BACKGROUND: Angiogenesis, the physiological process involving growth of new blood vessels from preexisting vessels, is essential for organ growth and repair. However, the imbalance in angiogenesis contributes to copious pathologies including cancer. Preceding the development of anti-angiogenic or proangiogenic agents, its evaluation is equally imperative; hence, precise and adequate models required. Valid mammalian models are expensive, time-consuming and not easy to set up, instigating legal and ethical aspects making it necessary to establish models with satisfactory activity and limited drawbacks...
April 17, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29664838/ovarian-yolk-sac-tumors-does-age-matter-erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29608939/testicular-yolk-sac-tumor-and-mature-teratoma-synchronous-bilateral-occurrence-in-an-infant
#6
Shuo Dong, Linsheng Zhao, Guanghua Pei, Yanjun Zhang, Shicheng Wang
Yolk sac tumor(YST) is a rare malignancy typically occurring in children. However, bilateral testicular YSTs are a quite rare situation, which can occur metachronously or synchronously with same histologic type, as well as different histology. We present a case of synchronous YST of the left testis and mature teratoma of the right in a 7-month-old infant treated with testis-sparing surgery at right testis and high radical orchiectomy at left. By follow-up of twenty eight-month, no atrophy or residual tumor in right testis and no recurrence or evidence of disease in left scrotum was found...
March 30, 2018: Urology
https://www.readbyqxmd.com/read/29600980/mediastinal-yolk-sac-tumor-infiltrating-the-heart
#7
R Imaniar, E Syahruddin, P Z Soepandi, A C Putra, F Nurwidya
BACKGROUND: As a rare tumor, yolk sac tumor is a type of neoplasm that appears like the yolk sac, extraembryonic mesenchyme, and allantois. The mediastinum is the second most frequent area after the gonadal area. CASE REPORT: We present an extremely rare case of 15 years old boy with mediastinal yolk sac tumor. The boy came with the chief complaint of swelling of the neck and face. Computed tomography scan of the chest revealed bulky mass with a cystic component that infiltrated the heart...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29593471/rare-metastatic-testicular-cancer-in-a-veteran
#8
Umar Karaman, Faye B Serkin, Jennifer M Taylor, Michael Constantinescu
Testicular yolk sac tumor (YST) is a nonseminomatous germ cell tumor that predominantly affects prepubescent boys. Pure endometrioid variant YST is rare, with only 1 report in the literature. We present the first reported case of en-dometrioid variant YST with mature teratoma in the retro-peritoneal specimen.
February 2018: Current Urology
https://www.readbyqxmd.com/read/29548872/a-rare-case-of-pediatric-vaginal-yolk-sac-tumor
#9
Michelle A Lightfoot, Aylin N Bilgutay, Andrew J Kirsch
A 14-month-old girl was evaluated for intermittent vaginal bleeding. Vaginoscopy revealed a friable tumor, and biopsy results confirmed a yolk sac tumor. Alpha-fetoprotein was elevated (1386 ng/mL) at diagnosis but quickly normalized with chemotherapy. The patient remained tumor-free 12 months after diagnosis without the need for radical surgery. Although rare, malignant tumors of the vagina must be included in the differential diagnosis of prepubertal girls who present with vaginal bleeding. Primary yolk sac tumor of the vagina is seen in girls less than 3 years of age and is treated with chemotherapy with or without surgical excision...
March 13, 2018: Urology
https://www.readbyqxmd.com/read/29538246/vaginal-yolk-sac-tumors-our-experiences-and-results
#10
Zhen Yuan, Dongyan Cao, Jiaxin Yang, Shen Keng, Huifang Huang
OBJECTIVE: Vaginal yolk sac tumors (YSTs) are rare malignant germ cell tumors largely affecting children younger than 3 years. Because of their low incidence, there is no consensus regarding diagnosis and treatment. In this article, we describe the presentation, diagnosis, treatment, and outcomes of 16 patients with vaginal YSTs diagnosed and managed at our center. METHODS: Diagnoses of YST of the vagina were confirmed by 2 experienced pathologists. All patients were treated with bleomycin, etoposide, and cisplatin (PEB) combination chemotherapy alone...
