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https://www.readbyqxmd.com/read/29774836/pulmonary-infections-with-nontuberculous-mycobacteria-catalonia-spain-1994-2014
#1
Miguel Santin, Irene Barrabeig, Pierre Malchair, Lucia Gonzalez-Luquero, Miguel A Benitez, Josefina Sabria, Merce Palau-Benavent, Concepcion Cañete, Joan A Lloret-Queraltó, Maria D Grijota-Camino, Jordi Dorca, Fernando Alcaide
In Spain, systematic reporting of pulmonary infections with nontuberculous mycobacteria is not mandatory. Therefore, to determine trends, we retrospectively identified cases for January 1994-December 2014 in Catalonia. Over the 21 years, prevalence increased and was associated with being male. Mycobacterium avium complex and M. abscessus prevalence increased; M. kansasii prevalence decreased.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773279/-non-tuberculous-mycobacterial-cervical-adenitis-in-children-2-cases
#2
N Sigg, S Bailleul, J-M Turmel, G Legrand, S Kettani, L Martin
BACKGROUND: Cervical lymphadenitis is the most common manifestation of infection with nontuberculous mycobacteria (NTM) in immunocompetent children. Nevertheless, it is poorly known by dermatologists. Its incidence, which is currently increasing since the cessation of BCG vaccination in 2007, raises several issues regarding its pathophysiology, diagnosis and management. PATIENTS AND METHODS: We report two cases of NTM adenitis: one in a 2-year-old girl vaccinated with BCG and one in an unvaccinated 22-month-old boy, in whom a misleading presentation led to delayed diagnosis...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#3
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773010/mycelial-growth-and-antimicrobial-activity-of-pleurotus-species-agaricomycetes
#4
Teresa A Castillo, Renata A Lemos, José Raimundo G Pereira, José Maria A Alves, Maria Francisca S Teixeira
The objective of this study was to analyze mycelial growth under different culture conditions and antimicrobial activity of Pleurotus ostreatus (Jacq.: Fr.) Kumm. (DPUA 1533) and P. ostreatus (Jacq.: Fr.) Kumm. cv. Florida (DPUA 1534) against fungi and bacteria of medical importance. The growth of Pleurotus species was evaluated in natural and complex media, with and without light, at 25°C and 28°C for 8, 15, and 30 days. Candida albicans (DPUA 1336), Cryptococcus laurentii (DPUA 1501), Aspergillus flavus (DPUA 1836), Escherichia coli (DAUPE 224), and Mycobacterium smegmatis (ATCC 607) were used to test antibiosis...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772918/cutaneous-nontuberculous-mycobacterial-infections-in-alberta-canada-an-epidemiologic-study-and-review
#5
Megan A Sander, Judith L Isaac-Renton, Gregory J Tyrrell
BACKGROUND: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. OBJECTIVES: A database review from 2006 to 2016 was done to assess species frequency, incidence, and trends of the most common cutaneous NTMs in the province of Alberta, Canada. We also reviewed major diagnostic and epidemiologic aspects of NTM cutaneous infections with a focus on Mycobacterium marinum...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29764749/prognosis-of-chronic-pulmonary-aspergillosis-in-patients-with-pulmonary-non-tuberculous-mycobacterial-disease
#6
Maiko Naito, Yu Kurahara, Shiomi Yoshida, Naoya Ikegami, Takehiko Kobayashi, Shojiro Minomo, Kazunobu Tachibana, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
BACKGROUND: Pulmonary non-tuberculous mycobacterial disease (PNTM) is a known risk factor for chronic pulmonary aspergillosis (CPA). However, few studies have focused on the prognosis of PNTM-associated CPA. In the present investigation, we aimed to elucidate the clinical course and prognostic factors of CPA in patients with PNTM. METHODS: We retrospectively investigated the medical records of 62 patients with CPA and a history of PNTM who were admitted to Kinki-chuo Chest Medical Center between 2010 and 2015...
May 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29763927/reactive-lymphoid-hyperplasia-or-tubercular-lymphadenitis-can-real-time-pcr-on-fine-needle-aspirates-help-physicians-in-concluding-the-diagnosis
#7
Vivek Gupta, Arvind Bhake
BACKGROUND: Enlarged lymph nodes in adult patients often present a diagnostic challenge. In the absence of granuloma or necrosis, the cytology/tissue findings are misleading and relate the enlarged lymph nodes to reactive lymphoid hyperplasia (RLH), because granuloma formation is an immunological response that usually takes 14-100 days to develop. This study assesses the role of real-time (RT)-PCR in the diagnosis of the Mycobacterium complex (MTBC) in lymph node aspirates compared with culture in cases of RLH...
May 15, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29762680/tuberculosis-and-the-art-of-macrophage-manipulation
#8
S Upadhyay, E Mittal, J A Philips
Macrophages are first-line responders against microbes. The success of Mycobacterium tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive cellular niche. This is a remarkable accomplishment, as the antimicrobial arsenal of macrophages is extensive. Normally bacteria are delivered to an acidic, degradative lysosome through one of several trafficking pathways, including LC3-associated phagocytosis (LAP) and autophagy. Once phagocytozed, the bacilli are subjected to reactive oxygen and nitrogen species, and they induce the expression of proinflammatory cytokines, which serve to augment host responses...
June 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29761597/the-mycobacterium-tuberculosis-complex-has-a-pathway-for-the-biosynthesis-of-4-formamido-4-6-dideoxy-d-glucose
#9
Haley A Brown, Evgeny Vinogradov, Michel Gilbert, Hazel M Holden
Recent studies have demonstrated that the O-antigens of some pathogenic bacteria such as Brucella abortus, Francisella tularensis, and Campylobacter jejuni contain quite unusual N-formylated sugars (3-formamido-3,6-dideoxy-d-glucose or 4-formamido-4,6-dideoxy-d-glucose). Typically, four enzymes are required for the formation of such sugars: a thymidylyltransferase, a 4,6-dehydratase, a pyridoxal 5'-phosphate or PLP-dependent aminotransferase, and an N-formyltransferase. To date, there have been no published reports of N-formylated sugars associated with Mycobacterium tuberculosis...
May 15, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29761519/evaluation-of-needle-trap-micro-extraction-and-solid-phase-micro-extraction-obtaining-comprehensive-information-on-volatile-emissions-from-in-vitro-cultures
#10
Peter Oertel, Andreas Bergmann, Sina Fischer, Phillip Trefz, Anne Küntzel, Petra Reinhold, Heike Köhler, Jochen K Schubert, Wolfram Miekisch
Volatile organic compounds (VOCs) emitted from in vitro cultures may reveal information on species and metabolism. Due to low nmol L-1 concentration ranges, pre-concentration techniques are required for gas-chromatography mass-spectrometry (GC-MS) based analyses. This study was intended to compare the efficiency of established micro-extraction techniques - solid-phase micro-extraction (SPME) and needle-trap micro-extraction (NTME) - for the analysis of complex VOC patterns. For SPME, a 75 μm Carboxen®/Polydimethylsiloxane fibre was used...
May 14, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29759945/diagnosis-of-local-hepatic-tuberculosis-through-next-generation-sequencing-smarter-faster-and-better
#11
Jing-Wen Ai, Yang Li, Qi Cheng, Peng Cui, Hong-Long Wu, Bin Xu, Wen-Hong Zhang
BACKGROUND: A 45-year-old man who complained of continuous fever and multiple hepatic masses was admitted to our hospital. Repeated MRI manifestations were similar while each radiological report suggested contradictory diagnosis pointing to infections or malignances respectively. Pathologic examination of the liver tissue showed no direct evidence of either infections or tumor. We performed next-generation sequencing on the liver tissue and peripheral blood to further investigate the possible etiology...