March 14, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29497026/right-ventricular-heart-failure-from-a-cardiac-yolk-sac-tumor
#11
Nicholas Isom, Aniket S Rali, Ivan Damjanov, Kevin Hubbard, Joel Grigsby, Kamal Gupta
BACKGROUND Cardiac involvement by a malignant tumor is rare. However, this is a case of right heart failure due to cardiac metastasis from a yolk sac tumor. Although a few case reports of cardiac metastasis from yolk sac tumors have been published, to our knowledge this is the first instance of multiple metastases to the right ventricular of yolk sac tumor in an adult male. CASE REPORT The patient is a 46-year-old male with a history of testicular cancer that presented with dyspnea on exertion. He was found to have two large right sided intracardiac masses on echocardiography...
March 2, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29483210/egf-receptor-and-mtorc1-are-novel-therapeutic-targets-in-nonseminomatous-germ-cell-tumors
#12
Kenneth S Chen, Nicholas J Fustino, Abhay A Shukla, Emily K Stroup, Albert Budhipramono, Christina Ateek, Sarai H Stuart, Kiyoshi Yamaguchi, Payal Kapur, A Lindsay Frazier, Lawrence Lum, Leendert H J Looijenga, Theodore W Laetsch, Dinesh Rakheja, James F Amatruda
Germ cell tumors (GCT) are malignant tumors that arise from pluripotent embryonic germ cells and occur in children and young adults. GCTs are treated with cisplatin-based regimens which, while overall effective, fail to cure all patients and cause significant adverse late effects. The seminoma and nonseminoma forms of GCT exhibit distinct differentiation states, clinical behavior, and response to treatment; however, the molecular mechanisms of GCT differentiation are not fully understood. We tested whether the activity of the mTORC1 and MAPK pathways were differentially active in the two classes of GCT...
May 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29482686/abdominal-supernumerary-testis-complicated-by-yolk-sac-tumor
#13
Safdar Shah, Muhammad Danial Ali Shah, Abeer Fatima, Fawad Nasrullah, Wajid Ali, Irfan Ahmed Gorya
We describe a case of a 26-year man with complaints of suprapubic pain and burning micturition for two weeks and intermittent hematuria for two months. On physical examination, there was palpable mobile pelvic mass measuring 10x10 cm. Both testes were palpable in the scrotum. CT scan abdomen revealed well-defined, soft tissue mass, about 11x10 cm between rectum and urinary bladder. Mass showed internal necrotic changes and enhancement along the walls. No calcification was seen. Exploratory laparotomy was done...
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29461339/neoadjuvant-bleomycin-etoposide-and-cisplatin-bep-chemotherapy-in-the-treatment-of-extensively-advanced-yolk-sac-tumors-a-single-center-experience
#14
Gong-Yi Zhang, Rong Zhang, Ling-Ying Wu, Bin Li, Shu-Min Li
OBJECTIVE: This study aimed to investigate the role of neoadjuvant bleomycin, etoposide, and cisplatin (BEP) regimen in patients with extensively advanced yolk sac tumors (YSTs). METHODS: Between July 1982 and December 2015, a total of 58 patients with YST were initially treated at our institution, among which 18 were evaluated to be inoperable and received neoadjuvant BEP regimen. They were either too debilitated by the disease [Eastern Cooperative Oncology Group Performance Status Scale (ECOG ps) ≥2] to undergo a major surgery or were with too extensively disseminated lesions to be optimally debulked...