May 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29757625/structure-and-kinetics-of-the-s-1-amino-2-propanol-dehydrogenase-from-the-rmm-microcompartment-of-mycobacterium-smegmatis
#12
Matthew S Kimber, Evan Mallette
S-(+)-1-amino-2-propanol dehydrogenase (APDH) is a short chain dehydrogenase/reductase associated with the incompletely characterized Rhodococcus and Mycobacterium bacterial microcompartment (RMM). We enzymatically characterized the APDH from M. smegmatis, and showed it is highly selective, with a low-micromolar Km for S-(+)-1-amino-2-propanol, and specificity for NADP(H). A paralogous enzyme from a non-microcompartment associated operon in the same organism was also shown to have similar activity. We determined the structure of APDH in both apo form (at 1...
May 14, 2018: Biochemistry
https://www.readbyqxmd.com/read/29755542/design-synthesis-and-antitubercular-evaluation-of-novel-series-of-pyrazinecarboxamide-metal-complexes
#13
Mohsin Ali, Mansoor Ahmed, Saleem Hafiz, Mustafa Kamal, Majid Mumtaz, Seyed Abdulmajid Ayatollahi
The interest in the synthesis of metallic complexes of different drugs to make them more efficient in biological environment of the human body is seen for the last few decades. Wide range of metal complexes are already used in clinical practice which encourages additional research for innovating new metal based drugs, such as metal-mediated antibiotics, anti-parasitic, antiviral, antibacterial, and anticancer compounds. Tuberculosis has been known as one of the most disastrous disease putting burden on health system worldwide...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29754051/label-free-nano-biosensing-on-the-road-to-tuberculosis-detection
#14
REVIEW
Behrouz Golichenari, Kelly Velonia, Rahim Nosrati, Alireza Nezami, Aref Farokhi-Fard, Khalil Abnous, Javad Behravan, Aristidis M Tsatsakis
Tuberculosis, an ailment caused by the bacterium Mycobacterium tuberculosis (Mtb) complex, is one of the catastrophic transmittable diseases that affect human. Reports published by WHO indicate that in 2017 about 6.3 million people progressed to TB and 53 million TB patients died from 2000 to 2016. Therefore, early diagnosis of the disease is of great importance for global health care programs. Common diagnostics like the traditional PPD test and antibody-assisted assays suffer the lack of sensitivity, long processing time and cumbersome post-test proceedings...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29753941/an-integrated-computational-approach-of-molecular-dynamics-simulations-receptor-binding-studies-and-pharmacophore-mapping-analysis-in-search-of-potent-inhibitors-against-tuberculosis
#15
Shivangi Agarwal, Ekta Verma, Vivek Kumar, Namrita Lall, Samaresh Sau, Arun K Iyer, Sushil K Kashaw
Tuberculosis is an infectious chronic disease caused by obligate pathogen Mycobacterium tuberculosis that affects millions of people worldwide. Although many first and second line drugs are available for its treatment, but their irrational use has adversely lead to the emerging cases of multiple drug resistant and extensively drug-resistant tuberculosis. Therefore, there is an intense need to develop novel potent analogues for its treatment. This has prompted us to develop potent analogues against TB. The Mycobacterium tuberculosis genome provides us with number of validated targets to combat against TB...
May 3, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29752576/in-silico-docking-and-molecular-dynamics-simulation-of-3-dehydroquinate-synthase-dhqs-from-mycobacterium-tuberculosis
#16
Mustafa Alhaji Isa, Rita Singh Majumdhar, Shazia Haider
The shikimate pathway is as an attractive target because it is present in bacteria, algae, fungi, and plants but does not occur in mammals. In Mycobacterium tuberculosis (MTB), the shikimate pathway is integral to the biosynthesis of naphthoquinones, menaquinones, and mycobactin. In these study, novel inhibitors of 3-dehydroquinate synthase (DHQS), an enzyme that catalyzes the second step of the shikimate pathway in MTB, were determined. 12,165 compounds were selected from two public databases through virtual screening and molecular docking analysis using PyRx 8...
May 11, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29752410/identification-and-structural-characterization-of-a-histidinol-phosphate-phosphatase-from-mycobacterium-tuberculosis
#17
Bhavya Jha, Deepak Kumar, Arun Sharma, Abhisek Dwivedy, Ramandeep Singh, Bichitra Kumar Biswal
The absence of a histidine biosynthesis pathway in humans, coupled with histidine essentiality for survival of the important human pathogen Mycobacterium tuberculosis ( Mtb ), underscores the importance of the bacterial enzymes of this pathway as major anti-tuberculosis drug targets. However, the identity of the mycobacterial enzyme that functions as the histidinol phosphate phosphatase (HolPase) of this pathway remains to be established. Here, we demonstrate that the enzyme encoded by the Rv3137 gene, belonging to the inositol monophosphatase (IMPase) family, functions as the Mtb HolPase and specifically dephosphorylates histidinol phosphate...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29746563/ancient-genomes-reveal-a-high-diversity-of-mycobacterium-leprae-in-medieval-europe
#18
Verena J Schuenemann, Charlotte Avanzi, Ben Krause-Kyora, Alexander Seitz, Alexander Herbig, Sarah Inskip, Marion Bonazzi, Ella Reiter, Christian Urban, Dorthe Dangvard Pedersen, G Michael Taylor, Pushpendra Singh, Graham R Stewart, Petr Velemínský, Jakub Likovsky, Antónia Marcsik, Erika Molnár, György Pálfi, Valentina Mariotti, Alessandro Riga, M Giovanna Belcastro, Jesper L Boldsen, Almut Nebel, Simon Mays, Helen D Donoghue, Sonia Zakrzewski, Andrej Benjak, Kay Nieselt, Stewart T Cole, Johannes Krause
Studying ancient DNA allows us to retrace the evolutionary history of human pathogens, such as Mycobacterium leprae, the main causative agent of leprosy. Leprosy is one of the oldest recorded and most stigmatizing diseases in human history. The disease was prevalent in Europe until the 16th century and is still endemic in many countries with over 200,000 new cases reported annually. Previous worldwide studies on modern and European medieval M. leprae genomes revealed that they cluster into several distinct branches of which two were present in medieval Northwestern Europe...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29746087/mechanism-of-action-of-mycobacterium-tuberculosis-gyrase-inhibitors-a-novel-class-of-gyrase-poisons
#19
Elizabeth G Gibson, Tim R Blower, Monica Cacho, Ben David Bax, James M Berger, Neil Osheroff
Tuberculosis is one of the leading causes of morbidity worldwide and the incidences of drug resistance and intolerance are prevalent. Thus, there is a desperate need for the development of new anti-tubercular drugs. Mycobacterium tuberculosis gyrase inhibitors (MGIs) are napthyridone/aminopiperidine-based drugs that display activity against M. tuberculosis cells and tuberculosis in mouse models [Blanco, D., et al. (2015) Antimicrob. Agents Chemother. 59, 1868-1875]. Genetic and mutagenesis studies suggest that gyrase, which is the target for fluoroquinolone antibacterials, is also the target for MGIs...
May 10, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29745925/-mechanism-of-action-of-intravesical-bcg-biological-bases-and-clinical-applicability
#20
Joaquín A Carballido, María Rodríguez Monsalve
The therapeutic approaches developed around immune system modulation find the therapeutic contribution of intravesical Bacillus Calmette Guerin (BCG) for transitional cell bladder cancer an unquestionable example as a proof of concept of antitumor immunotherapy since more than 30 years ago. Intravesical immunotherapy for urothelial carcinomas is considered with periodic intravesical instillations schedules, and the one with longer historic development and wider diffusion is BCG in the form of suspension. BCG is a unique strain obtained from Mycobacterium bovis at the end of the first third of the XX century and represents the historically most successful immunotherapeutic modality of all tumors with a high level body of evidence...
May 2018: Archivos Españoles de Urología
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