May 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29450608/imaging-findings-of-ovarian-dysgerminoma-with-emphasis-on-multiplicity-and-vascular-architecture-pathogenic-implications
#15
Takahiro Tsuboyama, Yumiko Hori, Masatoshi Hori, Hiromitsu Onishi, Mitsuaki Tatsumi, Makoto Sakane, Takashi Ota, Noriyuki Tomiyama
We report the imaging findings of three ovarian dysgerminomas that coexisted with other germ cell tumors or gonadoblastomas, focusing on the distribution of tumor nests and vascular architecture, which might provide information about the pathogenesis of dysgerminomas. In a 14-year-old female with dysgerminoma and coexisting gonadoblastomas, contrast-enhanced magnetic resonance imaging (MRI) demonstrated a solid mass in the right ovary, which presented as hyperintense lobules on diffusion-weighted imaging separated by fibrovascular septa...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29420371/high-dose-chemotherapy-is-efficacious-and-well-tolerated-in-a-toddler-with-aicardi-syndrome-and-malignant-sacrococcygeal-teratoma
#16
Jessica D Wharton, Shaina Johnson, James A Connelly, Tracy Hills, Lauren Gingles, Margaret Wood, Gabriella L Crane, Howard M Katzenstein
Aicardi syndrome (AS) is a rare neurodevelopmental disorder, predominantly seen in female individuals, which appears to have an increased risk of both benign and malignant neoplasia. We report the case of a child with AS who presented with metastatic malignant sacrococcygeal tumor (with yolk sac elements) which recurred and then was treated with 3 cycles of high-dose chemotherapy with autologous stem cell rescue. The patient tolerated therapy with acceptable toxicity and remains in clinical remission 3 months after the completion of therapy...
February 7, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29416867/onco-testicular-sperm-extraction-onco-tese-from-a-single-testis-with-metachronous-bilateral-testicular-cancer-a-case-report
#17
Itsuto Hamano, Shingo Hatakeyama, Rika Nakamura, Rie Fukuhara, Daisuke Noro, Hiroko Seino, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yoshihito Yokoyama, Chikara Ohyama
Background: Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Case presentation: Here we report the case of a 25-year-old man who underwent onco-TESE from his residual single testis with a nonseminomatous germ cell tumor that occurred 5 years after orchiectomy of the contralateral testis...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29390446/hepatic-angiosarcomatous-transformation-of-a-mediastinal-germinal-cell-tumor-a-care-case-report
#18
Giuseppe Corrias, Joanna G Escalon, Laura Tang, Serena Monti, Luca Saba, Lorenzo Mannelli
RATIONALE: Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare. PATIENT CONCERNS: We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness. DIAGNOSES: The x-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29332656/germ-cell-tumor-causing-pleural-effusion-a-diagnostic-dilemma
#19
Surabhi Jaggi, Reetu Kundu, Sanjeev Binji, Uma Handa, Varinder Saini
Straw colored pleural fluid with raised adenosine deaminase (ADA) levels in young healthy adults usually raises suspicion of tuberculosis, sometimes leading to laxity in carrying thorough physical examination and missing out some important clues with potential disastrous consequences. A 35-year-old male was diagnosed to have left pleural effusion and anti-tubercular treatment was started on the basis of straw colored, lymphocyte-predominant pleural fluid with significantly raised ADA levels. When there was no improvement after 1 month of treatment he was investigated further and found to have a mediastinal mass along with hydro-pneumothorax...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29324254/prdm14-is-expressed-in-germ-cell-tumors-with-constitutive-overexpression-altering-human-germline-differentiation-and-proliferation
#20
Joanna J Gell, Jasmine Zhao, Di Chen, Timothy J Hunt, Amander T Clark
Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate. To examine PRDM14 in human GCTs we profiled human GCT cell lines and patient samples and discovered that PRDM14 is expressed in embryonal carcinoma cell lines, embryonal carcinomas, seminomas, intracranial germinomas and yolk sac tumors, but is not expressed in teratomas...
March 2018: Stem Cell Research
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